• Journal of Korean Society on Water Environment
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• v.26 no.5
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• pp.775-780
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• 2010

Over 90% of the livestock excretions were treated and utilized by land application in Korea. Excessive application of the livestock manure as fertilizer has been issued as a main pollutant source in groundwater and watersheds. This study was seasonally conducted to identify the discharging characteristics with a certain artificial rainfall intensity (13 mm/hr) in terms of surface runoff, groundwater, and soil residue mass depending on the livestock manure types. A experimental field was constructed with three different sites that pig liquid fertilizer (LF), cattle manure (CM), and standard (S). The pig liquid fertilizer of 1,200 L and cattle manure of 900 kg were sprayed on each site ($50m^2$). The standard area was firmly prevented from any other contaminants. In the LF site, farmland discharging rate (FDR) was computed as 0.006 in CODcr, 0.015 in TN, and 0.029 in TP, resulted from the mass balance among total injection mass, surface runoff and groundwater. In the CM site, 29% of the nitrogen and phosphorus in each were discharged to the surface, and 64% and 58% of them were remained in the farmland. Surface runoff rate of the CM was higher than that of the LF, resulted from the solid form of the CM.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.2
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• pp.251-257
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• 2008

Food compost, having a higher organic contents than soil, could be an alternative material to prevent the proliferation of heavy metals contamination in soil. In this study we used a convection-dispersion local equilibrium sorption model(CDE) and a two-site non-equilibrium sorption model to find the effects on the adsorption and transportation of Pb by mixing food compost with soil and we also tried to find the effect of velocity and concentration of the injected solution on the characteristics of Pb. We measured Pb concentrations in injection-liquid and in effluent, and then applied them to CXTFIT program. As a result of column experiments, some parameters(D, R, ${\beta}$, ${\omega}$) used in two-site non-equilibrium adsorption model were obtained. Characteristics of Pb adsorption and transport were analyzed using the parameters(D, R, ${\beta}$, ${\omega}$) obtained from the CXTFIT program, We could know that mixed soil with food compost showed a higher adsorption capacity from the retardation factor(R) calculated from the breakthrough curve(BTCs) of Pb. Rs of soil and mixed soil are 20.45, 37.45 respectively, indicating that the adsorption and the transportation characteristics could be accessed quantitatively by using of two-site non-equilibrium adsorption model.

• Korean Journal of Biological Psychiatry
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• v.19 no.4
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• pp.187-192
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• 2012

Objectives Although antipsychotic drug clozapine has superior efficacy, this is hampered by metabolic side effects such as weight gain and diabetes. Recent studies demonstrate that clozapine induces insulin resistance. However, the identity and location of insulin resistance induced by clozapine has not been clarified. In this study, the effect of clozapine on central insulin response was investigated in rats. Methods Male Sprague-Dawley rats received intraperitoneal injection of clozapine or vehicle, which was followed by intracerebroventricular injection of insulin or its vehicle. The effects of clozapine on insulin-induced changes in blood glucose level and Akt phosphorylation in hypothalamus were investigated. Results Intraperitoneal injection of clozapine (20 mg/kg) increased blood glucose in rats. Intracerebroventricular injection of insulin reduced blood glucose in rats, which was blunted by pretreatment of clozapine. Accompanied with the antagonistic effect of clozapine to central insulin action in terms of blood glucose, clozapine inhibited the insulin-induced phosphorylation of Akt at Ser473 in rat hypothalamus. Conclusion Administration of clozapine inhibited the central insulin-induced changes in blood glucose and Akt phosphorylation in rat hypothalamus. These findings suggest that hypothalamus could be the site of action for the clozapine-induced insulin resistance.

