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Distribution of Radionuclide Labeled Liposome in Experimental Study (방사성동위원소표지 Liposome의 분포에 대한 실험적 연구)

  • Lee, Bum-Woo;Jeong, Jae-Min;Kim, Sang-Eun;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon;Ha, Sung-Whan
    • The Korean Journal of Nuclear Medicine
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    • v.24 no.2
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    • pp.317-324
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    • 1990
  • Liposome was labelled with $^{99m}Tc$ after negative charged liposome was formed with combination of a few lipid components. $^{99m}Tc$ liposome was injected through the tail vein of C3H mice bearing fibrosarcoma and biodistribution of $^{99m}Tc$ liposome was evaluated. The results were as follows: 1) We confirmed formation of liposome which was small unillamellar and multilamellar vesicles. 2) In this experiment the optimal concentration of $SnCl_2$ was $156{\mu}g/ml$ to label liposome with $^{99m}Tc$ and labelling efficiency was 95%. 3) The labelled liposome was stable when it was incubated with human serum for 24 hours. Mean labelling efficiency was 94% at 24 hour. 4) The main uptake sites of Tc-99m liposome were liver and spleen. It showed significantly higher uptake than $^{99m}Tc$ HSA (p < 0.001). 5) $^{99m}Tc$ liposome uptake in tumor tissue was not significantly higher than $^{99m}Tc$ HSA uptake. In conclusion, $^{99m}Tc$ liposome disclosed high labelling efficiency and was highly stable. Liver and spleen were main uptake sites of $^{99m}Tc$ liposome. The uptake mechanism of $^{99m}Tc$ liposome also seemed to be different from that of $^{99m}Tc$ HSA. We conclude that $^{99m}Tc$ liposome would be a promising agents for the imaging of some tumor.

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Scientific Study for the Standardization of the Preparation Methods for Paeksolgi(II) -for the Focus on the Volume of Adding Sugar and Steaming Time- (백설기 조리법의 표준화를 위한 조리과학적 연구(II) -첨가하는 설탕의 양과 찌는 시간을 중심으로-)

  • 한경선;김기숙
    • The Korean Journal of Food And Nutrition
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    • v.10 no.1
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    • pp.60-64
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    • 1997
  • This study attempted to examine the effect on sensory characteristics and texture of Paeksolgi in various volume of adding sugar and steaming time. The most favorite tendency on the quality was over 15% adding sugar and 20 minute steaming time. Evaluation was conducted through objective evaluation firstly and sensory evaluation secondly. The volume of adding sugar was the significant factors which affected the textual characteristics of Paeksolgi. But steaming time and interaction had not affected. In sensory evaluation on the various steaming time Paeksolgi made by steaming time for 20min and over 15% adding sugar showed the most favorite tendency on the overall quality. This condition corresponded to the high level of hardness, adhesiveness, gumminess in comparison with Rheoner measurement. In summary the most favorite factor was 12 hours of soaking time, 10% adding water, 1% of adding salt, over 15% adding sugar, 20 minutes steaming time.

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A Study on the Impact of Adaptive Selling Strategies on Customer Satisfaction and Customer Loyalty: Focused on the Restaurants of Deluxe Hotels in Seoul (종사원의 적응판매가 고객만족과 충성도에 미치는 영향 - 특급호텔 레스토랑을 중심으로 -)

  • Song, Heung-Gyu
    • Culinary science and hospitality research
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    • v.18 no.4
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    • pp.1-14
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    • 2012
  • The focus of this study is on investigating an appropriate selling strategy for the guests of a fine dining restaurant in deluxe hotels located on seoul. As survey methods, questionnaires were prepared and distributed to the customers who visited the restaurants of five-star hotels in Seoul. The survey was carried out from July 1 to August 30, 2010. Total 223 copies of questionnaire were used for final analysis. Frequency analysis, descriptive statistics, exploration factor analysis, and reliability analysis were conducted through SPSS 18.0 for final analysis, and path analysis was conducted through AMOS 18.0 for verification of hypotheses. The hypothesized relationships among the models were tested simultaneously by using a structure equation model(SEM). The proposed model provided an adequate fit to the date, $X^2$ = 143.934(df=120, p<.001), GFI=0.935. AGFI= 0.907, RMR=0.022, CFI=0.983. The study results are as follows. First, the restaurant employee's adaptive selling strategies consist of persuasion-suggestion, kindness-rapidity. Second, in the result of analysis to understand the influences between customer satisfaction and adaptive selling strategies, customer satisfaction is shown to have an influential relationships with persuasion-suggestion strategy and kindness-rapidity strategy of employee's adaptive selling. Third, all adaptive selling strategies did not affect customer loyalty. Finally, customers who are satisfied with such services have a significant effect on customer loyalty and supports the existing previous studies.

