• Tuberculosis and Respiratory Diseases
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• v.60 no.3
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• pp.314-320
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• 2006

Background : The overall response (20-30%) to chemotherapy in non-small cell lung cancer (NSCLC) is quite poor. Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme degradation. There is increasing evidence suggesting that the induction of HO-1 might have an important protective effect against oxidative stress including cisplatin containing chemotherapy. This study retrospectively investigated the relationship between HO-1 expression and the response to chemotherapy containing cisplatinin advanced NSCLC patients. Material and Methods : The medical records including the responses to chemotherapy of fifty nine cases were evaluated retrospectively, and the tissue samples of these patients were immunohistochemically stained for HO-1. Results : Forty three of the fifty nine patients(72.8%) showed positive staining for HO-1 in their cancer tissues. There was no significant difference according to the cell type, stage and tumor size. In addition, there was no correlation between HO-1 expression and the responses to chemotherapy. Conclusion : HO-1 expression in tumor tissue dose not predict the response to cisplatin containing chemotherapy in advanced NSCLC. Further prospective studies with a larger number of patients will be needed to confirm these results.

• Journal of Bio-Environment Control
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• v.23 no.4
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• pp.349-355
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• 2014

This study was performed to evaluate influences of tunnel covering materials and seeding dates on the growth and productivity of water spinach (Ipomoea aquatic F.) cultured early in unheated greenhouse. During tunnel installation period, from March 5 to April 30 and from October 11 to November 10, air and soil temperature in tunnel covered with polyethylene film (PEF) had risen $2.0-2.4^{\circ}C$ and $0.9-1.0^{\circ}C$, respectively, compared to those in non-tunnel (NT). Air and soil temperature in tunnel with illite non-fabric (INF) also had risen $1.6-1.8^{\circ}C$ and $0.6-0.8^{\circ}C$, respectively. Especially, it showed greater effects of the rise at low temperature time zones of the day. In plots of seeding on March 15 in tunnel covered with PEF or INF, temperature during emergence period, emergence days and rate were similar to plot seeding on April 5 in NT. There were two more harvesting in plots of seeding on March 5 or March 15 in tunnel, and increasing of total yield by 22.5-25.7% compared to plot of seeding on April 5 in NT. But there was observed no significant differences between PEF and INF. Whereas PEF was necessary to be removed at midday sometimes because it had risk of high temperature injury, INF was not necessary. All above suggest that it was suitable to sow seed on the middle of March in tunnel covered with INF, for early culture of water spinach in unheated greenhouse.

• Journal of Bio-Environment Control
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• v.26 no.1
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• pp.7-12
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• 2017

This experiment was conducted to analyze the effect of drainage reuse rate on the growth and fruiting of summer paprika in closed hydroponic cultivation. The experiment was carried out for 25 weeks from March to September 2015 with 0, 20, 30, 50% mixing ratio of waste nutrient solution using non - recycling hydroponic cultivation as a control. As a result, stem diameter of the test was different in the groups 1 and 2, but no difference showed as the group progressed more than 3 groups. L.A.I tended to decrease with increasing drainage mixing ratio. The number of nodes in the 50% reuse test group was 1.4 compared to the control group, but there was no significant difference. The number of harvested nodes was significantly different in the control group (11.1 nodes) and the 50% reuse test group (8.7 nodes), and the harvested nodes tended to decrease as the drainage was reused. The ratio of harvest was also the same as that of the harvesting node, and the control was the highest at 33.2% and the lowest at the 50% reuse test at 27.6%. Relative yields were reduced by 30%, 35% and 45% in the control group in the first group, and this tendency was also observed in the second and fourth groups. However, in the 3 and 5 groups, the production of 50% test group increased by 13% and 5%. The ratio of unmarketable fruit was increased 2%, 4%, 4%, and 7% in 0%, 20%, 30% and 50% reuse test, respectively. In conclusion, if the decrease in yield due to the decline in early growth is carefully managed, even if the imbalance of inorganic ions occurs after the mid-term growth, the growth of the crop will enter into a stable period and the re-use will not be worried about the growth and the yield decrease.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.7 no.2
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• pp.1-8
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• 2012

