• International Journal of Aerospace System Engineering
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• 제9권2호
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• pp.1-9
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• 2022

The NEA release mechanism is used to provide restraint and release functions with low shock for critical deployment operations on solar arrays after launch. The GK3 solar array consists of 2 wings and 6 hold down points per panel. The NEA SSD9103S1 is a part of the GK3 solar array hold-down and release mechanism. Each NEA unit is equipped with two Z-diodes which provide power to a NEA unit connected in series after actuation of the fuse wire. This paper presents the hot firing test results of a quadrature NEA SSD9103S1 configuration. One output powers a maximum of 4 NEA SSD9103S1 units simultaneously. The necessary actuation pulse duration has been determined to meet margin requirement for thermal energy of minimum 4. Actuation thermal energy difference is about 6.6% between each half of two fired serial NEAs. Thermal energy margin at worst case is minimum 5.9 in case of an actuation pulse duration of 500 ms. Two series Zener impedance depend on current applied has been characterized by an additional actuation after all fuse wires are open circuit. Total number of actuation commands to the GK3 NEA unit reduce drastically from 24 in case of single NEA configuration down to 8 in case of parallel and quadrature NEA configurations. It can be accommodated by the existing HP2U Pyro design without any impact.

• 문화기술의 융합
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• 제7권4호
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• pp.607-612
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• 2021

본 연구는 주택가격 상승 충격이 저출산에 미치는 영향과 각 변수들의 합계출산율 변동 기여도를 추정하였다. 본 연구는 기존 연구들이 시도하지 않았던 샤플리 분해와 패널 VAR의 예측오차분산분해를 통해 과거 출산율 하락 경험치에 대한 각 변수들의 기여도와 각 변수의 향후 기여도를 추정하여 차별성이 있다. 본 연구의 주요 분석결과는 다음과 같다. 우리나라 합계출산율의 하락은 최근 합계출산율 하락 흐름에 강한 영향을 받았으며, 이 영향력은 향후 미래에도 지속될 것으로 전망되었다. 주거비의 경우는 과거 주택 매매가격은 전세가격에 비해 상대적으로 합계출산율변동에 미친 기여도가 작았으나, 향후 미래에는 장기적으로 그 영향력이 커질 것으로 전망되었다. 주택 매매가격, 전세가격 이외 사교육비 역시 합계출산율 하락에 주요 원인으로 작동하였음을 실증하였고, 높은 사교육비 부담이 장기적으로도 합계출산율을 낮출 것으로 전망되었다.

• Journal of Animal Science and Technology
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• 제64권1호
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• pp.110-122
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• 2022

The reduction of milk yield caused by heat stress in summer is the main condition restricting the economic benefits of dairy farms. To examine the impact of hyperthermia on bovine mammary epithelial (MAC-T) cells, we incubated the MAC-T cells at thermal-neutral (37℃, CON group) and hyperthermic (42℃, HS group) temperatures for 6 h. Subsequently, the cell viability and apoptotic rate of MAC-T cells, apoptosis-related genes expression, casein and amino acid transporter genes, and the expression of the apoptosis-related proteins were examined. Compared with the CON group, hyperthermia significantly decreased the cell viability (p < 0.05) and elevated the apoptotic rate (p < 0.05) of MAC-T cells. Moreover, the expression of heat shock protein (HSP)70, HSP90B1, Bcl-2-associated X protein (BAX), Caspase-9, and Caspase-3 genes was upregulated (p < 0.05). The expression of HSP70 and BAX (pro-apoptotic) proteins was upregulated (p < 0.05) while that of B-cell lymphoma (BCL)2 (antiapoptotic) protein was downregulated (p < 0.05) by hyperthermia. Decreased mRNA expression of mechanistic target of rapamycin (mTOR) signaling pathway-related genes, amino acid transporter genes (SLC7A5, SLC38A3, SLC38A2, and SLC38A9), and casein genes (CSNS1, CSN2, and CSN3) was found in the heat stress (HS) group (p < 0.05) in contrast with the CON group. These findings illustrated that hyperthermia promoted cell apoptosis and reduced the transport of amino acids into cells, which inhibited the milk proteins synthesis in MAC-T cells.