• Development and Reproduction
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• v.20 no.3
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• pp.267-274
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• 2016

Cichlid fish species exhibit characteristic sexual behaviors according to not only reproductive stages but also social status. In a reproductive season, Astatotilapia burtoni males compete for females and a small number of dominant winners finally obtain the chance of spermiation. In addition to the characteristic behaviors, the dominant males have relatively bigger gonadotropin-releasing hormone 1 (GnRH1) neurons in the preoptic area (POA) of brain compared to those of subordinate males. Although the stimulatory effect of GnRH1 in vertebrate reproduction is well established, little is known about the triggering signal pathway to control GnRH1 neurons and GnRH1-mediated sexual behavior. In the present study, we evaluated the potential effect of TOR inhibitor rapamycin in relation to the cichlid male behaviors and GnRH1 neuron. After 14 h and 26 h of intraventricular injection of rapamycin, behavior patterns of chasing and courtship display did not show significant changes between rapamycin- and DMSO-injected males. Behaviors of spawning site entry increased in rapamycin-injected fish at 26 h post-injection than at 14 h post-injection significantly (P<0.05). Meanwhile, there was a tendency that GnRH1 neurons' soma size in the POA shrank by rapamycin injection, whereas the testes did not show notable changes. Taken together, these results suggest the possible role of TOR signal on GnRH1-mediated sexual behavior in cichlid dominant males, although further biological characterization of the TOR signaling pathway will be required to clarify this matter.

• Journal of Biosystems Engineering
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• v.35 no.3
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• pp.163-168
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• 2010

With income growth and "well-being" trends, sales of corn has been increased recently. Corns are processed at processing facilities on the main production site. Corn processing steps include removing bract, steaming, vacuum packing, and storing. To replace manual corn bract removing, some bract removing machines were imported and used. However, the machines were abandoned shortly, because of high damaging ratio of corns. In this research, factors of successful bract removing was studied with rotating rollers and air-injection nozzles to develop corn bract removing system. The test device was composed of a cylindrical roller, an air spray nozzle, a regulator, and a motor. Designing factors were roller type, diameter of air spraying nozzle, spraying angle, and spraying pressure. The measured factors were bract removing rate and damaging rate. It was found that optimum cylindrical roller surface shape was cylindrical roller and linear grove roller. This roller shape produced lowest damaging rate. Test results of the efficacy of preprocessing showed that the air spraying after preprocessing produced highest performance. The rotational speed and inclination of the roller didn't affect the bract removing performance. Optimum injection angle of the air jet nozzle was $70^{\circ}$. To increase bract removing rate and to reduce corn damage, required injection pressure and injection nozzle diameter were decided to less than 0.4 MPa and 2.5 mm, respectively. More than 3 times of nozzle passing produced good bract removing performance and there were no significant difference between the number of passing times.

• Journal of Pharmacopuncture
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• v.18 no.4
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• pp.38-44
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• 2015

Objectives: Radix Ginseng has been used for thousands of years to treat a wide variety of diseases. Radix ginseng has also been used as a traditional medicine for boosting Qi energy and tonifying the spleen and lungs. Traditionally, its effect could be obtained orally. Nowadays, a new method, the injection of herbal medicine, is being used. This study was performed to investigate the single-dose intravenous toxicity of water-soluble ginseng pharmacopuncture (WSGP) in Sprague-Dawley (SD) rats. Methods: All experiments were carried out at Biotoxtech, an institute authorized to perform non-clinical studies under the regulation of Good Laboratory Practice (GLP). At the age of six weeks, 40 SD rats, 20 male rats and 20 female rats, were allocated into one of 4 groups according to the dosages they would receive. The WSGP was prepared in the Korean Pharmacopuncture Institute under the regulation of Korea-Good Manufacturing Practice (K-GMP). Dosages of WSGP were 0.1, 0.5 and 1.0 mL/animal for the experimental groups, and normal saline was administered to the control group. The rat's general conditions and body weights, the results of their hematological and biochemistry tests, and their necropsy and histopathological findings were investigated to identify the toxicological effect of WSGP injected intravenously. The effect was examined for 14 days after the WSGP injection. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech. Results: No deaths were found in this single-dose toxicity test on the intravenous injection of WSGP, and no significant changes in the rat's general conditions and body weights, the results on their hematological and biochemistry test, and their necropsy findings were observed during the test. The local area of the injection site showed minial change. The lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results indicate that WSGP is safe at dosages up to 1 mL/animal.

