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Syntenin Is Expressed in Human Follicular Dendritic Cells and Involved in the Activation of Focal Adhesion Kinase

  • Cho, Whajung;Kim, Hyeyoung;Lee, Jeong-Hyung;Hong, Seung Hee;Choe, Jongseon
    • IMMUNE NETWORK
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    • v.13 no.5
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    • pp.199-204
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    • 2013
  • Syntenin is an adaptor molecule containing 2 PDZ domains which mediate molecular interactions with diverse integral or cytoplasmic proteins. Most of the results on the biological function of syntenin were obtained from studies with malignant cells, necessitating exploration into the role of syntenin in normal cells. To understand its role in normal cells, we investigated expression and function of syntenin in human lymphoid tissue and cells in situ and in vitro. Syntenin expression was denser in the germinal center than in the extrafollicular area. Inside the germinal center, syntenin expression was obvious in follicular dendritic cells (FDCs). Flow cytometric analysis with isolated cells confirmed a weak expression of syntenin in T and B cells and a strong expression in FDCs. In FDC-like cells, HK cells, most syntenin proteins were found in the cytoplasm compared to weak expression in the nucleus. To study the function of syntenin in FDC, we examined its role in the focal adhesion of HK cells by depleting syntenin by siRNA technology. Knockdown of syntenin markedly impaired focal adhesion kinase phosphorylation in HK cells. These results suggest that syntenin may play an important role in normal physiology as well as in cancer pathology.

Ruptured Aneurysm of Sinus Valsalva A report of 5 cases (대동맥동 동맥류 파열 5례 보고)

  • 박만실
    • Journal of Chest Surgery
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    • v.18 no.3
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    • pp.407-413
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    • 1985
  • Ruptured aneurysms of the sinus Valsalva are relatively rare, and the incidence seems to be higher in oriental than in western countries. Five patients underwent operative treatment in Catholic Medical Center in recent 2.5 year period. Three patients were male and two patients were female, ages ranged from 20 to 54 years. Bacterial endocarditis was suspected or proved in 3 patients. In 3 patients in our series had a ruptured congenital aneurysms and in 2 patients acquired aneurysms by bacterial endocarditis. Associated cardiac lesions were common; such as aortic insufficiency in 3 patients, atrial septal defect in 2 patients, mitral stenoinsufficiency in 1 patient and tricuspid insufficiency in 1 patient. All aneurysmal ruptures of the sinus Valsalva arose from right coronary sinus and in 4 patients ruptured into right ventricle and in 1 patient into right atrium. Surgical techniques consisted of direct closure 4 in patients and closure with Dacron patch in 1 patient. And we preferred double approach, that is, through both the aorta and the involved cardiac chamber in cases in whom aortic insufficiency was present. So additional aortic valve replacement performed in 2 patients due to severe aortic insufficiency and aortic valvuloplasty performed in 1 patient. One patient who underwent direct closure of ruptured sinus Valsalva and double valve replacement died due to low cardiac output syndrome just after the operation. Operative results were relatively good in remainders.

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A Study on the Relationship between Recurrent Aphthous Ulcer and Oral Mucosal Keratinization (재발성 아프타성 궤양과 구강점막 각화도의 관계에 대한 연구)

  • Yu-Kyung Lee;Woo-Cheon Kee
    • Journal of Oral Medicine and Pain
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    • v.20 no.2
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    • pp.449-459
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    • 1995
  • To investigate the relationship between recurrent aphthous ulcer and oral mucosal keratinization, exfoliative cytology in buccal mucosa, lip mucosa, tongue mucosa were performed on 25 recurrent aphthous ulcer patients and 25 controls whose age ranged from 10 to 65. Keratinization cell ratio was then measured. The results were as follows : 1. Yellow cell ratio in the control group was more than that in the patient group in buccal mucosa, lip mucosa, tongue mucosa. Red cell ratio in the control group was more than that in the patient group in lip mucosa. Blue cell ratio in the patient group was more than that in control group in all regions( p(0.01) 2. In the comparison by sex, the patient group showed no significant difference in all site but, the control group showed different results according to the site; males were more than females in yellow cell, but less than females in red cell Females were more than males in yellow cell, but less than males in red cell. 3. In the comparison by age, patient group showed no significant difference in all site, but the control group showed significantly high yellow cell ratio in buccal and tongue mucosa over the age of 50. In conclusion, there was close relationship between recurrent aphthous ulcer and decreased oral mucosal keratinization. In other words, reduced oral mucosal keratinization must be recommended for prevention of recurrent aphthous ulcer.

