• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.269-275
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• 1999

Background : In April 6, 1990, a male researcher who has worked at a research unit at the Basic Research Building of Seoul National University(SNU) College of Medicine admitted to SNU Hospital due to persistent fever. He was diagnosed serologically as hemorrhagic fever with renal syndrome(HFRS). Another female researcher in the same unit was also diagnosed as HFRS at the same hospital several days later. Epidemic investigation of HFRS was conducted to determine the magnitude of the problems since these two cases were strongly suspected to have laboratory-acquired infections of HFRS. Methods : All researchers and employees working at the Basic Research Building(BRB) of SNU College of Medicine as of April 1, 1996 were recruited for the study, information on symptoms of HFRS and history of contact to experimental animals were collected by self-administered questionnaires and serological tests among study subjects were also conducted by indirect immunofluorescent antibody(IFA) to hantavirus. The experimental animals were also serologically tested for infection with hantavirus by IFA. Results : Among 218 surveyed, six researchers and an animal caretaker had hantavirus antibodies above 1:20 in IFA titer. Five of seven sero-positive subjects had antibodies above 1:640 in IFA titer and had shown clinical symptoms compatible to HFRS during Jan. 1 to Apr, 20, 1996. The sero-positive persons had handled animals more frequently than sero-negative persons (OR, 19,68; 95% Cl, 1.11-350.40) and handling animals at the animal quarter at School of Public Health(SPH) had shown consistently higher risk to get infected with hantavirus irrespective of types of animals handled (OR, 4.90-6.37). Sero-positivity of rats of the aniamal quarter at BRB was 30-60%, whereas 80% of rats at SPH tested were shown sero-positivity. Conclusion: There was a epidemic of HFRS in research units of a medical school during the period from Jan. through Apr, Further investigation is needed to determine the extent and the mode of transmission of the laboratory-acquired infection with hantavirus in other research facilities.

• Journal of Preventive Medicine and Public Health
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• 제35권4호
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• pp.295-304
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• 2002

Objectives : This study was carried out to investigate the cause, magnitude and transmission route of the cholera outbreak in 2001 Methods : The study population were those persons who ingested foods at the restaurant, were confirmed as cholera patients, had symptoms of diarrhea and sewed as workers at the restaurant. A questionnaire survey and microbiological examinations on the microbes isolated from rectal swabs were conducted. Of the cases, 316 food histories were surveyed by an analysis of the restaurant menu. Results : There were 139 confirmed cases of cholera reported in Korea in 2001. Of these, 104 were related to the restaurant. By region, Gyeongsangbuk-do had the highest incidence with 91 cases. Of these 91 cases, 74 had ingested foods at the restaurant, 2 were employees and 3 were secondary infection cases within the families. The results of the odds ratio analysis of the 316 persons having ingested foods at the restaurant were as follows: sandwiches 5.07 (95% CI, 1.85-14.59), soybean curd 2.45 (95% CI, 1.09-5.56), noodles 2.34 (95% CI, 1.24-4.42), steamed squid 2.01 (95% CI, 1.17-3.47) and vinegared rice 1.82 (95%, CI, 1.08-3.09). It was certain the restaurant in question was the cause of the 2001 outbreak. Conclusions : We suspected that more than one restaurant employee contaminated foods served at the restaurant. In addition, eating raw fishes purchased at the Pohang Fisheries infected the employees of the restaurant. There is a possibility that these raw fishes were themselves contaminated by cholera bacilli in the sea.

