• Genomics & Informatics
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• v.21 no.3
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• pp.41.1-41.11
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• 2023

The Dengue virus M protein is a 75 amino acid polypeptide with two helical transmembranes (TM). The TM domain oligomerizes to form an ion channel, facilitating viral release from the host cells. The M protein has a critical role in the virus entry and life cycle, making it a potent drug target. The oligomerization of the monomeric protein was studied using ab initio modeling and molecular dynamics simulation in an implicit membrane environment. The representative structures obtained showed pentamer as the most stable oligomeric state, resembling an ion channel. Glutamic acid, threonine, serine, tryptophan, alanine, isoleucine form the pore-lining residues of the pentameric channel, conferring an overall negative charge to the channel with approximate length of 51.9 Å. Residue interaction analysis for M protein shows that Ala94, Leu95, Ser112, Glu124, and Phe155 are the central hub residues representing the physicochemical interactions between domains. The virtual screening with 165 different ion channel inhibitors from the ion channel library shows monovalent ion channel blockers, namely lumacaftor, glipizide, gliquidone, glisoxepide, and azelnidipine to be the inhibitors with high docking scores. Understanding the three-dimensional structure of M protein will help design therapeutics and vaccines for Dengue infection.

• Journal of Intelligence and Information Systems
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• v.17 no.3
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• pp.43-61
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• 2011

In this research, we propose a dynamic decision making using social context based on ontology. Dynamic adaptation is adopted for the high qualified decision making, which is defined as creation of proper information using contexts depending on decision maker's state of affairs in ubiquitous computing environment. Thereby, the context for the dynamic adaptation is classified as a static, dynamic and social context. Static context contains personal explicit information like demographic data. Dynamic context like weather or traffic information is provided by external information service provider. Finally, social context implies much more implicit knowledge such as social relationship than the other two-type context, but it is not easy to extract any implied tacit knowledge as well as generalized rules from the information. So, it was not easy for the social context to apply into dynamic adaptation. In this light, we tried the social context into the dynamic adaptation to generate context-appropriate personalized information. It is necessary to build modeling methodology to adopt dynamic adaptation using the context. The proposed context modeling used ontology and cases which are best to represent tacit and unstructured knowledge such as social context. Case-based reasoning and constraint satisfaction problem is applied into the dynamic decision making system for the dynamic adaption. Case-based reasoning is used case to represent the context including social, dynamic and static and to extract personalized knowledge from the personalized case-base. Constraint satisfaction problem is used when the selected case through the case-based reasoning needs dynamic adaptation, since it is usual to adapt the selected case because context can be changed timely according to environment status. The case-base reasoning adopts problem context for effective representation of static, dynamic and social context, which use a case structure with index and solution and problem ontology of decision maker. The case is stored in case-base as a repository of a decision maker's personal experience and knowledge. The constraint satisfaction problem use solution ontology which is extracted from collective intelligence which is generalized from solutions of decision makers. The solution ontology is retrieved to find proper solution depending on the decision maker's context when it is necessary. At the same time, dynamic adaptation is applied to adapt the selected case using solution ontology. The decision making process is comprised of following steps. First, whenever the system aware new context, the system converses the context into problem context ontology with case structure. Any context is defined by a case with a formal knowledge representation structure. Thereby, social context as implicit knowledge is also represented a formal form like a case. In addition, for the context modeling, ontology is also adopted. Second, we select a proper case as a decision making solution from decision maker's personal case-base. We convince that the selected case should be the best case depending on context related to decision maker's current status as well as decision maker's requirements. However, it is possible to change the environment and context around the decision maker and it is necessary to adapt the selected case. Third, if the selected case is not available or the decision maker doesn't satisfy according to the newly arrived context, then constraint satisfaction problem and solution ontology is applied to derive new solution for the decision maker. The constraint satisfaction problem uses to the previously selected case to adopt and solution ontology. The verification of the proposed methodology is processed by searching a meeting place according to the decision maker's requirements and context, the extracted solution shows the satisfaction depending on meeting purpose.

• Journal of Advanced Navigation Technology
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• v.14 no.1
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• pp.108-118
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• 2010

In this paper, we propose Context-based Music Recommendation (COMUS) ontology for modeling user's musical preferences and context and for supporting reasoning about the user's desired emotion and preferences. The COMUS provides an upper Music Ontology that captures concepts about the general properties of music such as title, artists and genre and also provides extensibility for adding domain-specific ontologies, such as Mood and Situation, in a hierarchical manner. The COMUS is music dedicated ontology in OWL constructed by incorporating domain specific classes for music recommendation into the Music Ontology. Using this context ontology, we believe that the use of logical reasoning by checking the consistency of context information, and reasoning over the high-level, implicit context from the low-level, explicit information. As a novelty, our ontology can express detailed and complicated relations among the music, moods and situations, enabling users to find appropriate music for the application. We present some of the experiments we performed as a case-study for music recommendation.

