• 여성건강간호학회지
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• 제27권4호
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• pp.318-325
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• 2021

Purpose: Although insulin is usually injected into the abdominal subcutaneous fat, in pregnancy women tend to avoid abdominal injections due to concern about fetal damage. Prior studies have been limited to only measuring skin-subcutaneous fat thickness (S-ScFT) at one site at specific pregnancy points. This study aimed to measure S-ScFT across several abdominal sites and over the gestational period in Korean pregnant women. This can identify which site would be relatively safe for subcutaneous injection during pregnancy. Methods: Healthy women over 24 weeks of pregnancy in Korea were invited to voluntarily participate in this descriptive study. For the 142 women, S-ScFT of 12 sites in the abdomen were measured by ultrasound, several times over the pregnancy. Each incidence was treated as a case and a total of 262 cases were analyzed. Results: The mean S-ScFT during pregnancy was 1.14±0.47 cm (1.25±0.54 cm at 24⁺⁰-27⁺⁶ weeks; 1.17±0.48 cm at 28⁺⁰-31⁺⁶ weeks; 1.09+0.40 cm at 32⁺⁰-35⁺⁶ weeks; and 1.06±0.47 cm at 36⁺⁰-40 weeks of pregnancy). Most S-ScFT were thicker than 10 mm. But S-ScFTs in the lateral abdomen and some sites were suboptimal (<6 mm), especially in the pre-pregnancy underweight body mass index group, who had a high rate of suboptimal thickness (27.1% overall and 33.9% in the lateral side). Conclusion: The whole abdomen seems to be appropriate for subcutaneous injection in most Korean women during pregnancy, with a 4 to 5-mm short needle. However, for the lateral abdomen, making the skin fold might be needed for fetal safety.

• 한국환경보건학회지
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• 제31권1호
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• pp.15-22
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• 2005

This study was conducted to evaluate air injection mode on stabilization of solid waste in lysimeter. For three lysimeters, one was maintained under anaerobic condition as control, and air was injected into two lysimeters in continuous mode (atmospheric pressure) and intermittent mode (high pressure of 2 bar). Distilled water was sprayed over solid waste in 1.4 l/$m^3$(solid waste)/day, supposing rainfall intensity of 1,200 mm/yr and 30% infiltration. Oxygen in landfill gas was not detected in control lysimeter during operational days. After 30 day-aeration, oxygen concentrations of continuous and intermittent modes were maintained in 14% and 6%, respectively. $COD_{Cr}$ removal efficiencies of continuous and intermittent modes were about 70% and 50%, and BOD5 removal efficiencies were about 80% and 20%, respectively. In view of oxygen supply, and $COD_{Cr}$ and $BOD_5$ removal, continuous air injection mode of atmospheric pressure was more effective than intermittent mode of 2 bar. Settling degree of solid waste in case of two air injection modes was 3 times higher than that of anaerobic condition as control. Considering the above results, it was thought that air injection (especially continuous atmospheric pressure) could improve degradation of solid waste and induce preliminary stabilization in landfill site.

• 한국도로학회논문집
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• 제18권2호
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• pp.61-71
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• 2016

PURPOSES: The objective of this study was to determine the optimum ratio of mix design, for a reclaimed asphalt pavement (RAP) content of 100%, for spray injection application. METHODS: A literature review revealed that spray injection is an efficient and cost-effective application for fixing small defective regions of an asphalt pavement. Rapid-setting polymer-modified asphalt mixtures prepared from two types of rapid-setting polymer asphalt emulsion were subjected to Marshall stability and wet track abrasion tests, in order to identify the optimum mix designs. RESULTS and CONCLUSIONS : Different mix designs of type A and type B emulsions were prepared using RAP and virgin aggregates, in order to compare the performance and determine the optimum mix design. The performance of mixtures prepared with RAP was superior to that of mixtures containing virgin aggregates. Moreover, for optimum ratio of the design, the binder content prepared from RAP was set to 1~2% lower than that consisting of virgin aggregates. Compared to their Type A counterparts, type B mixtures consisting of a reactive emulsion performed better in the Marshall stability and wet track abrasion tests. The initial results confirmed the advantages associated with using RAP for spray injection applications. Further studies will be performed to verify the difference in the optimum mix design and performance obtained in the lab-scale test and tests conducted at the job site by using the spray injection machine.

