• 제목/요약/키워드: Initial test

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의약품 사용기간 평가 기법을 활용한 원샷시스템의 최초시험 연수 결정 (Determination of the Initial Test Year for One-Shot System using Validity Assessment of Drugs)

  • 박지명;이홍철;장중순;박상철
    • 한국신뢰성학회지:신뢰성응용연구
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    • 제17권1호
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    • pp.1-10
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    • 2017
  • Purpose: This study aims at omitting the initial testing of the ASRP by determining the initial test year. Methods: This study is to determine of the initial test year for one-shot system using validity assessment of drugs. Results: Procedures for determining the initial test duration of the one shot system and examples of omitting the tests are presented. Conclusion: Using this method, the time and labor required for testing can be saved by omitting the initial testing of ASRP.

압력손실시험을 이용한 막 완결성 평가에서 초기압력 및 UCL 도출인자 민감도 분석 (Sensitivity Analysis of Initial Pressure and Upper Control Limit on the Pressure Decay Test for Membrane Integrity Evaluation)

  • 이주희;홍승관;허현철;이광제;최영준
    • 한국물환경학회지
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    • 제24권6호
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    • pp.793-800
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    • 2008
  • Recently domestic drinking water industry has recognized membrane-based technology as a promising alternative for water treatment. To ensure successful application of membrane processes, the integrity of membrane systems should be maintained. According to US EPA guidance, the pressure decay test based on the bubble point theory is recommended to detect any membrane defection of which size is close to the smallest diameter of Cryptosporidium oocysts, $3{\mu}m$. Proper implementation of the pressure decay test is greatly affected by initial test pressure, and the interpretation of the test results is associated with upper control limit. This study is conducted to investigate various factors affecting determination of initial test prtessure and upper control limit, including membrane-based parameters such as pore shape correction factor, surface tension and contact angle, and system-based parameters, such as volumetric concentration factor and total volume of system. In this paper, three different hollow fibers were used to perform the pressure decay test. With identical initial test pressure applied, their pressure decay tendency were different from each other. This finding can be explained by the micro-structure disparity of those membranes which is verified by FESEM images of those membranes. More specifically, FESEM images revealed that three hollow fibers have asymmetry, deep finger, shallow finger pore shape, respectively. In addition, sensitivity analysis was conducted on five parameters mentioned above to elucidate their relation to determination of initial test pressure and upper control limit. In case of initial pressure calculation, the pore shape correction factor has the highest value of sensitivity. For upper control limit determination, system factors have greater impact compared to membrane-based parameters.

피에조콘을 이용한 선행압밀하중 결정 신경망 모델의 초기 연결강도 의존성 개선 (Improvement of Initial Weight Dependency of the Neural Network Model for Determination of Preconsolidation Pressure from Piezocone Test Result)

  • 박솔지;주노아;박현일;김영상
    • 한국지반공학회:학술대회논문집
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    • 한국지반공학회 2009년도 춘계 학술발표회
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    • pp.456-463
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    • 2009
  • The preconsolidation pressure has been commonly determined by oedometer test. However, it can also be determined by in-situ test, such as piezocone test with theoretical and(or) empirical correlations. Recently, Neural Network(NN) theory was applied and some models were proposed to estimate the preconsolidation pressure or OCR. However, since the optimization process of synaptic weights of NN model is dependent on the initial synaptic weights, NN models which are trained with different initial weights can't avoid the variability on prediction result for new database even though they have same structure and use same transfer function. In this study, Committee Neural Network(CNN) model is proposed to improve the initial weight dependency of multi-layered neural network model on the prediction of preconsolidation pressure of soft clay from piezocone test result. It was found that even though the NN model has the optimized structure for given training data set, it still has the initial weight dependency, while the proposed CNN model can improve the initial weight dependency of the NN model and provide a consistent and precise inference result than existing NN models.

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구조해석에 의한 파이프서포트의 내력비교에 관한 연구 (A Study on the Strength Comparison of Steel Pipe Support using the Structural Analysis Program)

  • 백신원;박종근
    • 한국안전학회지
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    • 제23권4호
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    • pp.67-71
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    • 2008
  • Formwork is a temporary structure that supports its weight and that of fresh concrete as well as construction live loads. Slab formwork consists of sheathing, stringer, hanger and shore. In construction site, pipe supports are usually used as shores which are consisted of the slab formwork. In this study, compressive strength of 80 pipe supports was measured by knife edge test and plate test. Buckling load of pipe supports was analyzed by structural analysis program(MlDAS). Theoretical buckling load with/without initial deformation was got by theoretical analysis. According to these results, buckling load which was analyzed by structural analysis program(MlDAS) was larger than compressive strength of knife edge test and plate test. Theoretical buckling load without initial deformation was larger than compressive strength of knife edge test and plate test. But Theoretical buckling load with initial deformation was lower than compressive strength of knife edge test and plate test. Initial deformation equation for test method according to the pipe support length was suggested. Therefore, the present study results will be used to design the slab formwork safely.

