• 인터넷정보학회논문지
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• 제12권1호
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• pp.39-53
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• 2011

최근 정부의 미디어 관련법 개정으로 국내 미디어 산업 환경 및 산업 구조에 급격한 변화가 일어나고 있다. 특히 종합편성 채널의 도입 결정은 기존 전통적인 미디어 사업자와 종합편성채널 사업 진입에 가능성이 있는 국내 기업, 콘텐츠 사업자 등에 직 간접적인 영향을 미칠 것으로 예상된다. 따라서 본 연구에서는 국내 종합편성채널 사업자의 경쟁 방안에 관한 초기 연구로 써 Scenario Network Mapping 방법론을 통해 산업의 변화와 사업자의 경쟁방안을 분석하였다. 연구 결과 신규 사업의 경쟁력 확보, 정부의 정책적 지원, 콘텐츠 차별화 성공이 사업 정착의 주요 성공 요인으로, 장기적인 관점에서는 정책적 지원보다는 사업자의 자체 경쟁력이 더욱 중요하게 나타났다. 본 연구는 종합편성채널 사업 도입에 따른 이슈 분석 및 경쟁방안에 관한 초기 연구로 사업 진입을 고려하는 사업자와 정부에게 종합편성채널에 관한 이해를 돕고 전략 방향 설정 등에 유용한 시사점을 제공한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권1호
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• pp.71-82
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• 2008

Survivin is a member of the inhibitors of apoptosis (IAP) family that have been known to inhibit activated caspases in apoptosis. In contrast to most IAP family members, survivin mRNA is expressed during fetal development, is not found in normal adult tissues and is overexpressed again in the cancer. Though survivin expression has been documented in most human cancers, little is known about its expression in OSCC and its potential value as a predictor of cancer survival. The purpose of this study was to investigate survivin expression in OSCC and to evaluate its value as a prognostic marker. We evaluated survivin expressions in cancer lines and OSCC samples and investigated the relationships between survivin expressions and clini-co-pathological parameters including stage, differentiation, proliferation, lymph node metastasis, blood vessel density, and gelatinolytic activity. With immunohistochemistry, we analyzed survivin expression in 38 OSCCs. Patients' clinico-pathological parameters and their survival rate were analyzed to reveal their correlations with Survivin expressions. We cultured oral cancer cell lines and evaluated the correlation between gelatinolytic activities and survivin expressions of them. Survivin protein was observed both in nuclei and cytoplasm of tumor specimens while little or not observed in normal gingival mucosal tissues. Additionally, survivin expressions were correlated with lymph node metastasis, tumor proliferation and survival rate. Survivin expression was observed in 100% of 38 samples of OSCC and its expression levels are statistically associated with the proliferative activity of the tumors, lymph node metastasis and the survival of the patients. Based on these results, survivin is commonly expressed in OSCC and may thus provide valuable prognostic information related with lymph node metastasis, proliferation and survival rate as well as a potential therapeutic target in OSCC.

• 한국자원식물학회지
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• 제19권1호
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• pp.189-195
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• 2006

본 연구는 우리나라 특산수종이며 조경 및 원예적 가치가 높은 노각나무 유전변이를 조사하기 위해 6개 천연집단을 선발하여 DNA I-SSR 표지자를 사용, 유전다양성 및 유전구조를 조사하였다. 5개의 I-SSR primer(#813, 815, 818, 820, 823)에서 총 61개의 증폭산물을 관찰할 수 있었으며, 유전 다양성을 나타내는 P(Percentage of polymorphic loci)값과S.I.(Shannon's information Index)가 남쪽에 분포하는 오봉산(P=88.5%, S.I.=0.467), 금산(P=86.9%, S.I.=0.427), 바랑산(P=83.6%, S.I.=0.425)집단이 높았으며, 북쪽(내륙)에 분포하는 소백산(P=80.3%, S.I.=0.396), 지리산(P=77.1%, S.I.=0.368), 가야산(P=75.4%, S.I.=0.358)집단은 낮았다. 전체 유전변이 중 11.8%만이 집단간에 기인하는 것으로 나타났고, 나머지 88.2%는 집단내 개체간의 차이에서 기인하였다. 유전거리를 이용하여 UPGMA법에 의한 유집분석을 실시한 결과 지리적 분포에 대한 뚜렷한 경향은 나타나지 않았다.