• 지구물리와물리탐사
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• 제9권1호
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• pp.30-36
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• 2006

일본의 첫 번째 파일럿 규모의 $CO_2$격리실험이 Nagaoka 에서 약 1,100m 깊이의 육상 대수층에 10,400 톤의 $CO_2$를 주입하면서 행해졌다. 주입된 $CO_2$ 의 모니터링을 위해서 그 지역에서 행해진 다양한 측정들 중, P 파 속도의 변화를 이용하여 2 개의 관측정 사이에서 대수층 내의 $CO_2$ 분포를 알기 위해 시간차 시추공간 탄성파 토모그래피가 실시되었다. 이 논문은 탄성파 토모그래피에 대한 예비적인 결과들이다. 시추공간 탄성파 토모그래피 측정이 3 회에 걸쳐 실시되었는데, 한 번은 기준 조사로서 주입 전에, 나머지 두 번은 모니터링 조사를 위해 주입 중에 이루어졌다. 모니터링 조사로부터의 속도 분포도를 기준 조사 속도 분포도와 비교하여 속도 차 분포도가 만들어졌다. 속도 차 분포도는 주입된 $CO_2$가 퍼져있다고 예상되는 주입정 주변 대수층 부분에서 소도 감소 지역을 보여준다. 비록 탄성파 토모그래피가 $CO_2$주입에 따른 속도 감소 지역을 제공할 수 있었지만 속도 차 분포도에서 다소 이상한 속도 분포 지역이 관측되었다. 그러한 현상의 발생을 조사하기 위해서 조사 지역을 모사하는 수치모형 실험을 수행하였다. 그 결과 우리는 속도 차 분포도에서 발생한 이상한 속도 분포는 인위적인 오차이거나 이 지역에서 행해진 시추공간 탐사의 송수신기 배열에 의한 고스트라고 확신할 수 있었다. 토모그래피에 의해서 얻어진 최대 속도 감소 비율은 음파검층에 의해 관측된 것보다 아주 작았다. 비록 탄성파 토모그래피에 대한 수치모형 실험에 의해서도 불일치가 확인되었으나 음파검층에 의해 획득한 속도 값에 비교될 수 있는 좀 더 정확한 속도 값을 얻기 위해 앞으로 더 많은 연구가 필요하다.

• 신재생에너지
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• 제17권3호
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• pp.32-41
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• 2021

A groundwater source heat pump (GWHP) was developed in this study by adapting a borehole heat exchanger with closed-loop and open-loop systems in a new building. In the pilot test building, the air-conditioning on the second floor was designed to employ a closed-loop system and that on the third floor had an open-loop system. The GWHP design is based on the feasibility of groundwater resources at the installation site. For the hydrogeological survey of the study site, pumping and injection tests were conducted, and the feasibility of GWHP installation was evaluated based on the air-conditioning load demand of the building. The site was found to be satisfactory for the design capacity of the thermal load and water quality. In addition, the effect of groundwater movement on the performance of the closed-loop system was tested under three different operational scenarios of groundwater pumping. The performance of the system was sustainable with groundwater flow but declined without appropriate groundwater flow. From long-term observations of the operation, the aquifer temperature change was less than 2℃ at the observation well and 5℃ at the injection well with respect to the initial groundwater temperature. This pilot study is expected to be of guidance for developing GWHPs at fractured rock aquifers.