Recently the youth starting up a business has become a buzzword. Business plan is a fundamentals in starting up a business. Therefore, in this study, I investigated the business planning behavior of university students in Korea. Especially, I investigated whether university students in Korea dealt with business plan inside and outside or not, and examined university students' thought whether corporate performance is related to business plan or not, and if any, how closely they are. Meanwhile, existing studies and books are arguing that there is a high correlation between business plan and corporate performance, however, there are not many domestic and/or foreign studies that analyzed it empirically. In order to find an answer to this problem, this study was approached empirically. First, the components of business plan were selected through an extensive literature review including existing researches and through factor analysis, I classified them into the five factors of product management, product development, management support system building, organizational management and macro planning. Also, I classified corporate performance into quantitative and qualitative performance, and investigated the influences of business plan factors on those performances. As a result, I found belows. First, university students in Korea thought that the business plan components affected the quantitative and qualitative performances of corporate positively. Second, Korean students had high interests in starting up a business and wanted to run a service business but had almost no experience of business planning. Whilst, Foreign students had relatively high interests in starting up a business and experiences of business planning. They wanted starting up in various industry also. Meanwhile, I did't find the gender differences in those aspects. In this study, I empirically investigated the relation between business plan components and corporate performances in the university students' view, not that of company. So I believe that this study can shed lights on the direction of effective starting up education for increasing the success rate of youth starting up a business.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.4
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• pp.391-397
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• 2011

The use of Hydrogen as a fuel is receiving considerable attention and as a result, research on novel methods of hydrogen production is necessary so that the hydrogen demands in the future can be satisfied. This study presents experimental data on methanol Autothermal Reformation that quantifies the relationship between the oxygen-to-methanol ratio ($O_2/CH_3OH$) and reformer efficiency. For each catalyst configuration, the $O_2/CH_3OH$ was varied from 0.1 to 0.4, with an increment of 0.05, to investigate the effects of $O_2/CH_3OH$ on the reactor performance, including temperature profile, conversion, and efficiency. $O_2/CH_3OH$ was increased from 0.15 to 0.20, and the catalyst bed temperature increased by $235^{\circ}C$ to approximately $550^{\circ}C$. The catalyst bed temperature increased with increasing $O_2/CH_3OH$ as the reaction shifted from endothermic to exothermic reaction and as a result, excess heat, which raised the reactor temperature, was generated. The reactor performance was shown to be highly dependent on $O_2/CH_3OH$. The optimum $O_2/CH_3OH$ = 0.30 found in the experimental tests is 30% higher than the theoretical optimum of 0.23. This is attributed to a combination of factors such as the concentrations of the $O_2$ and $CH_3OH$ gas, reaction rate, catalyst effects, heat loss from the reactor, and the difference between the actual amounts of reaction products formed and the theoretical amounts of the reaction products.

• Clinical and Experimental Pediatrics
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• v.51 no.9
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• pp.992-997
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• 2008