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A Tendency of Romanticism Represented in Modern Fashion (현대 패션에 나타난 로맨티시즘 경향)

  • 유영선
    • Journal of the Korean Society of Costume
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    • v.45
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    • pp.55-70
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    • 1999
  • The purpose of this study is to offer a new inspiration for fashion design relating the "Romanticism" in art to one in fasion-examining the circumstance expressionad the latest trend which is involved with it. Since. 1990. Romanticism is motivated and represented in the middle of aridity in this age which is going on the end (of age). To say the details Romanticism in fashion is represented modernly in the compound of social grounds cultures and new techniques. Romanticism in fashion is represented modernly in the compound of social grounds cultures and new techniques. Romanticism in fashion is classified in four categories : Retro Avantgarde, Minimal and Ethnic. First Retro mood in Romanticism is represented by reappearing the costumes in medieval Renaissance Baroque Rococo, Romantic era Specially corsets crinolines bustle decorative ribbons frills and Medieval symbols in religion are important factors in intuitional symbolic Romanticism. Second Avantgrde mood in Romanticism is mainly represented in the oriental patterns colors items being motivated by Eastern customs images and cultures. Today they appear in modern concept reinterpreting 'fusion" "hybrid" and "cross-over". Romanticism in fashion is creating new forms and beauties absorbing the past and the present. In addition it is motivated by the nostalgic mood. the expectation for the future and the refineent. Romanticism would be an important fashion theme to offer new inspirations for the fashion in 21th century rather than remain at the reappearance.er than remain at the reappearance.

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Investigation of Efficacy of Lidocaine Spray for Sedated Esophagogastroduodenoscopy in Children

  • Basturk, Ahmet;Artan, Reha;Yilmaz, Aygen
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.20 no.2
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    • pp.87-93
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    • 2017
  • Purpose: Our aim in this study is to investigate efficacy of topical lidocaine spray for sedated esophagogastroduodenoscopy (EGD) in children. Methods: The endoscopy of children aged between 3-18 years who underwent EGD in our endoscopy unit. Intravenous (IV) midazolam and ketamine were used for sedation. Prior to sedation, endoscopy nurse applied topical lidocaine 10% with pump spray at 1 mg/kg dose in group 1, and distilled water via identically scaled pump spray in group 2, in a double blinded fashion. Results: Sedation was not applied in 24.1% of the cases in topical lidocaine spray group (LS group) and in 5.7% of the cases in distilled water spray group (DS group). Gag reflex was observed in 6.5% of cases in LS group and 33.3% of cases in DS group (p=0.024), increased oral secretion was observed in 9.3% of cases in LS group and 51.7% of cases in DS group (p=0.038), sore throat was observed in 3.7% of cases in LS group and 35.6% of cases in DS group (p=0.019) and the difference was statistically significant. Conclusion: The study showed that topical pharyngeal lidocaine reduces both requirement and amount of IV sedation before EGD in children and sore throat, gag reflex and decreased oral secretion increase.

Bibliometrics in Practice in Developing Nations: A Study on the Development of Scientometrics and Bibliometrics Careers in Iran

  • Asadi, Saeid;Deligani, Fatemeh Atash;Rasuli, Behrooz;Majd, Majid Shaian
    • Journal of Information Science Theory and Practice
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    • v.6 no.2
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    • pp.24-35
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    • 2018
  • Developing countries may pay attention to bibliometric indicators in accordance with their scientific development plans. Bibliometrics research topics and bibliometric indicators have grown dramatically in Iran since 2000 as a part of the post-war reconstruction programs. This paper aims to highlight how scientometrics may attract attention in developing countries such as Iran in response to national movements in education and science. An in-depth review on available guidelines for promotion of innovation, science, and technology in Iran was done followed by a review on previous research in this topic. Further data were gathered from Scopus and other sources. The findings show a considerable growth in research output of Iran in recent years and expansion of bibliometrics studies and jobs accordingly. Combined with research output measures, more attention was found in academia about cross-section development of science and technology in Iran. The demand in society has led to the foundation of scientometrics programs in Iranian universities as well as scientometrics departments in central libraries and research deputies in major academic institutions. The changing image of science and research in Iran has a relation with the growth of scientometrics academic and professional departments. The lessons taught from this mutual collaboration can be used in other developing nations.