• 자원환경지질
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• 제43권4호
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• pp.371-379
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• 2010

연안지역 염수와 담수가 혼재하는 전이대에서 해수침투 피해개선을 목적으로 균열암반을 통한 담수주입시험을 수행하고 그 효과를 모니터링하였다. 담수주입은 절대적으로 그 지역의 지질학적, 수리학적 특성에 따라 좌우되며, 특히 파쇄대나 투수성 미고결 지층 등의 특성 파악이 중요하다. 연구 지역의 염담수 분포특성을 고려하여 두 개의 주요 연안 대수층인 충적층과 균열암반 구간을 통한 담수주입이 가능하도록 시추공을 설계 및 굴착하였으며, 균열암반 대수층 내 담수주입을 위하여 현장에서의 시험 준비, 이동, 조립 및 장비의 유지보수가 간단하도록 착탈식인 모듈화되어 있는 주입시스템을 제작하여 적용하였다. 시추공영상화검층을 통해 전체적인 균열의 특성을 파악하였고, 이를 바탕으로 주입공 및 관측공 간 투수성 파쇄대의 확인을 위한 구간별 담수주입 및 모니터링을 실시하여 담수주입 구간을 선정하였다. 담수주입시험 결과, 관측공의 일정 심도에서 담수가 유입되어 시간이 경과함에 따라 상부 구간의 전기전도도도 점진적으로 감소함을 보였으며, 담수주입 중단 및 패커를 해지한 후에도 유입된 심도에서 점진적으로 전기전도도값이 증가하기는 하지만 그 증가폭이 전체적으로 낮아 담수주입의 효과가 있음을 확인하였다. 또한 장기적으로 전기전도도값을 모니터링함으로써 담수주입의 효과가 수개월 후에도 지속됨을 확인하였으며, 이는 담수주입에 의해 일정 정도의 해수침투 피해에 대한 개선효과를 기대할 수 있음을 시사한다.

• 지질공학
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• 제33권4호
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• pp.599-609
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• 2023

국내 항만 방파제의 내진보강시 현장여건, 현장상황 등으로 회수율이 불확실한 경우가 많아 문제점이 지속적으로 발생하고 있다. 따라서, 본 연구에서는 저유동성 몰탈주입 공법 적용 후 그라우팅 확인방법으로 시추조사를 통한 회수율 및 개량체의 압축강도를 분석하였으며, 추가적으로 다운홀 테스트 및 토모그래피로 탄성계수를 확인하여 지반개량 후 연약지반의 보강 증대 효과를 확인하고자 하였다. 실험결과, 다운홀테스트의 경우 BH-1번과 3번공에서 심도 28.0 m까지에 대한 지반의 평균 전단파속도는 229 m/s에서 288 m/s로 증가하였고, 심도 30.0 m까지에 대한 지반의 평균 전단파속도는 224 m/s에서 282 m/s로 증가하는 경향을 보였다. 이는 보강후 지반의 강성이 증대되어 나타난 결과로 판단된다. 토모그래피 탐사 결과, Site1번의 시료의 연약지반의 Vs가 113 m/s에서 214 m/s, Site2번 시료의 Vs는 120 m/s에서 224 m/s로 증가하였다. 이는 전단파속도에 따른 암질의 분류에서 Vs값이 180~360 m/s를 만족하는 값으로 내진보강 후의 지반의 강성이 단단한 흙으로 보강됨을 확인할 수 있다.

• The Korean Journal of Pain
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• 제7권2호
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• pp.162-169
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• 1994

