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A Case of Lung Cancer with Metastasis to the Right Fifth Toe (제 5 우족지의 전이를 동반한 폐암 1예)

  • Lee, Hong-Lyeol;Kim, Se-Kyu;Lee, Hwan-Mo;Shin, Dong-Hwan;Chang, Jung-Hyun;Kwak, Seung-Min;Chang, Joon;Kim, Sung-Kyu;Lee, Won-Young
    • Tuberculosis and Respiratory Diseases
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    • v.40 no.1
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    • pp.72-78
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    • 1993
  • Background: In malignancies, detection of metastatic foci is of value in making therapeutic plans for treatment of disease and prevention of life-threatening complications. Common sites for metastasis of bronchogenic cancer include lymph nodes, liver, brain, adrenals and bone. Skull, vertebrae, ribs and long bones are common sites for bone metastasis. But in epidermoid carcinoma, the incidence of bone metastasis is relatively low and especially to the distal phalangeal bone is rare. Methods: We experienced a case of epidermoid carcinoma with the first distant metastasis to the fifth distal phalangeal bone, right toe. Results: The initial stage in the diagnosis of epidermoid carcinoma was T4N3MO. During the third round of anticancer chemotherapy, we recognized the distant metastasis to the fifth distal phalangeal bone for the first time. Localized abnormal findings were noted by bone X-ray and scanning. By a histopathologic examination of the amputated toe, we confirmed the metastasis of epidrmoid bronchogenic carcinoma. Conclusion: If localized abnormal finding is discovered at an unusual site for metastasis, we recommend physicians to consider the possibility of metastasis even though it is very low.

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Two Dimensional Size Effect on the Compressive Strength of T300/924C Carbon/Epoxy Composite Plates Considering Influence of an Anti-buckling Device (T300/924C 탄소섬유/에폭시 복합재 적층판의 이차원 압축 강도의 크기효과 및 좌굴방지장치의 영향)

  • ;;;C. Soutis
    • Proceedings of the Korean Society For Composite Materials Conference
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    • 2002.10a
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    • pp.88-91
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    • 2002
  • The two dimensional size effect of specimen gauge section (length x width) was investigated on the compressive behavior of a T300/924 [45/-45/0/90]3s, carbon fiber-epoxy laminate. A modified ICSTM compression test fixture was used together with an anti-buckling device to test 3mm thick specimens with a 30$\times$30, 50$\times$50, 70$\times$70, and 90mm$\times$90mm gauge length by width section. In all cases failure was sudden and occurred mainly within the gauge length. Post failure examination suggests that $0^{\circ}$ fiber microbuckling is the critical damage mechanism that causes final failure. This is the matrix dominated failure mode and its triggering depends very much on initial fiber waviness. It is suggested that manufacturing process and quality may play a significant role in determining the compressive strength. When the anti-buckling device was used on specimens, it was showed that the compressive strength with the device was slightly greater than that without the device due to surface friction between the specimen and the device by pretoque in bolts of the device. In the analysis result on influence of the anti-buckling device using the finite element method, it was found that the compressive strength with the anti-buckling device by loaded bolts was about 7% higher than actual compressive strength. Additionally, compressive tests on specimen with an open hole were performed. The local stress concentration arising from the hole dominates the strength of the laminate rather than the stresses in the bulk of the material. It is observed that the remote failure stress decreases with increasing hole size and specimen width but is generally well above the value one might predict from the elastic stress concentration factor. This suggests that the material is not ideally brittle and some stress relief occurs around the hole. X-ray radiography reveals that damage in the form of fiber microbuckling and delamination initiates at the edge of the hole at approximately 80% of the failure load and extends stably under increasing load before becoming unstable at a critical length of 2-3mm (depends on specimen geometry). This damage growth and failure are analysed by a linear cohesive zone model. Using the independently measured laminate parameters of unnotched compressive strength and in-plane fracture toughness the model predicts successfully the notched strength as a function of hole size and width.