• BMB Reports
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• 제55권10호
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• pp.512-517
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• 2022

Traumatic brain injury (TBI) is brain damage which is caused by the impact of external mechanical forces. TBI can lead to the temporary or permanent impairment of physical and cognitive abilities, resulting in abnormal behavior. We recently observed that a single session of early exercise in animals with TBI improved their behavioral performance in the absence of other cognitive abnormalities. In the present study, we investigated the therapeutic effects of continuous exercise during the early stages of TBI in rats. We found that continuous low-intensity exercise in early-stage improves the locomotion recovery in the TBI of animal models; however, it does not significantly enhance short-term memory capabilities. Moreover, continuous early exercise not only reduces the protein expression of cerebral damage-related markers, such as Glial Fibrillary Acid Protein (GFAP), Neuron-Specific Enolase (NSE), S100β, Protein Gene Products 9.5 (PGP9.5), and Heat Shock Protein 70 (HSP70), but it also decreases the expression of apoptosis-related protein BAX and cleaved caspase 3. Furthermore, exercise training in animals with TBI decreases the microglia activation and the expression of inflammatory cytokines in the serum, such as CCL20, IL-13, IL-1α, and IL-1β. These findings thus demonstrate that early exercise therapy for TBI may be an effective strategy in improving physiological function, and that serum protein levels are useful biomarkers for the predicition of the effectiveness of early exercise therapy.

• 한국축산식품학회지
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• 제42권6호
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• pp.1061-1073
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• 2022

Receptor activator of NF-kB ligand (RANKL) is known to play a major role in bone metabolism and the immune system, and its recombinant form has been expressed in bacterial systems for research since the last two decades. However, most of these recombinant forms are used after purification or directly using living cells. Here, there were cell extracts of recombinant Lactococcus lactis expressing mouse RANKL (mRANKL) used to evaluate its biological activity in mice. Mice were divided into three groups that were fed phosphate-buffered saline (PBS), wild-type L. lactis IL1403 (WT_CE), and recombinant L. lactis expressing mRANKL (mRANKL_CE). The small intestinal transcriptome and fecal microbiome were then profiled. The biological activity of mRANKL_CE was confirmed by studying RANK-RANKL signaling in vitro and in vivo. For small intestinal transcriptome, differentially expressed genes (DEGs) were identified in the mRANKL_CE group, and no DEGs were found in the WT_CE group. In the PBS vs. mRANKL_CE gene enrichment analysis, upregulated genes were enriched for heat shock protein binding, regulation of bone resorption, and calcium ion binding. In the gut microbiome analysis, there were no critical changes among the three groups. However, Lactobacillus and Sphingomonas were more abundant in the mRANKL_CE group than in the other two groups. Our results indicate that cell extracts of mRANKL_CE can play an effective role without a significant impact on the intestine. This strategy may be useful for the development of protein drugs.

• 한국포장학회지
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• 제29권2호
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• pp.129-138
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• 2023

The proportion of agricultural products handled through the Agricultural Products Processing Center (APC) is also steadily increasing every year, and in the case of Seongju Korean melon, a total of 10 APCs of Nonghyup and farming association corporations are in operation, and the distribution ratio is about 60% based on total production. In this study, Seongju Korean melon was selected as a target to analyze the environment load during carrying (production farm ~ APC) in the production area and the transport environment load during distribution of domestic fruits, and to analyze the environmental load for handling at APC. The vertical average vibration intensity (overall G_rms of 1~250 Hz) of truck transport measured at three transport routes from Seongju Korean melon producer ~ APC, Seongju ~ Seoul and Seongju ~ Jeju was about three times larger than that in the lateral direction and 4.5 times larger than that in the longitudinal direction, respectively. The frequency of occurrence of high-amplitude events (G) in the vertical direction compared to the measuring time was deeply related to pavement conditions in the order of unpaved farm-roads, concretepaved farm-roads, and asphalt-paved main-roads, but overall G_rms for the entire frequency band is believed to have a greater impact on vehicle traveling speed than road conditions. On the other hand, the difference in the size and direction of the vibration intensity measured by the forklift truck's main-body and the attachment (fork carrier) during handling at Seongju Korean melon APC was clear, and the vibration intensity of the forklift truck's main-body was largely affected by the stiffness of the fork and the mast according to the handling weight. Based on the field-data of the transport environment during domestic distribution measured through this study, it is believed that it is possible to develop a lab-based simulation protocol for appropriate packaging design.

• Geomechanics and Engineering
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• 제29권5호
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• pp.567-582
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• 2022

In the present study, a series of physical experiments and numerical simulations were conducted to investigate the effects of mode I and mixed-mode I/II cracks on the fracture modes and stability of roadway tunnel models. The experiments and simulations incorporated different inclination angle flaws under both static and dynamic loads. The quasi-static and dynamic testing were conducted by using an electro-hydraulic servo control device and drop weight impact system (DWIS), and the failure process was simulated by using rock failure process analysis (RFPA) and AUTODYN software. The stress intensity factor was also calculated to evaluate the stability of the flawed roadway tunnel models by using ABAQUS software. According to comparisons between the test and numerical results, it is observed that for flawed roadways with a single radical crack and inclination angle of 45°, the static and dynamic stability are the lowest relative to other angles of fractured rock masses. For mixed-mode I/II cracks in flawed roadway tunnel models under dynamic loading, a wing crack is produced and the pre-existing cracks increase the stress concentration factor in the right part of the specimen, but this factor will not be larger than the maximum principal stress region in the roadway tunnel models. Additionally, damage to the sidewalls will be involved in the flawed roadway tunnel models under static loads.

