• 소성∙가공
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• 제13권2호
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• pp.180-187
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• 2004

A computer code was developed to simulate the filling stage of the injection/compression molding process by a finite element method. The constitutive equation used here was the compressible Leonov model. The PVT relationship was assumed to follow the Tait equation. The flow-induced birefringence was related to the calculated flow stresses through the linear stress-optical law. Simulations of a disk part under different process conditions including the variation of compression stroke and compression speed were carried out to understand their effects on birefringence variation. The simulated results were also compared with those by conventional injection molding.

• Computers and Concrete
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• 제22권1호
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• pp.53-62
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• 2018

Cracking of concrete cover induced by reinforcement corrosion is a critical issue for life-cycle design and maintenance of reinforced concrete structures. However, the critical degree of corrosion, based on when the concrete surface cracks, is usually hard to predict accurately due to the heterogeneity inherent in concrete. To investigate the influence of concrete heterogeneity, a modified rigid-body-spring model, which could generate concrete sections with randomly distributed coarse aggregates, has been developed to study the corrosion-induced cracking process of the concrete cover and the corresponding critical degree of corrosion. In this model, concrete is assumed to be a three-phase composite composed of coarse aggregate, mortar and an interfacial transition zone (ITZ), and the uniform corrosion of a steel bar is simulated by applying uniform radial displacement. Once the relationship between radial displacement and degree of corrosion is derived, the critical degree of corrosion can be obtained. The mesoscale model demonstrated its validity as it predicted the critical degree of corrosion and cracking patterns in good agreement with analytical solutions and experimental results. The model demonstrates how the random distribution of coarse aggregate results in a variation of critical degrees of corrosion, which follows a normal distribution. A parametric study was conducted, which indicates that both the mean and variation of critical degree of corrosion increased with the increase of concrete cover thickness, coarse aggregates volume fraction and decrease of coarse aggregate size. In addition, as tensile strength of concrete increased, the average critical degree of corrosion increased while its variation almost remained unchanged.

• 대한기계학회논문집B
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• 제20권6호
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• pp.1931-1940
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• 1996

The effect of periodic passing wake on the film-coolant flow issuing normally from a flat plate was investigated experimentally. The passing wake was generated by rotating thin circular bars. Depending on the rotational direction the test plate could be simulated as a pressure surface or a suction surface of a gas turbine blade. The phase-averaged velocity components were measured using an X-type hot-wire probe. The Reynolds number based on the free-stream velocity and injection hole diameter was 23, 500 and the velocity ratio which is the ratio of film coolant velocity to free-stream velocity was 0.5. The velocity-triangle induced by the wake was similar to that induced by the one generated at the blade trailing edge. The vertical velocity component induced by the passing wake, which approaches to the suction surface and moves away from the pressure surface, played a dominant role in the variation of the flow field. The variation in the phase-averaged velocity on the pressure surface was greater than on the suction surface, but the turbulence kinetic energy variation on the suction surface appeared larger than on the pressure surface.

• Journal of Veterinary Science
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• 제23권6호
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• pp.68.1-68.8
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• 2022

