• Journal of the Korean Applied Science and Technology
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• v.25 no.4
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• pp.539-555
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• 2008

It is well understood that developing new drugs is one of the highest value-added businesses in a country; however, the current governments' spending in pharmaceutical research and development(R&D) is minimal in Korea. This paper suggests that different governmental bodies should take in charge of different stages of the R&D process in order to maximize the use of limited government research funding. First, during the initial phase of the drug development, including clinical trials, the Ministry of Education, Science and Technology is the most appropriate governmental organization to support the research. For later procedures such as supporting the industries for exporting developed drugs, legislative approvals, and building infrastructure for future clinical trials should be supported by the Ministry of Knowledge and Economy and the Ministry of Health and Welfare along with the Korea Food and Drug Administration(KFDA). The KFDA, which is the main governmental agency approving newly developed drugs in the market, will need to take a crucial responsibility in the initial phase of the pharmaceutical R&D by guiding the industries with timely and proper information. As a first step, it is recommended to set up and operate a center for supporting new drugs, so that the industries can facilitate the development of marketable drugs which meet customers' needs. Later, in order to expedite the process of exporting and getting approvals of the newly developed drugs from foreign countries, it is necessary to develop new approval system, which includes introduction of the Good Manufacturing Practice (GMP), mandatory validation system, and education program for supporting expertise. Lastly, the KFDA needs to take an active role in developing Korean pharmaceutical industries by communicating with other foreign governments with regards to the globalization of the Korean pharmaceutical industries. For example, as a follow up after the Free Trade Agreement(FTA), active discussion on GLP of Mutual Recognition Agreement(MRA) with the United States of America, should be seriously considered.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.10
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• pp.274-280
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• 2017

The smart-car industry has emerged as the important variable that will decide the future industrial contour of the automotive industry, together with commercialization of electronic vehicles, connected cars, infotainment, telematics, and the autonomous/self-driving car. This study analyzes the strategic position of platform companies and car manufacturers that would determine the future of the smart-car market. The findings of this study show that despite the entry barriers in industrial factors, such as economies of scale, the industrial infrastructure, and global production networks, and technical factors like exclusive head-sector information, car manufacturers may be deprived of their industrial leadership by platform companies with map and user data, big data capabilities, and user interface experience if they lag behind ICT innovation. This insight is based on the emerging importance of software and platforms, and the simplification of car structures, proven by the successful commercialization of electronic vehicles. This study complements existing studies mainly focused on technical aspects of the smart-car industry by examining the strategic dimensions of platform companies and their approach to the future smart-car market by comparing them with existing car manufacturing multinationals.

• Journal of Korean Medicine Rehabilitation
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• v.23 no.3
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• pp.69-78
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• 2013

Objectives The purpose of this study was to investigate the effectiveness of the Gongjin-dan (Gongchen-dan, here in after GJD) in order to obtain the evidence for clinical application. Methods The GJD-related articles published from 1990 to 2013 were searched using "Korean Traditional Knowledge Portal", "Oriental Medicine Advanced Searching Integrated System (OASIS)", "Korean Association of Medical Journal Edition (Koreamed)", "Research Information Services (RISS4U)", "Korean Medicine Database (KMbase)", "National Discovery for Science Leader (NDSL)", "PubMed", "China National Knowledge Infrastructure (CNKI)". The search keywords were "Gongjin-dan", "Gongchen-dan". Thirty-nine articles were obtained. After excluding the eighteen article which did not meet inclusion criteria, finally twenty-one articles were included; five clinical articles and sixteen experimental articles. Results In clinical studies, GJD has the various effectiveness in cardiovascular diseases, alcoholic hepatitis, mild dementia, anemia. Also experimental studies related to the GJD show a variety of effects, such as anti-oxidative activity, neuroprotective activity, hepatoprotective activity, anti-inflammatory activity, immunological activity, reproductive recovery activity with fewer side-effects. Conclusions It has been suggested that there are various effects of GJD in treating a wide-range disease. However, in order to put GJD to use for many kinds of diseases in more reasonable ways, it is needed to publish well-design clinical trial based on the variety of results of experimental studies.

