• Journal of Cancer Prevention
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• 제22권1호
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• pp.1-5
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• 2017

Pancreatic cancer is a highly aggressive malignant tumor of the digestive system and radical resection, which is available to very few patients, might be the only possibility for cure. Since therapeutic choices are limited at the advanced stage, prevention is more important for reducing incidence in high-risk individuals with family history of pancreatic cancer. Epidemiological studies have shown that a high consumption of fish oil or ${\omega}3-polyunsaturated$ fatty acids reduces the risk of pancreatic cancers. Dietary fish oil supplementation has shown to suppress pancreatic cancer development in animal models. Previous experimental studies revealed that several hallmarks of cancer involved in the pathogenesis of pancreatic cancer, such as the resistance to apoptosis, hyper-proliferation with abnormal $Wnt/{\beta}-catenin$ signaling, expression of pro-angiogenic growth factors, and invasion. Docosahexaenoic acid (DHA) is a ${\omega}3-polyunsaturated$ fatty acid and rich in cold oceanic fish oil. DHA shows anti-cancer activity by inducing oxidative stress and apoptosis, inhibiting $Wnt/{\beta}-catenin$ signaling, and decreasing extracellular matrix degradation and expression of pro-angiogenic factors in pancreatic cancer cells. This review will summarize anti-cancer mechanism of DHA in pancreatic carcinogenesis based on the recent studies.

• 운동영양학회지
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• 제24권2호
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• pp.22-29
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• 2020

[Purpose] Exercise is thought to have a significant effect on chemotherapy, and previous studies have reported that exercise can increase patient survival. Thus, in this review, we aimed to summarize various animal models to analyze the effects of exercise on breast cancer. [Methods] We summarized types of breast cancer animal models from various reports and analyzed the effects of exercise on anti-cancer factors in breast cancer animal models. [Results] This review aimed to systematically investigate if exercise could aid in suppressing breast cancer. Our study includes (a) increase in survival rate through exercise; (b) the intensity of exercise should be consistent and increased; (c) a mechanism for inhibiting carcinogenesis through exercise; (d) effects of exercise on anti-cancer function. [Conclusion] This review suggested the necessity of a variety of animal models for preclinical studies prior to breast cancer clinical trials. It also provides evidence to support the view that exercise plays an important role in the prevention or treatment of breast cancer by influencing anticancer factors.

• Asia pacific journal of information systems
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• 제29권4호
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• pp.591-614
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• 2019

With the proliferation of social media, it has become easier for people to spread rumors online, which can aggravate the issues arising from online rumors. There are many individuals and organizations that are adversely affected by malicious online rumors. Despite their importance, there has been little research into why and how people spread rumors online, thus inhibiting the understanding of factors that affect the spreading of online rumors. With attention seeking to address this gap, this paper draws upon the dual process theory and the de-individuation theory to develop a theoretical model of factors affecting the spreading of an online rumor, and then empirically tests it using survey data from 211 individuals about a specific rumor. The results indicate that the perceived credibility of the rumor affects the individuals' attitudes toward spreading it, which consequently affects the rumor spreading behavior. Vividness, confirmation of prior beliefs, argument strength, and source credibility positively influence the perceived credibility of online rumors. Finally, anonymity moderates the relationship between attitude toward spreading online rumors and the spreading behavior.

• 한국식품과학회지
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• 제5권1호
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• pp.33-35
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• 1973

대두(大豆)를 침지(浸漬)후 $100^{\circ}C$에서 2분간 가열하면 불쾌한 풋 냄새의 발생을 충분히 억제할 수 있다. 건조한 대두(大豆)의 경우는 $100^{\circ}C$에서 3분간 가열하면 같은 효과를 나타낸다. 이와 같은 간단한 열처리(熱處理)는 병아리 사육시험의 결과 발육조해인자(發育阻害因子)를 불활성화(不活性化)시키기에는 불충분하다. 이취(異臭)의 조해(阻害)는 lipoxygenase 활성(活性)의 상실과 일치하며 이것이 그 원인인 것으로 생각된다.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2004년도 학술대회지
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• pp.107-125
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• 2004

