• Journal of Pharmacopuncture
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• v.27 no.2
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• pp.59-69
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• 2024

This study investigates the therapeutic potential of Indigo Naturalis (IN) in treating a Inflammatory Bowel Disease (IBD). The objective is to comprehensively examine the effects and pharmacological mechanisms of IN on IBD, assessing its potential as an novel treatment for IBD. Analysis of 11 selected papers is conducted to understand the effects of IN, focusing on compounds like indirubin, isatin, indigo, and tryptanthrin. This study evaluates their impact on Disease Activity Index (DAI) score, colon length, mucosal damage, and macrophage infiltration in Dextran Sulfate Sodium (DSS)-induced colitis mice. Additionally, It investigate into the anti-inflammatory mechanisms, including Aryl hydrocarbon Receptor (AhR) pathway activation, Nuclear Factor kappa B (NF-κB)/nod-like receptor family pyrin domain containing 3 (NLRP3)/Interleukin 1 beta (IL-1β) inhibition, and modulation of Toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MYD88)/NF-κB and Mitogen Activated Protein Kinase (MAPK) pathways. Immunomodulatory effects on T helper 17 (Th17)/regulatory T cell (Treg cell) balance and Glycogen synthase kinase-3 beta (GSK3-β) expression are also explored. Furthermore, the study addresses the role of IN in restoring intestinal microbiota diversity, reducing pathogenic bacteria, and increasing beneficial bacteria. The findings reveal that IN, particularly indirubin and indigo, demonstrates significant improvements in DAI score, colon length, mucosal damage, and macrophage infiltration in DSS-induced colitis mice. The anti-inflammatory effects are attributed to the activation of the AhR pathway, inhibition of inflammatory pathways, and modulation of immune responses. These results exhibit the potential of IN in IBD treatment. Notably, the restoration of intestinal microbiota diversity and balance further supports its efficacy. IN emerges as a promising and effective treatment for IBD, demonstrating anti-inflammatory effects and positive outcomes in preclinical studies. However, potential side effects necessitate further investigation for safe therapeutic development. The study underscores the need for future research to explore a broader range of active ingredients in IN to enhance therapeutic efficacy and safety.

• Journal of Navigation and Port Research
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• v.48 no.3
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• pp.155-163
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• 2024

As the demand for reducing carbon emissions increases, efforts to reduce the usage of fossil fuels and research on renewable energy are also increasing. Among the various renewable energy harvesting techniques, the floating offshore wind turbine has several advantages. Compared to other technologies, it has fewer installation limitations due to interference with human activity. Additionally, a large wind turbine farm can be constructed in the open ocean. Therefore, it is important to conduct motion analysis of floating offshore wind turbines in waves during the initial stage of conceptual design. In this study, a frequency motion analysis was conducted on a semi-submersible type floating offshore wind turbine. The analysis focused on the effects of varying trim on the motion characteristics. Specifically, motion response analysis was performed on heave, roll, and pitch. Natural period analysis confirmed that changing the trim angle did not significantly affect the heave and pitch motions, but it did have a regular impact on the roll motion.

• Journal of Environmental Health Sciences
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• v.50 no.3
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• pp.191-200
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• 2024

Background: Busan is a rapidly industrializing city with many mixed residential and industrial areas. Fine dust emissions from mobile pollution sources such as ships and vehicles are particularly high in Busan. Objectives: This study analyzed the spatial distribution of air pollutants over the past three years and identified the impact of air pollutants through mobile source data in Busan. Methods: We obtained air pollutant data on fine particulate matter (PM₁₀), ultrafine particulate matter (PM_2.5), nitrogen dioxide (NO₂), sulfurous acid gas (SO₂), and ozone (O₃) for the last three years (source: airkorea.or.kr) and analyzed the spatial distribution using SAS 9.4 and Surfer 23. For the mobile pollutant data, we used CCTV data from major intersections in Busan to identify truck and car traffic, and visualized traffic density with QGIS. Results: The analysis of the concentration of air pollutants over three years (2020~2022) showed that all were lower than the annual environmental standards with the exception of PM_2.5. PM₁₀ and PM_2.5 were found to be highly concentrated in the western part of the area, while NO₂ was high in the port area of Busan and SO₂ was high in the western part of the area and near the new port of Busan. In the case of O₃, it was high in the eastern part of the city. The traffic volume of freight vehicles by intersection was concentrated in the West Busan area, and the traffic volume for all cars was also confirmed to be concentrated at "Mandeok Intersection" located in the West Busan area. Conclusions: This study was conducted to determine the relationship between air pollutants emitted from motor vehicles and the distribution of air pollutants in Busan. The spatial distribution of PM₁₀ and PM_2.5 correlates with traffic volume, while high concentrations of SO₂ and NO₂ near the port are associated with ship emissions.

