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The Relationship between Heme Oxygenase-1 Expression and Response to Cisplatin Containing Chemotherapy in Advanced Non-Small Cell Lung Cancer  

Yang, Doo Kyung (Department of Internal Medicine, Dong-A University College of Medicine)
Roh, Mee Sook (Department of Pathology, Dong-A University College of Medicine)
Lee, Kyung Eun (Medical Research Center for Cancer Molecular Therapy, Dong-A University College of Medicine)
Kim, Ki Nam (Department of Radiology, Dong-A University College of Medicine)
Lee, Ki Nam (Department of Radiology, Dong-A University College of Medicine)
Choi, Pil Jo (Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine)
Bang, Jung Hee (Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine)
Kim, Bo Kyung (Department of Internal Medicine, Dong-A University College of Medicine)
Seo, Hyo Rim (Department of Internal Medicine, Dong-A University College of Medicine)
Kim, Min Ji (Department of Internal Medicine, Dong-A University College of Medicine)
Kim, Seul Ki (Department of Internal Medicine, Dong-A University College of Medicine)
Lee, Soo-Keol (Department of Internal Medicine, Dong-A University College of Medicine)
Son, Choon Hee (Department of Internal Medicine, Dong-A University College of Medicine)
Publication Information
Tuberculosis and Respiratory Diseases / v.60, no.3, 2006 , pp. 314-320 More about this Journal
Abstract
Background : The overall response (20-30%) to chemotherapy in non-small cell lung cancer (NSCLC) is quite poor. Heme oxygenase-1 (HO-1) is the rate-limiting enzyme in heme degradation. There is increasing evidence suggesting that the induction of HO-1 might have an important protective effect against oxidative stress including cisplatin containing chemotherapy. This study retrospectively investigated the relationship between HO-1 expression and the response to chemotherapy containing cisplatinin advanced NSCLC patients. Material and Methods : The medical records including the responses to chemotherapy of fifty nine cases were evaluated retrospectively, and the tissue samples of these patients were immunohistochemically stained for HO-1. Results : Forty three of the fifty nine patients(72.8%) showed positive staining for HO-1 in their cancer tissues. There was no significant difference according to the cell type, stage and tumor size. In addition, there was no correlation between HO-1 expression and the responses to chemotherapy. Conclusion : HO-1 expression in tumor tissue dose not predict the response to cisplatin containing chemotherapy in advanced NSCLC. Further prospective studies with a larger number of patients will be needed to confirm these results.
Keywords
Heme oxygenase-1; Non-small cell lung cancer; Cisplatin containing chemotherapy;
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