A bioremediation of petroleum-contaminated soil in Korea was evaluated for the optimization of enhanced biodegradation and the minimization of effects of seasonal variations, The short-term bioremediation in combination of biopile pretreatment and landfarming was performed by lowering contaminated levels and overcoming the inhibiting factors in the rainy and winter seasons. A microbial density was maintained with indigenous microbial addition for bioaugmentation and with fertilizers for biostimulation. A lesser volatile and biodegradable fraction due to their abiotic removals following the biopile pretreatment was effectively removed by the laterally applied landfarming. The optimal temperature in greenhouse was maintained by buffering of the soil temperature even with slight decreases in removal rates during the winter and extensive leaching of nutrients and contaminants was restricted with adjusting the water contents during the Korean rainy season. Although the tilling process was effective for biodegradation with aeration only, the simultaneous treatment due to apparent mixing of nutrients and microbes more favorably degraded the petroleum than the sequential treatment.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1458-1460
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• 2008

Tissue engineering is an interdisciplinary field that utilizes the principles of engineering and life sciences toward the creation of biological substitutes. Traditionally, major components of tissue engineering are cells, scaffolds, growth factors and recently biomechanical aspects have been given much attention. A large number of studies have reported that mechanical signals are of particular interest in either encouraging or inhibiting cellular responses. In tissue engineering, cell adhesion is a very important step, because quality of adhesion may determine a cell fate in the future. Elasticity of cell-adhesive substrate is found critical in regulating stem cell differentiation. Cells exert different contractile forces for cell migration, depending on substrate mechanics. Though tissue engineering is very interactive with diverse expertise, for a breakthrough, principles of biomechanics in tissue and cell level needs to be fully understood.

• Bulletin of the Korean Chemical Society
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• 제33권1호
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• pp.149-152
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• 2012

The (S)-(+)-decursin and its analogues are reported as potent inhibitors of melanin production in B16 murine melanoma cells. In order to understand the factors responsible for potency as well as inhibition of potency of (S)-(+)-decursin and its analogues, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed. Since receptor structures are not available, a pharmacophore model was constructed. Using PHASE, we generated 3 different models and selected the seven-site model, which returned excellent statistical values ($r^2$ = 0.9127, $Q^2$ = 0.6878, Pearson-R = 0.9014). Using the generated pharmacophore model, we screened a natural products library and obtained 4'-epi-decursin as the most related compound. 4'-epidecursin is similar to (S)-(+)-decursin, but shows additional interaction possibilities with tyrosinase. The study thus sheds some light on possibility of developing more potent tyrosinase inhibitors.

• 대한안전경영과학회지
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• 제13권4호
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• pp.237-245
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• 2011

The number of smartphone users in Korea is reaching around 20 million. We perform a research on the actual conditions, complaints and the types of losses, damages or injuries from smartphone users in Korea. Apart form that, we conduct an investigation on the current problems in promoting the use of smartphones. We would like to suggest some points for promoting global uses of smartphones through the analysis of and the comparison with the abroad cases, which precursed the wide-spread of smartphones in Korea.

• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.293-302
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• 2021

Being able to survive during the Covid19 pandemic is a big task for a company, as such, empowerment of employees is a must. The sample in this study was 300 employees who worked in Spas throughout Bali. The sampling technique was purposive sampling. Data analysis was using SEM and SMARTS as data processing. The results showed that green communication, namely communication that occurs between employees, superiors, and the environment, has a very good influence on the sustainability of employee performance. To become green management, a green organizational commitment that cares about the safety of employee health and the environment is an important factor as motivation in green dedication or positive employee productivity, but communication between work actors and justice is also a motivating factor. Work safety and job security for employees empower employees (which is a green line), especially for freelance work organizations so that further research in subsequent studies can make samples in a more varied industrial sector.

• Nuclear Engineering and Technology
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• 제54권3호
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• pp.984-990
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• 2022

Corrosion release behavior of Alloy 690 in high-temperature water was investigated under the conditions of injected Zn concentrations of 0 ppb, 10 ppb and 50 ppb. A protective oxide film composed of Zn(Fe_xCr_1-x)₂O₄ and Cr₂O₃ was formed with Zn injection, resulting in a better corrosion resistance. In comparison with the Zn-free condition, the corrosion release rate under the Zn-injection conditions was smaller. The corrosion release inhibiting factors were 1.7 and 1.9 under the conditions of 10 ppb and 50 ppb Zn-injection respectively. A foreseen application of the corrosion and corrosion release rates has been proposed and discussed.