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Changes in Available Lysine and Extractable Nitrogen, and Extent of Browning during the Storage of Dried Fish Meat (건어육저장중의 유효 Lysine 및 Ex분질소의 변화와 갈변)

  • LEE Kang-Ho;SONG Dong-Suck;You Byeong-Jin;KIM Mu-Nam
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.15 no.4
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    • pp.271-282
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    • 1982
  • The browning development, mainly through the Maillard reaction, occurring in the dried fish meat products during storage causes reduction of the nutritional value due to the loss of the essential amino acid such as available lysine as well as off -flavor resulting in the deterioration of the food quality thus shortening the shelflife. In the work, the changes in the amount of available lysine, extractable nitrogenous compounds (nonprotein-N, amino-N, trimethylamine oxide, trimethylamine, and free lysine) and development of browning were measured to assess the relationship between the shelflife and the quality loss in dried filefish under the steady state conditions (35,45, and $55^{\circ}C;a_{w}'s$ of 0.44 0.52, 0.65 and 0.75 at each temperature) and fluctuating temperature condition of $35/55^{\circ}C$ will. alternating 7 day periods at each water activity. The results indicated that the amount of available lysine and extractable nitrogenous compounds except TMA decreased rapidly with increasing temperatures and water activities while the rate of available lysine and extractable nitrogenous compounds must be involved in the initial stage of brown pigment formation. The available lysine loss of the dried filefish products stored under the fluctuating temperature conditions was greater than that stored under its fixed mean temperature, $45^{\circ}C$. The activation energies for lysine loss obtained from the Arrhenius plot ranged 6.9 to 4.4 Kcal/mol and $Q_{10}$ values at $40^{\circ}C$ were 1.4 to 1.2. The values for browning were 15.7 to 14.4 Kcal/mol and 2.2 to 2.0 respectively. Shelf-life, defined as the time to reach 0.15 O. D./g solid or the limit of off-color deterioration by browning reaction, was extented longer than the halflife of Iysine loss, actually corresponding $75\%$ loss of available lysine. This suggested that the halflife of lysine loss might not be adequate to assess the shelf-life of the food system with high potential of protein, nonproteinous nitrogen compounds, and lipids.

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Applying Evaluation of Soil Erosion Models for Burnt Hillslopes - RUSLE, WEPP and SEMMA (산불사면에 대한 토양침식모형의 적용 평가 - RUSLE, WEPP, SEMMA)

  • Park, Sang Deog;Shin, Seung Sook
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.31 no.3B
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    • pp.221-232
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    • 2011
  • Applicability of three soil erosion models for burnt hillslopes was evaluated. The models were estimated with the data from plots established after tremendous wildfire occurred in the east coastal region. Soil erosion and surface runoff were simulated by the Water Erosion Prediction Project (WEPP) and the Revised Universal Soil Loss Equation (RUSLE) of application mode for disturbed forest areas and the Soil Erosion Model for Mountain Areas (SEMMA) developed for burnt hillslopes. Simulated sediment yield and surface runoff were compared with the measured those. In maximum value of sediment yield, three models was under-predicted and RUSLE and WEPP had difference of over two times. SEMMA showed the best model response coefficient, determination coefficient and the model efficiency. In application of models to the soil erosion according to the elapsed year after wildfire, all models were underestimated in initial stage disturbed by wildfire. Evaluation of models in this burnt hillslopes was shown the tends to under-predict soil erosion for larger measured values. Although a lot of sediment can be generated in small rainfall event as fine-grained soil of the high water repellency was exposed excessively right after wildfire, this under-prediction was shown that those models have a limit to estimate the weighted factors by wildfire.

Algal Bioassay for the Treated and Raw Wastewater in the Kyongan Stream (경안천에서 하수처리수와 생하수에 대한 algal bioassay)

  • Lee, Ok-Hee;Hwang, Soon-Jin;Cho, Kyung-Je;Shin, Jae-Ki
    • Korean Journal of Ecology and Environment
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    • v.34 no.3 s.95
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    • pp.192-198
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    • 2001
  • The Kyongan Stream and the inlet part of Paltang Reservoir are under significant influence of the effluent of sewage wastewater treatment plant (SWTP) and untreated domestic wastewater (DOW). The fertility of wastewater was evaluated through bioassay using natural phytoplankton population diluted in five levels. The concentrations of $NH_4$, SRP and SRSi were positively correlated with the biomass of phytoplankton. P concentration showed stronger correlation (r = 0.959, p<0.001)than other nutrients. Compared with the initial concentrations, $NH_4$ concentrations in samples from SWTP and DOW decreased 96% and 7%, respectively during the cultivation, and those of SRSi decreased 97% and 60%. However, $NO_3$ concentrations in samples neither showed any particular change nor any increase. Chl-a concentration ranged between $20\;{\mu}g/l$ and $125\;{\mu}g/l$, which maximum value increased up to 83 times. Estimated from the relationship between chl-a and SRP, the P concentration that can maintain the biomass of algae under mesotrophic state (<25\;{mu}g$\;chl-a/l$) was $83\;{mu}g\; P/l$. The volume of flow to maintain this level solely by natural dilution was about $16{\sim}25$ times of in flowing volume in the stream. However, it is not feasible to tap water of such quantity. Therefore, it is imperative to build an advanced sewage wastewater treatment facility that can reduce $NH_4$ and SRP concentrations that promote the growth of phytoplankton in discharged water.

