• The Korean Journal of Pharmacology
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• v.23 no.2
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• pp.77-85
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• 1987

This study was carried out to determine the role of cholinoceptors in the ventrolateral medulla on central control of blood pressure (BP) and heart rate (HR). In rats anesthetized with urethane and paralyzed, microinjections of the neuroexcitatory amino acid L-glutamate (300 ng/site) were performed to functionally identity the vasopressor area (VLPA) and the vasodepressor area (VLDA) in the ventrolateral medulla oblongata. 1. The bilateral microinjection of carbachol (300 ng/site) into the VLPA produced significantly an increase in BP and HR which was not blocked by bilateral pretreatment of hexamethoium ($4\;{\mu}g/site$). 2. The bilateral microinjection of physostigmine (200 ng/site) and oxotremorine (300 ng/site) into the VLPA produced significantly an increase in BP respectively. 3. The bilateral microinjection of atropine ($4\;{\mu}g/site$) into the VLPA produced significantly a decrease in BP and HR. 4. The bilateral micro injection of acetylcholine (500 ng/site) and dimethylphenylpiperazinium (500 ng/site) into the VLDA produced significantly a decrease in BP and HR respectively. 5. The depressor and bradycardiac responses elicited by the bilateral microinjection of acetylcholine (500 ng/site) into the VLDA were blocked by bilateral pretreatment of hexamethonium ($4\;{\mu}g/site$). The results suggest that the activation of cholinoceptors in VLPA produce hypertensive and tachycardiac responses which may be mediated by muscarinic receptors, and the activation of cholinoceptors in VLDA produce hypotensive and bradycardiac responses which may be mediated by nicotinic receptors.

• Journal of Oral Medicine and Pain
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• v.30 no.1
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• pp.121-129
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• 2005

In this experiment, eleven volunteers were followed up for 15 months after the injection of botulinum toxin type A on right and left masseter muscles. The measurement of masseter muscle atrophy for each volunteer was performed by CT(computed tomography) three times: before the injection, three and fifteen months after the injection. The thickness and area of muscle were measured in three positions which are 10 (position 1), 20 (position 2), and 40 mm (position 3) above the inferior border of mandible(the injection site was nearest the position 1). The thickness of masster muscle was decreased in all three positions three months after the injection, but no significant change was observed fifteen months after the injection. On the other hand, the area of masster muscle was decreased in all three positions three months after the injection. Furthermore, the area was decreased significantly in positions 1 and 2, but not in position 3 fifteen months after the injection. As a result, toxin is still in effect even fifteen months after the injection. Finally, the present study shows that the measurement of muscle area provides more precise informations than that of muscle thickness does.

• The Journal of Engineering Geology
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• v.32 no.4
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• pp.643-659
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• 2022

Geologic sequestration technologies such as CCS (carbon capture and storage), EGS (enhanced geothermal systems), and EOR (enhanced oil recovery) have been widely implemented in recent years, prompting evaluation of the mechanical stability of storage sites. As fluid injection can stimulate mechanical instability in storage layers by perturbing the stress state and pore pressure, poroelastic models considering various injection scenarios are required. In this study, we calculate the pore pressure, stress distribution, and vertical displacement along a surface using commercial finite element software (COMSOL); fault slips are subsequently simulated using PyLith, an open-source finite element software. The displacement fields, are obtained from PyLith is transferred back to COMSOL to determine changes in coseismic stresses and surface displacements. Our sequential use of COMSOL-PyLith-COMSOL for poroelastic modeling of fluid-injection and induced-earthquakes reveals large variations of pore pressure, vertical displacement, and Coulomb failure stress change during injection periods. On the other hand, the residual stress diffuses into the remote field after injection stops. This flow pattern suggests the necessity of numerical modeling and long-term monitoring, even after injection has stopped. We found that the time at which the Coulomb failure stress reaches the critical point greatly varies with the hydraulic and poroelastic properties (e.g., permeability and Biot-Willis coefficient) of the fault and injection layer. We suggest that an understanding of the detailed physical properties of the surrounding layer is important in selecting the injection site. Our numerical results showing the surface displacement and deviatoric stress distribution with different amounts of fault slip highlight the need to test more variable fault slip scenarios.

