• Proceedings of the Korean Information Science Society Conference
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• 2010.06d
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• pp.170-173
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• 2010

최근 진보된 무선 통신 기술과 발전된 의료 기술로 인하여 u-Health의 핵심 기술인 WBAN에 대한 연구가 활발히 진행되고 있다. 인체에 이식 가능한 WBAN 장치는 전원 공급에 제한이 있으므로 소비전력을 최소화하기 위한 MAC 프로토콜이 필요하다. 본 논문은 WBAN 장치의 다양한 무선 통신 특성을 적용한 시뮬레이터에 관한 것으로 MICS 대역의 채널 특성을 적용하였고, 데이터의 신뢰성과 에너지 효율성을 향상시키기 위해 가변 패킷 및 비트맵 기반의 패킷 블록 전송기법을 적용한 MAC 프로토콜을 사용한다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2008.04a
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• pp.168-173
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• 2008

본 연구는 UKF Algorithm을 이용한 정전용량형 원격RF센서시스템을 개발하였다. 원격 RF센서 시스템이란 wireless, implantable 그리고 batterless을 만족하는 센서 시스템을 의미한다. 기존의 원격 RF센서 시스템은 보편적으로 집적회로 타입을 채택하지만, 그 구조의 복잡성과 전력소모의 제약을 받는다. 이러한 제약을 해결하기 위해 본 연구에서는 R, L 그리고 C만으로 구성되어있는 유도결합원리를 이용한 원격 RF센서 시스템을 제안하였다. 제안된 RF 센서 시스템은 압력 혹은 습도와 같은 환경의 변화를 정전용량 값으로 측정할 수 있으며 센서의 정전 용량 값을 측정하기 위해 비선형시스템의 파라메타추정에 적합한 Unscented Kalman Filter(UKF) 기법을 채택하였다. UKF 기법을 이용하기 위해 제안된 시스템은 페이저법을 사용하여 수학적으로 모델링되었다. 마지막으로, 제안된 UKF 알고리즘을 이용한 원력 RF센서시스템이 잡음환경에서도 정전용량값을 비교적 정확하게 추정가능함을 확인하였다.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.72-73
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• 1998

A new method for enzyme immobilization has been developed to remove interference by potential interferents in body fluids. Instead of using electron mediators, we chose direct hydrogen peroxide measurement route. Extremely hydrogen peroxide-selective polymer was coated as an inner membrane to exclude interferents and then glucose oxidase(GOx) was entrapped by electropolymerization of inert monomers. There was no solvent casting step throughout the whole fabrication procedure but all membranes on Pt-Ir electrode were formed by electropolymerization. Thus, membrane thickness, quantity of enzyme loaded and can be controlled by electrochemical parameters. As a result, reproducibility of biosensor characteristics becomes remarkably improved in terms of mass production.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.11
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• pp.937-941
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• 2016

Stand-alone cervical cage consists of a PEEK body, Ti plate, and screw, which are configured as a single-piece. Through a single operation, this implantable medical device is capable of completely fixing the cervical vertebral body. For example, instead of a plate, which is normally used, the intervertebral disc is removed and replaced with a cervical cage. It should be noted that in Korea, KFDA guidelines for a stand-alone cervical cage have not yet been suggested. Therefore, the aim of this study is to present the systematic study of the static compression test, static torsion test, dynamic compression test, and expulsion test. Further, the test method is designed to refer to the ASTM standard and relative literature.

• International Journal of Precision Engineering and Manufacturing
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• v.9 no.2
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• pp.81-83
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• 2008

The Rapid Prototyping (RP) technology has advanced in many application areas. In this research, two different types, cylinder and scaffold, of implantable Drug Delivery System (DDS) were fabricated using Nano Composite Deposition System (NCDS), one of the RP systems. The anti-cancer drug (5-fluorouracil, 5-FU), biodegradable polymer (PLGA(85: 15)), and bio ceramic (Hydroxyapatite, HA) were used to form drug-polymer composite material. Both types of DDS were evaluated in vivo environment for two weeks. For evaluation, the cumulative drug release and shape stability were measured. Test results showed that the scaffold DDS provide higher cumulative drug release and has better stability than cylinder DDS.

