• Journal of the Korean Chemical Society
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• v.20 no.5
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• pp.358-363
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• 1976

Kinetic studies on solvolytic reactions of 1-and 2-naphthalene sulfonyl chlorides in ethanol-water mixtures have been carried out by means of conductometry at several temperatures. The rate constant for 2-naphthyl compound was larger than that for 1-naphthyl compound. This was contrary to the prediction of MO theory and could be rationalized as due to the peri-hydrogen effect in the transition state for 1-naphthyl compound. Based on m values of Winstein plots and n values of Kivinen pacolots it was concluded that the solvolytic displacement of the two naphthalene sulfonyl chlorides in ethanol-water mixtures proceed via $S_N2$ process.

• Korean Journal of Head & Neck Oncology
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• v.11 no.1
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• pp.3-8
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• 1995

Tuberculous cervical lymphadenitis is one of common cause of neck mass in young adult in Korea. Tuberculous cervical lymphadenitis known as scrofula was being treated by the 'Royal Touch' in the 5th century and by surgery in the 17th century, yet the principle of the treatment is still controversal. We report the clinical evaluation and therapeutic result about 121 tuberculous cervical lymphadenitis. The result were as follows: 1) The annual incidence(1985-1994) was 30.5 % (37 cases: 1985-1986), 17.7 % (21 cases: 1990-1992). 19.8%(24 cases: 1994). 2) The age of highest incidence was 20-29 year old age group in 41.3% (50 cases) and female predominated over male by 1.8 : 1. 3) The duration of disease was less than 6 months, in 85.9% (104 cases). 4) The most commonly involved LN group was superficial cervical group in 69.4% (84 cases), and difference between Rt & Lt, was not significant. 5) The most common symptom and local finding(P/E) were, painless swelling of LN in 74.3 % (90 cases) and single mass in 59.5 % (72 cases). 6) In seasonal variation, 85.9% (104 cases) was spring and summer. 7) Procedures except biopsy for evaluation were chest PA, AFB smear & culture(sputum), Mantoux test, USG, CT and, Associated extracervical tuberculous lesions were lung, axilla, breast. 8) In operation method (involving biopsy), Excision was 68.5 % (83 cases), neck dissection was 6.6% (8 cases). 9) The Modality, Duration and side effect of antituberculous medication: INH-Rifampin­Ethambutol was 66.1 % (88 cases), duration was 1 year in 84.3% (102 cases), side effects were severe GI trouble (24.8%), liver function damage (3.3%). 10) 3 cases recurred on the same site after 2 yrs(2 cases) and 4 months(1 case) and its treatment was curretage or I & D, with antituberculous medication.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.69-90
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• 1999

Die vorliegende Arbeit setzte sich zum Ziel, deutsche verbale Phraseolexeme(vPL) auf der Grundlage einer Mehrebenenbeschreibung syntaktisch sowie semantisch zu untersuchen. Dabei $st\"{u}tzten$ wir uns vor allem auf die Valenz- und Kasustheorie sowie das 6-Stufen-Modell von G. Helbig(1983) und das Mehrebenenmodell $f\"{u}r$ vPL von B. Wotjak(1992), das seinerseits vom methodischen Ansatz her in engem Zusammenhang zu dem Beschreibungsansatz steht. Aber Wir modifizierten teilweise das Modell yon B. Wotjak(1992) und stellten einige vPL exemplarisch dar. Dieser Untersuchung lag eine verbozentrische Auffassung des Satzes zugrunde: Das Verb bildet das organisierende Zentrum des Satzes und ist fur die Grundstruktur des Satzes verantwortlich. Das Verb als $Valenztr\"{a}ger\;er\"{o}ffnet$ um sich herum bestimmte Leerstellen, deren Zahl und Art letztlich von der Verbbedeutung her determiniert sind. Auch vPL kann als $Valenztr\"{a}ger$ - wie das Verb - das strukturelle Zentrum des Satzes darstellen, d.h. vPL bildet als Ganzes das $Pr\"{a}dikat$, das wendungsextern eine bestimmte Zahl von Leerstellen $er\"{o}ffnet$ und determiniert im Satz mit seinen $inh\"{a}renten$ semantischen Merkmalen seine semantische und syntaktische Umgebung. Bei der Analyse von vPL gingen wir von der Auffassung von B. Wotjak aus, $da\ss$ Modelle zur Beschreibung von Verben prinzipiell auch auf die Beschreibung von verbalen PL anwendbar sind. In dieser Untersuchung verwendeten wir - in Anlehnung an B. Wotjak(1996:4f.) - den Terminus 'Phraseologismus' als Oberbegriff, der a) Kollokationen, $b)\;Funktionsverbgef\"{u}ge\;(FVG)$, c) Wortidiome (wortwertige idiomatische Redewendungen oder Phraseolexeme), d) Satzidiome(satzwertige idiomatische Redewendungen bzw. kommunikative Formeln/ Routineformeln), e) $Sprichw\"{o}rter\;umfa{\ss}t$. Wir $beschr\"{a}nkten$ uns den Gegenstand unserer Untersuchung auf verbale Phraseolexeme(vPL), d.h. wie oben genannte Wortidiome. VPL lassen sich $prim\"{a}r$ in bezug auf das wendungsexterne ($\"{a}u{\ss}ere$) Aktantenpotential(PLe) und $sekund\"{a}r$ in bezug auf die interne Kom­ponentenstruktur des PL(PLi) klassifizieren. Unsere Studie soil nicht nur Hintergrundwissen $f\"{u}r$ Lexikonein­tragungen vertiefen helfen, sondern auch $f\"{u}r$ den Fremdsprachen­unterricht von Nutzen sein.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.141-163
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• 1999