• Journal of The Korean Society of Clinical Toxicology
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• v.5 no.1
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• pp.71-73
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• 2007

Glyphosate is the active ingredient in widely used herbicides. It acts through inhibition of the shikimate metabolic pathway in plants. This pathway does not exist in mammals, however, so glyphosate is presumably less toxic to humans. Nevertheless, fatal cases of glyphosate poisoning in humans have still occurred. Cases of glyphosate poisoning reported in the previous literature were almost always caused by intentional ingestion. Therefore, intramuscular injection of glyphosate with suicidal intent has not been reported. We report a case of 43-year-old man with poisoning due to intramuscular injection of glyphosate herbicide. He was admitted to the emergency department with a chilling sensation, local hotness, swelling, and tenderness at the site of glyphosate injection. He was treated with intravenous antibiotics and analgesics for 10 days and was discharged without any other complication.

• The Journal of Engineering Geology
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• v.28 no.2
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• pp.247-258
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• 2018

In the demonstration-scale offshore $CO_2$ storage project, the monitoring team studies geophysical and geochemical monitoring of $CO_2$ injections in the Yeongil Bay, in which a $CO_2$ test injection (about 100t) was performed in January, 2017 and further injections in larger scales are planned for 2018 and 2019. In this study, the development status of the Korea-type Hydro-Geophone OBS (Ocean Bottom Sensor) and the geochemical baseline survey (focused on some anions of sediment pore water) are suggested as the preliminary results of the pre-injection test.

• The Journal of Pediatrics of Korean Medicine
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• v.23 no.1
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• pp.205-228
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• 2009

Objectives The purpose of this study is to investigate the current acupuncture therapy of cerebral palsy. Methods We investigated the Chinese clinical papers which were published in the last 10 years(from 1999 to 2008). We found these papers from the oriental medical library in university and we also used the China National Knowledge Infrastructure(CNKI) through the internet and selected 32 papers for analyzing. Results Most papers were described the effect of acupuncture or acupoint-injection. This is more effective way to treat than the general rehabilitation treatment such as the physical therapy, the occupational therapy, and the speech therapy. Acupuncture or acupoint-injection has overall $80{\sim}100%$ of rehabilitation rate. The younger the children were, the longer the treatment period was, and the more successful in treatment. The acupuncture was often used with the general acupuncture and scalp acupuncture. Commonly used major acupuncture points were sishencong(四神聰), bohui(百會), zusanli(足三里), yundongqu(運動區), pinghengqu(平衡區), quchi(曲池), and sanyinjiao(三陰交). Commonly used main meridian pathways were bladder, governor vessel, gallbladder, large intestine, stomach, small intestine meridian. Head is the common site for acupuncture. The main acupoint-injection points were zusanli(足三里), dazhui(大椎), shenshu(腎兪), yamen(啞門), neiguan(內關), and fengchi(風池). For the injection, brain activator, ganglioside M1, cerebroprotein hydrolysate, cytidine diphosphate choline, Vit B1, Vit B12, the salviae root, the safflower were commonly used. Conclusions Acupuncture and acupoint-injection have been shown as an effective treatment on cerebral palsy. The acupuncture was used often the general acupuncture and scalp acupuncture all together. Commonly used main acupuncture points were sishencong, bohui, zusanli, yundongqu, pinghengqu, quchi, sanyinjiao.

• Archives of Plastic Surgery
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• v.32 no.3
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• pp.311-313
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• 2005

Generally, many Asian women tend to dislike the square jaw, as they believe it makes the face look wider, giving a stubborn and strong impression. Contouring of the mandible is therefore a relatively common aesthetic procedure among Asians. These days, the use of botulinum toxin for contouring of the lower face offer simple alternative to surgery. Motor point, which is the site over a muscle where its contraction may be elicited by a minimal intensity short duration electrical stimulus, is the optimal injection point of botulinum toxin. Study was undertaken to identify the location of motor point of the masseter muscle and the skin surface landmark. First, the thickest point of the masseter muscle was inspected through palpation and inspection by 3 different individual plastic surgeons and then compound muscle action potentials(CMAPs) of masseter muscle in 15 health volunteers were recorded using EMG. For the localization of the measured points, line between lateral canthus to the mandibular angle was used. Location of motor points were mapped to skin surface from lateral canthus in a percentage of the distance along the landmark line and in distance in millimeters. The clinical injection point was located at 71.69 percentile and 7.3 mm of the landmark line. The motor point test was located at 72.54 percentile and 7.1 mm of the landmark line. The depth of motor point was 16mm. There was no statistically significant difference between the clinical injection point and the motor point. We conclude that surface mapping of motor point of the masseter muscle would increase accessibility and accuracy in botulinum toxin injection for contouring of the lower face.