• Journal of Cadastre & Land InformatiX
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• v.47 no.2
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• pp.5-18
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• 2017

The AMOEBA approach in this study supplements the Hotspot method that had not been fully capable of dealing with the ecotone issues in designating the Development Impact Fee (DIF) zones as had been seen in the preceding study by Kim and Choei (2017). The AMOEBA procedure shares the common Getis-Ord statistic with the Hotspot technique but is more adequate to figure out the ecotones. For the comparative purpose, simulations are run by both methods for a series of different scenarios in terms of analytic spatial units (here, the square grids) from 100m up to 400m; and the zonal outcomes by both methods are compared using a set of evaluative indicators. In terms of the numerical scores, the performances by the two methods are much comparable except that the former is slightly superior with respect to the avoidance of the oversized spread of the selected zones whereas so is the latter with respect to the ease of infrastructure installation. It remains yet to be investigated by the extended studies that include in-depth field surveys to figure out the causes as well as the meanings of such differences in zonal determinations.

• Korean Security Journal
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• no.51
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• pp.173-195
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• 2017

Recently, in South Korea, security management has been strengthened, but there have been an increasing number of cases where the main infrastructure of the country is hacked in the cyber space. South Korea is equipped with sophisticated information and communication technologies, such as Internet, but is threatened by cyber terrorism of North Korea and terrorist organizations. Nevertheless, there is a limit to how to develop a policy and strategic plan for the country, which is related to domestic terrorism and lacks legal and regulatory facilities, and therefore, in this study, proposed suggestions for building adaptive and efficient policy formulation. Based on the theoretical analysis framework of the Strategic Plan for achieving the objectives of the research, we compared the UK 's security strategy with the national security policy of the domestic government. As a result, several problems were derived: First, the domestic security strategy did not take into account the external environment. Secondly, lack of coordination with domestic cyber security goals setting and strategy is causing ambiguity and confusion. Third, the detailed plan of implementation of national security in each province is designed to ensure that there is a possibility that a mixed side effect between ministries and agencies will arise. Fourth, it was found that there was a limit to prepare the evaluation standards for the evaluation and return of domestic security policies in the country. Therefore, in order to establish a policy for the response of domestic cyber terrorism, we set up a vision from long-term perspectives and concrete targets based on the strategic approach of the security policy, It is necessary to present an assignment and formulate an efficient execution plan. It is necessary to maintain and improve the domestic safeguards in order to be able to complement the problems through evaluation and feedback.

• Journal of Korean Society of Transportation
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• v.27 no.4
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• pp.175-181
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• 2009

Intelligent Transportation Systems(ITS) enables road users to enhance efficiency of their trips in a variety of traffic conditions. As a significant part of ITS, information communication technology among vehicles and between vehicles and infrastructure has been being developed to upgrade current traffic data collection technology through location-based traffic surveillance systems. A wider and detailed range of traffic data can be acquired with ease by the technology. However, its performance level falls with environmental impediments such as large vehicles, buildings, harsh weather, which often bring about wireless communication failure. For imputation of vehicle trajectory data discontinued by the failure, several potential existing methods were reviewed and a new method to complement them was devised. AIMSUN API(Application Programming Interface) software was utilized to simulate vehicle trajectories data and missing vehicle trajectories data was randomly generated for the verification of the method. The method was proven to yield more accurate and reliable traffic data than the existing ones.

• Journal of Korea Water Resources Association
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• v.49 no.3
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• pp.187-196
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• 2016

Standardized Precipitation Evapotranspiration Index (SPEI) considering evapotranspiration and precipitation is generally used to quantify the drought severity. Also, Reconnaissance Drought Index (RDI) has been frequently used in the arid regions which is suffering severe droughts, but drought analysis in association with RDI has been the focus of few studies in South Korea. Therefore, this study compared two meterological drought indices based on precipitation and evapotranspiration using Thornthwaite, Hargreaves, and Blaney-Criddle evaportranspiration calculation methods. Meteorological data of sixteen weather stations which are operated by Korea Meteorological Administration (KMA) were used to quantify drought and to compare characteristics of drought for the Han River Basin from 1992 to 2015. As a result, in case of Han River Basin, severe drought sharply increased in recent years. While the correlation coefficients are relatively high between the SPEIs and RDIs, the drought severity and year of severe drought are partially different. Therefore, it is necessary that RDI will be also measured to quantify severity and occurrence year of drought.