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Combined effects of copper and temperature on Hematological constituents in the Rock fish, Sebastes schlegeli (조피볼락, Sebastes schlegeli의 혈액학적 성분변화에 미치는 구리 및 온도의 복합적 영향)

  • Baeck, SuKyong;Min, EunYoung;Kang, Ju-Chan
    • Journal of fish pathology
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    • v.27 no.1
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    • pp.57-65
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    • 2014
  • Copper ($CuSO_4$) has been widely used to control algae and pathogens in fish culture ponds. However, its toxic effects on fish depend not only on its concentration in water but also on water quality. The susceptibility of the rockfish, Sebastes schlegeli to copper was evaluated at three water-temperatures (WT; 18, 23 and $28^{\circ}C$) for 4 days. After the exposure of two copper concentrations (100 and $200{\mu}g/L$), a hematological effect was exerted on rockfish, by causing changes in red blood cell count and hematocrit value at $28^{\circ}C$. Total protein levels of the fish showed a tendency of co-increase with glucose depend on the WT, after copper exposure. However, the plasma calcium and magnesium levels were significantly increased at $200{\mu}g/L$ copper, regardless of the WT. Enzymes activities including ALT and LDH in serum were also significantly increased depend upon the copper treatment only. This indicates that inorganic components and enzymes activities were sensitive indexes to stress by toxicant such as copper. The cortisol levels were significantly elevated by both WT rising and copper treatment in serum of rock fish. In conclusion, these changes can be seen as an initial response to temperature stress and as a sustaining response to copper exposure. The present findings suggest that a simultaneous stress by temperature change and copper exposure could accelerate an alteration of hematological and plasma biological parameters in the rockfish.

Quality Characteristics of Small Package Kimchi according to Packing Material and Storage Temperature (포장재와 저장온도에 따른 소포장 김치의 품질특성)

  • Park, Hye-Young;Ahn, Ji-A;Seo, Hae-Jung;Choi, Hye-Sun
    • Korean journal of food and cookery science
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    • v.27 no.1
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    • pp.63-73
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    • 2011
  • Cabbage (Baechu) Kimchi in its truncated form was placed in four different packing materials, Ny/PE/LLDP, OPP/AL/PE, PP and PET, and quality changes were observed during storage. Changes in pH and total acidity showed an x-shaped cross-curve as pH decreased and total acidity increased during storage. PP tray showed the slowest change at $5^{\circ}C$ with time. The pH was initially 6.25, but decreased to 4.12~4.16 at 20 days, and total acidity showed a 4 to 4.8-fold increase after 20 days of storage compared to the initial value. During storage at $5^{\circ}C$, total bacterial count and lactic acid bacterial count rapidly increased after 4 days. The total bacterial quantity decreased after a period of time and there were differences according to packaging material; OPP/AL/PE packaging showed the most dramatic decrease. Change in microbial count mostly followed a similar pattern to that of total acidity for all packaging materials. Changes in the color of Kimchi liquid, when examined by color index in $L{\cdot}b$/a form, rapidly decreased over time, similar to pH. Small Ny/PE/PP and OPP/AL/PE packages of Kimchi were examined for changes in free volume inside the packaging. After 13 days of storage at $5^{\circ}C$, the volume was 243 mL, but storage at $20^{\circ}C$ resulted in a volume of 372 mL, a more than 1.5-fold increase in free volume. There were changes in the quality characteristics of small package Kimchi according to storage temperature and packaging material, and large changes in pH, total acidity, and microbial count were evident upon storage at $5^{\circ}C$ for 8 days, which was the optimum palatability period. Mostly, PP treatment showed the slowest quality changes upon storage at $5^{\circ}C$. However, due to small package Kimchi's fast consumption system, the appropriate choice of packaging material must consider the product's turnover ratio. Further, the varieties of small package Kimchi should be diversified according to different consumer preferences by offering Kimchi with different maturity levels. Further, since the leading consumer base ranges in age from the teens to thirties, the development of various products targeting such consumers is necessary.

