• Tuberculosis and Respiratory Diseases
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• 제66권3호
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• pp.236-240
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• 2009

저자들은 당뇨병의 과거력이 있는 57세 여자로 발열 및 호흡곤란을 주소로 내원하여 Mycoplasma pneumoniae에 의한 ARDS를 동반한 중증폐렴으로 오인되어 Levofloxacin 투여로 호흡곤란의 일시적인 호전 및 방사선적 소견상 호전을 보여 퇴원하였다. 퇴원 후 발열과 발한으로 시행한 HRCT 및 개흉 폐생검을 통해 속립성 결핵으로 진단되어 항결핵제 치료를 시행한 후 증상과 방사선학적 호전을 보였다. 폐렴의 치료 시 사용되는 fluoroquinolone제제의 결핵균에 대한 효과로 인해 결핵진단의 지연을 가져올 수 있어 급성 호흡곤란증후군과 같이 비전형적인 임상양상을 나타내는 속립성 결핵의 진단 시 주의를 기울여야겠다.

• 대한기계학회논문집B
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• 제32권4호
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• pp.283-289
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• 2008

An experimental investigation was conducted to investigate the heat/mass transfer for impingement/effusion cooling system with inclined jet. Jets with inclined angle of 60 are applied to impingement/effusion cooling. At the jet Reynolds number of 10,000, the experiments were carried out for blowing ratios ranging from 0.0 to 1.5. The local heat/mass transfer coefficients on the effusion plate are measured using a naphthalene sublimation method. The result indicates that the inclined jet causes the non-uniform and low heat/mass transfer compared to the vertical jet. At stagnation region, the peak position is shifted from the geometrical center of injection hole due to Coanda effect and its level is higher than that of vertical jet due to increase in turbulence intensity by steep velocity gradient near the stagnation region. Further, the secondary peak region disappears because the interaction between adjacent wall jets weakens. When the initial crossflow occurs, the distorted heat/mass transfer pattern appears. As the blowing ratio (crossflow rate) increases, the heat/mass transfer distributions become similar to those of the vertical jet. This is because the effect of crossflow is dominant compared to that of inclined jet under high blowing ratio $(M{\geq}1.0)$. At low blowing ratio $(M{\leq}0.5)$, averaged Sh value is 10% lower than that of vertical jet, whereas its value at high blowing ratio $(M{\geq}1.0)$ is similar to that of vertical jet.

• Geomechanics and Engineering
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• 제20권5호
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• pp.399-410
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• 2020

Cavities often develop behind the vault during the construction of double-arch tunnels, generally in the form of various defects. The study evaluates the impact of cavities behind the vault on the mechanical and failure behaviors of double-arch tunnels. Cavities of the same sizes are introduced at the vault and the shoulder close to the central wall of double-arch tunnels. Physical model tests are performed to investigate the liner stress variation, the earth pressure distribution and the process of progressive failure. Results reveal that the presence of cavities behind the liner causes the re-distribution of the earth pressure and induces stress concentration near the boundaries of cavities, which results in the bending moments in the liner inside the cavity to reverse sign from compression to tension. The liner near the invert becomes the weak region and stress concentration points are created in the outer fiber of the liner at the bottom of the sidewall and central wall. It is suggested that grouting into the foundation soils and backfilling injection should be carried out to ensure the tunnel safety. Changes in the location of cavities significantly impact the failure pattern of the liner close to the vault, e.g., cracks appear in the outer fiber of the liner inside the cavity when a cavity is located at the shoulder close to the central wall, which is different from the case that the cavity locates at the vault, whereas changes in the location of cavities have a little influence on the liner at the bottom of the double-arch tunnels.

• Restorative Dentistry and Endodontics
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• 제19권2호
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• pp.485-498
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• 1994

Porphyromonas endodontalis is a black-pigmented anaerobic Gram-negative rod which is associated with endodontal infections and this microorganism possesses a potential for pathogenicity. The purpose of this study was to compare the membrane components of Porphyromonas endodontalis and Porphyromonas gingivalis and to study the immune reaction patterns of Porphyromonas endodontalis with patients with periapical lesion. Porphyromonas endodontalis (ATCC 35406), Porphyromonas gingivals serotypea (381), serotype b(W50), serotype c(A7A1-28) were cultured in anaerobic condition. Rabbit antisera were prepared by intravenous injection of formalized whole cells and human sera were obtained from patients and dental students. Indirect immunofluorescence method was used to study on the cross reaction between Porphyromonas endodontalis and Porphyromonas gingivalis serotype a, b, c antigen. Total membrane protein profiles of Porphyromonas endodontalis antigen were studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis and the reactivity of antigenic components of Porphyromonas endodontalis against sera of patients and rabbit anti-Porphyromonas endodontalis antisera were assessed by Immunoblotting method. The following results were obtained : 1. Antigens of Porphyromonas endodontalis has multiple antigenic components, and both patients with periapical lesion and normal healthy individual showed immune response to this. 2. Patients group and healthy individual group showed a diversity of immune reaction pattern but they showed immune response against 43kd protein. 3. Patients with periapical lesion showed more diverse immune response than healthy individual and in some patients, much more bands appeared to lower molecular weight protein. 4. According to indirect immunofluorescence and Immunoblotting study, Porphyromonas endodontalis did not share common antigen with Porphyromonas gingivalis serotype a, b, c.