Im Rahmen der Prinzipien und Parametertheorie ist die $koh\"{a}rente$ Konstruktion umstritten in bezug auf die Frage, ob sie yon der satzwertigen, $inkoh\"{a}renten$ Konstruktion(i.e. Small Clause) herleitbar ist oder nicht. Die derivationellen Analysen wie Evakuierungsanalyse, Verbanhebungsanalyse und Reanalyse gehen von der Annahme aus, $da{\ss}\;die\;koh\"{a}rente$ Konstruktion eine von der $inkoh\"{a}renten$ Konstruktion derivierte Variation ist. Im Gegensatz dazu ist nach der Unifikationsanalyse die $koh\"{a}rente$ Konstruktion die basisgenerierte monosententiale Konstruktion. In der vorliegenden Arbeit wird versucht, die empirische und theoretische $Unad\"{a}quatheit$ der derivationellen Analysen zu zeigen. Wenn die derivationellen Analysen korrekt $w\"{a}ren,\;mu{\ss}te$ auch nach der Derivaton beim langen Passiv das Akkusativkomplement der Infinitivkonstruktion ohne Kasuskonversion bleiben. Aber in der Tat wird der Nominativkasus dem Komplement der Infinitivkonstruktion zugewiesen. In der empirischen Gesichtspunkten steht das lange Passiv nicht im Einklang rnit den derivationellen Analysen. Ferner $mu{\ss}$ nach Chomskys $\"{O}konomieprinzip$ die Derivation obligatorisch sein. Aber die derivationellen Analysen, nach denen der grammatische Satz vom grammatischen Satz deriviert wird, ist nicht obligatorisch, sondern fakultativ. Sie sind theoretisch nicht $ad\"{a}quat$. In dieser Arbeit wird die Resultativkonstruktionen als weitere $koh\"{a}rente$ Konstruktion vorgeschlagen. Dabei wird die Evidenz gegen die Small Clause Struktur, die nach den derivationellen Analysen als $urspr\"{u}ngliche$ Struktur der koharenten Konstruktion angenommen wurde, zweierlei wie folgt gezeigt: Skopus und Idiomatisierung. Wenn die Resultativkonstruktionen als Small Clause analysiert werden, kann ein Adverb innerhalb des Small Clause auftreten, das den weiten Skopus $\"{u}ber$ den Gesamtsatz hat. Aber unter der Small Clause Analyse kann $tats\"{a}chlich$ das Adverb wegen der K-Kommandobedingung keinen weiten Skopus. D.h. das Adverb kann das finite Verb nicht k-kommandieren. Idiomatisierung bildet vor der Transformation im Lexikon eine syntaktische Einheit. In der Resultativkonstruktion, die das $inh\"{a}rente$ Reflexivum enthalt, $k\"{o}nnen\;das\;Resultativpr\"{a}dikat$ und das Verb wie ein reflexives Verb analysiert werden. Aber unter der Small Clause Analyse ist Idiomatisierung des $Resultativpr\"{a}dikats\;und\;Verbs\;nicht\;m\"{o}glich$, weil sie in der D-Struktur keine syntaktische Einheit bilden.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.11
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• pp.3060-3065
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• 2009

A series of wholly aromatic Poly(ether-ether-ester)s with flexible side chain was synthesized by direct polycondensation from ether linkaged triad diol and 2,5-dialkoxyterephthalic acid. The chemical structures and physical properties of these polymers were investigated by using $^1H$-NMR, FT-IR, DSC and TGA. As results of investigations, the inherent viscosities($\eta$inh) measured at $40^{\circ}C$ in 1,1,2,2-tetrachloroethane(TCE) were 0.45~0.86 dl/g and initial decomposition(Td) in TGA occurred at 378~418 $^{\circ}C$ in N2 gas. The majority of these polymers were soluble in organic solvents used in this experiments at elevated temperatures. Melting temperatures(Tm) decreased with increasing the length of the side chain and showed odd-even effects.