Background: Studies on anesthetized dogs regarding pulse pressure variation (PPV) are increasing. The influence of respiratory rate (RR) on PPV, in mechanically ventilated dogs, has not been clearly identified. Objectives: This study evaluated the influence of RR on PPV in mechanically ventilated healthy dogs after hemorrhage. Methods: Five healthy adult Beagle dogs were premedicated with intravenous (IV) acepromazine (0.01 mg/kg). Anesthesia was induced with alfaxalone (3 mg/kg IV) and maintained with isoflurane in 100% oxygen. The right dorsal pedal artery was cannulated with a 22-gauge catheter for blood removal, and the left dorsal pedal artery was cannulated and connected to a transducer system for arterial blood pressure monitoring. The PPV was automatically calculated using a multi-parameter monitor and recorded. Hemorrhage was induced by withdrawing 30% of blood (24 mL/kg) over 30 min. Mechanical ventilation was provided with a tidal volume of 10 mL/kg and a 1:2 inspiration-to-expiration ratio at an initial RR of 15 breaths/min (baseline). Thereafter, RR was changed to 20, 30, and 40 breaths/min according to the casting lots, and the PPV was recorded at each RR. After data collection, the blood was transfused at a rate of 10 mL/kg/h, and the PPV was recorded at the baseline ventilator setting. Results: The data of PPV were analyzed using the Friedman test followed by the Wilcoxon signed-rank test (p < 0.05). Hemorrhage significantly increased PPV from 11% to 25% at 15 breaths/min. An increase in RR significantly decreased PPV from 25 (baseline) to 17%, 10%, and 10% at 20, 30, and 40 breaths/min, respectively (all p < 0.05). Conclusions: The PPV is a dynamic parameter that can predict a dog's hemorrhagic condition, but PPV can be decreased in dogs under high RR. Therefore, careful interpretation may be required when using the PPV parameter particularly in the dogs with hyperventilation.

• JSTS:Journal of Semiconductor Technology and Science
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• 제15권6호
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• pp.678-684
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• 2015

Near-threshold computing (NTC) is now regarded as a promising candidate for innovative power reduction, which cannot be achieved with conventional super-threshold computing (STC). However, performance degradation and vulnerability to process variation in the NTC regime are the primary concerns. In this paper, we propose a voltage- and frequency-tuning methodology for mitigating the process-variation-induced problems in NTC-based manycore architectures. To implement the proposed methodology, we build up multiple-voltage multiple-frequency (MVMF) islands and apply a voltage-frequency tuning algorithm based on the critical-path monitoring technique to reduce the effects of process variation and maximize energy efficiency in the post-silicon stage. Experimental results show that the proposed methodology reduces overall power consumption by 8.2-20.0%, compared to existing methods in variation-sensitive NTC environments.

• 한국항공운항학회지
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• 제24권2호
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• pp.19-24
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• 2016

Positional stability analysis based on aerodynamic forces and induced moments of formation flight using two small aircraft models is presented. The aerodynamic force and moments of the trailing aircraft are analyzed in the aspect of flight stability. The induced moments with the change of local flow direction by wing-tip vortex from the leading aircraft can affect the flight positional stability of aircraft in closed formation flight. Aerodynamic forces and moments of trailing aircraft model are measured by 6-component internal balance at the 49 locations with vertical and lateral space between two aircraft models. Results are shown that the positional stability of trailing aircraft in formation flight can be analyzed by positional stability derivatives with vertical and lateral space. It is concluded that flying positions can be important factors for aircraft position stability due to induced aerodynamic force and moments with vertical and lateral spacing by the variation of flow pattern from the leading aircraft in formation flight.

• 대한기계학회논문집A
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• 제36권11호
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• pp.1327-1334
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• 2012

본 논문은 4차 동적 시스템인 구동기를 구성하는 부품들의 변량 및 공기외란의 변량으로 인해 구동기 성능에 변량이 존재할 때, 구동기의 성능을 순응도 기반으로 최적화한 설계 결과를 제시하였다. 구동기는 BLDC 모터와 평기어 및 웜기어 조립체, 카나드로 구성된다. 구동기의 성능은 시간에 따라 변화하는 카나드 각도 정보를 이용하여 평가하였다. 고차 시스템의 성능은 해석적 접근을 통해 시스템 변수들의 함수로 표현하기 어렵기 때문에 반응표면모델을 기반으로, F-검정을 수행하여 유효한 시스템 변수들을 선정한 후 성능을 유효한 시스템 변수들의 함수로 근사화하였다. 본 연구에서 변량을 가지는 구동기 성능의 규격에 대한 순응도를 확률값으로 정의하였다. 순응도를 최적화하여 구한 설계변수는 부품 및 공기외란에 변량이 존재하더라도 고려한 규격을 모두 만족시킬 수 구동기를 제공할 수 있다.