• Convergence Security Journal
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• v.24 no.2
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• pp.181-188
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• 2024

Amid global geopolitical crises that are heightening tensions worldwide, the importance of national security is being reevaluated. Consequently, South Korea is gaining attention in the global defense market due to its superior technology, competitive pricing, and rapid delivery capabilities. The increasing international demand for defense materials offers opportunities for the development of the domestic defense industry and has the potential to lead to long-term defense strategies and an expansion of exports. In particular, the development of future advanced weapons systems and the expansion of defense exports are likely to be possible through a deep understanding of the international political and economic situation and proactive defense diplomacy. This study analyzes the impact of current global geopolitical crises on Korea's defense industry and presents effective strategies based on these findings, including innovative improvements to defense acquisition systems and the discovery of overseas defense cooperation partners to strengthen defense exports. This strategic approach aims to balance domestic consumption with exports, enhance military strength, and improve the country's standing in the international community. Therefore, efforts are needed to ensure the sustainable growth of the defense industry, enabling South Korea to achieve economies of scale and play a pivotal role in the global defense industry.

• Korean Circulation Journal
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• v.53 no.7
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• pp.425-451
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• 2023

Most patients with heart failure (HF) have multiple comorbidities, which impact their quality of life, aggravate HF, and increase mortality. Cardiovascular comorbidities include systemic and pulmonary hypertension, ischemic and valvular heart diseases, and atrial fibrillation. Non-cardiovascular comorbidities include diabetes mellitus (DM), chronic kidney and pulmonary diseases, iron deficiency and anemia, and sleep apnea. In patients with HF with hypertension and left ventricular hypertrophy, renin-angiotensin system inhibitors combined with calcium channel blockers and/or diuretics is an effective treatment regimen. Measurement of pulmonary vascular resistance via right heart catheterization is recommended for patients with HF considered suitable for implantation of mechanical circulatory support devices or as heart transplantation candidates. Coronary angiography remains the gold standard for the diagnosis and reperfusion in patients with HF and angina pectoris refractory to antianginal medications. In patients with HF and atrial fibrillation, longterm anticoagulants are recommended according to the CHA₂DS₂-VASc scores. Valvular heart diseases should be treated medically and/or surgically. In patients with HF and DM, metformin is relatively safer; thiazolidinediones cause fluid retention and should be avoided in patients with HF and dyspnea. In renal insufficiency, both volume status and cardiac performance are important for therapy guidance. In patients with HF and pulmonary disease, beta-blockers are underused, which may be related to increased mortality. In patients with HF and anemia, iron supplementation can help improve symptoms. In obstructive sleep apnea, continuous positive airway pressure therapy helps avoid severe nocturnal hypoxia. Appropriate management of comorbidities is important for improving clinical outcomes in patients with HF.

• Journal of Cadastre & Land InformatiX
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• v.54 no.1
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• pp.33-48
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• 2024

This study aims to establish the scope and statistics of the K-address information industry in Korea, estimating its size and prospects and estimates the economic effects through K-address information industry based on Input-Output analysis. Considering the characteristics and sectoral structure of the K-address information industry, the study delineates the scope and specific sectors, constructing sectoral statistics linked to the KSIC and the Bank of Korea's industrial classification. The study estimates the sectoral industry size, taking into account potential markets. Furthermore, it analyzes the economic impact of each sector within the K-address information industry. To figure out the economic effects, the study conducts Input-Output analysis by setting the K-address information industry as an exogenous sector in the input-output table. The results indicate that the overall size of the K-address information industry is estimated to grow from 406.1 billion KRW in 2021 to 3.65 trillion KRW in 2030. The economic effects of the K-address information industry vary by sector, emphasizing the importance of synergies and integration with related sectors, particularly those with significant inducement effects in high value-added manufacturing and service sectors. Furthermore, the industry's sensitivity to economic fluctuations is evident through the input-output analysis of inter-industry chain effects.