• Development and Reproduction
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• v.6 no.1
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• pp.31-35
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• 2002

The major urinary proteins(MUPs) of mice that bind hydrophobic molecules known as pheromones are regulated in part by the actions of growth hormone. The expression of the MUPs was therefore investigated in transgenic mice that express a human growth hormone-releasing factor gene from a metallothionein gene promoter(MT-GRF) and as a result have elevated growth hormone levels. MUPs were severely down-regulated in the urine of these animals compared to normal mice or to control transgenic mice expressing another gene(the inhibin a subunit) from the same metallothionein promoter(MT-Inh) and more MUPs disappeared in male mice than female ones. MUPs were also down-regulated in the urine of the UT-GRF-injected mice. In addition, it was observed that the urine of the MT-GRF mice included a high molecular weight protein that co-migrates with the major serum protein albumin, indicating an impairment in glomerular filtration within the kidney. The urinary loss of serum proteins was more severe in male MT-GRF mice than female ones. Thus the overexpression of human GRF mimics changes observed in MUP protein expression and glomerular function in other models of growth hormone hypersecretion with sex-dependent differential effects.

• Archives of Pharmacal Research
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• v.29 no.1
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• pp.26-33
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• 2006

Some new derivatives of 1,2,4-triazolo[2,3-a]benzimidazoles were synthesized through the reaction of 1,2-diaminobenzimidazole with carbon disulfide. The resulting 1,2,4-triazolo-[2,3a]benzimidazole-2-thione intermediate was reacted with one equivalent of alkyl halides to give the corresponding 2-alkylthio derivatives, which were further alkylated through the reaction with another one equivalent of different alkyl halides to afford the target compounds; 1-alkyl-2alkylthio-1,2,4-traizolo[2,3-a]benzimidazoles. On the other hand, the 1,2-disubstituted derivatives with two identical alkyl substituents were prepared by the reaction of 1,2,4-triazolo[2,3-a]benzimidazole-2-thione with two equivalents of the alkyl halides. The structures of the new compounds were assigned by spectral and elemental methods of analyses. The synthesized compounds were tested for their antibacterial and antifungal activities. Most of the tested compounds proved comparable results with those of ampicillin and fluconazole reference drugs. The study indicated that, the antibacterial as well as the antifungal activities of the test compounds were improved with increase in the bulkiness of the introduced alkyl groups. Also, some active antibacterial compounds were tested for their antimycobacterial activity. All the test compounds showed equipotent antitubercular activity as that of INH as a reference drug.

• Tuberculosis and Respiratory Diseases
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• v.63 no.5
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• pp.435-439
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• 2007

Standard antituberculous therapy, including isoniazid (INH), rifampin, ethambutol, and pyrazinamide (PZA), is widely used to treat active tuberculosis. The most important side effect is hepatotoxicity. In a standard four-drug regimen, PZA was the most common cause of drug-induced hepatitis and was dose-related. The incidence of drug-induced hepatitis is high at doses of 40~70 mg/kg per day but has fallen significantly since the recommended dose was reduced. Liver toxicity induced by PZA is rare at doses of 25 mg/kg per day or less. PZA-induced fulminant hepatic failure is also rare but fatal. We report a case of fulminant hepatic failure caused by a re-challenge of PZA.

• Perspectives in Nursing Science
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• v.5 no.1
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• pp.33-43
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• 2008

Objective: This study explored the reuse of data captured into an electronic nursing record system using the International Classification for Nursing Practice to support nursing research of inpatient's falls. Methods: Risk factors relevant to inpatients falls ;n an acute setting were identified from the literature review. Four risk assessment tools and two risk identification studies were selected. To examine the availability of coded data in an electronic nursing record system for the identified fall fisk factors, we reviewed 11.319 hospital-day records of 118 patients who were reported by the self-report system. Results: We identified 24 fall risk factors of five categories from the literature review, which were used to identify the standard nursing statements addressing fall risks. One hundred thirty five nursing statements were searched from the hospital's nursing data dictionary of statements and were matched with 14 fall fisk factors. Using the 135 statements. we found that mental status, catheter of drip in situ, abnormal gait, insomnia, surgical procedure. and dizziness/vertigo appeared frequently in the nursing records of inpatients with fall s. Also we found 6 risk factors more through the record review. Conclusion: The electronic records would be a good research source for inpatients' falls. Specifically international classification for nursing practice based nursing record system has the potential for promoting clinical researches.

• Journal of Microbiology and Biotechnology
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• v.17 no.5
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• pp.761-768
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• 2007

Serratia proteamaculans HY-3 isolated from the digestive tract of a spider produces an extracellular protease named arazyme, with an estimated molecular mass of 51.5 kDa. The purified enzyme was characterized as having high activities at wide pH and temperature ranges. We further characterized biochemical features of the enzymatic reactions under various reaction conditions. The protease efficiently hydrolyzed a broad range of protein substrates including albumin, keratin, and collagen. The dependence of enzymatic activities on the presence of metal ions such as calcium and zinc indicated that the enzyme is a metalloprotease, together with the previous observation that the proteolytic activity of the enzyme was not inhibited by aspartate, cysteine, or serine protease inhibitors, but strongly inhibited by 1,10-phenanthroline and EDTA. The araA gene encoding the exoprotease was isolated as a 5.6 kb BamHI fragment after PCR amplification using degenerate primers and subsequent Southern hybridization. The nucleotide sequence revealed that the deduced amino acid sequences shared extensive similarity with those of the serralysin family of metalloproteases from other enteric bacteria. A gene(inh) encoding a putative protease inhibitor was also identified immediately adjacent to the araA structural gene.