• Proceedings of the Korean Geotechical Society Conference
• /
• 2003.03a
• /
• pp.85-92
• /
• 2003

Generally, ordinary portland cement(OPC) is widely used for grouting to reduce permeability of ground under the foundations of structures. But, it is hard to be injected into the microscopic voids, fissures and crevices in soil or rock formation for the OPC material. Therefore new method what is called MSG(Micro Silica Grouting) has been developed recently to improve the weak point of the OPC material. In this case study, in order to verify performance of the MSG's water cut-off, trial injections were performed in rear of CIP(Cast in Place Pile) on the site A(weathered soil) and B(alluvial soil) that are constructed for the subway No. 9 nowadays. To take the proper grouting method of the MSG in the trial injecting, the injections are carried out for grouting types(constant pressure or fixed Quantity) and grouting methods(1.5shot or 2.0shot) and to confirm the effects of water cut-off and the injection range of the MSG, the tests of permeability and indicator(phenolphthalein) response were performed before and after the injection. Through the tests results, we could affirm the effects of water cut-off of the MSG and the injection range for the weathered and alluvial soil layers near the Han River. Finally we could make sure the application of the MSG method in actual construction under the layers.

• 한국신재생에너지학회:학술대회논문집
• /
• 2006.11a
• /
• pp.32-35
• /
• 2006

The validation of a groundwater source heat pump system installation site is estimated by bydrogeothermic model ing. The hydraulic characteristics of the aquifer system is evaluated from pumping and recovery tests. In addition, the temperature distribution by the pumping and the injection of groundwater, and water level fluctuations are simulated by numerical modeling. The total cooling and heating load for the building is designed as 120RT(refrigeration ton) and the ground water source heat pump system covers 50RT as a subsidiary system The scenario of heat pump operation is organized as pumping and inject ion of groundwater that is performed for 8 hours per day in cooling mode for 90 days during the summer season The heat transfer by the injected warm water is limited near the inject ion wells in the simulated temperature distribution. The reason is that the given operation time is too short to expect broad thermal diffusion in large volume of the aquifer in the simulation time The simulated groundwater level and temperature distribution can be used as important data to develope an energy effective pumping and injection well system. Also it will be very useful to evaluate the hydraulic capacity of a target groundwater reservoir.

• Journal of environmental and Sanitary engineering
• /
• v.18 no.1
• /
• pp.23-29
• /
• 2003

The effect of ozone oxidation on bio-degradability of leachate was studied. Ozone oxidation process was used as pre-treatment process to enhance performance of biological process in treating landfill leachate. Optimum ozone injection rate and contact time in this experiment was $160{\;}mg{\;}O_/{\ell}{\cdot}hr$ and 45 minutes, respectively. Bio-degradability was enhanced 5.08% by ozone oxidation. The ratio of ozone demand/DOC concentration was $0.049~0.091{\;}mg{\;}O_3/mg{\;}DOC$. The increase of bio-degradability depending on ozone injection rate(D) and contact time(T) can be expressed as follows ; The rate of bio-degradation of DOC was increased proportionally with the increase of ozone injection rate and contact time irrespective of landfill site age. The increase of bio-degradability by ozone addition was not satisfactory. It is hard to expect significant increase in bio-degradability by ozone treatment only. Thus, it is evaluated that ozone oxidation can not increase biodegradability significantly in concentrated wastewater composed of complex organic compound such as leachate.

• Journal of Pharmaceutical Investigation
• /
• v.17 no.4
• /
• pp.213-216
• /
• 1987

The distribution features of recombinant human $alpha-interferon(rHuIFN-{\alpha}A)$ and $^{14}C-radiolabeled\;rHuIFN-{\alpha}A\;(^{14}C-rHuIFN-{\alpha}A)$ were investigated in ICR mice after i.v. injection. The level of $rHuIFN-{\alpha}A$ in the kidney was significantly higher than those in lung and liver at 10min after the injection. But the level was reduced significantly at 60min. The level of radioactivity in the kidney was also significantly higher than those in other organs after i.v. injection of $^{14}C-rHuIFN-{\alpha}A$, but it was reduced at much slower speed than was $rHuIFN-{\alpha}A$. These results show that interferon is distributed repidly and the kidney is the main site of distribution and metabolism of $rHuIFN-{\alpha}A$.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.30 no.5
• /
• pp.347-354
• /
• 2016

This study evaluated the effects of Fructus Corni Officinalis water extract (FCE) on congnitive impairment and Aβ clearance induced by beta amyloid Aβ (1-42) injection in the hippocampus of rat. Aβ (1-42) was injected into the hippocampus using a Hamilton syringe and micropump (5 ㎍/5 ㎕, 1 ㎕/min, each hippocampus bilaterally). FCE was administered orally once a day (100, 250, 500 mg/kg) for 4 weeks after the Aβ (1-42) injection. The acquisition of learning and retention of memory were tested using the Morris water maze. Aβ accumulation and Aβ clearance in the hippocampus were observed using immunostaining. Aβ (1-42) level in plasma was confirmed using enzyme-linked immunosorbent assay (ELISA). FCE significantly shortened the escape latencies during acquisition training trials. FCE significantly increased the number of target heading to the platform site and significantly shortened the time for the 1^sttargetheadingduringtheretentiontesttrial.FCEsignificantlyattenuatedtheAβ accumulation in the hippocampus produced by Aβ (1-42) injection. FCE significantly increased LRP-1 expression around vessels in the hippocampus and Aβ (1-42) levels in plasma. The results suggest that FCE improved cognitive impairment by ameliorate Aβ clearance and Aβ accumulation in the hippocampus. FCE may be a beneficial herbal formulation in treating cognitive impairment including Alzheimer's disease.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.6 no.4
• /
• pp.86-100
• /
• 1998