Analysis about Stress Index and Resistance of Workers by Heart Rate Variability (근로자들의 스트레스에 대한 심박변이도 검사를 통한 분석)

  • Jang, Woo-Seok
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.25 no.4
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    • pp.728-733
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    • 2011
  • This study was designed to analyze the results of stress index by heart rate variability test. The subjects were workers in the automobile manufacturing industry. The subjects consisted of 23,767 workers who had answered about questionnaires of a job position, age, smoking, drinking, exercise state and sex. The stress index(SI) and stress resistance(SR) were examined by SA3000P. We analyzed the differences of SI and SR according to job positions, ages, the state of smoking, drinking, exercise and sex by T-test or ANOVA with SPSS ver. 17.0. Regarding the differences of SI among job positions, the SI was highest in sales positions. Among ages, the SI was highest in 30s. In smoking, the SI was lower in non-smoking group. In drinking, there was no significant differences in SI. In exercise, the SI was lower in exercise group. In sex, there was no significant difference. The case of SR, SR was lowest in sales positions. Among ages, the SR was lowest in 40s. In smoking, the SR was lower in smoking group. In drinking, there was no significant differences in SR. In exercise, there was no significant difference. In sex, the SR was lowest in male. According to these results, we should establish the methods of controlling stress from the perspective of Korean traditional medicine.

The Research on the Body Type Comparison between the Koreans Living in China and the Ones in Korea - Focused on Male in Their Twenties - (중국 및 국내 거주 한국인의 체형 비교 연구 -20대 남성을 중심으로-)

  • 석혜정;임순
    • Journal of the Korean Society of Clothing and Textiles
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    • v.28 no.910
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    • pp.1219-1230
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    • 2004
  • This study was conducted to compare the physical shapes of Korean males in their 20s between those residing in Yenbien, China and those living in Korea. Measurements were checked fur 57 items on 167 Korean male residents in Yenbien, China and 295 Korean male residents in Seoul and the other large cities around it. The conclusions are as follows: 1. The comparison of 58 items in physical measurements of Korean male residents in China and those in Korea showed differences in 49 items. Korean male residents in China had the smaller physical shapes short in limbs and height. 2. The comparison of the factor analysis results for physical measurements did not reveal big differences. In terms of the contribution of variables, however, obesity played an exceptionally large role fur Korean residents in China, while the importance of obesity and vertical length were similar for those in Korea. 3. The comparison of the physical shapes according to the grouping resulted in three types each for both groups, with different features for individual types. Korean residents in China were grouped according to the obesity factor rather than the changes in height, while those in Korea were classified according to both vertical length and obesity.

A comparative study on the light environment of the classroom classified by floor , time (강의실 빛 환경의 층별 , 시간대별 비교연구)

  • 곽경숙
    • Journal of the Korean housing association
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    • v.4 no.2
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    • pp.1-9
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    • 1993
  • This study is a basic research to analyze and estimate the light environment of the classroom by serial correlation of time. Its purpose lies in the comparison by time period in order In select floor for laboratory and to calculate the uniformity factor. The proving ground is T building in W university, Which is five floor of central hall type. The subject of investigating is eight classrooms, four rooms in South and North, from the second floor that is net influenced by the shelter. The results that compared and estimated them in the illumination of daylight, Uniformity factor, Daylight factor, are as follows1. The illumination of classroom in South and North is over 10001x, but the classroom in North is good and the classroom in South excellent.2. The uniformity factor of classroom in South is good and that of classroom in North is normal.3. The daylight factor of each classroom is over 5% but the classroom in South is above that in North. The classroom in South surpasses the classroom in North in the general light environment and the classroom in third and fourth floor is so better than that in second and fifth floor in the condition of laboratory In the uniformity factor, the classroom in fourth can be better than any classroom.

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Effects of Satisfaction Level in the Relationship between Mother-in-law and Daughter-in-law, Acculturative Stress and Stress Coping Strategies on Elderly Depression in Multi-cultural Families (다문화가정의 고부만족도, 문화적응스트레스 및 스트레스 대처전략이 노인 우울에 미치는 영향)

  • Jung, Eun-Sook
    • Journal of Home Health Care Nursing
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    • v.24 no.2
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    • pp.133-141
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    • 2017
  • Purpose: This descriptive study aims to analyze the effects of the satisfaction level in the relationship between mother-in-law and daughter-in-law, conflicts between them, acculturative stress and stress coping strategies on elderly depression in multi-cultural families. Methods: The survey was conducted on 89 mothers-in-law, aged 65 or older, in multi-cultural families with a foreign daughter-in-law. Data were collected through structured questionnaires, and then were used to conduct t-test, ANOVA, correlation and multiple regression analyses using the statistical program SPSS 21.0. Results: This study found several factors contributing to depression of mothers-in-law in multi-cultural families. Those factors include living alone without a spouse, poor health, a high level of perceived discrimination and a passive reaction in terms of stress coping strategies. Conclusion: A sense of discrimination perceived by the mothers-in-law having a foreign daughter-in-law implies that the people around them and the community should make efforts to reject distorted perspectives and remove prejudice against foreign daughters-in-law. In addition, the mothers-in-law should receive education and training to use more active and positive stress coping strategies in a stressful situation with the foreign daughter-in-law.