Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Determination of Optimal Scan Time for the Measurement of Downstream Metabolites in Hyperpolarized 13C MRSI

  • Lee, Hansol (Department of Electrical & Electronic Engineering, Yonsei University) ;
  • Lee, Joonsung (Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University) ;
  • Joe, Eunhae (Department of Electrical & Electronic Engineering, Yonsei University) ;
  • Yang, Seungwook (Department of Electrical & Electronic Engineering, Yonsei University) ;
  • Choi, Young-suk (Department of Radiology, Yonsei University College of Medicine) ;
  • Wang, Eunkyung (Department of Radiology, Yonsei University College of Medicine) ;
  • Song, Ho-Taek (Department of Radiology, Yonsei University College of Medicine) ;
  • Kim, Dong-Hyun (Department of Electrical & Electronic Engineering, Yonsei University)
  • Received : 2015.06.23
  • Accepted : 2015.09.10
  • Published : 2015.12.31
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Abstract

Purpose: For a single time-point hyperpolarized $^{13}C$ magnetic resonance spectroscopy imaging (MRSI) of animal models, scan-time window after injecting substrates is critical in terms of signal-to-noise ratio (SNR) of downstream metabolites. Pre-scans of time-resolved magnetic resonance spectroscopy (MRS) can be performed to determine the scan-time window. In this study, based on two-site exchange model, protocol-specific simulation approaches were developed for $^{13}C$ MRSI and the optimal scan-time window was determined to maximize the SNR of downstream metabolites. Materials and Methods: The arterial input function and conversion rate constant from injected substrates (pyruvate) to downstream metabolite (lactate) were precalibrated, based on pre-scans of time-resolved MRS. MRSI was simulated using two-site exchange model with considerations of scan parameters of MRSI. Optimal scan-time window for mapping lactate was chosen from simulated lactate intensity maps. The performance was validated by multiple in vivo experiments of BALB/C nude mice with MDA-MB-231 breast tumor cells. As a comparison, MRSI were performed with other scan-time windows simply chosen from the lactate signal intensities of pre-scan time-resolved MRS. Results: The optimal scan timing for our animal models was determined by simulation, and was found to be 15 s after injection of the pyruvate. Compared to the simple approach, we observed that the lactate peak signal to noise ratio (PSNR) was increased by 230%. Conclusion: Optimal scan timing to measure downstream metabolites using hyperpolarized $^{13}C$ MRSI can be determined by the proposed protocol-specific simulation approaches.

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References

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