• 펄프종이기술
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• 제43권5호
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• pp.34-42
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• 2011

A fiber processing method, which might be an alternative for conventional refining process, was introduced. The method consists of repetitive, gentle, mechanical impacts on fibers, followed by fiber uncurling process. This method was very effective for OCC and BCTMP for increasing WRVs (water retention value) while keeping fiber lengths from shortening. For OCC and BCTMP, gentle mechanical impacts on fibers using Hobart mixer increased breaking lengths and tear strengths simultaneously at fast drainage level, and straightening fibers using kady mill increased those strength properties further. For SwBKP and HwBKP, only mechanical impacts using the Hobart mixer were effective on increasing tensile and tear strength at fast drainage, but there were no further increase by kady mill treatment. The strength increases of BCTMP by this alternative fiber processing method were exceptionally high. An extensive engineering development should be followed to actualize this fiber processing mechanism in an energy-effect way.

• Animal Bioscience
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• 제37권2_spc호
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• pp.385-395
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• 2024

Ruminal ciliates are a fundamental constituent within the rumen microbiome of ruminant animals. The complex interactions between ruminal ciliates and other microbial guilds within the rumen ecosystems are of paramount importance for facilitating the digestion and fermentation processes of ingested feed components. This review underscores the significance of ruminal ciliates by exploring their impact on key factors, such as methane production, nitrogen utilization efficiency, feed efficiency, and other animal performance measurements. Various methods are employed in the study of ruminal ciliates including culture techniques and molecular approaches. This review highlights the pressing need for further investigations to discern the distinct roles of various ciliate species, particularly relating to methane mitigation and the enhancement of nitrogen utilization efficiency. The promotion of establishing robust reference databases tailored specifically to ruminal ciliates is encouraged, alongside the utilization of genomics and transcriptomics that can highlight their functional contributions to the rumen microbiome. Collectively, the progressive advancement in knowledge concerning ruminal ciliates and their inherent biological significance will be helpful in the pursuit of optimizing rumen functionality and refining animal production outcomes.

• International journal of advanced smart convergence
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• 제13권1호
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• pp.129-139
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• 2024

In digital marketing, the strategic use of emojis in social media advertising, particularly on the Xiaohongshu app, significantly influences consumer acceptance and purchase behavior. This study examines the impact of emoji-laden advertisements and the role of brand metaphorical warmth on consumer perceptions. Employing a tailored questionnaire, the research explores how emojis affect brand advertisement reception, filling a gap in empirical research on emoji advertising effectiveness. Findings indicate that emojis, when used judiciously, enhance consumer acceptance and contribute to a positive brand perception. However, excessive use may undermine trust. Brand metaphorical warmth emerges as a crucial factor, suggesting that emojis can effectively convey warmth, fostering a deeper emotional connection with consumers. These insights offer practical implications for refining social media marketing strategies, advocating for a balanced approach to emoji usage in advertisements to optimize engagement and influence consumer behavior.

• IMMUNE NETWORK
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• 제24권4호
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• pp.28.1-28.13
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• 2024

Vaccines are the most effective intervention currently available, offering protective immunity against targeted pathogens. The emergence of the coronavirus disease 2019 pandemic has prompted rapid development and deployment of lipid nanoparticle encapsulated, mRNA-based vaccines. While these vaccines have demonstrated remarkable immunogenicity, concerns persist regarding their ability to confer durable protective immunity to continuously evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. This review focuses on human B cell responses induced by SARS-CoV-2 mRNA vaccination, with particular emphasis on the crucial role of germinal center reactions in shaping enduring protective immunity. Additionally, we explored observations of immunological imprinting and dynamics of recalled pre-existing immunity following variants of concern-based booster vaccination. Insights from this review contribute to comprehensive understanding B cell responses to mRNA vaccination in humans, thereby refining vaccination strategies for optimal and sustained protection against evolving coronavirus variants.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8_spc호
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• pp.1275-1283
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• 2019

