• Journal of Microbiology and Biotechnology
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• v.22 no.2
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• pp.220-225
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• 2012

In batch culture for Poly(vinyl alcohol) (PVA)-degrading enzyme (PVAase) production by a mixed culture, higher pH (pH 7.5) was favorable for PVAase production at the prophase of cultivation, but lower pH (pH 7.0) was favorable at the anaphase. This situation was caused by the fact that the optimum pH for different key enzymes [PVA dehydrogenase (PVADH) and oxidized PVA hydrolase (OPH)] production is various. The activity and average specific production rate of PVADH reached the highest values at constant pH 7.5, whereas those of OPH appeared at pH 7.0. A two-stage pH control strategy was therefore developed and compared for its potential in improving PVAase production. By using this strategy, the maximal PVAase activity reached 2.05 U/ml, which increased by 15.2% and 24.2% over the fermentation at constant pH 7.5 and 7.0.

• Journal of Korean Institute of Industrial Engineers
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• v.28 no.1
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• pp.1-13
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• 2002

We study a multi-component production/inventory system in which individual components are made to meet various demand types. We assume that the demands arrive according to a Poisson process, but there is a fixed probability that a demand requests a particular kit of different components. Each component is produced by a flow line with several stations. The production of each component is operated by the CONWIP control mechanism. To analyse this system, we propose an approximation method based on aggregation method. In application of the aggregation method, a product-form approximation technique as well as a matrix-geometric method is used. Comparisons with simulation show that the approximation method provides fairly good results.

• International Journal of Quality Innovation
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• v.8 no.2
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• pp.32-56
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• 2007

Life Cycle Assessment (LCA) aims to analyze possible impact upon manufacturing process and availability of products, and also study the environmental considerations and potential influence during entire life cycle ranging from procurement, production and utilization to treatment (namely, from cradle to tomb). Based on high-density polyethylene (HDPE) pipe manufacturing of company A, this case study would involve evaluation of environmental influence during the production process. When the manufacturing process has been improved during "production process" and "forming cooling" stage, it is found that capital input on "electric power" and "water supply" could be reduced, thus helping to sharpen the competitive power of company A, and also ensure sustainable economic and industrial development in accordance with national policies on environmental protection.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.4 no.4
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• pp.15-24
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• 1981

The trouble of business management of the mining and manufacturing companies in Korea are constituted by that average 28.3% of production management in the worst trouble of business management from 1973 to 1980 So that Industrial productivity in Korea lower than an industrially advanced nation and then a change for the better of effective production management operations manufacturing companies are suggested by the application effects and achievement points of production management. Therefor Industrial Engineering technics is applied systematic route and the manufacturing company grow more than better its Business Physical condition for the improve productivity applied system approach for a rational product ion management system model.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.37 no.2
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• pp.55-61
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• 2014

Recently, the manufacturing system is being changed in a mass customization and small quantity batch production. MES is a powerful production management tool supporting production optimization from the process initiation to the final shipment. It is a production management system which plans and executes based on the production data in the shop floor. This study deployed the utilization of production data and web HMI system to process real-time production data through the collection with the shop floor. The developed system was applied to the equipment operating time and other production data could be processed with the real-time. The proposed system and web HMI can be applied for various production systems by using different logic.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.2B
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• pp.173-179
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• 2009

Industrial water supplied by water resource project is essential input materials along with labor, capital and land for companies. It is very important to stably secure these input materials in order for the industry to generate additional values. If the supply of industrial water is stopped, it is known damage for the industry is greater than domestic water or agriculture water based on same amount of supply. Like this, the actual value of industrial water has been highly acknowledged from the intuitive perspective, but study on the value and benefits of industrial water has been rarely conducted. Therefore, this study verified the value of industrial water supplied from water resource project, and used marginal production value as a measure to estimate the benefits of industrial water in the analysis of economic efficiency. As a result of empirical analysis using Cobb-Douglas production function and Translog production function, industries' average marginal production value was $5,427KRW/m^3$ and $5,583KRW/m^3$ respectively. The marginal production value for eleven industries were estimated by using same method. The marginal production value by industries presented by this study will be used as important data to calculate benefits of industrial water in the future. Moreover, the result of this study will provide reasonable criteria for decision making on the allocation of water in emergency situation, and problem of resource supply from water resource project.