• Asian-Australasian Journal of Animal Sciences
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• v.33 no.4
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• pp.634-639
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• 2020

Objective: This study was conducted to investigate the effect of heating of foot-and-mouth disease (FMD) vaccine before injection, on the incidence of lesions at the injection site (pork butt), amount of discarded meat, and economical benefit. Methods: In total, 101,086 piglets raised in 30 farms, were vaccinated in the neck with 2 mL of FMD vaccine at 56 d and 84 d of age using a commercial syringe. The heat treatment group (48,511 pigs) was injected with the FMD vaccine after it had been heated in a water bath at 40℃ for 20 min. After slaughter, the incidence of lesions on the pork butt was inspected, and the subsequent amount of discarded meat was recorded. Results: Heat treatment of FMD vaccine reduced the incident rate of lesions on the pork butt (p<0.01). Overall, 17.81% of the pigs in the heat treatment group had lesions, while the incident rate in the control group was 21.70%. The amount of discarded meat per head of total pigs and per head of pigs with lesions were significantly lower in the heat treatment group than the control group (p<0.01). Thus, the proportion of discarded meat to dressed carcass was lower in the heat treatment group (0.249%) compared with the control group (0.338%) (p<0.01). Farms that rear 1,000 sows can gain 1,863,289 KRW (1,600 USD) in one year when they adopt heat treatment of FMD vaccine before injection. Conclusion: Heat treatment of FMD vaccine using simple heat equipment (water bath) can be effective in reducing lesions caused by FMD vaccination and increase the economic benefits in pig farms.

• Progress in Medical Physics
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• v.17 no.1
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• pp.32-39
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• 2006

To assess the ability of an extravasation detection accessory (EDA) system to detect clinically important extravascular injection of iodinated contrast material delivered with an automated power injector. Fifty patients referred for contrast material enhanced body computed tomography studied in a prospective, observation study in which the EDA system was used to identify and interrupt any injection associated with clinically Important extravasation. The presence or absence of extravasation was definitively established with multi-detector CT at the injection site (injection rate, $2.0{\sim}2.5$ mL/sec). There were two true positive, extravasation volumes $22{\sim}25$ mL. The EDA system had sensitivity in the detection of clinically important extravasation. The EDA system is easy to use, safe, and accurate In the monitoring of intravenous injections for extravasation, which may prove especially useful in CT applications.

• Convergence Security Journal
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• v.12 no.3
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• pp.99-106
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• 2012

Today, the typical web hacking attacks are cross-site scripting(XSS) attacks, injection vulnerabilities, malicious file execution and insecure direct object reference included. Web hacking security systems, access control solutions, access only to the web service and flow inside but do not control the packet. So you have been illegally modified to pass the packet even if the packet is considered as a unnormal packet. The defense system is to fail to appropriate controls. Therefore, in order to ensure a successful web services diagnostic system development is necessary. Web application diagnostic system is real and urgent need and alternative. The diagnostic system development process mu st be carried out step of established diagnostic systems, diagnostic scoping web system vulnerabilities, web application, analysis, security vulnerability assessment and selecting items. And diagnostic system as required by the web system environment using tools, programming languages, interfaces, parameters must be set.

• Journal of the Korean GEO-environmental Society
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• v.12 no.9
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• pp.79-87
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• 2011

This study conducted the research on the method of grouting quality management and the improvement effect by applying grouting construction's quality management technology to automatic injection management equipment through measure of liquefaction based on the case of reinforcement applying grouting at the region where liquefaction happened at section 12 site of highway construction. The pressure(p), speed(q), grouting penetration radius(R) value from injection pressure, injection speed, characteristics of grain size, and characteristics of viscosity through p-q-t chart analysis was applied to the automatic grouting system which could improve the quality management of grouting. Standard penetration test results after injection showed that N values represented 5-20 and the prevention of liquefaction became possible.