• Journal of Pharmaceutical Investigation
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• v.23 no.2
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• pp.71-80
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• 1993

The purpose of this study was to compare the intrinsic absorptivity of piperacillin in the jejunum and the nasal cavity, to investigate the effect of bile salts, fatty acids and their mixed micelles on the intestinal and nasal absorption of piperacilIin, to examine the reversibiIity of bile salt-fatty acid mixed micelles absorption promoting action and to design an effective intranasal drug delivery system for antibiotics. And absorption promoters used were bile salts [sodium cholate (NaC), sodium glycocholate (NaGC)], unsaturated fatty acids [oleic acid (OA), linoleic acid (LA)] and their mixed micelles (NaC-LA). The present study employed the in situ nasal and intestinal perfusion technique in rats. The apparent permeabilities $(P_{app})$ of piperacillin were $0.40{\pm}0.04{\times}10^{-5}cm/sec(mean{\pm}S.E)$ in the jejunum and $1.32{\pm}0.08{\times}10^{-5}\;cm/sec$ in the nasal cavity, which indicated that intrinsic absorptivity of piperacillin was greater in the nasal cavity than in the jejunum. When absorption promoters were used in the rat nasal cavity, the decreasing order of apparent piperacillin permeability $(P_{app},\;10^{-5}\;cm/sec)$, corrected for surface area of absorption, was NaC-LA $(4.62{\pm}0.16)$> NaC $(4.36{\pm}0.32)$>LA$(2.24{\pm}0.26)$ NaGC $(2.17{\pm}0.21)$>OA $(1.53{\pm}0.16)$. The increase in permeability of piperacillin was 3.5-fold in the rat nasal cavity and 1.5-fold in the rat jejunum for formulations containing NaC-LA mixed micelles as compared to those without absorption enhancer. The effect of NaC-LA mixed micellar solutions was synergistic and was greater than that with single adjuvant. The reversibility of nasal mucosal permeability was observed within approximately 2 hr after removal of NaCLA mixed micelles from the nasal cavity. These results suggest that NaC-LA mixed micelles can be used as nasal mucosal absorption promoters of poorly absorbed drugs.

• Journal of the Korean earth science society
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• v.42 no.5
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• pp.536-555
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• 2021

Sea-surface wind is an important variable in ocean-atmosphere interactions, leading to the changes in ocean surface currents and circulation, mixed layers, and heat flux. With the development of satellite technology, sea-surface winds data retrieved from scatterometer observation data have been used for various purposes. In a complex marine environment such as the Korean Peninsula coast, scatterometer-observed sea-surface wind is an important factor for analyzing ocean and atmospheric phenomena. Therefore, the validation results of wind accuracy can be used for diverse applications. In this study, the sea-surface winds derived from ASCAT (Advanced SCATterometer) mounted on MetOp-A/B (METeorological Operational Satellite-A/B) were validated compared to in-situ wind measurements at 16 marine buoy stations around the Korean Peninsula from January to December 2020. The buoy winds measured at a height of 4-5 m from the sea surface were converted to 10-m neutral winds using the LKB (Liu-Katsaros-Businger) model. The matchup procedure produced 5,544 and 10,051 collocation points for MetOp-A and MetOp-B, respectively. The root mean square errors (RMSE) were 1.36 and 1.28 m s^-1, and bias errors amounted to 0.44 and 0.65 m s^-1 for MetOp-A and MetOp-B, respectively. The wind directions of both scatterometers exhibited negative biases of -8.03° and -6.97° and RMSE values of 32.46° and 36.06° for MetOp-A and MetOp-B, respectively. These errors were likely associated with the stratification and dynamics of the marine-atmospheric boundary layer. In the seas around the Korean Peninsula, the sea-surface winds of the ASCAT tended to be more overestimated than the in-situ wind speeds, particularly at weak wind speeds. In addition, the closer the distance from the coast, the more the amplification of error. The present results could contribute to the development of a prediction model as improved input data and the understanding of air-sea interaction and impact of typhoons in the coastal regions around the Korean Peninsula.

