• Korean Journal of Acupuncture
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• 제19권1호
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• pp.25-33
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• 2002

Substantial evidence suggests that behavioral and reinforcing effects of cocaine can be mediated by the mesolimbic dopaminergic system. Injections of cocaine can produce one of the immediate-early gene, c-fos expression in the brain and behavioral activation. Acupuncture as a therapeutic intervention is widely used for the treatment of many mental disorders such as drugs of abuse. In order to investigate whether acupuncture has an influence on cocaine-induced reinforcing and behavioral effects, we examined the effect of acupuncture on cocaine-induced locomotor activity and c-Fos expression in the nucleus accumbens and the striatum using Fos-like-immunoreactivity(FLI). Male SD rats received acupuncture for 1 min after injection of cocaine hydrochloride(1 mg/kg, i.v.). The employed acupuncture point, Shenmen$(HT_7)$, has been clinically used to treat mental and psychosomatic disorders. Injections of cocaine produced a marked increase in locomotor activity and FLI in the nucleus accumbens and the striatum. Acupuncture at $HT_7$, but not at control points($PC_6,\;TE_4$ or tail), significantly attenuated cocaine-induced increase in locomotor activity and Fos-like immunoreactivity. These results demonstrated that reduction in locomotor activity by acupuncture may be reflected by reduction of postsynaptic neuronal activity in the nucleus accumbens and the striatum. Our results suggest that acupuncture may have a therapeutic effect on cocaine addiction.

• 한국구조물진단유지관리공학회 논문집
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• 제17권2호
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• pp.83-93
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• 2013

일반적으로 송전철탑 부재들의 보강은 적절한 그라우팅재를 활용한 인젝션과 구조 보강재 부착을 이용한 단면 확장에 따른 강성보강 방식을 주로 사용한다. 이와 같은 그라우팅 인젝션 및 단면보완은 주로 축력능력을 확장시키는 데에 의미를 갖는다. 그렇지만 보다 안정적 상태를 유지케 할 수 있는 보강방안이 적극 요구되는데 그 방법은 좌굴에 의해 손상을 받은 부재를 원상태의 길이로 환원시키고, 또한 내부적 보강효과를 동시에 갖는 새로운 부재로 교체하는 것이다. 본 연구에서는 기초침하로 구조적 손상을 받은 송전철탑의 손상회복을 위한 실증적 과정으로 우선 현장에서의 손상도 확인점검과 손상상태 및 회복상태에 대한 수치 해석적 결과를 도출하였고, 새롭게 고안한 잭킹시스템을 이용하여 보강된 부재를 교체하는 과업을 수행하였다. 이 결과는 송전철탑 유지관리의 차원상승 효과를 갖게 한다.

• 한국가스학회지
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• 제15권2호
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• pp.82-87
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• 2011

열매체유는 화학공장의 가열시스템, 열교환 시스템, 가스플랜트 공정, 사출성형 시스템 및 펄프제지 공정 등에 사용된다. 열매체유는 고열이나 산화분해에 아주 안정하고 저항성이 있으며, 누출이나 방출의 경우 점화원을 만나면 쉽게 발화한다. 본 논문은 열메체유의 신유와 사용유에 대해 인화성과 열적 안정성을 고찰하였다. 열매체유의 인화성은 인화점과 자연발화점을 측정하여 평가하였고, 열적안정성은 열안정성시험기와 시차주사열량기를 사용하여 평가하였다. 실험결과로부터 열매체유의 적절한 사용과 취급과 관련된 안전대책 수립을 위해 화재 위험 특성을 제시하였다.

• 한국추진공학회지
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• 제21권3호
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• pp.41-48
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• 2017

전단 동축형 인젝터를 통해 분사된 친환경 이원추진제 기체메탄-기체산소의 연소특성을 규명하기 위한 연구를 수행하였다. DSLR카메라를 이용하여 다양한 연소조건에서 화염을 촬영하였고, 이미지 후처리 기법을 통해 화염형상을 정량화한 후 그 특성을 분석하였다. 안정화 관점에서 확산화염은 anchored flame regime과 blow-off regime으로 구분될 수 있었으며, 산화제 레이놀즈 수($Re_o$)가 증가함에 따라 부착화염의 형성, 화염의 길이가 증가하는 경향을 나타냈다. 본 실험에 이용된 전단 동축형 인젝터는 추진제 제트의 운동량 확산에만 종속하고 그리 양호하지 않은 혼합으로 인해 분사방향으로 길이가 긴 화염을 형성하게 되므로 보다 큰 연소실 길이직경비가 요구됨을 확인할 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제19권4호
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• pp.212-217
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• 2015