• Parasites, Hosts and Diseases
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• 제44권4호
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• pp.367-372
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• 2006

In order to determine the distribution and prevalence of human cryptosporidiosis on western and southern coastal islands of Jeollanam-do (Province), fecal samples were collected from 2,541 people residing on 25 islands, 13 in the western coasts and 12 in the southern coasts, during July and August 2000. Fecal smears were prepared following formalin-ether sedimentation of the samples and stained by a modified acid-fast procedure. The presence of Cyptosporidium oocysts was determined by light microscopy. Cyptosporidium oocysts were detected in 38 specimens (1.5%). The oocyst positive rate varied (0-6.0%) according to island; the highest was detected on Oenarodo (6.0%), followed by Naenarodo (5.6%) and Nakwoldo (5.4%). The majority (35 persons, 94.6%) of Cryptosporidium-infected individuals were older than 50 years of age. Men (22/1, 159; 1.9%) were infected at a higher rate than women (16/1, 382; 1.2%). The results of the present survey indicate that human Cyptosporidium infections (due to Cyptosporidium hominis and/or C. parvum) are maintained at a relatively low prevalence on coastal islands of Jeollanam-do, Republic of Korea.

• 농촌의학ㆍ지역보건
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• 제4권1호
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• pp.62-70
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• 1979

In order to evaluate the present status of hook-worm infection in the rural areas in Korea, stool examinations were undertaken in several selected rural villages in each year of 1970 and 1977. The methods employed were cellophane thick smear technique and brine floatation technique in 3,454 specimens collected from 7 different rural villages for the prevalence rate of hookworm infection and Stoll's dilution egg counting technique for the intensity of hookworm infection. The incidences of Ancylostoma duodenale and Necator americanus infections were determind by polyethylene tube coproculture and by the evacuated adult worms after treatment with anthelmintics to the patients who were infected by hookworms. The results are as follows : 1) In 1970, 323(18.6%) out of 1,737 specimens collected from 4 different rural areas were positive for hook worm infection and the ranges of prevalence rates in those suveyed areas were shown as 6.9 to 38.2 per cent. On the other hand, 144(8.2%) out of 1,717 specimens collected from 3 different rural areas in 1977 were shown as positive for hookworm infection and 7.5 to 10.6 per cent of prvalence rates were shown in the surveyed areas. 2) In the age group under 10 years, there was no infection of hookworm in the studied areas in 1977, however in 1970 the prevalence of the hookworm infection was shown as very low in the age group of 5~9. On the whole, the hookworm prevalence steadily increased from the age of 15 in the studied areas in 1970, however in 1977 the prevalence increased from the age of 20 to the older age groups. 3) There was not observed much differences in the intensity of hookworm infection among the studied areas in 1970 and 1977. The mean EPG in each studied areas were shown under 1,000 EPG and mean numbers of evacuated worms per infected persons were counted as 9.4 to 15. 1. 4) Both A.duodenale and N.americanus have been found in all studied areas but the incidences and st-ate of distribution of two species of hookworn were shown as different in each localities.

• 대한치과의료관리학회지
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• 제8권1호
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• pp.1-7
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• 2020

Dental settings have unique characteristics that warrant specific infection control considerations, including (1) prioritizing the most critical dental services and provide care in a way that minimizes harm to patients due to delayed care, or harm to personnel from potential exposure to persons infected with the COVID-19 disease, and (2) proactively communicate to both personnel and patients the need for them to stay at home if sick. For health care, an interim infection prevention and control recommendation (COVID-19) is recommended for patients suspected of having coronavirus or those whose status has been confirmed. SARS-CoV-2, which is the virus that causes COVID-19, is thought to be spread primarily between people who are in close contact with one another (within 6 feet) through respiratory droplets that are produced when an infected person coughs, sneezes, or talks. Airborne transmission from person-to-person over long distances is unlikely. However, COVID-19 is a new disease, and there remain uncertainties about its mode of spreads and the severity of illness it causes. The virus has been shown to persist in aerosols for several hours, and on some surfaces for days under laboratory conditions. COVID-19 may also be spread by people who are asymptomatic. The practice of dentistry involves the use of rotary dental and surgical instruments, such as handpieces or ultrasonic scalers, and air-water syringes. These instruments create a visible spray that can contain particle droplets of water, saliva, blood, microorganisms, and other debris. While KF 94 masks protect the mucous membranes of the mouth and nose from droplet spatter, they do not provide complete protection against the inhalation of airborne infectious agents. If the patient is afebrile (temperature <100.4°F)* and otherwise without symptoms consistent with COVID-19, then dental care may be provided using appropriate engineering and administrative controls, work practices, and infection control considerations. It is necessary to provide supplies for respiratory hygiene and cough etiquette, including alcohol-based hand rub (ABHR) with 60%~95% alcohol, tissues, and no-touch receptacles for disposal, at healthcare facility entrances, waiting rooms, and patient check-ins. There is also the need to install physical barriers (e.g., glass or plastic windows) in reception areas to limit close contact between triage personnel and potentially infectious patients. Ideally, dental treatment should be provided in individual rooms whenever possible, with a spacing of at least 6 feet between the patient chairs. Further, the use of easy-to-clean floor-to-ceiling barriers will enhance the effectiveness of portable HEPA air filtration systems. Before and after all patient contact, contact with potentially infectious material, and before putting on and after removing personal protective equipment, including gloves, hand hygiene after removal is particularly important to remove any pathogens that may have been transferred to the bare hands during the removal process. ABHR with 60~95% alcohol is to be used, or hands should be washed with soap and water for at least 20 s.