• Journal of Plant Biotechnology
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• 제5권1호
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• pp.25-31
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• 2003

As a consequence of tissue culture of rice, RAPD analysis was peformed to determine whether extended culture periods as undifferentiated calli affected the subsequent genetic constancy, and whether any resulting DNA rearrangements could be detected between sibling plants produced from the same callus. Somaclonal variation was induced at the initial stage of tissue culture and it increased with the length of culture maintenance. Of the 192 total bands, the number of polymorphic bands was 22 (11.5%), 33 (17.2%), and 49 (25.5%) in the callus of 1,3, and 6 months culture, respectively. A significantly higher level of genotypic polymorphisms between regenerants from two different somaclones was also detected, although all the regenerants were derived from a single genotype. In comparison of DNA polymorphisms between regenerants from non-irradiated and from irradiated calli, a scope of variation spectrum by gamma ray irradiation was larger than that by tissue culture. Consideration must be given to this genomic variation where attempts are to be made to use desirable somaclonal variants for plant breeding purpose and in genetic engineering program.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.112-121
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• 2017

Drug-induced liver injury (DILI) is the serious and fatal drug-associated adverse effect, but its incidence is very low and individual variation in severity is substantial. Acetaminophen (APAP)-induced liver injury accounts for >50% of reported DILI cases but little is known for the cause of individual variations in the severity. Intrinsic genetic variation is considered a key element but the identity of the genes was not well-established. Here, pre-biopsy method and microarray technique was applied to uncover the key genes for APAP-induced liver injury in mice, and a cause and effect experiment employing quantitative real-time PCR was conducted to confirm the correlation between the uncovered genes and APAP-induced hepatotoxicity. We identified the innately and differentially expressed genes of mice susceptible to APAP-induced hepatotoxicity in the pre-biopsied liver tissue before APAP treatment through microarray analysis of the global gene expression profiles (Affymetrix $GeneChip^{(R)}$ Mouse Gene 1.0 ST for 28,853 genes). Expression of 16 genes including Gdap10, Lpl, Gabra3 and Ccrn4l were significantly different (t-test: FDR <10%) more than 1.5 fold in the susceptible animals than resistant. To confirm the association with the susceptibility to APAP-induced hepatotoxicity, another set of animals were measured for the expression level of selected 4 genes (higher two and lower two genes) in the liver pre-biopsy and their sensitivity to APAP-induced hepatotoxicity was evaluated by post hoc. Notably, the expressions of Gabra3 and Lpl were significantly correlated with the severity of liver injury (p<0.05) demonstrating that these genes may be linked to the susceptibility to APAP-induced hepatotoxicity.

• Smart Structures and Systems
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• 제15권3호
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• pp.505-522
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• 2015

Variation of temperature is a primary environmental factor that affects the behavior of structures. Therefore, understanding the mechanisms of normal temperature-induced variations of structural behavior would help in distinguishing them from anomalies. In this study, we used the structural health monitoring data of the Shanghai Yangtze River Bridge, a steel girder cable-stayed bridge, to investigate the mechanisms of thermally induced vertical deflection ($D_T$) at mid-span of such bridges. The $D_T$ results from a multisource combination of thermal expansion effects of the cable temperature ($T_{Cab}$), girder temperature ($T_{Gir}$), girder differential temperature ($T_{Dif}$), and tower temperature ($T_{Tow}$). It could be approximated by multiple linear superpositions under operational conditions. The sensitivities of $D_T$ of the Shanghai Yangtze River Bridge to the above temperatures were in the following order: $T_{Cab}$ > $T_{Gir}$ > $T_{Tow}$ > $T_{Dif}$. However, the direction of the effect of $T_{Cab}$ was observed to be opposite to that of the other three temperatures, and the magnitudes of the effects of $T_{Cab}$ and $T_{Gir}$ were found to be almost one order greater than those of $T_{Dif}$ and $T_{Tow}$. The mechanisms of the thermally induced vertical deflection variation at mid-span of a cable-stayed bridge as well as the analytical methodology adopted in this study could be applicable for other long-span cable-stayed bridges.