• 한국유체기계학회 논문집
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• 제8권4호
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• pp.39-47
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• 2005

The present study has been performed to investigate the influences of rectangular fins on heat transfer in an impingement/effusion cooling system with crossflow. To simulate the impingement/effusion cooling system with initial crossflow, two perforated plates are placed in parallel and staggered arrangements with a gap distance of 2 times of the hole diameter. The crossflow passes between the plates, and various rectangular fins are installed on the plates. Reynolds number based on the hole diameter is fixed to 10,000 and the flow rate of crossflow is changed from 0.5 to 1.5 times of that of the impinging jet. A naphthalene sublimation method is used to obtain the heat/mass transfer coefficients on the effusion plate. Also to analyze the flow characteristics, a numerical calculation is performed. When rectangular fins are installed, the flow and heat transfer pattern is changed greatly from the case without fins. In the injection hole region, the jet impinges on effusion plate without deflection and wall jet spreads symmetrically. In the effusion region, the crossflow accelerates due to the decrease of cross-sectional area in the channel. Local heat/mass transfer coefficients are enhanced significantly compared to the case without fins. As the blowing ratio increases, the effect of rectangular fins against the crossflow becomes more significant and then the higher average heat/mass transfer coefficients are obtained than the case without fins. However, the increase of blockage effect gives more pressure loss in the channel.

• 한국자동차공학회논문집
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• 제22권2호
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• pp.156-165
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• 2014

This paper is the first investigation on the effect of flow control methods on the part load performance in a spark ignition engine. For comparison of the methods, two control devices, port throttling and masking, were applied to a conventional engine without any design change of the intake port. Steady flow evaluation shows that steady flow rates per unit opening area and swirl ratio are very low compared with the port throttling and saturated from mid-stage valve lift, however, swirl increases slightly as the lift is higher in case of 1/4 masking control. In the part load performance, the effect of simple port throttling on lean misfire limit expansion is limited and insufficient; on the other hand a masking improves the limit considerably without any port modification for increasing swirl. Also the results show that the intake flow control improves the combustion with following two mechanisms: stratification induced by the combination of the flow pattern and the fuel injection timing attribute to ignition ability and the intensified flow ensure fast burn. In addition fuel consumption reduces under the flow controls and the reduction rate is different according to the operation conditions and control methods. At the Stoichiometric and/or low speed and low load the throttling method is more advantageous; however vice versa at lean and high load condition. Finally, the throttling is more efficient for HC reduction than masking, on the other side the NOx emissions increase under the masking and decrease under the port throttling compared with conventional port scheme.

• The Korean Journal of Physiology and Pharmacology
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• 제1권3호
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• pp.241-249
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• 1997

The aim of the present study is to examine the brainstem sites where the electrical stimulation produces a suppression of dorsal horn neuron responses of neuropathic rats. An experimental neuropathy was induced by a unilateral ligation of L5-L6 spinal nerves of rats. Ten to 15 days after surgery, the spinal cord was exposed and single-unit recording was made on wide dynamic range (WDR) neurons in the dorsal horn. Neuronal responses to mechanical stimuli applied to somatic receptive fields were examined to see if they were modulated by electrical stimulation of various brainstem sites. Electrical stimulation of periaqueductal gray (PAG), n. raphe magnus (RMg) or n. reticularis gigantocellularis (Gi) significantly suppressed responses of WDR neurons -to both noxious and non-noxious stimuli. Electrical stimulation of other brainstem areas, such as locus coeruleus. (LC) and n. reticularis paragigantocellularis lateralis (LPGi), produced little or no suppression. Microinjection of morphine into PAG, RMg, or Gi also produced a suppression as similar pattern to the case of electrical stimulation, whereas morphine injection into LC or LPGi exerted no effects. The results suggest that PAG, NRM and Gi are the principle brainstem nuclei involved in the descending inhibitory systems responsible for the control of neuropathic pain. These systems are likely activated by endogenous opioids and exert their inhibitory effect by acting on WDR neurons in the spinal cord.