• 대한미생물학회지
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• 제20권1호
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• pp.65-72
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• 1985

Vitamin C is known as an integral element for the formation and maintenance of intercellular supporting structures. Ascorbic acid has been used for the treatment of certain poisonings and hypovitaminosis(scurvy) but also known as a powerful reducing agent, and can kill a variety of bacteria and detoxify bacterial exotoxins including various clostridial exotoxins in vitro. For viruses, vitamin C inactivates herpes virus, vaccinia virus and influenza virus and has been used for the prevention and treatment of the common cold. Thus ascorbic acid plays an important role in antimicrobial action. Scurvy also promotes the development of tubercles in experimentally infected guinea pig and the tuberculosis patients require more vitamin C than normal persons. However there is no reports that ascorbic acid could inhibit the growh of M. tuberculosis. In this paper, antibacterial effects of ascorbic acid against M. tuberculosis were studied. The results are as follows: 1. The single use of the ascorbic acid exhibited antibacterial effect in vitro against $5{\times}10^3/ml$ of M. tuberculosis $H_{37}$ Rv at the concentration of ascorbic acid 0.625mg/ml over 3 hours exposure and 0.05mg/ml over 9 hours exposure. 2. In vivo mice administered with ascorbic acid 50mg/day for 5, 10 and 15 days respectively were protected from M. tuberculosis $2LD_{50}$, $3LD_{50}$, $4LD_{50}$ and $5LD_{50}$ given intravenously.

• 보험의학회지
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• 제1권1호
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• pp.123-132
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• 1984

Among the person who want to insure, there are not only fair persons who want to become the insurance with not realizing that one was not infected with certain disease but also someones on purpose to overcome the disease through the insurance company with be recognized by oneselves. However, it was found that the ultrasonography and exact effects of medical examination with the existing medical equipments of the insurance company could not be expected. We present some several proven examples for the purpose of getting the advanced effects in medical examination by utilizing the ultrasonic device which is not harmful to human body presently as far as known. We could find affirmation through the check of ultrasonography from 907 cases, in our Department of Medical selection that many portion of the cases checked the medical examination have the present condition of illness even though they enjoy social life with good health and finally the conclusions we have learned are as follows; The aged cases show the increase of rate of possessing disease and man shows 2.2 times of possessing disease than woman. Fatty infiltration of liver take portion of 74.7% from the case checked. 12 cases of cholelithiasis are not conscious of symptom at all. Through the check of ultrasonography in obstetrics and gynecology, myoma uteri be showed high rate of 72.2% from the case of possessing disease. In Case of the potential pregnancing woman it made clear to find pregnancy which was undistincted still more also know the existence and nonexistence of fetal death when pregnancy expected.