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Study of the safety education condition and injury occurrence in dental technicians- in Seoul and Gyeonggi (치과기공사의 안전교육 실태 및 상해발생 조사연구 -서울·경기 지역을 중심으로)

  • Kim, Jin;Choi, Se-Woong;Shin, Su-Jeong;Cho, Yoon-Sang;Lim, Su-Min;Shim, Jeong-Seok;Lee, Jung-Soo;Bae, Eun-Jeong
    • Journal of Technologic Dentistry
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    • v.39 no.3
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    • pp.179-185
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    • 2017
  • Purpose: It is intended to raise awareness of importance of protective equipment and necessity of safety education by examining the actual condition of measures to deal with accident, occurrence of injury, whether safety education is received or not, the actual condition of wearing protective equipment, and working environment of dental lab and dental technician. Methods: A self-administered survey was conducted for a total of 150 dental technologists. A chi-squared test and independent-samples t-test was carried out by using SPSS WIN Program (version 12.0) in order to analyze the actual condition of safety education according to work experience and position and whether injury occurred according to whether to wear protective equipment. Significance level was 0.05. Results: With regard to whether injury occurred according to whether safety education was received, there was 'receiving the safety education-injured (71.8%)', 'not receiving the safety education-injured (79.7%)', 'receiving the safety education-not injured (28.2%)', and 'not receiving the safety education-not injured (20.3%)'. The statistical results of injury occurrence according to safety education were not significant. With regard to whether to be injured according work experience, there was 'less than 10 years-injured (68.4%)', 'less than 10 years- not injured (31.6%)', '10 years or above-injured (89.1%)', and '10 years or above-not injured (10.9%)'. The statistical results of injury occurrence according to work experience were significant (p<0.001). Conclusion: Dental lab and specialized agencies should continue to be interested in periodic safety training, recommending wearing protective equipment and personal protective equipment support and so on.

Screening of Natural Herb Resources for Anti-oxidative Effects in Korea (국내 자생 자원식물들의 항산화 활성 검색)

  • Yang, Yoon-Jung;Kim, Hyun-Jun;Kang, Shin-Ho;Kang, Se-Chan
    • Korean Journal of Plant Resources
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    • v.24 no.1
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    • pp.1-9
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    • 2011
  • In the present study, the anti-oxidative properties of 80% ethanol extracts from 140 kinds of natural plants were investigated. Persicaria perfoliata had the highest anti-oxidative relative potency(VitaminE, $ORAC_{PE}$=1.0), followed by Sorbaria sorbifolia var. stellipila, Rosa multiflora, Lysimachia vulgaris var. davurica, Quercus aliena, Quercus mongolica and Lespedeza bicolor ($ORAC_{PE}$ ${\geq}$ 1.50). Among them, the anti-oxidative activity values of the n-hexane, $CH_2Cl_2$, EtOAc, n-BuOH, and water fractions of the 80% EtOH extracts of P. perfoliata and S. sorbifolia in the ORAC assay system were $1.13{\pm}0.002$, $1.10{\pm}0.004$, $3.67{\pm}0.232$, $1.62{\pm}0.049$ and $1.05{\pm}0.003$; $1.02{\pm}0.007$, $1.00{\pm}0.016$, $2.94{\pm}0.130$, $1.80{\pm}0.019$ and $1.04{\pm}0.012$, respectively, with marked anti-oxidative activity in the ethyl acetate fraction from selected the 2 plant extracts.