• Parasites, Hosts and Diseases
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• 제31권2호
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• pp.83-90
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• 1993

간흡충에 감염된 담관은 확장되면서 상피세포의 수가 크게 증식하여 점막층이 두꺼워지고 과식증에 의해 점막의 단면이 유두상으로 관찰된다. Bromodeoxyuridine (BrdU)이 세포가 핵산을 복제할 때에 끼어 들어가는 성질을 이용하여, 이 연구에서는 담관 상피세포 중에서 합성기(Sphase)에 있는 세포의 분율을 파악하고자 하였다. 흰쥐에 간흡충의 피낭유충을 100 개씩 경구 감염시키고, 15주까지 간의 각 엽에 있는 담관의 조직절편을 만들어서 다세포군항체와 ABC complex를 이용한 염색을 실시하였다. 그 결과 충제가 들어 있는 담관에서는 감염 1주에 상피 세포의 2.9-10.2%가 염색에 양성이었고, 2주에 7.3-12.8%가, 5주에는 7.3-13.4%가, 15주에 8.4-14.8%가 BrdU를 함유하였다. 대조군 흰쥐나 실험군 동물의 감염되지 않은 담관의 경우에는 0-2.7%가 염색에 양성으로 나타났다. 염색된 상피세포는 주로 점막 상피세포층의 기저부에서 관찰되었다. 이 결과에 의하면 간흡충과 직접 접촉하는 담관의 상피세포가 뚜렷하게 증식하고 있어 충체의 어떠한 물리적인 또는 화학적인 자극이 있더라도 가까운 부위에서 주로 작용하고 있다고 판단하였다.

• Biomolecules & Therapeutics
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• 제4권4호
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• pp.349-353
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• 1996

The present study examined pharmacokinetic profiles of KBP31705-Cl27 and KBP30603-901, new platinum coordination complexes synthesized as anticancer candidates, in comparison with two well-known platinum-containing anticancer agents, cisplatin and carboplatin in rats. Under sodium pentobarbital anesthesia of male Sprague-Dawley rats, urinary bladder, and femoral artery and vein were catheterized for urine collection, blood sampling and drug injection, respectively Following i.v. administration of cisplatin (2 mg/kg), KBP31705-C127 (2 mg/kg), carboplatin (20 mg/kg) or KBP30603-901 (20 mg/kg), blood samples were collected at 2, 4, 6, 8, 10, 15, 20, 30, 45, 60 and 120 minutes. Urine samples were collected at 1-hr interval for 4 hr. Platinum concentrations in plasma and urine were measured using an inductively coupled plasmamass spectrometer. The plasma concentration-time curves were biphasic for all drugs during the time period studied. Compared with cisplatin, KBP31705-C127 showed similar decay patters in the alpha- and betaphases with slightly lower plasma concentrations. Urinary platinum excretion for cisplatin and KBP31705-C 127 was 56 and 52% of the administered dose in 4 hr, respectively. With regard to carboplatin and KBP 30603-901, a similar decay pattern was also observed in the alpha-phase. The half life of KBP30603-901 in the beta-phase, however, was much longer than that of carboplatin, which was consistent with the urinary excretion results that 46 and 59% of the administered dose were excreted in the urine in 4hr, respectively. The results suggest that platinum coordination complexes are primarily excreted via the renal route and KBP30603-901 can elicit longer duration of action due to slower renal excretion compared to carboplatin.

• 대한수의학회지
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• 제24권1호
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• pp.1-7
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• 1984

This macroscopic observation was performed to investigate the aortic arch and their branches of the Korean native goat. Ten Korean native goats with black hairs ranging in body weight from 15 to 20kg were used. The findings were based on the latex cast of the vessels made by injection of neoprene latex. The results obtained were as follow; 1. The aortic arch of the Korean native goat gave off only one vessel, the Truncus brachiocephalicus. 2. The Truncus brachiocephalicus gave off the A. subclavia sinistra, the A. subclavia dextra and the Truncus bicaroticus. 3. The A. subclavia sinistra gave off the Truncus costocervicalis, the A. cervicalis superficialis and the A. thoracica interna, and continued as the A. axillaris sinistra. 4. The Truncus costocervicalis sinistra arose from the A. subclavia sinistra in all cases and gave off the A. scapularis dorsalis suprema and the A. cervicalis profunda, and continued as the A. vertebralis sinistra. 5. The branching pattern of the A. subclavia dextra was similar to that of the A. subclavia sinistra except the Truncus costocervicalis. The Truncus costocervicalis dextra was arisen together with the A. subclavia dextra in 8 out of 10 cases, while one of the remaining 2 cases arose as the first branch of the A. subclavia dextra and the other was given off directly from the Truncus brachiocephalicus. 6. The Truncus bicaroticus was continued from the Truncus brachiocephalicus after branching off the A. subclavia dextra in 8 out of 10 cases, but the Aa. carotidas communes sinistra and dextra were directly branched from the Truncus brachiocephalicus without forming the Truncus bicaroticus in the remaining 2 cases.