Purpose: For a single time-point hyperpolarized $^{13}C$ magnetic resonance spectroscopy imaging (MRSI) of animal models, scan-time window after injecting substrates is critical in terms of signal-to-noise ratio (SNR) of downstream metabolites. Pre-scans of time-resolved magnetic resonance spectroscopy (MRS) can be performed to determine the scan-time window. In this study, based on two-site exchange model, protocol-specific simulation approaches were developed for $^{13}C$ MRSI and the optimal scan-time window was determined to maximize the SNR of downstream metabolites. Materials and Methods: The arterial input function and conversion rate constant from injected substrates (pyruvate) to downstream metabolite (lactate) were precalibrated, based on pre-scans of time-resolved MRS. MRSI was simulated using two-site exchange model with considerations of scan parameters of MRSI. Optimal scan-time window for mapping lactate was chosen from simulated lactate intensity maps. The performance was validated by multiple in vivo experiments of BALB/C nude mice with MDA-MB-231 breast tumor cells. As a comparison, MRSI were performed with other scan-time windows simply chosen from the lactate signal intensities of pre-scan time-resolved MRS. Results: The optimal scan timing for our animal models was determined by simulation, and was found to be 15 s after injection of the pyruvate. Compared to the simple approach, we observed that the lactate peak signal to noise ratio (PSNR) was increased by 230%. Conclusion: Optimal scan timing to measure downstream metabolites using hyperpolarized $^{13}C$ MRSI can be determined by the proposed protocol-specific simulation approaches.

• 한국분무공학회지
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• 제10권2호
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• pp.1-9
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• 2005

An experimental study was carried out to obtain the fundamental data about the effects of radical ignition on premixture combustion. A CVC(constant volume combustor) divided into the sub-chamber and the main chamber was used. Numerous narrow passage holes are arranged between the main chamber and the sub-chamber. The products including radicals generated by spark ignition in tile sub-chamber derives the simultaneous multi-point ignition in the main chamber. We have examined the effects of the sub-chamber volume, the diameter and number of passage holes, and the equivalence $ratio({\Phi})$ on the combustion characteristics by means of burning pressure measurement and flame visualization. In a CVC, the overall burning time including the ignition delay became very short and the maximum burning pressure was slightly increased by the radical ignition(RI) method in comparison with those by the conventional spark ignition(SI) method. Combustible lean limit by RI method is extended by ${\Phi}=0.25$ compared with that by SI method. Also, In cases of charging the number and the diameter for the fixed total cross section of the passage holes, combustion period increased significantly at a sub-chamber with a single hole, but those of the other conditions had almost a similar tendency in the sub-chamber with 4 or more holes. regardless of equivalence ratio. Therefore, it was Proved that a critical cross section exists with the number of passage holes.

• 기본간호학회지
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• 제6권1호
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• pp.18-34
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• 1999

Nurse's caring behaviors are essential to help patients cope with their health problems. The purpose of this study was to investigate the importance of nurse's caring behaviors as perceived by staff nurses and patients. The subjects were 295 staff nurses and 340 patients from five medical centers in Taegu. Data collection was done from Dec. 10, 1997 to Jan. 31, 1998. The tool for this study was a 7 point Likert type scale with 27 earing behaviors developed by Lee(1996). Cronbach alpha of the tool was .9701 in staff nurses and .9618 in patients. Data were analyzed with SAS using t-test, ANOVA and Spearman rank correlation program. The results are as follows : 1. The a verage score of perceived importance of nurse's taring behaviors for the 27 items was 5.65 in staff nurses and 4.97 in patients. 2. The most important caring behaviors perceived by the nurses was 'Nurse gives painless and cautious injection and treatment for patients' and for the patients, 'Nurse gives hygienic treatment and nursing care'. 3. The caring behavior which showed a significant difference between the ranks of perceived importance by staff nurses and patients was 'to treat the patient with tenderness and friendship'. 4. The Spearman rank correlation coefficient between the ranks of importance perceived by staff nurses and patients was 0.8302. With the results of this study, the staff nurses could be recognized to have much enthusiasm and passion about caring. It is suggested that nurses let the public know about the nurses' caring roles. In the future, research to investigate the actual practice of nurses' caring behavior is necessary.

