• Explosives and Blasting
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• v.23 no.3
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• pp.1-10
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• 2005

Blast-induced ground vibration nay cause an environmental impact such as neighbour's complaints or damage on adjacent structures and facilities. Complaints associated with blasting have often become a target of public grievances. One of the difficulties to solve the problem is that we do not have a national standard for the acceptance level of blast-induced ground vibration. A peak particle velocity criterion, which was suggested for urbane underground construction, has often been widely used. Efforts have been made to establish more rational criteria. It seems that differing cultures have often differing thresholds of the toleration of vibration, and that technical data or rational grounds for establishing the limits are hardly provided. In this paper, national standards for allowable limit of blast vibration were presented and discussed.

• Geomechanics and Engineering
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• v.23 no.5
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• pp.405-418
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• 2020

Deep excavation may have impact on the adjacent tunnels. It is obvious that the excavation will adversely affect and even damage the existing tunnels if the induced deformation exceeds the capacity of tunnel structures. It hence creates a high necessity to predict tunnel displacement induced by nearby excavation to ensure the safety of tunnel. In this paper, a simplified method to evaluate the heave of the underlying tunnel induced by adjacent excavation is presented and verified by field measurement results. In the proposed model, the tunnel is represented by a series of short beams connected by tensile springs, compressional springs and shear springs, so that the rotational effect and shearing effect of the joints between lining rings can be captured. The proposed method is compared with the previous modelling methods (e.g., Euler-Bernoulli beam, a series of short beams connected only by shear springs) based on a field measured longitudinal deformation of subway tunnels. Results of these case studies show a reasonable agreement between the predictions and observations.

• Earthquakes and Structures
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• v.9 no.1
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• pp.127-143
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• 2015

In conventional seismic design, structures are assumed to be fixed at the base. To reduce the impact of earthquake loading, while at the same time providing an economically feasible structure, minor damage is tolerated in the form of controlled plastic hinging at predefined locations in the structure. Uplift is traditionally not permitted because of concerns that it would lead to collapse. However, observations of damage to structures that have been through major earthquakes reveal that partial and temporary uplift of structures can be beneficial in many cases. Allowing a structure to move as a rigid body is in fact one way to limit activated seismic forces that could lead to severe inelastic deformations. To further reduce the induced seismic energy, slip-friction connectors could be installed to act both as hold-downs resisting overturning and as contributors to structural damping. This paper reviews recent research on the concept, with a focus on timber shear walls. A novel approach used to achieve the desired sliding threshold in the slip-friction connectors is described. The wall uplifts when this threshold is reached, thereby imparting ductility to the structure. To resist base shear an innovative shear key was developed. Recent research confirms that the proposed system of timber wall, shear key, and slip-friction connectors, are feasible as a ductile and low-damage structural solution. Additional numerical studies explore the interaction between vertical load and slip-friction connector strength, and how this influences both the energy dissipation and self-centring capabilities of the rocking structure.

• Proceedings of the Korean Society For Composite Materials Conference
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• 2004.04a
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• pp.95-102
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• 2004

For the simultaneous measurement of strain and damage signal, a fiber Bragg grating sensor system with a dual demodulator was proposed. One demodulator using a tunable Fabry-Perot filter can measure low-frequency signal such as strain and the other demodulator using a passive Mach-Zehnder interferometer can detect high-frequency signal such as damage signal or impact signal. Using a proposed fiber Bragg grating sensor system, both the strain and damage signal of a cross-ply laminated composite beam under tensile loading were simultaneously measured. Analysis of the strain and damage signals detected by single fiber Bragg grating sensor showed that sudden strain shifts were induced due to transverse crack propagation in the 90 degree layer of composite beam and vibration with a maximum frequency of several hundreds of kilohertz was generated.

• International Journal of High-Rise Buildings
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• v.10 no.4
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• pp.323-334
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• 2021

Concrete structures may rarely collapse in fire incidents but fire induced damage to structural members is inevitable as a result of material degradation and thermal expansion. This requires certain repairing measures to be applied to restore the performance of post-fire members. A brief review on investigation of post-fire damage of concrete material and concrete structural members is presented in this paper, followed by a review of post-fire repair research regarding various types of repairing techniques (FRP, steel plate, and concrete section enlargement) and different type of structural members including columns, beams, and slabs. Particularly, the fire scenarios adopted in these studies leading to damage are categorized as three levels according to the duration of gas-phase temperature above 600℃ (t₆₀₀). The repair effectiveness in terms of recovered performance of concrete structural members compared to the initial undamaged performance has been summarized and compared regarding the repairing techniques and fire intensity levels. The complied results have shown that recovering the ultimate strength is achievable but the stiffness recovery is difficult. Moreover, the current fire loading scenarios adopted in the post-fire repair research are mostly idealized as constant heating rates or standard fire curves, which may have produced unrealistic fire damage patterns and the associated repairing techniques may be not practical. For future studies, the realistic fire impact and the system-level structural damage investigation are necessary.

• BMB Reports
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• v.56 no.11
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• pp.612-617
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• 2023

Pleiotropic regulator 1 (PLRG1), a highly conserved element in the spliceosome, can form a NineTeen Complex (NTC) with Prp19, SPF27, and CDC5L. This complex plays crucial roles in both pre-mRNA splicing and DNA repair processes. Here, we provide evidence that PLRG1 has a multifaceted impact on cancer cell proliferation. Comparing its expression levels in cancer and normal cells, we observed that PLRG1 was upregulated in various tumor tissues and cell lines. Knockdown of PLRG1 resulted in tumor-specific cell death. Depletion of PLRG1 had notable effects, including mitotic arrest, microtubule instability, endoplasmic reticulum (ER) stress, and accumulation of autophagy, ultimately culminating in apoptosis. Our results also demonstrated that PLRG1 downregulation contributed to DNA damage in cancer cells, which we confirmed through experimental validation as DNA repair impairment. Interestingly, when PLRG1 was decreased in normal cells, it induced G1 arrest as a self-protective mechanism, distinguishing it from effects observed in cancer cells. These results highlight multifaceted impacts of PLRG1 in cancer and underscore its potential as a novel anti-cancer strategy by selectively targeting cancer cells.