Blockade of cervicothoracic sympathetic ganglion (stellate ganglion controls pain on face, head, neck, shoulder, upper limbs, and upper chest, including their viscera and sympathetically maintained pain. This procedure also increases blood flow to the above areas and relieves hyperreactivity of sympathetic nervous system. Clinically, repeated stellate ganglion blocks with local anesthetic agent may become difficult with complications such as accidental intravascular or subdural injection, recurrent laryngeal nerve or bracheal plexus paralysis, pneumothorax and edema on injection site. Therefore, at times long-term cervicothoracic ganglion block with neurolytics is necessitated but its applications are prohibited by the critical structures surrounding ganglion. There are also few reports of neurolytic stellate ganglion block. This study was performed to observe the complications, gross changes of surrounding structures, and microscopic findings of ganglion cells after neurolytic block and to certify the possibility of clinical use of neruolytic stellate ganglion block. The unilateral superior cervical sympathetic ganglion of rabbit was blocked with absolute ethyl alcohol 0.4 ml at the level of cricoid cartilage. Normal ganglion was used as a control and 5 animals were sacrificed at each intervals of 7, 15 and 50 days after block. The results were as follows; 1) All experimental animals showed no specific changes of behavior, motor function. No necrotic tissues were present in the block area during the observation period. There were some gross scar tissues along the fascia of muscles surrounding the needle injection site, but gross atrophy of muscles or injured major vessels were not found. 2) Microscopically, structures of normal ganglion of rabbit were very similar to those of humans. Seven days after absolute ethyl achohol injection there were marked edema of ganglion cells and nuclei with irregular nuclear membrane. Some of the ganglion cells lost their nuclei and showed degenerative changes. Fifteen days after block, cell edema were decreased and loss of the Nissl's body was prominant. The ganglion cell structures looked close to normal but the cytoplasm and nucleus were generally contracted 50 days after block. These results suggest absolute ethyl alcohol injection on cervical sympathetic ganglion with above method mainly blocks pre- and post-synaptic fibers and the long-term neurolytic blockade of this ganglion may be possible in rabbits.

• 생명과학회지
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• 제17권11호
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• pp.1497-1504
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• 2007

사람의 혈소판조절인자 (TPO)의 분비와 기능을 분석하기 위하여 사람 간 cDNA로부터 TPO cDNA를 분리하여 동물세포에서 재조합체를 생산하였다. 또한, 당쇄의 기능분석을 위하여 6개의 당쇄첨가부위를 Ala으로 치환하여 각각의 돌연변이체 재조합체도 생산하여 이들의 생리활성분석을 위하여 피하주사하여 혈소판의 증가여부를 분석하였으며, 체내 약동학검사를 위하여 꼬리 정맥에 재조합체를 주사하여 24시간까지 혈액을 채취하였다. Wild-type TPO는 효과적으로 분비하였으나, 크로닝에서 분석되어 진 116개 아미노산이 삭제된 돌연변이체는 배양상층으로 분비되지 않았다. N-linked 당쇄첨가 부위는 3번과 4번을 제외하고는 거의 비슷한 발현양상을 나타내었다. 특히 4번당쇄부위는 TPO의 분비에 중요한 역할을 하는 것으로 나타났다. 재조합체 10ng을 피하주사에 의하여 체내 혈소판이 유의적으로 증가하였으며, 5ng을 이용한 약동학 분석결과 1시간에 최대로 증가하였으며 그 이후 급격하게 감소하여 10시간에는 거의 존재하지 않았다. 따라서, 이러한 연구는 고 활성을 가지는 유전자 재조합체 TPO의 생산을 가능하게 하고, 또한 새로운 분자의 TPO를 가능하게 할 것으로 사료된다.

• Geosciences Journal
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• 제22권6호
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• pp.1041-1052
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• 2018

A single-well push-drift-pull tracer test using two different tracers ($SF_6$ and salt) was performed at the Environmental Impact Test (EIT) site to determine suitable locations for monitoring wells and arrange them prior to artificial $CO_2$ injection and leak tests. Local-scale estimates of hydraulic properties (linear groundwater velocity and effective porosity) were obtained at the study site by the tracer test with two tracers. The mass recovery percentage of the volatile tracer ($SF_6$) was lower than that of the non-volatile tracer (salt) and increased drift time may make degassing of $SF_6$ intensified. The $CO_2$ leakage monitoring results for both unsaturated and saturated zones suggest that the $CO_2$ monitoring points should be located near points at which a high concentration gradient is expected. Based on the estimated hydraulic properties and tracer mass recovery rates, an optimal $CO_2$ monitoring network including boreholes for monitoring the unsaturated zone was constructed at the study site.