• Journal of Cadastre & Land InformatiX
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• v.54 no.1
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• pp.49-61
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• 2024

South Korea faces a declining population and rural areas vanishing due to urbanization. Infrastructure, especially medical facilities, may not be sustainable for a long-term. This may impact vulnerable groups like children, teens, and the elderly, worsened by an aging population and low birth rates. Gangwon-do, notably Chuncheon-si, suffers from rural depopulation and poor healthcare self-sufficiency. In this paper, using 2SFCA(Two-Step Floating Catchment Area), we analyze healthcare access in Chuncheon-si, identifying gaps and vulnerable areas. LISA analysis helps map medical vulnerability, considering patient demand and supply. The Gini coefficient assesses spatial inequality. We propose distributing healthcare services and personnel based on age and region. The aim is to identify locations for additional hospitals catering to the elders, Infants, Children, and Adolescents,considering spatial accessibility.

• The Korean Journal of Quaternary Research
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• v.34 no.1
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• pp.41-51
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• 2024

The Sincheon wetland shows a remarkable diversity of fluvial landforms, such as river islands, anastomosing channels, braided channels, and sand-gravel bars, which contribute to its rich ecological habitat. The wetland area is characterized by a ecological diversity of herbaceous and woody plants. Significant changes in land cover within the wetlands were observed from 2008 to 2020. Notably, there was a rapid decrease in agricultural area from 18% to 0.04%, while the vegetation area expanded from 45% to 54%. Concurrently, the water area also experienced a notable increase from 34% to 41%. The surface sediment composition in the studied area displays sandy loam characteristics and exhibits acidic soil properties. Sediment acidity tends to increase downstream and in the central part of channels. Variations in acidity are also observed at nearby collection sites due to the tributaries and local discharge. The presence of dense vegetation in river islands and bars has led to a significant transformation of sediments into soil, with this change being more pronounced downstream, particularly near the weirs. The installation of a weir in Sincheon wetland is believed to have a significant impact on altering flow velocities between upstream and downstream sections, as well as influencing erosion and sediment deposition patterns. However, given the formation of landforms in response to weirs, effective administration and management are essential to address potential risks of catastrophic environmental disruptions, such as the removal of weirs and/or the maintenance of river channels.

• Knowledge Management Research
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• v.25 no.2
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• pp.115-134
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• 2024

In an age where consumers can easily search and pass on their opinions of products and purchasing decisions through the internet, Electronic-word-of-mouth(Ewom) plays an important role in decision making of other potential customers. In this study, we empirically analyze the impact EWOM on consumer purchase decisions, when contradictory Ewom is presented from varying sources of information, such as experts and general consumers. First, we find that when there is a consensus among different information sources there exists a positive relationship between Ewom sentiment and purchase intent, confirming the results of previous literature. However, when expert opinion and consumer opinion do not match we find that consumer opinion is more impactful on purchasing decisions compared to the expert opinion, regardless of product types. The findings of this study add insight to the current literature by examining the effect of contradictory Ewom on purchase decisions, and also to industry marketers by presenting a more efficient strategy in promoting positive Ewom for different product types.

• Knowledge Management Research
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• v.25 no.2
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• pp.193-218
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• 2024

The current study investigated the factors influencing the buyer's repurchase intention for second-hand products. This study first identified perceived risk and purchase value as the two primary influencing variables. Additionally, some exogenous variables influencing these two variables were examined. Statistical analysis using Partial Least Squares (PLS) revealed that product uncertainty, seller uncertainty, and site trust had statistically significant relationships with perceived transaction risk. However, while economic benefit showed a significant impact on purchase value, product scarcity and resale value did not exhibit a significant relationship with purchase value. Perceived transaction risk was found to have an insignificant relationship with repurchase intention, but indirectly influenced repurchase intention through purchase value. Purchase value was identified as having a significant influence on repurchase intention. Therefore, it was concluded that purchase value is the most important factor influencing repurchase intention in the purchase of second-hand products, while transaction risk indirectly influences repurchase intention through purchase value. The study indicates that product uncertainty and economic benefit are the most significant exogenous factors influencing transaction risk and purchase value, respectively.