Purpose : Hypertension (HTN) is no longer an exclusively adult disease; the prevalence of pediatric HTN is increasing. To understand the evaluation and treatment of childhood HTN in Korea, we investigated, via a questionnaire, how hypertensive children are currently assessed and managed by pediatric cardiologists (CA) and nephrologists (NE). Methods : We surveyed 82 pediatric CA and 77 NE, regarding how they manage hypertensive children in Korea. Results : A total 75 replies were received to our questionnaire request (response rate: 47.15%). Routine blood pressure (BP) checks were more frequently performed by NE (CA: 5.7%, NE: 25%, P=0.03), but most respondents (86%) did not check BP routinely. Mercury sphygmomanometers were the most commonly used devices and ambulatory blood pressure monitoring was not frequently used. The goal BP in treated patients was set at the 95th percentile by 61% of respondents. NE used a lower BP goal in hypertensive children with renal disease (CA: 24%, NE: 64%, P=0.004) or DM (CA: 12.5%, NE: 50%, P=0.003). Angiotensin converting enzyme (ACE) inhibitors were the most commonly used agents (mean: 59%); following ACE inhibitors, CA preferred diuretics for hypertensive children with renal disease or cardiovascular disease, and NE preferred calcium channel blockers, regardless of underlying disease. Self-monitoring was the most frequent method for BP monitoring at home. Conclusion : In Korea, BP measurement is not yet a routine examination in treating hypertension. There are some differences in management strategies vis-$\grave{a}$-vis hypertension, between pediatric cardiologists and nephrologists. For the appropriate management and prevention of secondary disease in long-term studies, standard guidelines and education are needed for pediatricians.

• Journal of Bio-Environment Control
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• v.26 no.4
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• pp.418-423
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• 2017

In hydroponics, the nutrient solution is supplied considering the water and nutrient uptake characteristics of crops. However, as the ionic uptake characteristics are changed as a result of the weather conditions or the growth response of the crops, the root zone can not be maintained in optimal condition. In addition, the coir substrate has been used mainly for the tomato cultivation in place of the inorganic substrate, there are few studies on long-term cultivation using coir substrate. Therefore, this study was conducted to investigate the effect of EC level of irrigation solution on tomato growth and inorganic ions of root zone in soilless culture using coir. Coir substrate mixed with 5 : 5 chip and dust was used. EC level of irrigation solution was 1.0, 1.5, 2.0, and $3.0dS{\cdot}m^{-1}$. At the initial stage, $NO_3-N$, P, Ca and Mg in the drainage were lower than the irrigation level at 1.0 and $1.5dS{\cdot}m^{-1}$. However, EC $2.0dS{\cdot}m^{-1}$ or higher, all the ions except P were highly concentrated in the drainage. The average fruit weight was not significantly different between 1.0 and $1.5dS{\cdot}m^{-1}$ until 3th cluster, but from the next cluster, the higher the EC level, the smaller the weight. The number of fruit and yield to 6th cluster was the highest at $1.5dS{\cdot}m^{-1}$. From the next cluster, The yield was decreased with the higher EC level. At the early stage of growth, BER occurred only in EC $3.0dS{\cdot}m^{-1}$, but increased in all treatments with increasing irradiation. The incidence rate of EC $3.0dS{\cdot}m^{-1}$ was higher than that of the lower EC level treatment.

• Childhood Kidney Diseases
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• v.17 no.1
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• pp.19-24
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• 2013

Purpose: Recently, enterococcus spp. have become one of the most common nosocomial pathogens with increasing rates of multi-drug resistance. However, study on enterococcal urinary tract infections (UTIs) in children is very limited, especially community acquired UTIs. We studied the clinical characteristics of enterococcus spp. in community acquired UTIs and antibiotic resistance within our urban area. Methods: All children with first episode of community acquired UTIs due to enterococcus spp. and Echerichia coli who were admitted in Pusan National University Children's Hospital between January 2010 and January 2013 were included in our study. We retrospectively reviewed their medical records. Results: During the study period, 201 patients were identified to have first episode of community acquired UTIs. 154 cases were E.coli UTIs (76.6%) and 11 cases were enterococcal UTIs (5.5%) and all enterococcus spp. were Enterococcus feacalis. In enterococcal UTI group, voiding cystourethrogram(VCUG) was performed in 7/11 patients and demonstrated 4 vesicoureteral refluxes (VURs) with renal scar and 3 patients underwent corrective surgery. In E.coli UTI group, VCUG was performed in 121/154 patients and demonstrated 23 VURs and 11 patients underwent corrective surgery. Enterococcal group had significant high rate of underlying urinary abnormalities and surgical corrections compared with E. coli group. All enterococcus spp. were susceptible to ampicillin, vancomycin and linezolid, but all were resistant to tetracycline. They also showed 71.4% resistance to trimethoprim-sulfamethoxazole and 20% resistance to ciprofloxacin. Conclusion: Community acquired enterococcal UTIs in children were rare within our urban area. However, they could be indicative of severe underlying urinary tract abnormalities.