• 대한지역사회영양학회지
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• 제16권1호
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• pp.155-168
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• 2011

This study was conducted to assess needs of self-management nutrition program for diabetic patients. The survey was conducted among 100 diabetic patients, and the mean age of the subjects was 54.2 years old. Thirty three percent of the subjects were diagnosed diabetes less than 2 years ago. The average nutrition knowledge score about diabetes was 10.2 point, and percentages of correct answers were very high in 'foods rich in fiber' (97.0%), 'relevance of exercise and insulin' (97.0%), 'quantity of insulin injection' (91.0%), and 'diabetes menu' (91.0%). The sources of nutrition information were hospitals/healthcare centers (56.1%), TV/radio (19.2%), and internet (13.1%). Sixty nine percent of the subjects have experienced nutrition education on subjects as 'menu planning skills'(22.4%), 'selecting foods' (22.4%), 'relevance of blood glucose and eating foods' (21.5%) by personal counseling (54.4%). The total score of eating behavior was higher after diagnosed diabetes (35.3) than before (30.0) (p < 0.001). The preferred topics in developing diabetes nutrition information websites were 'diabetes mellitus', 'relevance of blood glucose and foods', and 'selecting foods for diabetes'. The subjects wanted the websites developed by 'using mainly illustrations, pictures, tables' (22.8%) and 'using simple design' (19.6%). The preferred contents in developing diabetes self-management nutrition program were 'dietary life diagnosis', 'chronic disease risk diagnosis', 'calorie control by selecting foods and cooking skills', and 'dietary assessment'. In designing the program, the subjects' most wanted designs were 'be handy and simple in using' (29.3%), 'using simple design' (17.9%), and 'using mainly illustrations, pictures, tables' (15.7%).

• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.40-53
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• 1998

Mast cells play an important role in the pathophysiologlcal changes observed in acute cutaneous and inflammatory diseases In order to see whether Kum-Hwang-San has an influence on mast cell- mediated immediate cutaneous reactions, the author has undertaken an animal study. Ears of mice were treated with a compound 48/80 solution topically at 30 min after the cutaneous application of Kum-Hwang-San. At each point, an ear swelling response was measured with a digimatic thickness micrometer. Ear swelling response induced by compound 48/80 was significantly suppressed dose-dependently by Kum-Hwang-San 30 min before topical application as compared with that in nonapplicated control mice, and the value returned to normal levels by 120 min. Compound 48/80- induced mast cell degranulation by Kum-Hwang-San was also remarkably decreased in accordance with the suppression in ear swelling response. Kum-Hwang-San dose-dependently inhibited histamine release from the rat peritoneal mast cells activated by compound 48/80. Another way to test acute cutaneous reaction is to induce passive cutaneous anaphylactic reaction. Kum-Hwang-San significantly inhibited passive cutaneous anaphylactic reaction activated by anti-dinitrophenyl IgE on both topical application and intradermal injection. Kum-Hwang-San also inhibited histamine release from the rat peritoneal mast cells induced by anti-DNP IgE. This study provides evidence that Kum-Hwang-San will be beneficial in the treatment of acute cutaneous diseases.

• 대한기관식도과학회지
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• 제14권2호
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• pp.31-37
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• 2008

Background and Objectives: In most cases of benign neck cysts, surgical excision has been considered as treatment of choice. However, sometimes complete excision is very difficult, and recurrences has been occured due to insufficient surgery frequently. In this point of view, non-surgical treatment has been attempted with sclerosing agents such as picibanil(OK-432). In this study, we evaluated the efficacy of picibanil sclerotherapy for benign neck cysts. Materials and methods: We retrospectively reviewed 53 patients(27 males, 26 females) who had undergone sclerotherapy with picibanil for benign neck cysts such as ranula, lymphangioma, thyroglossal duct cyst and branchial cyst. Information was gathered with respected to age, sex, number of injections, side effect and outcome of treatment. All patients were treated with intralesional aspiration of cystic contents and injection of picibanil, and followed on neck ultrasonography or neck CT. Results: 53 patients received sonoguided sclerotherapy using picibanil(OK-432). 31 patients(41.3%) showed total shrinkage, near total shrinkage(more than 90% of volume) in 7 patients(9.3%), marked shrinkage(more than 70%) in 5 patients(6.6%) and partial shrinkage(less than 70%) in 17 patients. 15 patients(20%) reaveled no response and 8 patients showed recurrences with repeated sclerotherapy. The side effects of therapy were observed by symptoms such as fever, localized pain and odynophagia. However, these complications disappeared after several days in all cases. Conclusions: We recognized that picibanil(OK-432) sclerotherapy for benign neck cyst is a safe and effective procedures as a primary treatment before considering surgery.