• Biomolecules & Therapeutics
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• v.28 no.1
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• pp.98-103
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• 2020

Marfan syndrome (MFS), a connective tissue disorder caused by mutations in the fibrillin-1 (Fbn1) gene, has vascular manifestations including aortic aneurysm, dissection, and rupture. Its vascular pathogenesis is assumed to be attributed to increased transforming growth factor β (TGFβ) signaling and blockade of excessive TGFβ signaling has been thought to prevent dissection and aneurysm formation. Here, we investigated whether galunisertib, a potent small-molecule inhibitor of TGFβ receptor I (TβRI), attenuates aneurysmal disease in a murine model of MFS (Fbn1^C1039G/+) and compared the impact of galuninsertib on the MFS-related vascular pathogenesis with that of losartan, a prophylactic agent routinely used for patients with MFS. Fbn1^C1039G/+ mice were administered galunisertib or losartan for 8 weeks, and their ascending aortas were assessed for histopathological changes and phosphorylation of Smad2 and extracellular signal-regulated kinase 1/2 (Erk1/2). Mice treated with galunisertib or losartan barely exhibited phosphorylated Smad2, suggesting that both drugs effectively blocked overactivated canonical TGFβ signaling in Fbn1^C1039G/+ mice. However, galunisertib treatment did not attenuate disrupted medial wall architecture and only partially decreased Erk1/2 phosphorylation, whereas losartan significantly inhibited MFS-associated aortopathy and markedly decreased Erk1/2 phosphorylation in Fbn1^C1039G/+ mice. These data unexpectedly revealed that galunisertib, a TβRI inhibitor, showed no benefits in aneurysmal disease in MFS mice although it completely blocked Smad2 phosphorylation. The significant losartan-induced inhibition of both aortic vascular pathogenesis and Smad2 phosphorylation implied that canonical TGFβ signaling might not prominently drive aneurysmal diseases in MFS mice.

• The Journal of Industrial Distribution & Business
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• v.9 no.1
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• pp.89-97
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• 2018

Purpose - The Regional Comprehensive Economic Partnership (RCEP) among 16 countries including South Korea, the largest free trade agreement in the Asia-Pacific region, will be concluded next year. The participating countries decided to pursue a comprehensive and high -quality agreement, while ensuring flexibility considering development level of each country. In this study, trade structures between nations from 2005 through 2016 were examined to see the impact that this agreement will have on Korea and to come up with effective countermeasures. Research design, data, and methodology - The method of analysis includes the analysis of the trade matrix, which is useful for identifying the dependency of the individual countries on the market in the region and the reciprocal dependency of the member countries on the market, and the index of intensity of trade, which is useful for figuring out the share of trade between the parties in total trade. Results - The results showed that first, the international trade coefficients of Vietnam and Philippines are higher than those of China and Japan. Secondly, the international inducement coefficients between China and Japan were high, and that between Indonesia and Burma were low, indicating that Korea's exports did not have much effect on export increase of these countries. Third, as a result of analyzing Korea's trade intensity, it was found that export intensity and import intensity were greater than 1 in Vietnam and Philippines, which shows that there is a high degree of relational bond with these countries. India and Laos countries still have a low level of relational bond, which indicates that there is room for improvement in economic relations when the agreement is concluded. After the signing of the agreement in the future, more diverse industrial structures should be continuously studied. Conclusions - The analysis of trade matrix, trade structure, trade inducement coefficient and trade intensity between Korea and RCEP participating countries shows that the majority of the countries have the high level of economic relationship with Korea. Korea should drive a harder bargain when negotiating the terms of the RCEP, in comparison with the level of the existing FTA agreement excluding Japan.

• Journal of Drive and Control
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• v.14 no.4
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• pp.1-8
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• 2017

The Down-the-Hole hammer is one of the pneumatic drill equipment used for grinding, drilling, and mining. One the advantages of which is that a reduction work efficiency at deep site are relatively small compared to other drilling methods. Due to the large vibration in the underground area, it is difficult to measure the performance of the hammer, and hammer testing requires substantial production cost and operating expenses so research on the development of the hammer is insufficient. Therefore, this study has developed a dynamic simulation model that apprehends the operating principles of an 8-inch DTH hammer and calculates performance data such as performance impact force, piston speed, and BPM. By using the simulation model, design factors related to strike force and BPM were selected, and the influence of each design factors on performance was analyzed through ANOVA analysis. As a result, be the most important for BPM and the strike force are position of upper port that push the piston in the direction of the bit and in BPM, the size of the empty space between the bits and the piston is the second most important design factor.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.10
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• pp.19-26
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• 2021