• Journal of Microbiology and Biotechnology
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• v.25 no.2
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• pp.185-195
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• 2015

Glucoamylase is an important industrial enzyme. Glucoamylase production by industrial Aspergillus niger strain featured with two major problems: (i) empirical substrate feeding methods deteriorating the fermentation performance; and (ii) the high raw materials cost limiting the economics of the glucoamylase product with delegated specification. In this study, we first proposed a novel three-stage varied-rate substrate feeding strategy for efficient glucoamylase production in a 5 L bioreactor using the standard feeding medium, by comparing the changing patterns of the important physiological parameters such as DO, OUR, RQ, etc., when using different substrate feeding strategies. With this strategy, the glucoamylase activity and productivity reached higher levels of 11,000 U/ml and 84.6 U/ml/h, respectively. The performance enhancement in this case was beneficial from the following results: DO and OUR could be controlled at the higher levels (30%, 43.83 mmol/l/h), while RQ was maintained at a stable/lower level of 0.60 simultaneously throughout the fed-batch phase. Based on this three-stage varied-rate substrate feeding strategy, we further evaluated the economics of using alternative carbon sources, attempting to reduce the raw materials cost. The results revealed that cornstarch hydrolysate could be considered as the best carbon source to replace the standard and expensive feeding medium. In this case, the production cost of the glucoamylase with delegated specification (5,000 U/ml) could be saved by more than 61% while the product quality be ensured simultaneously. The proposed strategy showed application potential in improving the economics of industrial glucoamylase production.

• Journal of Microbiology and Biotechnology
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• v.31 no.11
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• pp.1465-1480
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• 2021

Violacein, a purple pigment first isolated from a gram-negative coccobacillus Chromobacterium violaceum, has gained extensive research interest in recent years due to its huge potential in the pharmaceutic area and industry. In this review, we summarize the latest research advances concerning this pigment, which include (1) fundamental studies of its biosynthetic pathway, (2) production of violacein by native producers, apart from C. violaceum, (3) metabolic engineering for improved production in heterologous hosts such as Escherichia coli, Citrobacter freundii, Corynebacterium glutamicum, and Yarrowia lipolytica, (4) biological/pharmaceutical and industrial properties, (5) and applications in synthetic biology. Due to the intrinsic properties of violacein and the intermediates during its biosynthesis, the prospective research has huge potential to move this pigment into real clinical and industrial applications.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.17 no.29
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• pp.23-29
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• 1994

In a newly developed production control system, a safety control ought to be included as a means of ensuring a more rational control system for achieving efficiency. Such a system does not hold any meaning in itself unless accompanied with appropriate ways to make it practicable. A firm would have a number of function groups. Each of these groups would have specific functions or duties to perform. Their production activities would be planned at the level of departmental management. The planning will take such forms as production, quality and safety planning, and so far as each department would order the line from its own standpoint, scientific production activities could not be expected. All the programmes must, therefore, be integrated and coordinated by a supervisor.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.29 no.3
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• pp.79-86
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• 2006

Especially, MTO(Make-To-Order) companies take collaborative approaches with their partner companies to make low-price products and/or technologically low intensive products. The collaborative approach to manufacturing requires collaboration with partner companies for inventory review, production plan, and manufacturing to fulfill customer's orders. However, frequent changes of partnerships binder partner companies from sharing production information in effective ways since their information systems have different data architectures and platforms. Therefore, it is required flexible and standardized system integration approach fir effective information sharing. This research studies current status and problems of collaborative production system, proposes an architecture for collaborative production systems based on Web Services which is a standard information technology, and discusses expected effects and the vision of Web Services.