Effects of High Protein Diet Containing Barley on Growth Performance and Carcass Characteristics in Finishing Pigs (보리함유 고단백질 사료의 급여가 비육돈의 생산성 및 도체특성에 미치는 영향)

  • Shin, Seung-Oh;Yoo, Jong-Sang;Lee, Jea-Hyun;Jang, Hae-Dong;Kim, Hyo-Jin;Chen, Ying-Jie;Cho, Jin-Ho;Kim, In-Ho
    • Food Science of Animal Resources
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    • v.28 no.3
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    • pp.349-354
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    • 2008
  • This study was conducted to evaluate the effects of a high protein diet containing barley on the growth performance and carcass characteristics of finishing pigs. A total of fifty six [(Landrace${\times}$Yorkshire${\times}$Duroc)] pigs (85.08 kg in average initial body weight) were used for a 6-week study. Dietary treatments included 1) Basal diet (CON) and 2) High protein diet with barley 5% (HB5). During the entire test periods, there were no significant differences in Average daily gain (ADG), Average daily feed intake (ADFI) and gain/feed ratio between treatments (p>0.05). The b value of M. logissimus dorsi muscle color was significantly increased in CON fed pigs compared to pigs fed the HB5 diet (p<0.05). The water holding capacity (WHC) was higher in HB5 than CON fed pigs (p<0.05). Also, drip loss was significantly decreased in HB5 compared to CON fed pigs (p<0.05). Backfat thickness, live weight, cold carcass weight, dressing, and carcass grade were not significantly affected by either treatment (p>0.05). In conclusion, the results of this study indicate that a high protein diet with 5% barley affects meat color, WHC and drip loss in finishing pigs.

Comparison of Quality of Peeled Lotus Roots Stored in Various Immersion Liquids during Storage (침지액을 달리한 박피 연근의 저장중 품질 비교)

  • Jeong, Jin-Woong;Park, Kee-Jai;Sung, Jung-Min;Kim, Jong-Hoon;Kwon, Ki-Hyun
    • Korean Journal of Food Science and Technology
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    • v.38 no.4
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    • pp.526-533
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    • 2006
  • This study was carried out to investigate the efficacy of strong acidic electrolyzed acid water (SAEW; Strong acidic electrolyzed water, pH 2.76, ORP 1,128 mV, HClO 105.0 ppm) and low alkaline electrolyzed water (LAEW; Low alkaline electrolyzed water, pH 8.56, ORP 660 mV, HClO 73.8 ppm) as storing liquid for peeled lotus root. During storage at $5^{\circ}C$, it was showed that SAEW and LAEW inhibit growth of microorganisms until at least 5 days of storage. Total phenolic contents, polyphenol oxidase (PPO) activity, and color differences value $({\Delta}E)$ of peeled lotus roots stored in SAEW and LAEW were lower than that of one stored in TW (tap water). The hardness decrement of lotus roots stored in SAEW and LAEW were lower than that of lotus root stored in TW too. Contents of moisture crude protein crude fat, crude ash, crude fiber, and total sugars were gradually decreased during storage. Whereas vitamin C content of lotus root stored in 0.6% acetic acid was most rapidly decreased to 25% as compared with one of initial days of storage that of lotus roots stored in SAEW and LAEW was not decreased significantly as compared with one stored in TW. Sensory characteristic during storage was preferable on lotus root stored in SAEW to the other treatments.

Solderability of thin ENEPIG plating Layer for Fine Pitch Package application (미세피치 패키지 적용을 위한 thin ENEPIG 도금층의 솔더링 특성)

  • Back, Jong-Hoon;Lee, Byung-Suk;Yoo, Sehoon;Han, Deok-Gon;Jung, Seung-Boo;Yoon, Jeong-Won
    • Journal of the Microelectronics and Packaging Society
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    • v.24 no.1
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    • pp.83-90
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    • 2017
  • In this paper, we evaluated the solderability of thin electroless nickel-electroless palladium-immersion gold (ENEPIG) plating layer for fine-pitch package applications. Firstly, the wetting behavior, interfacial reactions, and mechanical reliability of a Sn-3.0Ag-0.5Cu (SAC305) solder alloy on a thin ENEPIG coated substrate were evaluated. In the wetting test, maximum wetting force increased with increasing immersion time, and the wetting force remained a constant value after 5 s immersion time. In the initial soldering reaction, $(Cu,Ni)_6Sn_5$ intermetallic compound (IMC) and P-rich Ni layer formed at the SAC305/ENEPIG interface. After a prolonged reaction, the P-rich Ni layer was destroyed, and $(Cu,Ni)_3Sn$ IMC formed underneath the destroyed P-rich Ni layer. In the high-speed shear test, the percentage of brittle fracture increased with increasing shear speed.