In fine-particle injection processing, hard fine particles, such as silicon carbide or aluminum oxide, are injected - using high-pressure air, and a small amount of material is removed by applying an impact to the workpiece by spraying at high speeds. In this study, a two-axis stage device capable of sequence control was developed to spray various shapes, such as circles and squares, on the surface during the micro-particle jetting process to understand the surface-shape micro-particle-processing characteristics. In the experimental device, two stepper motors were used for the linear movement of the two degree-of-freedom mechanism. The signal output from the microcontroller is - converted into a signal with a current sufficient to drive the stepper motor. The stepper motor rotates precisely in synchronization with the pulse-signal input from the outside, eliminating the need for a separate rotation-angle sensor. The major factors of the processing conditions are fine particles (silicon carbide, aluminum oxide), injection pressure, nozzle diameter, feed rate, and number of injection cycles. They were identified using the ANOVA technique on the design of the experimental method. Based on this, the surface roughness of the spraying surface, surface depth of the spraying surface, and radius of the corner of the spraying surface were measured, and depending on the characteristics, the required spraying conditions were studied.

• Nuclear Engineering and Technology
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• v.51 no.7
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• pp.1738-1748
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• 2019

Previous research has shown that the inclined condition has an impact on the natural circulation (natural circulation) mode operation of Floating Nuclear Power Plant (FNPP) mounted on the movable marine platform. Due to its compact structure, small volume, strong maneuverability, the Integral Pressurized Water Reactor (IPWR) is adopted as marine reactor in general. The OTSGs of IPWR are symmetrically arranged in the annular region between the reactor vessel and core support barrel in this paper. Therefore, many parallel natural circulation loops are built between the core and the OTSGs primary side when the main pump is stopped. and the inclined condition would lead to discrepancies of the natural circulation drive head among the OTSGs in different locations. In addition, the flow rate and temperature nonuniform distribution of the core caused by inclined condition are coupled with the thermal hydraulics parameters maldistribution caused by OTSG group operating mode on low power operation. By means of the RELAP5 codes were modified by adding module calculating the effect of inclined, heaving and rolling condition, the simulation model of IPWR in inclined condition was built. Using the models developed, the influences on natural circulation operation by inclined angle and OTSG position, the transitions between forced circulation (forced circulation) and natural circulation and the effect on natural circulation operation by different OTSG grouping situations in inclined condition were analyzed. It was observed that a larger inclined angle results the temperature of the core outlet is too high and the OTSG superheat steam is insufficient in natural circulation mode operation. In general, the inclined angle is smaller unless the hull is destroyed seriously or the platform overturn in the ocean. In consequence, the results indicated that the IPWR in the movable marine platform in natural circulation mode operation is safety. Selecting an appropriate average temperature setting value or operating the uplifted OTSG group individually is able to reduce the influence on natural circulation flow of IPWR by inclined condition.

• Membrane and Water Treatment
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• v.10 no.1
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• pp.45-55
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• 2019

Climate change has significantly affected the rainfall characteristics which can influence the pollutant build-up and wash-off patterns from the catchment. Therefore, this study explored the influence of varying rainfall characteristics on urban and agricultural runoff pollutant export using statistical approaches. For this purpose, Mann-Kendall and Pettitt's test were applied to detect the trend and breakpoint in rainfall characteristics time series. In addition, double mass curve and correlation analysis were used to drive the relationship between rainfall-runoff and pollutant exports from both catchments. The results indicate a significant decreased in total rainfall and average rainfall intensity, while a significant increased trend for antecedents dry days and total storm duration over the study periods. The breakpoint was determined to be 2013 which shows remarkable trend shifts for total rainfall, average rainfall intensity and antecedents dry days except total duration. Double mass curve exhibited a straight line with significant rainfall-runoff relationship indicates a climate change effect on both sites. Overall, higher pollutant exports were observed at both sites during the baseline period as compared to change periods. In agricultural site, most of the pollutants exhibited significant (p< 0.05) association with total rainfall, average rainfall intensity and total storm duration. In contrast, pollutants from urban site significantly correlated with antecedent dry days and average rainfall intensity. Thus, total rainfall, average rainfall intensity and total duration were the significant factors for the agricultural catchment while, antecedents dry days and average rainfall intensity were key factors in build-up and wash-off from the urban catchment.

• Journal of Preventive Medicine and Public Health
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• v.54 no.1
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• pp.22-30
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• 2021

Objectives: The coronavirus disease 2019 (COVID-19) pandemic is a public health emergency posing unprecedented challenges for health authorities. Social media may serve as an effective platform to disseminate health-related information. This study aimed to assess the extent of social media use, its impact on preventive behavior, and negative health effects such as cyberchondria and information overload. Methods: A cross-sectional observational study was conducted between June 10, 2020 and August 9, 2020 among people visiting the outpatient department of the authors' institution, and participants were also recruited during field visits for an awareness drive. Questions were developed on preventive behavior, and the Short Cyberchondria Scale and instruments dealing with information overload and perceived vulnerability were used. Results: The study recruited 767 participants with a mean age of about 45 years. Most of the participants (>90%) engaged in preventive behaviors, which were influenced by the extent of information received through social media platforms (β=3.297; p<0.001) and awareness of infection when a family member tested positive (β=29.082; p<0.001) or a neighbor tested positive (β=27.964; p<0.001). The majority (63.0%) of individuals often searched for COVID-19 related news on social media platforms. The mean±standard deviation scores for cyberchondria and information overload were 9.09±4.05 and 8.69±2.56, respectively. Significant and moderately strong correlations were found between cyberchondria, information overload, and perceived vulnerability to COVID-19. Conclusions: This study provides evidence that the use of social media as an information- seeking platform altered preventive behavior. However, excessive and misleading information resulted in cyberchondria and information overload.