• Journal of the Institute of Electronics and Information Engineers
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• v.54 no.5
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• pp.133-137
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• 2017

The purpose of this study was to validate for GATE (Geant4 Application for Tomographic Emission) simulation by comparing the results of GATE simulation and experiment in real SPECT system. Futhermore, we want to prove that it is possible that the quantitative research of gamma camera/SPECT imaging for therapeutic radio isotope by using GATE simulation. In this study, the SPECT system on simulation referred to the parameters of Stream-R Forte version 1.2 (Philips Medical System, Best and Heerlen, Netherlands). To understand the I-131 image of gamma camera/SPECT system, we acquired the energy spectrum and measured the full width at half maximum (FWHM) which comes from line spread function (LSF) with and without scatter material in real SPECT system. And to compare with experiment, we also measured the FWHM and acquired the energy spectrum without scatter material in GATE simulation. As a result, without scatter material, the energy peak was almost same location, which are located nearby 364 keV, and other spectrum factors are same tendency in both cases. The FWHM was increased by increasing the distance of source to detector, and the error rate was approximately 3.8%. When we used the line source with scatter material, energy spectrum also indicated similar tendency in both cases. As you confirmed earlier, GATE simulation included real instrument and radioisotope characters for therapeutic radioisotope. Therefore this result that it was possible that various quantitative study for therapeutic radioisotope imaging in gamma camera/SPECT using GATE simulation.

• Horticultural Science & Technology
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• v.35 no.2
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• pp.178-187
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• 2017

The aim of this study was to investigate the effect of different light sources on the levels of glucosinolates (GSLs) in rocket salad (Eruca sativa L.). The light sources used in the study were: natural light (Control-1 or 2), red light-emitting diodes(LEDs), blue LEDs, mixed red and blue LEDs (R+B LEDs), white LEDs, fluorescent lamps (FL), and fluorescent lamps plus UV-C (FL+UV-C). Two separate experiments were conducted [Experiment I: Control-1, Red LED, Blue LED, Mix (R+B) LED and Experiment II: Control-2, White LED, FL, FL+UV-C] because of the limited number of growth chambers in our laboratory. The rate of increase in the length of rocket salad leaves was the highest under red LEDs and, FL confirming that red LED and, FL affect the growth of rocket salad. We separated and identified seven types of GSLs from the rocket salad:glucoraphanin, diglucothiobeinin, glucoerucin, glucobrassicin, dimeric 4-mercaptobutyl GSL, 4-methoxyglucobrassicin, and gluconasturtiin. The highest total GSL contents in Eexperiment I was found in plants grown under in red LEDs ($4.30{\mu}mol{\cdot}g^{-1}\;dry$ weight, DW), and the lowest under blue LEDs ($0.17{\mu}mol{\cdot}g^{-1}\;DW$). The highest total GSL contents in Experiment II was found in plants grown under FL ($13.45{\mu}mol{\cdot}g^{-1}\;DW$), and the lowest in FL+UV-C ($0.39{\mu}mol{\cdot}g^{-1}\;DW$). Especially in Experiment II, the content of dimeric 4-mercaptobutyl, which has a strong aroma and spicy flavor in rocket salad, was higher under FL and white LEDs than in Control-2, increasing by approximately 14.9 and 3.2-fold respectively. Therefore, light sources such as red LEDs, white LEDs and FL affected the accumulation of GSLs in rocket salad.