• 복식문화연구
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• 제26권3호
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• pp.265-281
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• 2018

Government policy supporting the fashion industry in Korea has focused on the future development of rising fashion designer's brands, and as a part of this support, several Fashion Creative Studios are presently operated. The purpose of this study is to identify the meaning of these facilities and suggest development strategies for their effective utilization. This paper presents a conceptual understanding based on a literature review, and deduces the direction of Fashion Creative Studios through an exploratory analysis of various case studies and in-depth interviews with five designers, who have graduated from the Seoul Fashion Creative Studio. The results are as follows. Firstly, fashion educational institutions have to provide sufficient information about the Fashion Creative Studios to students. They can also consider adding short-term residencies to the curriculum in which students prepare collections or portfolios for the studios. Secondly, Fashion Creative Studios are required to intensify business and marketing programs to increase real-world support. It would be helpful to provide 1:1 management programs with several segmented stages for the design brands, or connect them to investors who could provide financial support and business expansion. Thirdly, Fashion Creative Studios need to find a way to strengthen textile differentiation and craft characteristics to increase designer brand competitiveness. Broadening participation with textile designers, connecting with experts and ateliers, and promoting collaboration with artists and artisans in the Arts Creative Studios can be further examined to this end.

• 정보화정책
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• 제22권2호
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• pp.19-34
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• 2015

급속한 융합 현상에 의해 미디어 간 차별성이 줄어들고 대체성이 증가하고 있다. 본 연구는 융합에 따른 경쟁 미디어 간의 대체성 변화가 가입자에 어떠한 영향을 미치는지를 국내 디지털 유료방송 시장을 통해 알아본다. 분석을 위해 경쟁 미디어인 IPTV와 디지털 케이블 TV의 가입자 시계열 자료를 수리생태학의 경쟁 확산 모형인 Lotka-Volterra 모형에 적용하여 시뮬레이션을 위한 기초 모형을 구축하였다. 이후 대체성과 관련된 독립변수를 조절하며 미디어별 가입자 수를 추정하는 시뮬레이션을 진행하였다. 분석 결과 디지털 케이블 TV와 IPTV는 포식자-피식자 관계로 디지털 케이블 TV가 상대적 우위에 있는 대체 관계로 나타났다. 시뮬레이션 결과 융합에 의해 대체성이 증가하면 시장규모가 축소되어 두 미디어 모두 손실을 볼 것으로 나타났다. 특히 후발주자이며 뉴미디어인 IPTV가 가장 큰 손실을 볼 것으로 추정된다. 반대로 경쟁 미디어간의 차별화 전략에 의해 대체성이 감소하면 시장규모가 확대되어 경쟁 미디어 모두가 윈윈하며, IPTV가 가장 큰 혜택을 볼 것으로 추정된다.

• Journal of Pharmaceutical Investigation
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• 제34권3호
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• pp.185-192
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• 2004

The objective of this study was to evaluate the effects of surfactant type and concentration upon dissolution rates of carbamazepine from an immediate-release tablet. The dissolution media used in this study were aqueous solutions containing 0.1-2% sodium lauryl sulfate, cetyltrimethylammonium bromide, or polysorbate 80. The solubility of carbamazepine in the dissolution media was determined at first. A dissolution study was then conducted by using the USP dissolution apparatus II (paddle method) with an agitation rate of 75 rpm. Aliquots of the dissolution media were taken at predetermined time intervals, and the amount of carbamazepine dissolved was measured spectrophotometrically at 285 nm. The dissolution data obtained were fitted into a biphasic exponential equation with four parameters. Excellent correlations were observed between the experimental data and the theoretical ones predicted by the equation. This equation permitted the calculation of $T_{50%}$ (the time required for dissolving 50% of carbamazepine) under various experimental conditions. Differentiation of the equation also led to the attainment of dissolution rates at dissolution time points. The addition of a surfactant to an aqueous solution led to increasing the solubility of carbamazepine by 3- to 12-folds, depending upon its type and concentration. This event also resulted in enhancing the magnitude of a sink condition during the dissolution study. As a result, the dissolution rate of carbamazepine was affected by the aqueous surfactant concentration in a proportional manner. Subsequently, $T_{50%}$ values declined rapidly, as the surfactant concentration increased. Such effects were observed in decreasing order of sodium lauryl sulfate, cetyltirmethylammonium bromide, and polysorbate 80. These results clearly demonstrated that it was possible to tailor a dissolution rate and $T_{50%}$ of carbamazepine by manipulating the type and concentration of a surfactant. Relevant information would be beneficial to setting up dissolution specifications for poorly water-soluble drug products.