A Study on the Evaluation of Nutrient Intake of Middle School Students in Kangneung (강릉지역 중학생의 영양소 섭취평가에 관한 연구)

  • 김복란;조영은
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.30 no.4
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    • pp.739-746
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    • 2001
  • To assess the nutrient intakes and diet quality of middle school students living in Kangneung area a dietary survey using th 3-day food record was conducted with 226 subjects. Mean daily energy intake was 2114$\pm$502 kcal with 61.6% of energy supplied by carbohydrate 16.4% by protein and 22.0% by fat. As well as insufficiencies in calcium and iron intakes the bioavailability of calcium and iron consumed is considered to low because most of them came from plant origins. For calcium iron vitamin A and vitamin B$_2$the proportions of subjects with intake levels less than 75% of RDA were all over 46%. The mean adequacy ratio(MAR) an index of overall dietary quality was 0.70 for males and 0.73 for females. The indexes of nutritional quality (INQ) were over 1 for most nutrients except 4 nutrients; 0.48 of calcium 0.64 of iron 0.73 of vitamin A and 0.79 of vitamin B$_2$. Nutrient intake levels less than 75% of RDA may be appropriate as a criteria for insufficiency of nutrient intakes. Based on these results it is evident that some of middle school students in Kangneung area did not consume enough nutrients especially calcium iron and vitamin A.

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A Study on Food Behaviors and Food Preferences of the Tourism Transportation Business Managers in Daegu Areas by Age (대구지역 관광운수 영업자의 연령별 식행동 특성 및 음식 기호도 조사 연구)

  • Kim Jeong-Sook;Jeong Se-Hoon
    • Journal of the East Asian Society of Dietary Life
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    • v.14 no.6
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    • pp.529-541
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    • 2004
  • This study was carried out to survey the eating behaviors and the food preferences of the tourism transportation business managers in Daegu areas by age. The survey was performed from 17 to August 25, 2003 by questionnaires and the subjects were 365 males. As a general factor, the subjects of survey were male drivers in their thirties to sixties. Their education level was middle school(44.9%) and high school(45.8%) diploma. This study showed that the managers eat three meals per day with high percentage(75.9%) and a large number of managers(24.1%) eat two meals only. 77.8% of the subjects responded that their diet life were irregular due to the property of their job. Frequency of eating-out turned out to be much higher in managers aged 60 over(p<0.001). They considered taste of the food firstly, and the prices of the food secondly, but the nutritional value of the food was considered with a low percentage(22.7%). We found that their BMI were overweight from 23.5 to 26.01, their calorie and some nutrient intakes were below their RDA. The most insufficiently consumed nutrient(less than 75% of RDA) was vitamin B₂ followed by calcium. The food preferences of subjects showed that the managers preferred boiled rice to any other rice as a staple foods. Their favorite menu of one-course Korean style meal turned out to be the bibimbob(boiled rice mixed with assorted vegetable and meat). As for subsidiary foods, out of all various meat soups, beef soups and beef-rib soups were most preferred. The most preferred stew were soybean paste stew and kimchi stew, and the most preferred cooked vegetables were cooked spinach, seasoned cucumber. Baechu kimchi(white cabbage kimchi) were the most preferred kind of kimchi. For desserts there was a very high preference for the watermelons, apples, and pears. For beverages the most preferred were ginseng tea, fruit juices and dietary fiber drinks. From the results listed above, the nutritional education needed to be done to the tourism transportation business managers to set the proper menu considering the characteristics of the preference each age group of managers.

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The effect of exercise on cognitive function in the elderly : A systematic review and meta-analysis (운동이 노인의 인지기능에 미치는 영향 : 체계적 문헌고찰 및 메타분석)

  • Chung, Bok Yae;Han, Ji Young
    • Journal of the Korean Data and Information Science Society
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    • v.27 no.5
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    • pp.1375-1387
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    • 2016
  • The purpose of this study was to evaluate the effect of exercise on cognitive function in the elderly through a systematic literature review and meta-analysis. For the study purpose, 14 studies were selected through a systematic process of using several databases and 11 studies were used to estimate the effect size of exercise on cognitive function. Meta-analysis was performed using a random effects model, and the effect size on cognitive function was calculated. The effect size for cognitive function of exercise intervention was Hedges' g=1.05 (95% CI: 0.61~1.50), indicating a large effect size. For heterogeneity, moderator analysis was performed using intervention, number of times per week, intervention duration, and cognitive function measurement. Cognitive function measurement was statistically significant, the other moderators did not significant difference. Results support that exercise has significant positive effects on cognitive function in elderly in korea. It also provided a basis that can be applied to exercise intervention design for cognitive function.