• Structural Engineering and Mechanics
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• v.33 no.2
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• pp.113-136
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• 2009

The seismic induced interaction between multistory structures with unequal story heights (inter-story pounding) is studied taking into account the local response of the exterior beam-column joints. Although several parameters that influence the structural pounding have been studied sofar, the role of the joints local inelastic behaviour has not been yet investigated in the literature as key parameter for the pounding problem. Moreover, the influence of the infill panels as an additional parameter for the local damage effect of the joints on the inter-story pounding phenomenon is examined. Thirty six interaction cases between a multistory frame structure and an adjacent shorter and stiffer structure are studied for two different seismic excitations. The results are focused: (a) on the local response of the critical external column of the multistory structure that suffers the hit from the slab of the adjacent shorter structure, and (b) on the local response of the exterior beam-column joints of the multistory structure. Results of this investigation demonstrate that the possible local inelastic response of the exterior joints may be in some cases beneficial for the seismic behaviour of the critical column that suffers the impact. However, in all the examined cases the developing demands for deformation of the exterior joints are substantially increased and severe damages can be observed due to the pounding effect. The presence of the masonry infill panels has also been proved as an important parameter for the response of the exterior beam-column joints and thus for the safety of the building. Nevertheless, in all the examined inter-story pounding cases the presence of the infills was not enough for the total amelioration of the excessive demands for shear and ductility of the column that suffers the impact.

• Advances in aircraft and spacecraft science
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• v.4 no.1
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• pp.37-52
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• 2017

Gas turbines operating in dusty or sandy environment polluted with micron-sized solid particles are highly prone to blade surface erosion damage in compressor stages and molten sand attack in the hot-sections of turbine stages. Commercial/Military fixed-wing aircraft engines and helicopter engines often have to operate over sandy terrains in the middle eastern countries or in volcanic zones; on the other hand gas turbines in marine applications are subjected to salt spray, while the coal-burning industrial power generation turbines are subjected to fly-ash. The presence of solid particles in the working fluid medium has an adverse effect on the durability of these engines as well as performance. Typical turbine blade damages include blade coating wear, sand glazing, Calcia-Magnesia-Alumina-Silicate (CMAS) attack, oxidation, plugged cooling holes, all of which can cause rapid performance deterioration including loss of aircraft. The focus of this research work is to simulate particle-surface kinetic interaction on typical turbomachinery material targets using non-linear dynamic impact analysis. The objective of this research is to understand the interfacial kinetic behaviors that can provide insights into the physics of particle interactions and to enable leap ahead technologies in material choices and to develop sand-phobic thermal barrier coatings for turbine blades. This paper outlines the research efforts at the U.S Army Research Laboratory to come up with novel turbine blade multifunctional protective coatings that are sand-phobic, sand impact wear resistant, as well as have very low thermal conductivity for improved performance of future gas turbine engines. The research scope includes development of protective coatings for both nickel-based super alloys and ceramic matrix composites.

• Journal of Aerospace System Engineering
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• v.17 no.6
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• pp.35-45
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• 2023

In this paper, we analyze the influence of indirect lightning strikes based on the structure of shielded cables used in an aircraft and propose a cable structure to enhance shielding effectiveness. Cables in an aircraft account for the largest proportion among components and play a crucial role in connecting aircraft frames and electronic devices; thus, making them highly influential. In particular, indirect lightning strike noise can lead to malfunctions and cause damage in aircraft electronic equipment, making the utilization of shielded cables essential for mitigating damage caused by indirect lightning strike noise. We conducted an analysis of the impact of indirect lightning strikes on aircraft shielded cables considering factors, such as the presence of shielding layers, core, and insulation in the cable structure. Furthermore, we validated our findings through simulations and experiments by applying the internationally recognized standard for indirect lightning, RTCA DO-160G Sec. 22.

• Journal of Microbiology and Biotechnology
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• v.34 no.4
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• pp.812-827
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• 2024

Phloroglucinol (PG) is one of the abundant isomeric benzenetriols in brown algae. Due to its polyphenolic structure, PG exhibits various biological activities. However, the impact of PG on anagen signaling and oxidative stress in human dermal papilla cells (HDPCs) is unknown. In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3β) at serine 9. Treatment with the selective phosphoinositide 3-kinase/AKT inhibitor, LY294002, restored the increased AKT/GSK3β/β-Catenin signaling and anagen-inductive proteins induced by PG. Moreover, conditioned medium from PG-treated HDPCs promoted the proliferation and migration of human epidermal keratinocytes via the AKT signaling pathway. Subsequently, we assessed the antioxidant activities of PG. PG ameliorated the elevated oxidative stress markers and improved the decreased anagen signaling in hydrogen peroxide (H₂O₂)-induced HDPCs. The senescence-associated β-galactosidase staining assay also demonstrated that the antioxidant abilities of PG effectively mitigated H₂O₂-induced senescence. Overall, these results indicate that PG potentially enhances anagen signaling and improves oxidative stress-induced cellular damage in HDPCs. Therefore, PG can be employed as a novel therapeutic component to ameliorate hair loss symptoms.