• Korean Journal of Plant Resources
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• v.35 no.1
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• pp.10-22
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• 2022

This study investigated field data to understand the spatio-temporal distribution of pollinating insects and buckwheat flowers. We set the in-situ observation sites in different locations to get altitude and cropping system distribution data for five years (2016 to 2020) in Korea. Twenty-five different insect species, belonging to 8 orders, were recorded. Over the past five years, species from the orders Diptera and Hymenoptera were the principal visitors. Hymenoptera was mainly represented by honey bees (Apis cerana), while Diptera was represented by bean seed fly (Delia platura) and several other species. Some bees and other Hymenoptera species could, however, act as co-pollinators because of their high relative frequency and activity. Compared with open-field cultivation (conventional), the pollination mediating effect of flies and bees was superior in net house, so the yield was high, and it was also found to be slightly higher in the mixed treatment of flies and bees than in the single treatment. Based on the above results, flies and bees were found to be the most active pollinating insects in buckwheat and it is necessary to actively utilize the selected insects to improve buckwheat productivity. This relationship will be utilized in establishing the system of seed production on pollinating regulation of a primary plant.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.18 no.2
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• pp.65-69
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• 2013

In situ measurement of a primary production in East Sea, a marginal sea with a fair accessibility, is nonetheless an arduous task because of dynamic variability. In this study, we estimated the mean value of background (gross) primary production over the warm region of the East Sea based on a biogeochemical hypothesis. We propose an immiscible-shoaling hypothesis for the estimation of primary production, which assumes that primary production in the warm region occurred only by the nutrient supply through the Korea Strait. Annual primary production thus estimated is $209\;gC\;m^{-2}\;y^{-1}$, which is comparable to the satellite-based estimates of net primary production in the region. However, since this hypothesis assumes that primary production is based on only the new nutrients supplied to the system, primary production would increase by 40% if we release the assumption, and assume f = 0.6. This suggests that nutrient influx through the Korea Strait alone is more than enough to support primary production previously reported. Primary production may increase as much as two times if we considered other external perturbations excluded intentionally to estimate the background level of primary production, such as coastal upwelling, submerged ground water discharge, aeolian input, ocean dumping, and mixing by typhoons as well as the contribution of cyanobacteria that has not been quantified in the region. This implies the primary production in the warm region of the East Sea would be comparable to that of the Peru upwelling region with f = 0.6.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.10
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• pp.128-135
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• 2018

Currently, vertical closed ground heat exchangers are the most widely utilized geothermal heat pump systems and the major influencing parameters on the performance of ground heat exchangers are the ground thermal conductivity(k) and borehole thermal resistance($R_b$). In this study, the borehole thermal resistance was calculated from the in-situ thermal response test data and the individual effects of design parameters (flow rate, number of pipe, grout composition) on the borehole thermal resistance were analyzed. The grout thermal resistance was also compared with the correlations in the literatures. The borehole thermal resistance of the investigated ground heat exchanger results in 0.1303 W/m.K and the grout thermal resistance (66.6% of borehole thermal resistance) is the most influencing parameter on borehole heat transfer compared to the other design parameters (pipe thermal resistance, 31.5% and convective thermal resistance, 1.9%). In addition, increasing the thermal conductivity of grout by adding silica sand to Bentonite is more effective than the other design improvements, such as an increase in circulating flowrate or number of tubes on enhancing borehole heat transfer.

• Membrane Journal
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• v.14 no.2
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• pp.108-116
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• 2004

In this study, the pore-filled ion-exchange membranes were prepared by using the asymmetric PVDF membrane as a nascent membrane. First, the solution of PVBCI having the chlorornethylate aryl ring of 80 percents and DABCO was made with the mixed solvent of THF and DU (8:2). These mixed solution was then, filled in the pores of PVDF membrane, and left for a day to complete the gelation. Finally the pore-filled anion-exchange membrane is obtained fallowed by the amination of the remaining chloromethyl groups with trimethylamine (TMA, 40 wt% in water) forming the positive ammonium ion sites. This 2 step procedure enabled us to produce the pore-filled membranes without change of size, and to control the properties of final membrane with various degree of cross-linking. The results of SEM and AFM showed the polyelectrolyte existed in the pores of nascent membrane as a certain configuration. From the investigation of the solvent affecting much to the permeability and rejection, it was found that the membranes using mixed solvent of THE and DMF (8:2) showed better performances than the membranes produced by THF only. The result of an investigation for the water permeability of the final membrane at low pressure (100 Kpa) showed a typical ultrafiltration membrane's permeability (8 ∼ 10 kg/$m^2$hr) and good values of rejection (55∼60 percent).