• 한국농공학회지
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• 제38권6호
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• pp.51-63
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• 1996

This study is about the problems found in the process of the current governments planning rural settlement area development. As a measure to solve them, It proposed the analysis method of village characteristic in terms of standard score and tried to use this method as a basic material in planning more effective rural settlement area development. On the basis of the above analysis, which is an objective basic material to solve the problems revealed in the process of the bottom-up development planning by the residents' demands, It shows the following conclusion about what method should be applied to each part according to a village's characteristics and its development level. 1. Accessibility can be a basic material for setting the local area, analyzing its settlement system, and them such development facilities as village-linking roads, rural road, or various kinds of bridges and determining the investment priority. 2. With the index of the industrial basis, we can see what village has plenty of social, economical resources including advanced industrial facilities and looking into the advance level of the industrial basis, we can get some information about determining the local area development direction such as estashing the plan to build a farm product gathering center, a collective work place, storage facilities, and special housing development. 3. Since the issue about living environment is raising it's head, compared to weakened agricultural competitive power, with the analysis of this living environment, we can get an objective basic material for solving problems caused by the local egoism and the effective investment strategy of the limited resources. Therefore, It is necessary that we should abstain from expert-centered planning and formal public opinion-collecting and on the basis of this analytic result, we should plan development. We need to continue our research about index selecting and differentiation, weight etc. and using these analysis methods, we should make up a systematic development plan by analyzing village characteristics and setting the development direction.

• 한국의료질향상학회지
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• 제22권1호
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• pp.29-37
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• 2016

Readmission which reflects capacity to manage patients and general level of medical services has been known for one of the causes of medical expenditure due to inefficient service. Compared to disease-specific readmission, hospital wide readmission (HWR) is relatively easy to understand, and has merit to get over limitation of collateral medical services assessment; therefore, a growing interest in development and usage of readmission indicator as quality of care indicator focusing on all-disease is detected. In this study, we investigate current state of risk standardized readmission rate indicator used in the United States, the United Kingdom, and Canada, and examine the considerations when using readmission rate as quality indicator in Korea. Differences in risk-adjustment methods were showed among countries. The United States do not control race not to hide socio-demographic factors on readmission. Canada shows differentiation compared to other countries about reflecting community factors. All three-countries utilize readmission rate as monitoring quality of care rather than incentives or penalty due to the fact that readmission rate could not represent the whole quality of hospital and has a limitation at controlling socio-economic factors. Therefore, for usage readmission rate as quality indicator in Korea, preparing readmission classification standard for Korean medical environment and additional methods for acquiring information by using discharge summary is need. Moreover, continued discussion with clinical specialists is needed for obtain clinical reliability and validity.

• 한국경제지리학회지
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• 제1권1호
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• pp.33-56
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• 1998

본 연구는 서비스 경제화 추세가 진전되면서 공간에 어떠한 변용을 가져오고 있는가를 고찰하였다. 경제의 서비스화가 진전되면서 서비스업에 대한 수요와 공급의 공간적 패턴은 상당한 차이를 나타내고 있으며, 이에 따른 차별적인 서비스업의 성장과 그에 따른 입지는 공간구조에 커다란 영향을 미치고 있다. 지난 15년간 가장 높은 성장률을 보이고 있는 서비스업종은 생산활동과 연계가 깊은 생산자서비스업으로, 이 업종은 서울을 중심으로 한 수도권으로 집중하는 경향을 보이고 있다. 본사기능이 주로 집적되어 있는 핵심지역이 기술, 정보, 지식 집약적인 생산자서비스에 대한 수요가 상대적으로 높기 때문에 이들 지역으로 생산자서비스업체들이 집중하고 있다고 볼 수 있다. 앞으로 서울을 세계 대도시들 속에서 경쟁력있는 도시로 성장시키기 위해서는 고차적 생산자서비스업을 육성시키는 것이 바람직하지만 다른 지역들과의 성장격차를 심화시키지 않는 방안이 강구되어야 할 것이다.

• Journal of Periodontal and Implant Science
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• 제30권4호
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• pp.747-757
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• 2000

Cyclosporin A(CsA) is an immunosuppressive agent widely used for preventing graft rejecting response in organ transplantation. The basic properties of CsA to osteoblast has not been well known yet. A better understanding of the mechanisms of CsA function on bone could provide valuable information regarding basic properties of bone remodeling, pharmacotherapeutic intervention in metabolic bone disease, and the consequences of immunosuppression in bone physiology. The purpose of this study was to investigate the effect of CsA on osteoblast by evaluating parameters of proliferation, collagen synthetic activity, alkaline phosphatase activity, and ALP mRNA expression in mouse calvarial cell. 1. CsA ($3{\mu}g/m{\ell}$) treated mouse calvarial cell showed statistically significant increase in cell proliferation.(P<0.05) 2. CsA($1,\; 3{\mu}g/m{\ell}$) treated MC3T3 cell line showed statistically significant increase in cell proliferation. 3. The amount of collagen of CsA($3{\mu}g/m{\ell}$) treated mouse calvarial cell was decreased statistically significantly. 4. Alkaline phosphatase activity was increased statistically significantly in CsA treated group($1{\mu}g/m{\ell}$). 5. mRNA expression of ALP was increased in CsA treated group These results suggest that CsA could affect bone remodeling by modulating proliferation & differentiation of osteoblast.