• 대한화학회지
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• 제67권4호
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• pp.306-310
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• 2023

• 대한화학회지
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• 제7권4호
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• pp.230-237
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• 1963

2-Methyl-5,5'-gem-disubstituted-$\Delta^2$-thiazoline系 化合物의 合成을 1,1'-gem-dusubstituted thiiranes의 三員環을 ammonis로 開環하여 骸當하는 N-또는 S-acetyl-amino mercaptan을 얻고 그것을 다시 閉環하는 方法과 또 하나는 같은 三員環인 gem-disubstitutes imines을 thiolacetic acid 로 開環하고 그것을 直接 다시 閉環하여 얻은 두가지 方法에 의하여 硏究하엿다. 前者는 thiirane ring은 gem-disubtitution의 compression 效果에 의하여 極히 安定化되어 여러가지 强力한 反應條件下에서의 sodium amide를 利用한 ammonia nuclephile에 頑强한 抵抗을 나타냈으며 反對로 後者의 三員環 imine은 같은 gem-disubstitution 效果를 받음에도 不拘하고 容易하게 開環하였다. 이 gem-disubstitution 效果에 의한 環狀化合物의 開環阻止性과 閉環促進性을 立體化學的인 見地에서 考察하였으며 本硏究로서 環狀化合物의 安定性에 미치는 gem-disubstitution의 compression 效果는 所謂 Thorpe-Ingold bond angle deformation에 緣由하는 것이 아니고 오히려 gem-dusubstituents와 異節環狀化物內의 hetero atom(s)이 미치는 bond interaction에 起因하다는 結論을 얻었다.

• Bulletin of the Korean Chemical Society
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• 제35권12호
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• pp.3433-3436
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• 2014

A new method for the synthesis of 2,2-dimethyl-6-substituted 4-piperidone was developed; two equivalents of acetone were annulated with N-unsubstituted imines in-situ generated from benzyl azides using a ruthenium catalyst in the presence of $\small{L}$-proline.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.237.2-237.2
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• 2003

A pathway for synthesis of N-methylspiro [1,2,3,4-tetrahydro-naphthalene-1,2'- pyrrolidine] was developed. Formation of the imine compound from ${\alpha}$-tetralone and methylamine using titanium tetrachloride followed by ddition of allylmagnesium bromide gave (1-allyl-1,2,3,4-tetrahydro-naphthalen-1-yl)methylamine. (omitted)

• 대한화학회지
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• 제55권2호
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• pp.218-229
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• 2011

Imine 화합물 1을 hydrazine hydrate와 같은 nitrogenous 시약과 반응시켜서 치환된 pyrimidines 화합물을 합성하였다. 얻어진 화합물 2를 다양한 반응조건, 즉 propionic acid, formic acid, ethyl chloroformate, acdetic anhydride, carbon disulphide, cyanogene bromide, triflauroacetic acid 및 ethyl chloroacetate와 반응시켜서 대응하는 화합물을 좋은 수율로 얻었으며, 반응은 Dimroth-type 자리옮김 반응을 통하여 진행되었다.

• Bulletin of the Korean Chemical Society
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• 제32권2호
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• pp.498-502
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• 2011

The divergent synthesis of novel phosphorus-containing dendrimer with 4,4'-sulphonyldiphenol at the core has been accomplished involving simple condensation reactions using $P(O)Cl_3$, $P(S)Cl_3$, 3-amino-phenol, 3-hydroxy-benzaldehyde, and 2-butyn 1, 4-diol. The final compound was a Schiff's base macromolecule possessing 4 imine bonds, 8 acetylenic bonds and 8 OH groups at the periphery. The structures of intermediate compounds were confirmed by IR, NMR ($^1H$, $^{13}C$ and $^{31}P$), LC-Mass and C, H, N analysis. The structure of the final dendrimer (5) was confirmed by IR, NMR ($^1H$, $^{13}C$ and $^{31}P$), MALDI-TOF-MS, and C, H, N analysis. The surface morphological characteristics of the final dendrimer were understood by Scanning Electronic Microscopic study (SEM). The thermal stability of the final dendrimer was studied by TGA/DTA analysis.

• Journal of Applied Biological Chemistry
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• 제54권2호
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• pp.143-146
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• 2011

Novel pyrazoline (4) was synthesized from chalcone (3) which was prepared from 2'-hydroxy-l'acetonaphthone (1) and 4-methoxy benzaldehyde (2). Pyrazoline (4) forms resonance assisted hydrogen bond between naphthol hydroxyl group and imine nitrogen in a pyrazoline ring. Pyrazoline (4) shows Poly ADP-ribose Polymerase (PARP) cleavage ability as a proof of apoptosis in cancer cell, which reveals its anti-cancer property.

• Bulletin of the Korean Chemical Society
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• 제33권1호
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• pp.43-47
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• 2012

An efficient synthetic method for the preparation of quinolines through indium(III) chloride-catalyzed tandem addition-cyclization-oxidation reactions of imines with alkynes was developed. The processes can provide a diverse range of quinoline derivatives in good yields from simple imines and alkynes.

• Bulletin of the Korean Chemical Society
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• 제26권10호
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• pp.1501-1502
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• 2005

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.362.2-362.2
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• 2002

Antofine belongs to the Phenathroindolizidine group of alkaloids. This natural products exhibit interesting biological properties such as antitumour activity. and anti-inflammentory. Wittig reaction of phenathrenealdehyde with the phosponium salt provided the phenathreneazidealkene in good yield. Intramolecular 1.3-dipolar cycloaddition of the resulting azidealkent in refluxing benzene proceeded the imine. It was reduced with cyanoborohydride of Noyori's Asymmetric Hydrogenation. (omitted)