항공기 Run-Up 진동 환경에서의 관성항법장치 초기 정렬 방법 설계 및 평가 (Design and Evaluation of INS Initial Alignment under Vibration Environment of Aircraft Run-up)

  • 유해성;이인섭;오주현;김천중;박흥원
    • 제어로봇시스템학회논문지
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    • 제21권7호
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    • pp.691-698
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    • 2015
  • Inertial Navigation Systems (INS) are widely used as the main navigation device for aircraft. To get the initial attitude, the INS requires the initial alignment before navigation starts. An aircraft also needs an engine test procedure that causes some vibrations before flight. An INS can't be aligned in a vibration environment so the initial alignment is performed before the aircraft engine test. Therefore, the initial alignment time of an INS has been a major factor in limiting an aircraft's takeoff response time. In this paper, we designed an initial alignment algorithm that can be executed even in disturbances such as aircraft run-up. We demonstrated verification of the algorithm that is embedded on the real INS and testing methods to evaluate the alignment of the INS. We also analyzed the test results of the proposed initial alignment algorithm that is performed during a real aircraft run-up.

초치료 폐결핵 환자들에 있어서 초회 약제내성률 (The Prevalence of Initial Drug Resistance among Pulmonary Tuberculosis Patients)

  • 공재환;이상석;강하얀;박재석
    • Tuberculosis and Respiratory Diseases
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    • 제64권2호
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    • pp.95-101
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    • 2008
  • 연구배경: 결핵의 치료력이 없는 결핵환자에서 발생하는 초회 약제내성은 결핵관리에 있어서 심각한 문제이다. 그러나 우리나라, 특히 민간의료기관에서 치료받는 폐결핵환자들의 초회 약제내성률에 대해서 잘 알려져 있지 않다. 본 연구에서는 천안지방의 한 3차병원에서 폐결핵환자들의 초회 약제내성률과 약제내성의 위험요소에 대해서 알아보았다. 방법: 2005년 9월부터 2007년 9월까지 단국대학교병원에서 객담 결핵균 배양검사 양성인 초치료 폐결핵환자 모두에 대해서 일차약과 이차약에 대한 약제감수성 검사를 시행하고 초회 약제내성의 양상과 함께 약제내성의 위험요소을 분석하였다. 또한 약제감수성 검사 결과가 치료 처방에 미치는 영향을 분석하였다. 결과: 총 156명의 초치료 폐결핵 환자에 대해서 약제 감수성 검사를 시행하였는데 한 가지 이상의 약제에 내성을 보인 환자는 21명(15.6%)이었으며 이소니아지드와 리팜핀에 동시 내성을 보이는 다제내성 환자는 1명(0.6%)이었다. 임상소견 중 초회 약제내성을 예측할 수 있는 독립적인 위험요소는 없었다. 약제감수성 검사 결과에 의해 15명(9.6%)의 환자에서 치료처방의 변경이 있었다. 결론: 폐결핵에서 초회 약제내성은 흔히 관찰되며 초 치료 폐결핵환자에서 약제감수성 검사는 환자치료에 도움이 된다.

가시 레이저 광을 이용한 치아우식활성검사에 관한 연구 (A STUDY ON THE CARIES ACTIVITY TEST WITH VISIBLE LIGHT INDUCED BY LASER)

  • 이상호;이난영
    • 대한소아치과학회지
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    • 제27권1호
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    • pp.161-168
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    • 2000
  • 본 연구는 치아우식을 유발할 수 있는 모든 요인이 종합적으로 작용하여 이루어진 치면의 최초의 변화 즉, 법랑질 초기우식증의 정도를 아르곤 레이저를 이용한 형광법으로 조기에 탐지하고 이와 같은 방법이 향후 개인에서의 우식이 유발될 수 있는 가능성을 예측할 수 있는 우식 활성검사법으로서의 이용 가능성 이 있는지의 여부를 규명하고자 하는데 목적이 있다. 조선대학교 부속치과병원 소아치과에 내원한 아동중 유구치의 탈락이 없는 $7\sim10$세 사이의 어린이 30명을 대상으로 하여 치아의 순면과 협면에 레이저 조사하고 특수 필터를 사용하여 우식치아의 개수를 측정하여 기존의 우식활성도 측정방법인 $Cariescreen^{(R)}$ test, 구강환경검사인 우식경험치아의 수(dDfFtT) 등 각종 검사법들과 상관관계를 비교, 평가한 바 다음과 같은 결론을 얻었다. 1. 레이저 형광법에 의한 관찰이 육안에 의한 관찰에 비해 초기우식병소를 더 많이 관찰하였다. 2. 아르곤 레이저 형광법을 이용한 우식활성도 측정법은 기존의 $Cariescreen^{(R)}$ test, 그리고 dDfFtT 검사 등과 높은 상관 관계를 나타냈다.

