• Wind and Structures
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• v.29 no.5
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• pp.299-312
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• 2019

Due to the rugged terrain, metro lines in mountain city across numerous wide rivers and deep valleys, resulting in instability of high-pier bridge and insecurity of metro train under crosswind. Compared with the conditions of no-wind, crosswind triggers severer vibration of the dynamic system; compared with the short-pier viaduct, the high-pier viaduct has worse stability under crosswind. For these reasons, the running safety of the metro vehicle traveling on a high-pier viaduct under crosswind is analyzed to ensure the safe operation in metro lines in mountain cities. In this paper, a dynamic model of the metro vehicle-track-bridge system under crosswind is established, in which crosswind loads model considering the condition of wind zone are built. After that, the evaluation indices and the calculation parameters have been selected, moreover, the basic characteristics of the dynamic system with high-pier under crosswind are analyzed. On this basis, the response varies with vehicle speed and wind speed are calculated, then the corresponding safety zone is determined. The results indicate that, crosswind triggers drastic vibration to the metro vehicle and high-pier viaduct, which in turn causes running instability of the vehicle. The corresponding safety zone for metro vehicle traveling on the high-pier is proposed, and the metro traffic on the high-pier bridge under crosswind should not exceed the corresponding limited vehicle speed to ensure the running safety.

• Structural Engineering and Mechanics
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• v.13 no.2
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• pp.187-209
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• 2002

The infrastructure system in the United States has been aging faster than the resource available to restore them. Therefore decision for allocating the resources is based in part on the condition of the structural system. This paper proposes to use neural network to predict the overall rating of the structural system because of the successful applications of neural network to other fields which require a "symptom-diagnostic" type relationship. The goal of this paper is to illustrate the potential of using neural network in civil engineering applications and, particularly, in bridge evaluations. Data collected by the Tennessee Department of Transportation were used as "test bed" for the study. Multi-layer feed forward networks were developed using the Levenberg-Marquardt training algorithm. All the neural networks consisted of at least one hidden layer of neurons. Hyperbolic tangent transfer functions were used in the first hidden layer and log-sigmoid transfer functions were used in the subsequent hidden and output layers. The best performing neural network consisted of three hidden layers. This network contained three neurons in the first hidden layer, two neurons in the second hidden layer and one neuron in the third hidden layer. The neural network performed well based on a target error of 10%. The results of this study indicate that the potential for using neural networks for the evaluation of infrastructure systems is very good.

• Advances in aircraft and spacecraft science
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• v.3 no.1
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• pp.29-43
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• 2016

Composite materials are rapidly gaining popularity as an alternative to metals for structural and load bearing applications in the aerospace, automotive, alternate energy and consumer industries. With the advent of thermoplastic composites and advances in recycling technologies, fully recyclable composites are gaining ground over traditional thermoset composites. Stamp forming as an alternative processing technique for sheet products has proven to be effective in allowing the fast manufacturing rates required for mass production of components. This study investigates the feasibility of using the stamp forming technique for the processing of thermoplastic, recyclable composite materials. The material system used in this study is a self-reinforced polypropylene composite material (Curv$^{(R)}$). The investigation includes a detailed experimental study based on strain measurements using a non-contact optical measurement system in conjunction with stamping equipment to record and measure the formability of the thermoplastic composites in real time. A Design of Experiments (DOE) methodology was adopted to elucidate the effect of process parameters that included blank holder force, pre heat temperature and feed rate on stamp forming. DOE analyses indicate that feed rate had negligible influence on the strain evolution during stamp forming and blank holder force and preheat temperature had significant effect on strain evolution during forming.

• Earthquakes and Structures
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• v.3 no.3_4
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• pp.549-561
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• 2012

Many building foundations are embedded, however it is not easy to compact the backfill around the foundation especially for the deeply embedded ones. The soil condition around the embedded foundation may affect the seismic response of a building due to the weak contact between the soil and the foundation. In this paper, the response accelerations in the short-period range and at the period of 1 second (in the long-period range) for a seismic design spectrum specified in the IBC design code were compared considering perfect and poor backfills to investigate the effect of backfill compaction around the embedded foundation. An in-house finite-element software (P3DASS) which has the capability of horizontal pseudo-3D seismic analysis with linear soil layers was used to perform the seismic analyses of the structure-soil system with an embedded foundation. Seismic analyses were carried out with 7 bedrock earthquake records provided by the Pacific Earthquake Engineering Research Center (PEER), scaling the peak ground accelerations to 0.1 g. The results indicate that the poor backfill is not detrimental to the seismic response of a building, if the foundation is not embedded deeply in the soft soil. However, it is necessary to perform the seismic analysis for the structure-soil system embedded deeply in the soft soil to check the seismic resonance due to the soft soil layer beneath the foundation, and to compact the backfill as well as possible.