• Clinical and Experimental Reproductive Medicine
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• 제51권1호
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• pp.28-41
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• 2024

Objective: Chronic scrotal hyperthermia (SHT) can lead to serious disorders of the male reproductive system, with oxidative stress playing a key role in the onset of these dysfunctions. Thus, we evaluated the impact of caffeine, a potent antioxidant, on cellular and tissue disorders in mice with chronic SHT. Methods: In this experimental study, 56 adult male NMRI mice were allocated into seven equal groups. Apart from the non-treated control group, all were exposed to heat stress. Two groups, termed "preventive" and "curative," were orally administered caffeine. The preventive mice began receiving caffeine immediately prior to heat exposure, while for the curative group, a caffeine regimen was initiated 15 consecutive days following cessation of heat exposure. Each treated group was subdivided based on pairing with a positive control (Pre/ curative [Cur]+PC) or a vehicle (Pre/Cur+vehicle). Upon conclusion of the study, we assessed sperm characteristics, testosterone levels, stereological parameters, apoptosis, antioxidant and oxidant levels, and molecular markers. Results: Sperm parameters, testosterone levels, stereological parameters, biochemical factors (excluding malondialdehyde [MDA]), and c-kit gene expression were significantly elevated in the preventive and curative groups, especially the former, relative to the other groups. Conversely, expression levels of the heat shock protein 72 (HSP72) and nuclear factor kappa beta (NF-κβ) genes, MDA levels, and apoptotic cell density were markedly lower in both caffeine-treated groups relative to the other groups, with more pronounced differences observed in the preventive group. Conclusion: Overall, caffeine attenuated cellular and molecular abnormalities induced by heat stress in the testis, particularly in the mice treated under the preventive condition.

• 한국산림과학회지
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• 제90권2호
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• pp.217-226
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• 2001

이 연구는 건축허가면적의 변화가 임산물수입량에 마치는 영향을 우리나라 시장을 대상으로 분석하였다. 첫번째 목적은 건축허가면적의 변화가 임산물수입량 변화의 원인이 되는지, 즉 인과관계를 파악하는 것이고, 두번째 목적은 건축허가면적의 변화가 임산물수입량에 얼마만큼 얼마동안 영향을 미치는지, 즉 동태적 영향을 추정하는 것이다. 건축허가면적과 임산물수입량의 관계는 자기회귀모형이나 오차수정모형에 의해 만들어졌다. 인과관계 파악은 Granger가 고안한 인과성검정을 이용하였고, 동태분석은 분산분해분석과 충격반응분석을 이용하였다. 결과에 의하면 건축허가면적의 변화는 임산물 중에서 고밀도섬유판수입량 변화의 원인이 되었다. 고밀도섬유판의 경우에 어느 시기의 수입량은 그 시기 이전의 건축허가면적에 의해 10%, 그 시기 이전의 수입량에 의해 90% 가량 설명되었다. 또한 건축허가면적의 변화는 고밀도섬유판수입량에 6개월까지 영향을 미쳤다. 즉 건축허가면적의 변화가 고밀도섬유판수입량에 영향을 미쳤더라도 단기간에 불과했다.

• 방사성폐기물학회지
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• 제4권2호
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• pp.139-152
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• 2006

사용후핵연료 건식저장용기는 낙하사고조건에서 캐니스터의 건전성이 입증되어야 한다. 낙하사고조건은 캐니스터를 건식저장용기에 장입하기 위하여 저장용기의 상부에서 크레인으로 취급하는 도중에 캐니스터가 저장용기 내부의 받침대로 자유 낙하하는 조건이다. 저장용기 내부의 받침대는 이러한 조건에서 캐니스터의 구조적 건전성을 유지하도록 완충효과가 좋아야 한다. 본 연구에서는 다양한 저장용기 내부 받침대 에 대한 3차원 유한요소해석을 통하여 낙하사고조건에서 캐니스터의 구조적 건전성을 향상시킬 수 있는 구조를 결정하였다. 저장용기 내부 받침대는 탄소강으로 만들어진 원통 쉘의 내부에 콘크리트를 장입한 구조와 받침대 높이의 변화 없이 콘크리트 높이의 1/4정도에 탄소강과 폴리우레탄폼을 이용한 구조물을 사용하여 완충효과를 보완하고자 수정된 구조를 고려하였다. 완충체의 형상 및 구조를 결정하기 위하여 십자형상이나 원형의 탄소강 구조물을 받침대 상부에 위치하여 그 영향을 알아보았다. 이때 탄소강 구조물의 두께를 24 mm, 12 mm, 6mm로 변화를 주었다. 또한, 탄소강 구조물 사이에 충진하는 폴리우레탄폼의 밀도에 대한 영향을 알아보았다.