Goats (Capra hircus) were domesticated during the late Neolithic, approximately 10,500 years ago, and humans exerted minor selection pressure until fairly recently. Probably the largest genetic change occurring over the millennia happened via natural selection and random genetic drift, the latter causing genes to be fixed in small and isolated populations. Recent human-influenced genetic changes have occurred through biometrics and genomics. For the most part, biometrics has concentrated upon the refining of estimates of heritabilities and genetic correlations. Heritabilities are instrumental in the calculation of estimated breeding values and genetic correlations are necessary in the construction of selection indices that account for changes in multiple traits under selection at one time. Early genomic studies focused upon microsatellite markers, which are short tandem repeats of nucleic acids and which are detected using polymerase chain reaction primers flanking the microsatellite. Microsatellite markers have been very important in parentage verification, which can impact genetic progress. Additionally, microsatellite markers have been a useful tool in assessing genetic diversity between and among breeds, which is important in the conservation of minor breeds. Single nucleotide polymorphisms are a new genomic tool that have refined classical BLUP methodology (biometric) to provide more accurate genomic estimated breeding values, provided a large reference population is available.

• 환경영향평가
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• 제24권6호
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• pp.549-560
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• 2015

농공단지에 입주제한된 31개 업종의 업종별 배출특성에 따른 화학적 유해성을 근거로 업종별 환경영향을 계량화하여 입지규제 우선순위을 도출하였다. 농공단지에 입주제한된 31개 업종의 환경상의 악영향과 환경기술발전에 따른 환경유해성 저감을 동시에 고려한 합리적 토지이용 관리방안을 수립하기 위하여 업종별로 수계, 토양 및 대기의 매체별 배출량 및 배출물질 $LC_{50}$ 자료에 의해 산정된 인체위해성과 생태위해성을 노출평가와 독성평가로 분석하는 화학적 등급화기법(CRS : Chemical Ranking and Scoring System)에 PRTR (Pollutant Release and Transfer Registers) 자료를 활용하였다. 농공단지 폐수배출관련 31개 업종에 대한 환경유해성을 도출한 결과에 의하면 2012년 기준으로 도금 착색 및 기타 표면처리강재 제조업, 생물학적 제제 제조업, 동 제련정련 및 합금 제조업, 솜 및 실 염색가공업, 그외 기타 1차철강 제조업, 기타 비철금속 압연압출 및 연신제품 제조업 등 6개 업종은 환경영향 점수가 상대적으로 낮게 산출되어 제조공정상에서 특정수질유해물질을 배출허용기준 이하로 배출된다고 인정하는 경우에 농공단지 입주제한을 완화시킬 수 있는 업종으로 평가된다.

• 펄프종이기술
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• 제30권4호
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• pp.18-27
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• 1998

Biopulping is defined as the treatment of wood chips with lignin-degrading fungi prior to pulping. Fungal pretreatment prior to mechanical pulping reduces electrical energy requirements during refining or increases mill throughput, improves paper strength, reduces the pitch content, and reduces the environmental impact of pulping. Our recent work involved scaling up the biopulping process towards the industrial level, investigating both the engineering and economic feasibility. We envision the process to be done in either a chip-pile or silo-based system for which several factors need to be considered: the degree of decontamination, a hospitable environment for the fungus, and the overall process economics. Currently, treatment of the chips with low-pressure steam is sufficient for decontamination and a simple, forced ventilation system maintains the proper temperature, humidity, and moisture conditions, thus promoting uniform growth of the fungus. The pilot-scale trial resulted in the successful treatment of 4 tons of wood chips (dry weight basis) with results comparable to those on a laboratory. Larger, 40-ton trials were also successful, with energy savings and paper properties comparable with the laboratory scale. The overall economics of the process also look very favorable and can result in significant annual savings to the mill. Although the current research has focused on biopulping for mechanical pulping, it is also beneficial for sulfite chemical pulping and some applications to recycled fiber have been investigated.