• Archives of Pharmacal Research
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• v.27 no.7
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• pp.763-768
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• 2004

To investigate the feasibility of developing a new quercetin transdermal system, a preformulation study was carried out. Therefore, the effects of vehicles and pressure-sensitive adhesives (PSA) on the in vitro permeation of quercetin across dorsal hairless mouse skin were studied. Among vehicles used, propylene glycol monocaprylate (PGMC) and propylene glycol mono-laurate were found to have relatively high permeation flux from solution formulation (i.e., the permeation fluxes were 17.25$\pm$1.96 and 9.60$\pm$3.87 $\mu\textrm{g}$/$\textrm{cm}^2$/h, respectively). The release rate from PSA formulations followed a matrix-controlled diffusion model and was mainly affected by the amount of PSA and drug loaded. The overall permeation fluxes from PSA formulations were less than 0.30 $\mu\textrm{g}$/$\textrm{cm}^2$/h, which were significantly lower compared to those obtained from solution formulations. The lower permeation fluxes may be due to the decrease of solubility and diffusivity of quercetin in the PSA layer, considering the fact that the highest flux of 0.26 $\mu\textrm{g}$/$\textrm{cm}^2$/h was obtained with the addition of 0.2％ butylated hydroxyanisole in PGMC-diethyl-ene glycol monoethyl ether co-solvents (80-85 ： 15-20, v/v). Taken together, these observations indicate that improvement in the solubility and diffusivity of quercetin is necessary to realize fully the clinically applicable transdermal delivery system for the drug.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.18 no.10
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• pp.826-834
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• 2006

A heat sink system using nanofluidic thermosyphon for electronics systems was studied. The experimental results indicate that a cooling capacity of up to 150 W at an overall temperature difference of $50^{\circ}C$ can be attainable. The heat sink design program also showed that a computer simulation can predict the most of the parameters involved. In the experimental study, the volume concentration of nano particles affect the system performance. Nanofluidic thermosyphon with 0.5% volume concentration showed the best performance. Nanofluid can increase CHF of the system compared with water as a working fluid. The current simulation results were close to the experimental results in acceptable range. The simulation study showed that the design program can be a good tool to predict the effects of various parameters involved in the optimum design of the heat sink.

• Journal of the Korea Institute of Military Science and Technology
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• v.21 no.6
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• pp.731-743
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• 2018

In this paper, a study result to decide the accuracy specifications of inertial sensors satisfying the performance requirements of SINS(ship's inertial navigation system) is proposed. To do this, the performance specifications of overseas SINS is surveyed and the detailed error analysis of SINS at stationary condition is performed. Also, a new performance index to indicate the performance of SINS is derived. Modelling and simulation results show that the accuracy specifications of inertial sensors to meet the performance requirements of SIGMA40XP, a typical overseas SINS, can be determined through the newly derived performance index in this paper.

• Journal of Information Processing Systems
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• v.15 no.4
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• pp.724-736
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• 2019

Dynamic thermal rating technology can effectively improve the thermal load capacity of transmission lines. However, its availability is limited by the quantity and high cost of the hardware facilities. This paper proposes a new dynamic thermal rating technology based on global/regional assimilation and prediction system (GRAPES) and geographic information system (GIS). The paper will also explore the method of obtaining any point meteorological data along the transmission line by using GRAPES and GIS, and provide the strategy of extracting and decoding meteorological data. In this paper, the accuracy of numerical weather prediction was verified from the perspective of time and space. Also, the 750-kV transmission line in Shaanxi Province is considered as an example to analyze. The results of the study indicate that dynamic thermal rating based on GRAPES and GIS can fully excavate the line power potential without additional cost on hardware, which saves a lot of investment.

• Advances in concrete construction
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• v.7 no.3
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• pp.131-141
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• 2019

Irregular distribution of mass in elevation is regarded as a structural irregularity by which the modes with high energy levels are excited and in addition, it can lead the structure to withstanding concentration of nonlinear deformations and consequently, suffer from unpredictable local or global damages. Accordingly, with respect to the lack of knowledge and insight towards the performance of concrete buildings making use of tunnel-form structural system in seismic events, it is of utmost significance to assess seismic vulnerability of such structures involved in vertical mass irregularity. To resolve such a crucial drawback, this papers aims to seismically assess vulnerability of RC tunnel-form buildings considering effects of irregular mass distribution. The results indicate that modal responses are not affected by building's height and patterns of mass distribution in elevation. Moreover, there was no considerable effect observed on the performance levels under DBE and MCE hazard scenarios within different patterns of irregular mass distribution. In conclusion, it appears that necessarily of vertical regularity for tunnel-form buildings, is somehow drastic and conservative at least for the buildings and irregularity patterns studied herein.

• Journal of Microbiology and Biotechnology
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• v.31 no.8
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• pp.1079-1087
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• 2021

Gentisic acid (GA), a benzoic acid derivative present in various food ingredients, has been shown to have diverse pharmaceutical activities such as anti-carcinogenic, antioxidant, and hepatoprotective effects. In this study, we used a co-culture system to investigate the mechanisms of the anti-inflammatory and anti-adipogenic effects of GA on macrophages and adipocytes, respectively, as well as its effect on obesity-related chronic inflammation. We found that GA effectively suppressed lipopolysaccharide-stimulated inflammatory responses by controlling the production of nitric oxide and pro-inflammatory cytokines and modulating inflammation-related protein pathways. GA treatment also inhibited lipid accumulation in adipocytes by modulating the expression of major adipogenic transcription factors and their upstream protein pathways. Furthermore, in the macrophage-adipocyte co-culture system, GA decreased the production of obesity-related cytokines. These results indicate that GA possesses effective anti-inflammatory and anti-adipogenic activities and may be used in developing treatments for the management of obesity-related chronic inflammatory diseases.