Tuberculosis Surveillance and Monitoring under the National Public-Private Mix Tuberculosis Control Project in South Korea 2016-2017

  • Min, Jinsoo;Kim, Hyung Woo;Ko, Yousang;Oh, Jee Youn;Kang, Ji Young;Lee, Joosun;Park, Young Joon;Lee, Sung-Soon;Park, Jae Seuk;Kim, Ju Sang
    • Tuberculosis and Respiratory Diseases
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    • v.83 no.3
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    • pp.218-227
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    • 2020
  • Background: The national Public-Private Mix (PPM) tuberculosis (TB) control project provides for the comprehensive management of TB patients at private hospitals in South Korea. Surveillance and monitoring of TB under the PPM project are essential toward achieving TB elimination goals. Methods: TB is a nationally notifiable disease in South Korea and is monitored using the surveillance system. The Korea Centers for Disease Control and Prevention quarterly generates monitoring indicators for TB management, used to evaluate activities of the PPM hospitals by the central steering committee of the national PPM TB control project. Based on the notification date, TB patients at PPM hospitals were enrolled in each quarter, forming a cohort, and followed up for at least 12 months to identify treatment outcomes. This report analyzed the dataset of cohorts the first quarter of 2016 through the fourth quarter of 2017. Results: The coverage of sputum, smear, and culture tests among the pulmonary TB cases were 92.8% and 91.5%, respectively. The percentage of positive sputum smear and culture test results were 30.7% and 61.5%, respectively. The coverage of drug susceptibility tests among the culture-confirmed cases was 92.8%. The treatment success rate among the smear-positive drug-susceptible cases was 83.2%. The coverage of latent TB infection treatment among the childhood TB contacts was significantly higher than that among the adult contacts (85.6% vs. 56.0%, p=0.001). Conclusion: This is the first official report to analyze monitoring indicators, describing the current status of the national PPM TB control project. To sustain its effect, strengthening the monitoring and evaluation systems is essential.

Optimization of the re-extraction process of ethanol from catechin components from Korean green tea extract (한국산 녹차추출물 catechin 성분의 ethanol 재추출 공정 최적화)

  • Jo, In-Hee;Kim, Myung-Kyoo;Jang, Suh-Yoon;Kim, Na-Ra;Lee, Won-Young
    • Food Science and Preservation
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    • v.23 no.5
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    • pp.696-703
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    • 2016
  • The purpose of this study was to determine the optimum re-extraction conditions of ethanol from catechin in Korean green tea (Camellia sinensis L.) using response surface methodology (RSM). The experiments were carried out according to a five level and two variable central composite design (CCD). The two independent variables were solvent ratio to sample content (1, 4, 7, 10, 13 mL/g) and extraction temperature (-20, -10, 0, 10, $20^{\circ}C$) on the dependent variables including yield, epigallocatechin (EGC), epicathchin (EC), epigallocatechingallate (EGCG), epicatechingallate (ECG), total catechin and caffeine. ANOVA results showed that Coefficients of determination ($R^2$) of estimated models for dependent variables were ranged from 0.9054~0.9778, while $R^2$ of caffeine were estimated 0.8770. The optimum ranges for the maximized extraction including yield, EGC, EC, EGCG, ECG, caffeine and total catechin were 4.5~7.5 mL/g in ratio of ethanol to sample and $-8{\sim}8^{\circ}C$ in extraction temperature. The actual values of yield, EGC, EC, EGCG, ECG, caffeine and total catechin, respectively, at the optimized conditions were 35.02%, 13.31%, 3.978%, 19.11%, 4.29%, 5.30% and 40.68%.