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Laboratory investigation for engineering properties of sodium alginate treated clay

  • Cheng, Zhanbo;Geng, Xueyu
    • Structural Engineering and Mechanics
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    • 제84권4호
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    • pp.465-477
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    • 2022
  • The formation of biopolymer-soil matrices mainly depends on biopolymer type and concentration, soil type, pore fluid and phase transfer to influence its strengthening efficiency. In this study, the physical and mechanical properties of sodium alginate (SA) treated kaolinite are investigated through compaction test, thread rolling teat, fall cone test and unconfined compression test with considering biopolymer concentration, curing time, initial water content, mixing method. The results show that the liquid limit slightly decreases from 69.9% to 68.3% at 0.2% SA and then gradually increases to 98.3% at 5% SA. At hydrated condition, the unconfined compressive strength (UCS) of SA treated clay at 0.5%, 1%, 2% and 3% concentrations is 2.57, 4.5, 7.1 and 5.48 times of untreated clay (15.7 kPa) at the same initial water content. In addition, the optimum biopolymer concentration, curing time, mixing method and initial water content can be regarded as 2%, 28 days, room temperature water-dry mixing (RD), 50%-55% to achieve the maximum unconfined compressive strength, which corresponds to the UCS increment of 593%, compared to the maximum UCS of untreated clay (780 kPa).

Correlation between Colon Transit Time Test Value and Initial Maintenance Dose of Laxative in Children with Chronic Functional Constipation

  • Kim, Mock Ryeon;Park, Hye Won;Son, Jae Sung;Lee, Ran;Bae, Sun Hwan
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • 제19권3호
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    • pp.186-192
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    • 2016
  • Purpose: To evaluate the correlation between colon transit time (CTT) test value and initial maintenance dose of polyethylene glycol (PEG) 4000 or lactulose. Methods: Of 415 children with chronic functional constipation, 190 were enrolled based on exclusion criteria using the CTT test, defecation diary, and clinical chart. The CTT test was performed with prior disimpaction. The laxative dose for maintenance was determined on the basis of the defecation diary and clinical chart. The Shapiro-Wilk test and Pearson's and Spearman's correlations were used for statistical analysis. Results: The overall group median value and interquartile range of the CTT test was 43.8 (31.8) hours. The average PEG 4000 dose for maintenance in the overall group was $0.68{\pm}0.18g/kg/d$; according to age, the dose was $0.73{\pm}0.16g/kg/d$ (<8 years), $0.53{\pm}0.12g/kg/d$ (8 to <12 years), and $0.36{\pm}0.05g/kg/d$ (12 to 15 years). The dose of lactulose was $1.99{\pm}0.43mL/kg/d$ (<8 years) or $1.26{\pm}0.25mL/kg/d$ (8 to <12 years). There was no significant correlation between CTT test value and initial dose of laxative, irrespective of the subgroup (encopresis, abnormal CTT test subtype) for either laxative. Even in the largest group (overall, n=109, younger than 8 years and on PEG 4000), the correlation was weak (Pearson's correlation coefficient [R]=0.268, p=0.005). Within the abnormal transit group, subgroup (n=73, younger than 8 years and on PEG 4000) correlation was weak (R=0.267, p=0.022). Conclusion: CTT test value cannot predict the initial maintenance dose of PEG 4000 or lactulose with linear correlation.

45노트급 고속정의 초기선형 개발과 저항성능에 관한 연구 (A Study on the Initial Hull Form Development and Resistance Performance of a 45 Knots Class High-Speed Craft)

  • 김주남;정우철;박제웅;김도정
    • 한국해양공학회지
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    • 제20권1호
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    • pp.32-36
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    • 2006
  • The initial hull form of a 100 tan, 45 knot class high-speed craft is newly developed. The resistance performances are investigated using a model test at high speed in a circulating water channel. The effect of the initial trim is studied together. Wave patterns are observed to clarify the relationship between the resistance performance and the wave characteristics. It can be found that the initial trim plays a role in increasing the resistance performance above a certain velocity.