• 대한한방내과학회지
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• 제26권2호
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• pp.341-352
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• 2005

Objectives: This study was carried out to investigate the effects of Jecksodoodangkuisan(JD) and Jecksodoodangkuisankahyunjicho(JH) against Colonic Mucosal Ulcer induced by indomethacin in mouse. Methods: The normal group consisted of mice that were not inflammation-induced. The control group was untreated gastro-inflammation-elicited mice. The sample group mice were those administered BO, JD and JH after gastro-inflammation elicitation. Results: In the immunohistochemical change, the distribution of COX-1 in mice treated with BO, JD and JH noticeably increased than control group(P<0.05). The distributions of $NF-{\kappa}B$, p50, COX-2, ICAM-1, HSP70 and Substance P in mice treated with BO, JD and JH noticeably decreased more than control group(P<0.05). And JH was most effective treatment against Colonic Mucosal Ulcer in the immunohistochemical change. Conclusions: According to the above results, Jecksodoodangkuisan and Jeckmdoodangkuisankahyunjicho are applicable treatments for Colonic Mucosal Ulcer.

• 융합정보논문지
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• 제10권10호
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• pp.109-114
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• 2020

이번 연구는 소화기계 출혈, 궤양 등에 대해 치료와 예방을 목적으로 사용되는 rebamipide에서 농도 의존적 장관 수축성 조절 기전에 대해 조사하고자 한다. 소화기 수축은 근육의 섬유의 조절에 의하여 일어난다. 실험용 쥐의 회장 과 결장을 적출하여 carbachol로 회장 과 결장의 근육수축을 유발하여 연구를 진행하였다. rebamipide 단독으로 장관수축을 억제하지 않고 소폭으로 carbachol 유도 수축을 높이는 것으로 관찰되었다. 소화기계 부작용을 일으키는 indomethacin 과 rebamipide를 흔히 병용하기에, 병용 효과를 관찰하였다. Indomethacin과 병용된 rebamipide는 장관 중 회장의 수축성을 증대시켰다. rebamipide는 장관중 회장에서 수축성을 증대시키고, NSAIDs에 의한 궤양에 대한 항궤양효과 외에 운동성도 일부 조절하는 것으로 생각된다.

• KSBB Journal
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• 제31권4호
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• pp.291-299
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• 2016

In this study, Indomethacin, the poorly water soluble drug, was selected and prepared dispersing oral disintegrating films according to the molecular weight of polyethylene glycol (PEG) which are sort of dispersing agents. Also the molecular weight and content of PEG were evaluated effect on the degree of dispersion, physical property and dissolution when making oral dispersing film containing indomethacin to find appropriate condition and suggested guidelines of making oral dispersing film. The appropriate dispersing ratio of the amount of surfactants and dispersing agent were 1% and 4%, also the stability dropped in the PEG molecular weight of 4000 or more. Drying time of oral dispersing film was $90^{\circ}C$ for 10 minutes to 12 minutes that dispersing film's property about flexibility, detachability were very good. The oral dispersion film's content used PEG 400 was $98.6{\pm}0.5%$ and the most uniform. As the molecular weight of PEG increased, dissolution time also increased. On the basis of evaluation parameter, PEG with 400~600 of molecular weight was selected as good dispersing agent in oral dispersing film. Therefore, it can be suggested guideline of preparation application study in oral dispersing film.

• Journal of Yeungnam Medical Science
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• 제10권2호
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• pp.506-511
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• 1993

미숙아 동맥관 개존증에 대한 약물 치료로서 mefenamic acid는 널리 사용되고 있는 indomethacin과 같이 효과적으로 생각되며, 더 많은 연구를 통해 치료 효과에 대해 indomethacin과의 비교 분석이 이루어 진다면, 부작용이 경미하고 정확한 정량 사용이 가능하기 때문에, indomethacin대신 미숙아 동맥관 개존증 치료제로 사용될 수 있을 것으로 생각된다.

• 동의생리병리학회지
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• 제21권6호
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• pp.1394-1400
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• 2007

This study was designed to investigate the effects of Samul-tang Extract and Bambusae caulis in liquamen(SEB) on the changes in regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats. The results were as follows ; SBE significantly increased rCBF in a dose-dependent manner, and increased MABP in a dose-dependent manner. This result suggests that SBE significantly increased rCBF by dilating pial arterial diameter. Increase of SBE-induced rCBF was significantly inhibited by pretreatment with indomethacin (1 mg/kg, i.p.), an inhibitor of cyclooxygenase and increase of SBE-induced rCBF was inhibited by pretreatment with methylene blue ($10\;{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. Increase of SBE-induced MABP was significantly increased by pretreatment with methylene blue but increase of SBE-induced MABP was decreased by pretreatment with indomethacin. These results suggested that the action of SBE was mediated by cyclooxygenase.

