• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.16-28
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• 2023

Lung adenocarcinoma accounts for about 40% of all lung cancers. With the recent development of gene profiling technology, studies on mutations in oncogenes and tumor suppressor genes, which are important for the development and growth of tumors, have been actively conducted. Companion diagnosis using next-generation sequencing helps improve survival with targeted therapy. In this study, formalin-fixed paraffin-embedded tissues of non-small cell lung cancer patients were subjected to hematoxylin and eosin staining for detecting genetic mutations that induce lung adenocarcinoma in Koreans. Immunohistochemical staining was also performed to accurately classify lung adenocarcinoma tissues. Based on the results, next-generation sequencing was applied to analyze the types and patterns of genetic mutations, and the association with smoking was established as the most representative cause of lung cancer. Results of next-generation sequencing analysis confirmed the single nucleotide variations, copy number variations, and gene rearrangements. In order to validate the reliability of next-generation sequencing, we additionally performed the existing genetic testing methods (polymerase chain reaction-epidermal growth factor receptor, immunohistochemistry-anaplastic lymphoma kinase (D5F3), and fluorescence in situ hybridiation-receptor tyrosine kinase 1 tests) to confirm the concordance rates with the next-generation sequencing test results. This study demonstrates that next-generation sequencing of lung adenocarcinoma patients simultaneously identifies mutation.

• Journal of the Korean Geotechnical Society
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• v.23 no.4
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• pp.161-167
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• 2007

In this study, ultimate lateral load capacity of piles is analyzed with consideration of lateral stress effect. Based on results obtained in this study, a method for the estimation of ultimate lateral load capacity is proposed. This makes it possible to more realistically estimate the ultimate lateral load capacity under various stress states caused by in-situ soil condition and pile installation process. Calibration chamber test results with various soil conditions were used in the analysis. From the test results, it was found that effect of the lateral stress was greater than that of the vertical stress on the ultimate lateral load capacity of piles. It was also found that, as the relative density increases, displacements required to reach the ultimate state increases, showing relative displacements of around 14% and 18-25% for $D_R$ : 55% and 86%, respectively. Based on results obtained in this study, a methodology for the estimation of ultimate lateral load capacity of piles using correction factors was proposed. Results from proposed method matched well measured results.

• Safety and Health at Work
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• v.3 no.1
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• pp.22-30
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• 2012

Objectives: To challenge the problem of slipperiness, various slipmeters have been developed to assess slip hazard. The performance of in-situ slipmeter is, however, still unclear under the various floor conditions. The main objectives of this study were to evaluate the performance of three kinds of slipmeters under real conditions, and to find their dynamic and kinematic characteristics, which were compared with gait test results. Methods: Four common restaurant floor materials were tested under five contaminants. Slipmeters and human gaits were measured by high speed camera and force plate to find and compare their dynamic and kinematic characteristics. Results: The contact pressures and built-up ratio were below those of subjects. The sliding velocity of British Pendulum Tester was above those of subjects, while those of BOT-3000 and English XL were below those of subjects. From the three meters, the English XL showed the highest overall correlation coefficient (r = 0.964) between slip index and $R_a$, while the rest did not show statistical significance with surface roughness parameters ($R_a$, $R_z$). The English XL only showed statistical significance (p < 0.01) between slip index and contaminants. The static coefficient of friction obtained with the BOT-3000 showed good consistency and repeatability (CV < 0.1) as compared to the results for the BPT (CV > 0.2) and English XL (CV < 0.2). Conclusion: It is unclear whether surface roughness can be a reliable and objective indicator of the friction coefficient under real floor conditions, and the viscosity of contaminants can affect the friction coefficient of the same floors. Therefore, to evaluate slipperiness, the performance of the slipmeters needed to improve.

• Journal of the Microelectronics and Packaging Society
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• v.15 no.1
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• pp.33-37
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• 2008

A noticeable amount of Kirkendall voids formed at the Sn-3.5Ag solder joint with electroplated Cu, and that became even more significant when an additive was added to Cu electroplating bath. With SPS, a large amount of voids formed at the $Cu/Cu_3Sn$ interface of the solder joint during thermal aging at $150^{\circ}C$. The in-situ AES analysis of fractured joints revealed S segregation on the void surface. Only Cu, Sn, and S peaks were detected at the fractured $Cu/Cu_3Sn$ interfaces, and the S peak decreased rapidly with AES depth profiling. The segregation of S at the $Cu/Cu_3Sn$ interface lowered interface energy and thereby reduced the free energy barrier for the Kirkendall void nucleation. The drop impact test revealed that the electrodeposited Cu film with SPS degraded drastically with aging time. Fracture occurred at the $Cu/Cu_3Sn$ interface where a lot of voids existed. Therefore, voids occupied at the $Cu/Cu_3Sn$ interface are shown to seriously degrade drop reliability of solder joints.