• Asian-Australasian Journal of Animal Sciences
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• v.18 no.4
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• pp.524-531
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• 2005

Two experiments were conducted to standardize in ovo injection of amino acids (AA) and to evaluate the effect of in ovo injection of limiting AA(s) on pre and post hatch growth performance, immune response and development of digestive organs. Combinations of essential and non-essential amino acids (Lys+Arg, Lys+Met+Cys, Thr+Gly+Ser, Ile+Leu+Val and Gly+Pro) were injected into 50 eggs in each treatment group at 14 d of embryonic age. Standardization of injection site, needle length and embryonic age revealed that when AA were injected in to the broad end of the egg with a 11 mm needle and at the narrow end with a 24 mm needle both at the 7$^{th}$ and 14$^{th}$ d of incubation there was poor hatchability. However, better hatchability was recorded when the AA were injected in the narrow end of the egg with a 11 mm needle and in the broad end with a 24 mm needle on the 14$^{th}$ d of incubation. The chick to egg weight ratio was higher (p<0.018) when AA were injected on the 14$^{th}$ d of incubation. When a combination of amino acids were injected a 63.6 or 63.2 g difference in body weight of bird at 21 d was recorded between uninjected control and Ile+Leu+Val or Gly+Pro group, respectively. Higher feed intake (p<0.047) was recorded in the AA injected groups and feed conversion ratio (FCR) was numerically better in Gly+Pro, Lys+Met+Cys AA injected groups than in the uninjected control. Significantly higher immune response to cell mediated (p<0.033) and humoral (p<0.002) immunity was observed in in ovo amino acid injected birds, especially in Lys+Met+Cys, Thr+Gly+Ser or Ile+leu+Val groups. The digestive organ weights at 21 d did not differ between specific AA injected groups and the uninjected control. In ovo injected amino acids may act as immunomodulators and their role in gastrointestinal development needs further research.

• Journal of the Korean Geosynthetics Society
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• v.19 no.4
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• pp.11-20
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• 2020

This study introduced the compact grouting method that can be used for improving soft ground and restoring buildings with unequal subsidence. The pump used in the traditional compact grouting method is a system that injects one hole each, which reduces the construction efficiency, and the analog injection method manually manages the construction by field workers, making it difficult to manage consistent quality. Pump and quality control system were developed to solve problems in existing construction. Since field supervisor determines amount of injected materials by using analog equipment and controls manually, it is difficult to manage consistent quality of construction. Therefore, the quality control system was developed in order to solve that problem. The quality control system consists of automatic mixing system of injection materials, multiple simultaneous injection pumps, and injection management monitoring system. Performance of the quality control system was verified through on-site testing, and ground improvement performance was verified through quality testing after testing and testing of the compact grouting method. Therefore, it is expected that the integrated quality control system developed will improve the quality assurance and efficiency and stability of construction at sites where construction and quality verification are difficult.

• Journal of Korean Society of Environmental Engineers
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• v.27 no.10
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• pp.1043-1051
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• 2005

In this stduy, adsorption and transport characteristics of Fe in the soil were investigated using convection-dispersion local equilibrium sorption model and two-site non-equilibrium sorption model. In batch experiments with different Fe concentration, characteristics of Fe adsorption was investigated using Freundlich and linear isotherm. Column experiments with different flow rate, organic matter content md Fe concentration were also carried out. We measured Fe concentrations in injection-liquid and in effluent, and then applied them to CXTFIT program. As a result of column experiments, some parameters(D, R, ${\beta}$, ${\omega}$) used in two-site non-equilibrium adsorption model were obtained. Characteristics of Fe transport were analyzed using the parameters(D, R, ${\beta}$, ${\omega}$) obtained from the CXTFIT program, Consequently, characteristics of Fe transport in the soil were predicted through two-site non-equilibrium adsorption model.