• 대한한의학회지
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• 제24권2호
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• pp.94-108
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• 2003

Objectives : This study was carried out to investigate the anti-ulcer effects of Pyeongwibunsoeum extract and Misoprostol on indomethacin-induced gastric mucosal lesions of mice. Methods : Experimental groups were classified into non-treated group, non-administered group, Misoprostol-administered group and Pyeongwibunsoeum-extract-administered group. This study examined the morphological change, distribution of mast cells and apoptic cells, PNA reaction, COX-1, BrdU, NF-B p50, COX-2, IL-2R-, and ICAM-1of gastric mucosa. Results : 1. The hemorrhagic erosion of gastric mucosa was reduced in the Misoprostol-administered and Pyeongwibunsoeum-extract-administered groups. 2. The Misoprostol-administered group and Pyeongwibunsoeum-extract-administered group showed positive reaction on the PNA distribution. 3. The distribution of apoptic cells, activity of NF-B p50, COX-2, IL-2R-, and ICAM-1 decreased in both the Misoprostol-administered group and Pyeongwibunsoeum-extract-administered group. 4. The Misoprostol-administered and Pyeongwibunsoeum-extract-administered groups showed increase on COX-1, BrdU. Conclusions : As the results indicate, hemorrhagic erosion of gastric mucosa were reduced in both the Misoprostol-administeredand Pyeongwibunsoeum-extract-administered groups, and severe inflammatory reaction of gastric mucosa was reduced. The effects on the Pyeongwibunsoeum-extract-administered group were superior to those on the Misoprostol-administered group. Pyeongwibunsoeum extract can be widely administered for gastric ulcer disease in clinical treatments.

• 대한한의학회지
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• 제28권2호통권70호
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• pp.224-240
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• 2007

Objectives : This study was carried out to investigate the effect of Jiyu-tang on gastric and ileac mucosal ulcer induced by indomethacin in mouse. Methods : The normal group was that no inflammation elicited mouse. Control group is that water administered mouse after gastro-inflammation elicitation. Sample group is that Jiyu-tang administered mouse after gastro-inflammation elicitation. Results : In the common morphology and histochemical change, control group were observed various injury by hemorrhagic erosion, while sample group was noticeably decreased than control group. In the immunohistochemical change, the distributions of COX-1 treated with Jiyu-tang noticeably increased than control group(p<0.05). The distributions of COX-2, MAC 387 and HSP-70, PCNA and TUNEL treated with Jiyu-tang noticeably decreased than control group(p<0.05). Conclusions : According to the above results, it is supposed that Jiyu-tang is applicable to gastric and ileac mucosal ulcer.

• Clinical and Experimental Pediatrics
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• 제52권5호
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• pp.619-621
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• 2009

돌발 반두통은 일측성이고 짧은 시간동안 심한 통증이 있는 경우이며, 대부분 두개의 자율신경계 증상을 동반한다. 이는 군발 두통의 통증, 동반 증상과 징후와 비슷하지만, 돌발 반두통은 지속시간이 더 짧고, 더 빈번하며, 인도메싸신에 잘 반응한다. 1992년에 Sjaastad에 의해 돌발 반두통이 반대쪽으로도 이동한다고 처음 보고하였으며, 문헌에는 단지 4례가 보고되었다. 4례 중 3례는 자율신경계 증상을 동반하지 않았으며, 1례만 자율신경계 증상 동반을 하였다. 저자는 10세 소아에서 자율신경계 증상을 동반한 전형적인 증상과 인도메싸신으로 치료된 양측 돌발 반두통 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 동의생리병리학회지
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• 제19권6호
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• pp.1599-1603
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• 2005

The study was designed to investigate the effects of Leonuri herba extract (LHE) on the change of regional cerebral blood flow (rCBF) and mean arterial blood pressure (MABP) in normal rats, and further to determine the mechanism of action of LHE. The results in normal rats were as follows, LHE significantly increased rCBF in a dose-dependent manner, and MABP did not change in a dose-dependent manner. This results were suggested that LHE significantly increased rCBF by dilating pial arterial diameter. The LHE-induced increase in rCBF was significantly inhibited by Pretreatment with indomethacin(1 mg/kg, i.p.), an inhibitor of cyclooxygenase, and was significantly inhibited by methylene blue($10{\mu}g/kg$, i.p.), an inhibitor of guanylate cyclase. The LHE-induced MABP did not change by pretreatment with indomethacin but was significantly inhibited by methylene blue. This results were suggested that the mechanism of LHE was mediated by cyclooxygenase.

• Advances in Traditional Medicine
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• 제4권4호
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• pp.253-260
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• 2004

Zosterin is a pectin from a seagrasses of the family Zosteraceae. Zosterin was given to rats intragastrically once 1h before the emotional stress or injection of indomethacin, or administration of 2, 4-D solution daily for seven days at dose of 100 mg/kg. The data obtained demonstrate that zosterin enhances resistance of the stomach tissue to various ulcerogenic factors (emotional stress, indomethacin, pesticide 2, 4-D). It was shown to possess a gastroprotective effect, which is accompanied by diminution of the number and sizes of destructive regions in the gastric mucosa during the ulcer affection, as well as reduction of ATP and glycogen deficit, decrease of lactate excess, and normalization of the energy balance in the gastric mucosa. According to its antiulcer effect, zosterin may be recommended for application in prevention and treatment of stomach diseases together with the basic therapy.