• Smart Structures and Systems
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• v.29 no.1
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• pp.251-266
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• 2022

Structural Health Monitoring (SHM) of critical infrastructure comprises a major pillar of maintenance management, shielding public safety and economic sustainability. Although SHM is usually associated with data-driven metrics and thresholds, expert judgement is essential, especially in cases where erroneous predictions can bear casualties or substantial economic loss. Considering that visual inspections are time consuming and potentially subjective, artificial-intelligence tools may be leveraged in order to minimize the inspection effort and provide objective outcomes. In this context, timely detection of sensor malfunctioning is crucial in preventing inaccurate assessment and false alarms. The present work introduces a sensor-fault detection and interpretation framework, based on the well-established support-vector machine scheme for anomaly detection, combined with a coalitional game-theory approach. The proposed framework is implemented in two datasets, provided along the 1st International Project Competition for Structural Health Monitoring (IPC-SHM 2020), comprising acceleration and cable-load measurements from two real cable-stayed bridges. The results demonstrate good predictive performance and highlight the potential for seamless adaption of the algorithm to intrinsically different data domains. For the first time, the term "decision trajectories", originating from the field of cognitive sciences, is introduced and applied in the context of SHM. This provides an intuitive and comprehensive illustration of the impact of individual features, along with an elaboration on feature dependencies that drive individual model predictions. Overall, the proposed framework provides an easy-to-train, application-agnostic and interpretable anomaly detector, which can be integrated into the preprocessing part of various SHM and condition-monitoring applications, offering a first screening of the sensor health prior to further analysis.

• Journal of Drive and Control
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• v.21 no.2
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• pp.36-43
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• 2024

The yield is basic and necessary information in precision agriculture that reduces input resources and enhances productivity. Yield information is important because it can be used to set up farming plans and evaluate farming results. Yield monitoring systems are commercialized in the United States and Japan but not in Korea. Therefore, such a system must be developed. This study was conducted to develop a yield monitoring system that improved performance by correcting a previously developed flow sensor using a grain tank-weighing system. An impact-plated type flow sensor was installed in a grain tank where grains are placed, and grain tank-weighing sensors were installed under the grain tank to estimate the weight of the grain inside the tank. The grain flow rate and grain weight prediction models showed high correlations, with coefficient of determinations (R2) of 0.9979 and 0.9991, respectively. A main controller of the yield monitoring system that calculated the real-time yield using a sensor output value was also developed and installed in a combine harvester. Field tests of the combine harvester yield monitoring system were conducted in a rice paddy field. The developed yield monitoring system showed high accuracy with an error of 0.13%. Therefore, the newly developed yield monitoring system can be used to predict grain weight with high accuracy.

• Asia-Pacific Journal of Business
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• v.15 no.2
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• pp.1-22
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• 2024

Purpose - The Chinese fan community includes a significant number of young and middle-aged individuals, playing a crucial role in emotional mobilization and social engagement. In recent years, the impact of Celebrity Pairing or Character Pairing (CP) on Weibo has grown notably, partly due to features like Super Topics and Hot Searches. This phenomenon has enhanced fan engagement, resulting in heightened participation in discussions and interactions on the platform. Our study targets CP fans of movies and television dramas on Weibo and aims to identify the factors that drive their emotional sharing. Design/methodology/approach - The research methodology integrates Self-Determination Theory and Social Sharing of Emotion Theory within the EASI (Emotion, Attachment, and Social Integration) model. This approach aims to uncover how CP fans meet their emotional needs via social media and determine the factors influencing their sharing intentions and behaviours. Data were collected through online surveys, yielding 504 valid responses Findings - The analysis, performed with SPSS and Smart PLS software, reveals that self-determination, interpersonal relationships, and social media tolerance significantly affect fans' intentions to share content. Specifically, intrinsic motivation, driven by self-determination, is a critical factor in CP fans' propensity to share content, highlighting the importance of 'inward socialization.' Additionally, the study finds that external factors, like the social media environment, play a more minor role than internal motivators. Research implications or Originality - This research enhances quantitative research methodologies by identifying intrinsic and extrinsic motivations that satisfy the emotional needs of CP fans. It distinguishes between individual, interpersonal, and collective/social factors as motivational elements, providing insights into the emotional and psychological needs of the Chinese movie and TV drama fan community.