• Proceedings of the Korea Water Resources Association Conference
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• 2018.05a
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• pp.228-228
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• 2018

강변여과는 지하수 인공함양 방식 중 유도함양(induced recharge) 또는 간접함양 방식에 속한다. 이는 하천 및 강변 부근에 집수시설을 설치한 후, 미고결층 대수층(unconsolidated aquifer)의 자연 오염 저감능을 이용하여 지표수를 간접 취수하는 방식으로 수질이 불량한 지표수가 대수층을 관류하면서 희석, 화학적 이온 교환 및 반응, 흡착, 생물막(biofilm; 미생물에 의한 자연저감), 여과 등을 통하여 수질이 개선된다. 강변여과수내의 용존 농도가 높은 철과 망간은 수처리 비용증가, 용수관정 및 시설물의 수명단축을 초래한다. 따라서 강변여과 지역의 미고결 대수층에서 효과적인 철과 망간 동시 제거(vyredox)를 위해 에어서징(air surging)과 블록 서징(block surging)을 실시하기 위해서 실내 물탱크 모델(water tank model)에서 에어서징에 따른 공기 순환 우물시스템을 관찰하였으며, 이를 바탕으로 현장시험(Test bed)에 적용하였다. 미고결 대층수층에서의 철 망간은 음용수 기준치(각각 0.3 mg/L)를 초과하고 있으며, 강변여과 취수 개발 및 이용을 제한하는 요인이 되고 있다. 본 연구에서 사용된 에어서징과 블록서지 기술은 자갈층 및 미고결 대수층에 충진된 슬라임 및 폐색(clogging)을 제거함과 동시에 관정 주변의 대수층의 투수성 개선과 산화환경으로 치환되며, 대수층에 잔존하는 철/망간의 산화물들을 관정내로 빼낼 수 있는 방법이다. 따라서 서징에 따른 폐색 제거효율을 검토한 결과에서 철 망간 이온농도 저감효과와 관정 주변의 수리전도도(hydraulic conductivity) 및 저류계수(coefficient of storage)가 증가한 것으로 나타났다. 이와 같이 강변여과에 의한 폐색은 미고결층내 공기주입 및 블록서지를 통하여 철/망간 이온농도 저감 및 수리특성 개선 효과에 유용한 것으로 평가된다.

• The Journal of Engineering Geology
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• v.30 no.2
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• pp.147-160
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• 2020

Unsaturated hydraulic conductivity of near-surface unconsolidated layers depends on the physical properties and water content of the unconsolidated layers. So far, many studies have been conducted on the unsaturated hydraulic conductivity of near-surface unconsolidated layers. However, researches on hydraulic conductivity of unsaturated fractured rocks have been relatively rare. In relation to the construction of a low/intermediate level radioactive waste surface-disposal facility, this study compared and analyzed van Genuchten parameters (α, n) in the laboratory and the hydraulic conductivity obtained in field tests for fractured hornfels at a radioactive-waste disposal site of Korea. The relationship between the field hydraulic conductivity and van Genuchten parameters using data from the ten depth intervals of three boreholes resulted in that the correlation coefficient (R) between the hydraulic conductivity and the van Genuchten parameter α was 0.7607, showing positive correlation whereas the R between the hydraulic conductivity and the van Genuchten shape-defining parameter n was -0.8720, showing negative correlation. Hence, this study confirmed the relationship between the field hydraulic conductivity and the van Genuchten unsaturated functions for the unsaturated fractured hornfels.

