• 대한수의학회지
• /
• 제33권1호
• /
• pp.93-99
• /
• 1993

This study was conducted to investigate the cause of a new duck disease occured in southern part of Korea. A meat type duck farm located in Kangjin, Chonnam Province had experienced outbreaks of septicemic disease at around 20 days of age in nearly every batch of ducklings from early spring to early summer in 1989. Main symptoms of the birds were eye and nasal discharge, depression, inappetence, diarrhea and nervous signs such as tremor and ataxia. Some birds died suddenly without any signs. Mortality reached from 20% to 80% in severe cases. The autopsy findings of the affected ducklings revealed consistantly severe airsacculitis, fibropericarditis, perihepatitis and occasionaly enteritis and distended ureter with urate deposit. A rod shaped gram-negative bacterium was isolated purely from brain and liver of the diseased ducks by culturing the specimens on blood agar for 48 hours in candle jar. The isolate neither produced hemolysis nor grew on MacConKey Agar. It formed colony relatively slowly being recognizable at least 36 hours after culturing, reaching colony size of about 1mm in diameter at 48 hours culture. The colony looked iridescent under oblique light and had muddy odor. The isolate did not ferment carbohydrates tested but produced gelatinase, hippuricase and oxidase which were considered as characteristics of P anatipestifer. The isolate induced similar signs and lesions when infected experimentally into ducks of 3 to 38 days age via intraperitoneum or intratrachea. However it did not produce any clinical signs wen inoculated via intranasal route. It produced only mild signs in chicken just injected with a very large dose. The bacteria did not produce any signas or lesions in mice. It was concluded through biochemical and physiological tests and animal inoculation tests that the new disease was caused by P anatipestifer.

• 대한수의학회지
• /
• 제52권4호
• /
• pp.213-221
• /
• 2012

A total of 18 Newcastle disease virus (NDV) isolates that were recovered from 1949 through 1997 were characterized and pathotyped. All viruses were highly virulent as determined by intracerebral pathogenicity indices ${\geq}1.81$ in day-old. These pathotypes are typical for viscerotropic velogenic NDV (VVNDV) pathotype viruses. Some differences were observed for the chicken red blood cell elution rate and thermostability of the hemagglutinin at $56^{\circ}C$. Three antigenic groups were identified by a hemagglutination-inhibition assay using NDV monoclonal antibodies. And the predominant gross lesions were as follows: discharge from the nasal cavity, tracheal mucus, petechial hemorrhage in the heart fat, kidney urates and hemorrhage with or without necrosis in the gastrointestinal tract. Severe hemorrhagic or necrotic lesions were also noted in the lymphoid organs and were localized primarily in the spleen and cecal tonsil. However, differences in the occurrence and frequency of the gross lesions were observed between the virus strains. Among them, NDV strains that induced neurological symptoms belonged only to genotype VI. This strain had spread throughout Korea during the late 1980s to the 1990s, which suggests that specific VVNDVs genotypes might result in neurological symptoms.

• 한국재료학회지
• /
• 제18권9호
• /
• pp.457-462
• /
• 2008

Through the electrostatic interaction between the poly-diallydimethylammonium chloride (PDDA) modified Multi-walled carbon nanotube (MWNT) and $SnO_2$ suspension in 1mM $NaNo_3$ solution, MWNT-$SnO_2$ nanocomposites (MSC) for anode electrodes of a Li-ion battery were successfully fabricated by colloidal heterocoagulation method. TEM observation showed that most of the $SnO_2$ nanoparticles were uniformly deposited on the outside surface of the MWNT. Galvanostatic charge/discharge cycling tests showed that MSC anodes exhibited higher specific capacities than bare MWNT and better cyclability than unsupported nano-$SnO_2$ anodes. Also, after 20 cycles, the MSC anode fabricated by heterocoagulation method showed more stable cycle properties than the simply mixed MSC anode. These improved electrochemical properties are attributed to the MWNT, which adsorbs the mechanical stress induced from volume change and increasing electrical conductivity of the MSC anode, and suppresses the aggregation between the $SnO_2$ nanoparticles.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
• /
• pp.199-199
• /
• 2013