• Journal of the Korean Recycled Construction Resources Institute
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• v.1 no.1
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• pp.98-107
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• 2005

In other to recycle the waste concrete produced in stiu on the construction and management in highway, the recycled aggregates were experimentally examined in a practical application for anti-freezing layer and lean concrete base course. From the results, the mobile impact crusher and the eccentric-mounted cone and jaw were superior to the others for the graded aggregates. In the case of anti-freezing layer, the recycled one was easily controlled since the dry densities, contrary to natural one, were not largely changed with the moisture contents. It was found that the 7days compressive strengths of lean concrete were above the 10MPa regardless of the crushing types. From the result of testing the bearing capacity of anti-freezing layer, it was found that when the recycled aggregates mixed with natural sand would be within the required gradations, the layer meets the requirements of limitation and the percentage to passing 2-20mm sieve increased by 5~13% because the flimsy mortars on aggregate were re-crushed by vibrated-roller compactor. Although the compressive strength of lean concrete was 71~85% of the natural coarse aggregate, the recycled aggregates are applicable to the lean concrete because they largely exceeded the required strength, 5.8MPa.

• KSBB Journal
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• v.24 no.5
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• pp.446-452
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• 2009

Oleyl alcohol, butyl butyrate, and two different ionic liquids were evaluated for the extraction of butanol from culture broth without toxic effect to cells. The tested solvents showed more than 50% extraction efficiency, and oleyl alcohol was chosen as the best extractant for butanol among the used extractants with a partition coefficient of 2.89. When oleyl alcohol was used as an extractant, more than 80% of butanol was extracted in the wide range of butanol concentrations (1-20 g/L) and pH values (pH 4-5.5). In extractive fermentation using oleyl alcohol only, there was 11% more butanol production and glucose consumption when compared to that without extractive fermentation, implicating a reduced inhibitory effect of butanol due to butanol removal to the oleyl alcohol phase. In addition, oleyl alcohol did not inhibit cell growth, while a mixture of oleyl alcohol and butyl butyrate with the volume ratio of 9:1~7:3 inhibited either butanol production or cell growth significantly due to the toxicity of butyl butyrate to cells. In conclusion, oleyl alcohol can be used as an efficient and non-toxic solvent for extractive fermentation for butanol production.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.2
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• pp.301-321
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• 2019

The development of a rapidly hardening seal material applicable to steel pipe multistage grouting is described in this paper. In the multistage technique, seal materials are inserted to prevent the backflow of main grouting material. The grouting material must be inserted only after sufficient time has passed for the seal material to reach a gel state. Otherwise, the fluid seal material mixes with the main grouting material and a backflow of the grouting material occurs, thereby making its in situ insertion difficult. Furthermore, if the seal material remains in the gel state for too long a time, it solidifies; and the main grouting material will not be able to seep into the soil. The gel time, i.e., the time needed for the fluid seal material to turn into a gel state, determines the construction period of steel pipe multistage grouting. The gel time is one of the important factors in this technique, because it impacts the total tunnel construction period significantly. This study develops a rapidly hardening calcium aluminate material, which can reduce the gel time and shorten the construction period while retaining proper sealing function. It also presents a method to determine whether the seal material has reached the gel state as well as the quality standard and bleeding rate testing method for the seal material in the gel state.

• Analytical Science and Technology
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• v.37 no.3
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• pp.174-188
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• 2024

This review summarized research trends regarding sample collection methods, pretreatment method, and types of analysis devices for microplastics (MPs) in soil and groundwater matrices. Soil sampling considers the selection of sampling location, depth, and volume. The typically sampling depth is within 15 cm (topsoil), and about 1 kg of mixed each sample. Among spot sampling and continuous flow sampling, groundwater sampling mainly used a continuous flow sampling, with collection rates 2 to 6 L/min in the range of 300~1,000 L, and followed by immediate on-situ filtration. Pretreatment method, applied to soil and groundwater, consist of organic digestion and density separation. In the organic digestion method, H₂O₂ is recommended among H₂O₂, acidic, alkaline, and enzymatic method. NaCl is primarily used as a reagent in density separation. However, depending on the density of MPs, other regents can be selectively used like ZnCl₂, ZnBr₂, and etc. Representative analysis device includes Fourier Transform Infrared (FTIR) and Raman spectroscopy for non-destructive analysis and Pyrolysis Gas Chromatography Mass Spectrometry (Py-GC/MS) for destructive analysis. µ-FTIR and Raman can count MPs of larger than 10 and 1 ㎛, and analyze MPs materials. However, it is need to sufficiently remove interference, like organic matter, in spectroscopic analysis using essential pretreatment method. Py-GC/MS is being continuously researched because it doesn't require complex pretreatment method and allows quantitative analysis of specific materials.