The impingement of the fuel spray on the wall within the combustion chamber in compact high-pressure injection engines and on the intake port wall in port-fuel-inje- ction type engines is unavoidable. It is important to understand the characteristics of impinging spray because it influences on the rate of fuel evaporation and droplet distrib- ution etc. In this study, the numerical study for the characteristics of spray/wall interaction is performed to test the applicability and reliability of spray/wall impingement models. The impingement models used are stick model, reflect model, jet model and Watkins and Park's model. The head of wall-jet eminating radilly outward from the spray impingement site contains a vortex. Small droplets are deflected away from the wall by the stagnation flow field and the gas wall-jet flow. While the larger droplets with correspondingly higher momentum are impinged on the wall surface and them are moved along the wall and are rolled up by wall-jet vortex. Using the Watkins and Park's model the predicted results show the most reasonable trend. The rate of increase of spread and the height of the developing wall-spray is predicted to decrease with increased ambient pressure(gas density).

• YAKHAK HOEJI
• /
• v.43 no.3
• /
• pp.404-410
• /
• 1999

Administration of capsaicin produces acute pain and subsequent long-lasting antinociception. The antinociceptive action site of capsaicin is primarily small afferent nerve fibers. However, the effect of capsaicin on the neural activity of dorsal horn neurons are not well understood. The goal of the present experiment was to study the action of capsaicin on activity of dorsal horn neurons using c-fos immunoreactivity in the spinal cord. Intradermal injection of formalin in the hindpaw produced inflammation in the foot pad and increased the number of cells exhibiting Fos-like immunoreactivity (FLI) in the dorsal horn of the spinal cord, suggesting the hyperalgesia because of the apparent inflammation. Intradermal injection of capsaicin prior to formalin injection significantly reduced the number of cells exhibiting FLI induced by formalin and increased the paw-withdrawal latency, suggesting the hypoalgesic effect of capsaicin. Coadministeration with capsaicin of capsazepine and ruthenium red, antagonists of capsaicin receptor reversed the reduction of formalin-induced FLI by capsaicin. he antagonists also partially antagonized the antinociceptive effect of capsaicin in the paw-withdrawal test. These results further suggest that capsaicin reduces prsponses of dorsal horn neurons to the inflammatory nociceptive stimuli in the periphery. Thus, the reduction of FLI subserves the neural mechanisms underlying analgesia produced by capsaicin.

• Archives of Pharmacal Research
• /
• v.22 no.6
• /
• pp.549-553
• /
• 1999

The antipruritic effect of DA-5018m a capsaicin derivative, was examined in mice. Male ICR mice were topically pretreated with Zostrix-HP (0.075% capsaicin cream), 0.1%, 0.3% DA-5018 cream or cream base (control) twice daily for 4 days. One hour after the last application, itch was induced either by compound 48/80 ($50{\mu}g$, s.c.) or leukotriene B4 (0.03 nmol, i.d.) injection into the rostral back of the animals, and the number of scratches made by the animals at the injection site was counted for 60 min post-injection. DA-5018 cream (both 0.1 and 0.3%) significantly inhibited compound 48/80-induced scratching when compared with the cream base control (p<0.01), which Zostrix-HP showed minimal inhibition of the scratching behavior. In leukotriene B4-induced itch model, Zostrix-HP and 0.3% DA-5018 cram significantly inhibited the scratching during the first 10-min period (p<0.01). The results suggest that DA-5018 cream can be used as an antipruritic agent and warrant clinical evaluation.

• BioChip Journal
• /
• v.12 no.4
• /
• pp.309-316
• /
• 2018

Microneedles (MNs) are being developed to overcome the limitations of the conventional hypodermic needle, e.g. the injection pain. In this study, we conducted an analysis of clinical pain and bleeding at the site of MN insertion and evaluated the insulin pharmacodynamic profile compared with parameters obtained with a conventional pen needle. MN insertion into the skin of 25 healthy adults or 15 patients with type 2 diabetes (T2D) revealed significantly less pain relative to a conventional hypodermic pen needle, thus reducing pain scores from $2.1{\pm}1.9$ to $21.3{\pm}1.4$ ($mean{\pm}standard$ deviation [SD]). Besides, no bleeding was observed when the MN was used. In the insulin pharmacodynamic assay, no significant differences were observed in the blood glucose-lowering effect between the pen needle and MN. Based on these results, the MN is expected to be a good substitute for conventional hypodermic pen needles and improve the quality of life of patients by significantly reducing the pain associated with insulin treatment.

• Journal of The Korean Astronomical Society
• /
• v.36 no.spc1
• /
• pp.21-27
• /
• 2003

In the present study, we have investigated morphology and evolution of small-scale Ha dynamic features on the quiet sun by analyzing video magnetograms and high resolution Ha images simultaneously taken for 5 hours at Big Bear Solar Observatory on April 18, 1997. From comparisons between time sequential longitudinal magnetograms and H$\alpha$ images covering $150" {\times} 150"$, several small-scale H$\alpha$ dynamic features have been observed at a site of magnetic flux cancellation. A close relationship between such features and cancelling magnetic fluxes has been revealed temporarily and spatially. Our results support that material injection by chromospheric magnetic reconnect ion may be essential in supporting numerous small-scale H$\alpha$ dynamical absorption features, being in line with recent observational studies showing that material injection by chromospheric magnetic reconnect ion is essential for the formation of solar filaments.