• Journal of Advanced Marine Engineering and Technology
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• v.37 no.2
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• pp.242-251
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• 2013

Recently, while global concern over offshore resources exploration and development is being increased rapidly, offshore plant industry is highlighted as an industry of high added value. Along with this global trend, domestic concern over offshore plant development is being increased as well. In the overseas case, a marine geotechnical survey guideline for confirming characteristics of seabed sediments is available at the time of installation of offshore plant but such guideline is not available in our country. In this study, survey techniques fit for domestic marine environment was applied according to overseas guideline at southern coastal area, Korea. Among the marine geophysical survey techniques being proposed abroad, magnetic survey and seabed photograph were excluded. However, highly reliable data analysis was enabled for marine geophysical survey, which includes in-situ coring investigation and laboratory soil test. In addition, continuous ocean current survey was included to find scour potential due to the current around the offshore plant. Although coring depth is not so deep, we predicted geological structure through the analysis of amplitude features of seismic data. Characteristics of seabed sediments cold be obtained regionally and directly through combined analysis of marine geophysical survey data and coring data.

• The Journal of Engineering Geology
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• v.12 no.2
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• pp.137-150
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• 2002

Recently, plane failure mode occurred frequently along the bedding plane having low angle dip about 20 degree when cutting slopes were constructed in sedimentary rock region of the Gyeongsang Basin. Landslide of the Whangryeong Mountain which was occurred at Busan Metropolitan City in 1999 belongs to the category mentioned above. Reconstruction for cutting slope of the Whangryeong Mountain has finished in 2000 and final grade of reconstructed cutting slope is 1:2.0. To analyze slope failure mode for landslide of the Whangryeong Mountain, various analyses were performed such as in-situ investigation and test, drilling, laboratory test, aerial photograph interpretation, X-ray diffraction analysis, and slope stability analysis using Stereographic Projection and Limit Equilibrium methods. As the result, it is identified that tension cracks had been developed one year before the landslide took place. The tension crack semis to be formed by merging several joint sets. It appears that failure blocks broke down along the sliding planes of different layers. Risk of plane failure is conformed as a result of stability analysis using Stereographic Projection and Limit Equilibrium methods in case that greenish gray tuffaceous shales, regared as sliding planes, are weathered. From now on, a detailed investigation is needed for the thin layers which is sensitive to weathering, and stability analysis for this layer is performed at cut slope construction site having similar geological condition.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.3
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• pp.37-42
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• 2022

Recently, the semiconductor package structures are becoming thinner and more complex. As the thickness decrease, interfacial delamination due to material mismatch can be further maximized, so the reliability of interface is a critical issue in industry field. Especially, the polymers, which are widely used in semiconductor packaging, are significantly affected by the temperature and moisture. Therefore, in this study, the delamination prediction at the interface of package structure was performed through finite element analysis considering the moisture absorption and desorption under the various temperature conditions. The material properties such as diffusivity and saturated moisture content were obtained from moisture absorption test. The hygro-swelling coefficients of each material were analyzed through TMA and TGA after the moisture absorption. The micro-shear test was conducted to evaluate the adhesion strength of each interface at various temperatures considering the moisture effect. The finite element analysis of interfacial delamination was performed that considers both deformation due to temperature and moisture absorption. Consequently, the interfacial delamination was successfully predicted in consideration of the in-situ moisture desorption and temperature behavior during the reflow process.

• Journal of the Korean Geotechnical Society
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• v.25 no.10
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• pp.17-30
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• 2009

Underground construction such as tunneling can induce damages on the surrounding rock mass, due to the stress concentration of in situ stresses and excessive energy input during construction sequence, such as blasting. The developed damage on the rock mass can have substantial influence on the mechanical and hydraulic behaviors of the rock masses around a tunnel. In this study, investigation on the generation of damage around an opening in a jointed rock model under biaxial compression condition was conducted. The joint dip angles employed are 30, 45, and 60 degrees to the horizontal, and the synthetic rock mass was made using early strength cement and water. From the biaxial compression test, initiation and propagation of tensile cracks at norm to the joint angle were found. The propagated tensile cracks eventually developed rock blocks, which were dislodged from the rock mass. Furthermore, the propagation process of the tensile cracks varies with joint angle: lower joint angle model shows more stable and progressive tensile crack propagation. The development of the tensile crack can be explained under the hypothesis that the rock segment encompassed by the joint set is subjected to the developing moment, which can be induced by the geometric irregularity around the opening in the rock model. The experiment results were simulated by using discrete element method PFC 2D. From the simulation, as has been observed from the test, a rock mass with lower joint angle produces wider damage region and rock block by tensile cracks. In addition, a rock model with lower joint angle shows progressive tensile cracks generation around the opening from the investigation of the interacted tensile cracks.