The distinctive cellular and mitochondrial dysfunctions of a human epithelial lung cancer cell line (H460) from a human lung fibroblastic normal cell line (MRC5) have been studied by dielectric barrier discharge (DBD) plasma treatment. The DBD plasma device have generated large amount of H2O2 and NOx in culture media which is dependent on plasma exposure time. It is found that the cell number of lung cancer cell H460 has been reduced more than the lung normal cell MRC5 as being increased exposure and incubation time. Also these both cell lines have showed mitochondria fragmentation under 5 minutes' plasma exposure, which is a clue of apoptosis. It is noted in this study that AnnexinV staining has showed not only early apoptosis, but also late apoptosis in lung cancer cell H460. Mitochondria enzyme activity and ATP generation have been also much reduced in lung cancer cell H460. Their mitochondrial membrane potential (${\Delta}{\psi}m$) has been found to be reduced in magnitude and shifted to the induced-potential level of cccp, while MRC5 mitochondrial membrane potential has been shifted slightly to that. These distinctively selective responses of lung cancer cell H460 from lung normal cell MRC5 gives us possibility of applying plasma to cancer therapy.

• 한국해안해양공학회지
• /
• 제17권1호
• /
• pp.47-54
• /
• 2005

목포해역과 같이 수심이 복잡하고 조간대가 광범위하게 발달되어 있는 곳의 수심자료를 용이하게 입력하고 수치모형 운용을 경제적으로 수행할 수 있는 기법을 개발하였다. 이를 청계만의 조간대 모의에 적용하여 조간대와 관련된 목포해역의 동수역학적 해석을 수행하였다. 하구언과 방조제 건설에 따라 목포항 인근을 비롯해 청계만 수역까지 조석확폭현상이 발생한 바 있는데, 이로 인해 청계만의 조간대 규모가 증대되었으며 낙조우세가 더욱 심화되었다. 청계만의 심화된 낙조우세현상은 목포항 쪽의 해수유통량 증가에 기인하였는데 이러한 영향성 증대로 인해 목포항 부근의 낙조우세 역시 심화된 결과를 초래하였다.

• 지질공학
• /
• 제14권3호
• /
• pp.287-300
• /
• 2004

Visual Modflow를 이용하여 터널 굴착 시 터널 내 지하수 유입 량과 영항반경에 영향을 미치는 수리 인자들에 대한 민감도 분석을 수행하였다. 터널의 심도 및 수리전도도의 민감도가 가장 크게 나타났으며, 굴착 후 경과 시간에 따라 민감도의 순위가 달라지는 것으로 분석되었다. 비산출률의 경우 굴착 후 시간이 경과함에 따라 민감도가 지속적으로 증가하는 것으로 나타나 배수형 터널 설계 시 수리전도도와 함께 중요하게 고려되어야 할 변수인 것으로 밝혀졌다. 터널굴착 및 방수 처리 과정을 모사할 수 있는 부정류 모델링 기법을 제시하였으며, 실제 터널 설계 지역에 적용하여 굴착과정에서 발생하는 터널 내 지하수 유입량 주변 지역 지하수계의 변화를 예측하였다. 예측 모델의 결과는 모델 보정을 통하여 설정한 수리 전도도에 매우 민감하므로, 사후 모니터 링을 통한 모델 검증이 요구된다.

• 지질공학
• /
• 제17권1호
• /
• pp.135-142
• /
• 2007

토목구조물의 기초가 되는 암반은 암석자체로서는 강도가 높고 투수성이 작지만 공학적 성질은 암반내의 존재하는 크랙, 절리 등 불연속면의 영향을 크게 받는다. 천부 암반내에 지배적으로 분포하는 것은 절리이지만 그 수가 적은 지하심부에 있어서 지하수 투수성의 가능성을 고려하면 암석자체의 미소크랙의 연결성이 투수성 크랙으로서 충분히 고려되어져야 한다. 이 연구에서는 절리성 암반의 절리분포 및 투수성 해석 모델화 방법을 화강암 공시체의 미소크랙에 응용하여 손상진행에 따른 화강암의 투수 특성을 추정하는 것을 목적으로 하였다. 미소크랙 데이터로부터 투수모델을 작성하여 해석한 결과 평균투수계수에 있어서 실제의 투수시험 값과 잘 일치하는 것으로 나타났다. 또한 3차원 모델의 가시화를 가지고 모델표면에서의 미소크랙과의 비교로부터 손상발달에 의한 미소크랙 발생수와 유출면으로부터 계산한 평균투수계수는 비례관계로 실험결과와 잘 일치하는 것으로 해석되었다.