• Journal of Korea Multimedia Society
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• v.10 no.4
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• pp.483-491
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• 2007

This paper proposes a Situation Simulation Framework for implementing computer game and describes the possibility of analyzing game with unfolding situation. In last few years game systems have been evolving from the performance of physical engine, network traffic in the on line game to the representation of rendering physical phenomena. In computer game, a situation hierarchy structure which allows the designer for simulating high-level specifications of game structure. Logically simulated environment is created by defining situations and events based on hierarchy structure of the situation. We classify events into explicit event is occurred by user and implicit event is occurred by system. Our study defines the existence of objects is the most prevalent factor applied to any event in game world. The advantages of this approach are able to allow for providing the conceptual design for simulation game and analyzing the situation in the game world. And this method allows us to decrease the complexity of system design and abstraction modeling for the simulation game. Specially, the introduction of the definition of events allows us to approach game design in a structural manner rather than by their classification. The proposed method was implemented in the "Shooting BaDuk" among games.

• Journal of KIISE:Databases
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• v.27 no.2
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• pp.227-237
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• 2000

A Web database System is a large-scaled multimedia application system that has multimedia processing facilities and cooperates with relational/Object-Oriented DBMS. Conventional hypertext modeling methods and DB gateway have limitations for Web database because of their restricted versatile presentation abilities and inefficient concurrency control caused by bottleneck in cooperation processing. Thus, we suggest a Dynamic Navigation Model & Virtual Graph Structure. The Dynamic Navigation Model supports implicit query processing and dynamic creation of navigation spaces, and introduce node-link creation rule considering navigation styles. We propose a mapping methodology between the suggested hypertext model and the relational data model, and suggest a dynamic allocation scheduling technique for query processing server based on weighted value. We show that the proposed technique enhances the retrieval performance of Web database systems in processing complex queries concurrently.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.10
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• pp.5243-5250
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• 2013

BIM(Building Information Modeling) enables 3D model-base management for all information produced by construction project during its life cycle. Also as a national policy, BIM has been institutionalized as design criteria. But, on the matter of 2D drawing using BIM software (Revit Architecture), it has been recognized as difficult to realize the same quality drawing drawn by CAD. The purpose of this study is verifying the possibility of printable design drawing implemented by BIM software at the same quality of 2D shop drawing drawn by 2D CAD. Through the analysis of basic design elements of 3D BIM software and 2D CAD software, with the case of partial cross sectional drawing which is most faithful representation of the basic design elements, this study find out that the 3D BIM software can produce the same quality 2D printable drawing utilizing its implicit function.

• Journal of Digital Contents Society
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• v.16 no.2
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• pp.335-343
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• 2015

This paper describes a quantitative approach to the BIM-enabled assessment of building circulation by using quantitative data and applying its weight. Assessment of building circulation plays an important role before construction stage because of related requirements regulated by design guide, building codes, etc. and design decision making as well. In this paper, Qualitative issue is mainly dealt with that are usually excluded from rule checking objects due to their implicit definition such as 'comfortable circulation'. A weighting framework is suggested using weighted data of circulation properties such as 1) metric distance, 2) number of passing spaces, 3) number of turning spaces, 4) window area of passing space, etc.

• Journal of the Korea Computer Graphics Society
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• v.8 no.1
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• pp.37-45
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• 2002

We present a cloth simulation technique that is very stable yet also responsive. The stability of the technique allows the use of a large fixed time step when simulating various types of fabrics and character motions. The animations generated using this technique are strikingly realistic. Wrinkles form and disappear in a quite natural way, which is the feature that most distinguishes textile fabrics from other sheet materials. Significant improvements in both the stability and realism were made possible by overcoming the post-buckling instability as well as the numerical instability. The instability caused by buckling arises from a structural instability and therefore cannot be avoided by simply employing an implicit method. Addition of a damping force may help to avoid instabilities; however, it can significantly degrade the realism of the cloth motion. In this paper, a new buckling model based on immediate buckling assumption is proposed. A cloth element is assumed to reach a stable configuration immediately once it begins to buckle. This assumption makes it possible to simulate the fabric buckling stably without introducing any fictitious damping force. Consequently, it produces highly responsive cloth motion as well as improves the stability by modeling the fabric-specific buckling property adequately.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.1
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• pp.88-99
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• 1996

The explicit scheme for finite element analysis of sheet metal forming problems has been widely used for providing practical solutions since it improves the convergency problem, memory size and computational time especially for the case of complicated geometry and large element number. The explicit schemes in general use are based on the elastic-plastic modeling of material requiring large computataion time. In the present work, a basic formulation for rigid-plastic explicit finite element analysis of plain strain sheet metal forming problems has been proposed. The effect of some basic parameters involved in the dynamic analysis has been studied in detail. Thus, the effective ranges of parameters have been proposed for numerical simultion by the rigid-plastic explicit finite element method. A direct trial-and-error method is introduced to treat contact and friction. In computation, sheet material is assumed to possess normal anisotropy and rigid-plastic workhardening characteristics. In order to show the validity and effectiveness of the proposed explicit scheme, computations are carried out for cylindrical punch stretching and the computational results are compared with those by the implicit scheme as well as with a commercial code. The proposed rigid-plastic exlicit finite element method can be used as a robust and efficient computational method for analysis of sheet metal forming.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.39 no.8
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• pp.52-63
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• 2002

In this paper, we developed a numerical analysis model by using ADI-FDTD method to analyze three-dimensional interconnect structure. We discretized maxwell's curl equation by using ADI-FDTD. We introduced PML(Perfectly Matched Layer) absorbing boundary condition to solve the effect of the reflected wave at the interface. Evaluating the numerical model of PML and ADI-FDTD, we simulated the electric field distribution in time domain. We compare standard FDTD with ADI-FDTD, and analysis the result.