• 한국의료질향상학회지
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• 제2권2호
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• pp.72-111
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• 1996

Background: Group occupational health program by non-for-profit agency, started five years ago, for management of health problems in small and medium sized industries, is one of the measures to cope with limited human and financial resources in occupational health. The program has been rapidly expanding to include 54 participating institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. Objectives : The aim of this study are to develop and apply criteria to assess quality of newly developed Korean group occupational health program. Methods : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, we included followings as core elements of sound occupational health program; accessibility, continuity, intersectoral collaboration, comprehensiveness, community participation, technical quality, adequacy, focus on preventive services, acceptability, and workers' satisfaction. Again we divided each elements into five major components of national health system infrastructures developed by World Health Organization; development of health resources organized arrangement or resources, delivery of health care, economic support, and management. In turn, we categorized each component into input, process and outcome aspects. After discussions in expert panel, several criteria were selected for evaluation of program. The criteria were modified according to each group of interviewees. Results: We developed five sets of questionnaire that evaluate the quality of 'Group occupational health program'. Conclusion : The refining of the measurement tool and the continuing evaluation process for the 'Group occupational health institute' should be done further.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5191-5197
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• 2015

A partial response or resistance to chemotherapeutic agents is considered as a main obstacle in treatment of patients with cancer, including breast cancer. Refining taxane-based treatment procedures using adjuvant or combination treatment is a novel strategy to increase the efficiency of chemotherapy. PPM1D is a molecule activated by reactive oxygen species. whose expression is reported to modulate the recruitment of DNA repair molecules. In this study we examined the impact of arsenic trioxide on efficacy of paclitaxel-induced apoptosis in paclitaxel-resistant MCF-7 cells. We also investigated the expression of PPM1D and TP53 genes in response to this combination treatment. Resistant cells were developed from the parent MCF-7 cell line by applying increasing concentrations of paclitaxel. MTT assays were applied to determine the rate of cell survival. DAPI staining using fluorescent microscopy was employed to study apoptotic bodies. Real-time RT-PCR analysis was also applied to determine PPM1D mRNA levels. Our results revealed that combination of arsenic trioxide and paclitaxel elevates the efficacy of the latter in induction of apoptosis in MCF-7/PAC resistant cells. Applying arsenic trioxide also caused significant decreases in PPM1D mRNA levels (p<0.05). Our findings suggest that arsenic trioxide increases paclitaxel-induced apoptosis by down regulation of PPM1D expression. PPM1D dependent signaling can be considered as a novel target to improve the efficacy of chemotherapeutic agents in resistant breast cancer cells.

• 한국정보과학회논문지:소프트웨어및응용
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• 제33권2호
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• pp.186-200
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• 2006

분석 모델은 오직 시스템의 기능적 요구사항에 초점을 두며, 비 기능적인 요구사항과 구현과 관련된 이슈들은 이후의 설계 작업이 착수될 때까지 미루어진다. 설계 활동은 분석 모델을 상세화하고 명확하게 하는 방식으로 수행된다. 따라서, 분석 모델의 품질은 설계 모델에 지대한 영향을 미친다. 그러므로, 정확한 분석 모델을 구축하기 위하여 많은 노력을 기울여야 한다. 본 논문에서는 전형적인 객체지향 개발 방법론의 분석 모델이 항상 충족해야 하는 구조적 제약 사항을 제안한다. 제약 사항은 개별 클래스에 관한 제약사항, 클래스간의 관계에 대한 제약 사항과 클래스의 사용에 대한 제약사항으로 분류된다. 각 제약사항 변로 정형적인 정의와 OCL을 이용한 기술이 제공된다. 또한, 2개의 산업체 프로젝트를 대상으로 수행된 사례 연구를 통하여 제안된 기법이 객체지향 분석 모델에 존재하는 심각한 오류를 발견하고 이를 수정하는 데 도움을 줄 수 있음을 보여 준다.