• Journal of Korean Society for Quality Management
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• v.44 no.3
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• pp.639-648
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• 2016

Purpose: Existing precedent studies include success factors of individual management innovation activities constantly. However, those studies have limitations about the common key success factors of individual management innovation activities. Methods: For this study, we investigate the key success factors using literature research of the most typical management innovation activities adopted and implemented by many companies in Korea, such as 6sigma, TQM, Lean 6sigma, ERP, TPM, BPR, Project Management, System Engineering. Factors emerging repeatedly was combined into common factors and inherent factors that are necessary for the success of individual management innovation activities are designated to essential factors. Results: 'Essential factors for Six Sigma' consist of 5 items. Black belt operating system, personnel management system linkage, the correct management of the data, perform improvement projects associated with financial performance financial result, linked to financial performance improvement project, project progress management. 'Essential factors of TQM' are arranged 4 items. Quality team's independence and role, goal-setting, Quality Information System, corporate's philosophy of quality first. 'Essential factors of Lean Six Sigma' are the selection of value stream which is based on the customer needs and the value creation and identify the project based on the selected value in the company. 'Essential factors of ERP' are investigated 6 items. Ongoing system maintenance and upgrades, the measurement and support of user satisfaction, the operating systems and the policies for the maintenance, IT infrastructure, change adaption condition monitoring, focusing on improving business performance. 'Essential factors for TPM' are arranged 4 items. Motivated and energetic Bottom-Up, CEO's recognition of the importance facility management, long-term perspective of necessity and ongoing patience. 'Essential factors for BPR' are the pursuit of change process and the staff's sense of crisis management. 'Essential factors for Project Management' are the strategy that reduce the risk management skills through risk management and the understanding and organized management for the project participant's needs. 'Essential factors for System Engineering' consist of 2 items. The first is the design for the best balanced system with pre-analysis about the compromise the cost, schedule and the performance. The second is the analysis of large problem into small problems which can solved. We have found the solution considering components of the interface through the systematic perspective. Conclusion: Common factors and essential factors presented in this study will properly help to introduce the individual management innovation activities for the each business sector and implement management innovation. After this study, new literature research that reflect new studies should accomplish steadily.

• Journal of Korean Society of Transportation
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• v.27 no.1
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• pp.179-190
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• 2009

Travel time is one of the most important traffic parameters to evaluate operational performance of freeways. A variety of methods have been proposed to estimate travel times. One feasible solution to estimating travel times is to utilize existing loop detector-based infrastructure since the loops are the most widely deployed detection system in the world. This study proposed a new approach to estimate travel times for freeways. Inductive vehicle signatures extracted from the loop detectors were used to match vehicles from upstream and downstream stations. Ground-truthing was also conducted to systematically evaluate the performance of the proposed algorithm by recognizing individual vehicles captured by video cameras placed at upstream and downstream detection stations. A lexicographic optimization method vehicle reidentification algorithm was developed. Vehicle features representing the characteristics of individual vehicles such as vehicle length and interpolations extracted from the signature were used as inputs of the algorithm. Parameters associated with the signature matching algorithm were calibrated in terms of maximizing correct matching rates. It is expected that the algorithm would be a useful method to estimate freeway link travel times.

• The Korean Society of Law and Medicine
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• v.12 no.1
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• pp.99-131
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• 2011

To strengthen the protection of human research subjects and human materials, the Korean Ministry of Health and welfare proposed the amendment bill of Bioethics and Safety Law(2010) to the Congress. It includes so many meaningful clauses. According to the bill, the scope that this act shall apply will be expended to the research involving human subjects and human materials. In the bill, there are the principles of this act; the protection of the life, health, and dignity of the human subjects, the obtaining of the adequate informed consent, the protection of the human subject's information confidentiality and the human subject's privacy, the assessment and minimizing of the risks involved and the guarantee of the safety for the human subjects, the preparation of the special protection program for the vulnerable human subjects, and so on. According to the bill, Institutional Bioethics Review Board(the same as Institutional Review Board) will be responsible for the auditing and monitoring on the research that was approved by IBRB, conducting the education program for the researchers, IBRB members and administrative staffs, preparing of the special protection program for the vulnerable human subjects, and forming the guidelines for the researchers as well as the review of the research protocols. And the State and local governments shall take necessary measures to support the expending of the social infrastructure. In addition to, IBRB will have to be assessed and to be gained the accreditation by the Korean Ministry of Health and welfare. So, if Bioethics and Safety Law is amended, it will contribute enormously to enhance the level of the human research subjects protection. Also, if this Law is amended, IBRB will play a major role for the conduct of the ethically, scientifically, and legally proper research. But now, as a matter of fact, the capability of IBRB members and IBRB office members is not enough to charge of this role because some people and some organizations does not know the importance of IBRB exactly. In spite of, IBRB shall be able to this role to protect the human subjects and to develop the level of the research On the international level. Therefore, the State, local governments and the Organization shall back up the administrative and financial terms of the IRB and IRB Office.