• 대한기계학회논문집A
• /
• 제25권3호
• /
• pp.510-519
• /
• 2001

The tensile and fracture toughness tests have been conducted to investigate the degradations of mechanical properties induced mainly by neutron irradiations in Zr-2.5Nb CANDU pressure tube materials operated in Wolsung Unit-1. the tests were performed at room, 150, 200, 250, 300 $\^{C}$ for the irradiated and unirradiated specimens in hot cell. The specimens were directly machined from the tube retaining original curvature using specially designed electric discharge machine(EDM). From the tensile tests of the irradiated specimens, it was found that tensile strength was increased and total elongation was decreased compared to those of the unirradiated ones. The active voltages in the fracture toughness tests for the irradiated showed the discontinuous abrupt increases caused by crack jumping in lower temperature. In the crack resistance curves we found the stable crack growth in the unirradiated, whereas the unstable and three crack growth stages in the irradiated specimens due to the accumulated irradiation defects. The various fracture characteristic values in the irradiated are remarkably lower than those of the unirradiated. Through the fractography, we found in the irradiated that smaller dimple and shorter fissures than the unirradiated, and that the fractured surface had three regions that were flat, transition and slant/shear area. These can explain the difference in the crack growth characteristic values of the irradiated and the unirradiated ones.

• 대한한방내과학회지
• /
• 제40권6호
• /
• pp.1145-1151
• /
• 2019

Objectives: The purpose of this study was to investigate liver function test results in admitted patients before and after herbal treatment. Methods: 54 subjects admitted to hospital had liver function tests (aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, total bilirubin) before and after herbal treatment from 1 March 2017 to 30 June 2019. Results: Aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were not significantly changed (p>0.05). On admission, 11 patients had abnormal liver function, while seven patients had abnormal results in alkaline phosphatase upon discharge. Three of the seven were normal when they were hospitalized. Conclusions: This study suggests that herbal treatment may have no effect on liver injury.

• 한국임상수의학회지
• /
• 제5권1호
• /
• pp.43-52
• /
• 1988

These studies were taken experimentally to clarify the clinical and histopathological findings of listeriosis in Korean native goat(KNC). Four KNGs of 4 to 5 months of age were inoculated orally or in-travenously (IV) with Listeria monocytogenes isolated from a field case of KNG. 1. On the clinical findings, depression, anorexia and fever were observed in all inoculated goats, and nasal discharge, keratoconjunctivitis and diarrhea in 3 of 4 goats. Highest rectal temperature after in-oculation was 2.5$^{\circ}C$ higher in IV inoculated goats and 1.9$^{\circ}C$ higher in orally inoculated than normal rectal temperature observed before inoculation. Durations of clinical course after inoculation in IV and orally inoculated goats were 5 days and 8 days, respectively. 2. On the gross lesions, swelling of the lymph nodes, hemorrhage and .inflammation of the small intestine and rigor mortis were observed in 4 of 4 goats, and keratoconjunctivitis, hemorrhage and inflammation of the large intestine, swelling of the spleen, pneumonia and hydropericardium in 3 of 4 goats. Congestion of the visceral organs and ecchymosis of the sin in a fetus were observed. Keratoconjunctivitis, hemorrhage of the abomasum, swelling of the lymph node, hemorrhage and inflammation of the small intestine, swelling of the spleen, necrosis of the liver and pneumonia were observed as severe lesions. These lesions were more severe in IV inoculated goats than those in orally inoculated goats. 3. On histopathological findings, focal necrosis found throughout the livers occurred mainly on peripheral areas of hepatic lobules. These necrotic foci consisted of neutrophils, lymphocytes, macrophages, short rod bacteria and necretic hepatic cells. Suppurative pneumonia of the lung, hyperemia, congestion, epithelial necrosis and sloughing of the small and large intestine, swelling in periventricular regions of the central nervous system, swelling of the kidney, spleen and lymph node were observed as listerial lesions.