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.86-86
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• 1996

연축성 발성장애(spasmodic dysphonia)는 아직까지 그 원인을 정확히 밝혀내지 못하고 있는 만성적인 발성장애로 과거에는 경직성 발성장애(spastic dysphonia)로 불리던 질환이다. 연축성 발성장애는 두 종류 즉, 내전형(adductor)과 외전형(abductor)으로 나누어지며 이중 내전형이 대부분이다. 외전형 연축성 발성장애는 발성도중에 성대가 갑자기 불수의적으로 외전되면서 음성이 중단되므로 원활히 대화하기가 힘든 질환이다. 이러한 질환은 국소적 근긴장이상(fecal dystonia)의 일종이다. 현재까지 연축성 발성장애의 치료법으로 사용되고 있는 것으로는 언어치료, botulium 독소주입술, 편측반회후두신경절 단술, 반회후두신경분쇄술, 상후두신경절단술, 갑상연골성형술, implantable stimulator 등이 있다. 연축성 발성장애 환자에 $Botox^{circledR}$ 주입에 관한 보고는 주로 내전형에 대해서만 보고되고 있으며 외전형에 대하여 보고된 예는 매우 적다. (중략)

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.1062-1065
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• 2002

We have evaluated the ability of a time-delayed artificial neural network (TDANN) to predict muscle forces using only eletromyographic(EMG) signals. To achieve this goal, tendon forces and EMG signals were measured simultaneously in the gastrocnemius muscle of a dog while walking on a motor-driven treadmill. Direct measurements of tendon forces were performed using an implantable force transducer and EMG signals were recorded using surface electrodes. Under dynamic conditions, the relationship between muscle force and EMG signal is nonlinear and time-dependent. Thus, we adopted EMG amplitude estimation with adaptive smoothing window length. This approach improved the prediction ability of muscle force in the TDANN training. The experimental results indicated that dynamic tendon forces from EMG signals could be predicted using the TDANN, in vivo.

• The Korean Journal of Pain
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• v.22 no.2
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• pp.117-123
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• 2009

The intrathecal drug administration system (ITDAS) has recently been introduced for treating chronic intractable pain patients who have failed with conservative pain treatments. The obvious advantages of its use are the direct intrathecal delivery of drugs, which yields reduced adverse effects and the increased strength of drugs, as compared to its oral or intravenous route. This article offers a review of the ITDAS with a brief review of its evidence-based effectiveness, the technical approach, and the complications.

• The Korean Journal of Pain
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• v.27 no.3
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• pp.297-300
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• 2014

This report describes the long term safety and efficacy of intrathecal therapy using Sufentanil for the management of chronic intractable neuropathic pain in 12 chronic pain patients. Standardized psychological screening was used to determine treatment suitability. Evaluation data included the Visual Analog Scale (VAS), Wong-Baker Faces Scale, Brief Pain Inventory (BPI), Disability of Arm, Shoulder, and Hand (DASH), McGill Quality of Life Questionnaire, and complications (granulomas, toxicity, withdrawal, or deaths). SPSS version 18 was used for data analysis. Pre- and post- treatment BPI measures and pain scale scores showed a statistically significant difference. There were no complications directly related to drug toxicity, nor drug withdrawals, granulomas, or deaths. Intrathecal therapy with Sufentanil therapy offers a good treatment alternative for those cases that have failed both surgery and standard pain treatment. Strict patient selection based on psychological screening, control of co-morbidities, a proper pain management may contribute to successful outcome.

• Archives of Pharmacal Research
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• v.18 no.1
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• pp.18-21
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• 1995

Poly(ethylene glycol)(PEG) macrocers teminated with acrylate groups and semi-interpenetrating polymer networks (IPNs) composed of poly-.epsilon.-capolactone(PCL) and PEG macromer were syntheswized with the aim of obtaining a bioerodible hydrogel that could be used to release drugs for implantable delivery system. Polymerization of PEG macromer resulted in the formation of cross-linked gels due to the multifunctionality of macromer. Non-crosslinked PCL chains were interpenetrated into the cross-linked three-dimensions networks of PEG. The IPNs, largw drug loading lower concentration of PEG macromer in the IPNs concentration and the higher molecular weight of PEG macromer. Also, 5-FU was more fast released than hydrocortisone to the increased water solubility.