• 보건교육건강증진학회지
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• 제16권2호
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• pp.1-17
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• 1999

AIDS (Acquired Immunodeficiency Syndrome) known as 20th century's pest is spreading rapidly internationally, and the number of patients are increasing. Since the prevention vaccine has not been developed yet, the only available effective method for preventing AIDS is the health education. Most of the AIDS-infected persons are males, and especially over twenties of age. Therefore, it is necessary to measure the knowledge and attitudes on AIDS of male workers. The purpose of this study is to examine the knowledge, attitudes and education-needs of male workers on AIDS. The data were collected by a questionnaire survey of 977 workers who work in Seoul and Kyungki areas from September 1 thru October 4, 1997. The results were as follows: 1. We examined the level of knowledge on AIDS transmission, symptoms, diagnoses, and prevention methods. Even though respondents had a moderate level of AIDS-related knowledge, still sizable numbers believed that AIDS could be transmitted through casual contact. White-collar workers, higher education groups, higher income groups or those with age thirties showed respectively higher level of knowledge than the other comparison groups. 2. 85％ of the respondents recognized AIDS as a serious problem. Statistical analysis revealed that white-collar workers, higher education groups or those with age twenties had more positive attitudes towards a AIDS patient than their counterparts. 3. Over 80％ of the respondents replied that AIDS education in schools, work places, social agencies or by mass-media was necessary. 62.8％ of the respondents mentioned that government should play the major role in developing AIDS education program. 4. The prediction model of AIDS-education needs was examined with using the multiple logistic regression method. The education level and AIDS-related knowledge were turned to be statistically significant factors influencing positively the perceived needs of AIDS education.

• 스마트미디어저널
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• 제9권3호
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• pp.122-129
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• 2020

전 세계적으로 무증상의 코로나바이러스 감염증-19 감염자가 자신이 감염된 것을 모르고 주변인들에게 전파할 수 있다는 가능성은 국민이 전염병 확산에 대한 불안과 두려움에서 벗어나지 못하고 있다는 점에서 여전히 매우 중요한 이슈이다. 본 논문에서는 K-평균 군집화 알고리즘 및 딥러닝 기반 군중 집계를 이용한 전염병 확진자 접촉 가능성 여부 판단 모니터링 시스템을 제안하였다. 모든 입력 학습 영상에 대해 300회 반복 학습한 결과, PSNR값은 21.51, 전체 데이터 셋에 대한 최종 MAE값은 67.984였다. 이는 확진자와 주변인과의 거리와 감염률 산출, 잠재적 환자 동선 주변 인원의 위험도 순 그룹 및 감염률 예측에 대한 영상 속 화질 정보, 관측치 간의 평균 절대 오차를 의미하며 각 CCTV 장면에서 군중의 수가 4,000명 이하일 때에는 평균 절대 오차 값이 0에 가까움을 증명하였다.

• Parasites, Hosts and Diseases
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• 제26권3호
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• pp.199-206
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• 1988

경북 청송군 일부 하천 유역에서 호르텐스극구흡충의 유행양상을 조사하는 한편 이 흡충 의 인체감염시 나타나는 임상적 및 기생충학적 특성을 관찰하였다. 주민 263명을 대상으로 실시한 검편에서 호르텐스극구흡충란 양성자는 59명 (22.4%)이었으며, 제2중간숙주인 담수어 조사에서는 미꾸리, 얼룩동사리 및 몰개로부터 호르텐스극구흡충의 피낭유충이 검출되었다. Pragiquantel 투여 후 시행한 충체 수집검사에서 감염자 1인당 1∼649(평균 51)마리의 충체가 검출되었고, 혈액학적 검사에서 호산구가 l∼24%(평균 6%)로 나타났다. 개인별 충란 및 충체검출 성적을 토대로 할 때, 충체 마리당 1일 평균 산란수는 1,478개로 계산되었다. 따라서 이 연구 결과, 경북 청송군 일부 하천 유역이 호르텐스극구흡충의 고도 유행지임을 알 수 있었다.