• 비파괴검사학회지
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• 제26권2호
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• pp.115-121
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• 2006

유한 요소 해석을 위해서는 형상과 경계, 하중 조건 그리고 물성을 결정하여야 한다. 그러나 살아 있는 인체에 대해서는 실험이 어렵기 때문에 정확한 형상과 물성을 얻기가 매우 어렵다. 본 논문에서는 한국인 표준체형을 가진 젊은 남성의 생체 자기 공명 영상(MRI : magnetic resonance imaging)을 이용하여 내부 장기를 38가지로 구역화 하고 이것을 이용하여 정밀 유한 요소 모델을 만들었다. 또한 인체를 이루고 있는 다양한 물질들 가운데 뼈에 대한 물성을 얻기 위한 연구를 시행하였다. 인체 뼈의 이방성을 표현할 수 있는 물성을 얻기 위해 성인 남성과 여성의 사체에서 얻은 대퇴골두 시편을 RUS(resonant ultrasound spectroscopy)를 사용하여 탄성 계수 행렬을 얻을 수 있었다.

• Journal of the Optical Society of Korea
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• 제13권3호
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• pp.310-315
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• 2009

We report the fabrication of double clad fiber (DCF) and DCF coupler, suitable for fiber based imaging systems requiring the dual-channel transmission. Unlike the conventional DCF which uses silica for both cladding layers, the proposed DCF uses a low-index polymer for its outer-cladding layer coated over the conventional silica inner-cladding layer. The DCF is drawn with a conventional SMF preform but a low-index polymer coating is used for both jacket and outercladding of the fiber. To achieve the cladding mode coupling, a DCF coupler is fabricated by simply twisting two pieces of the proposed DCF after removing the polymer-coating at contacting regions. A cladding mode coupling ratio of 30% was achieved with a contact length of 16 cm. The proposed DCF and DCF coupler were employed in a composite optical coherence tomography (OCT) and fluorescence spectroscopy (FS) system, and both OCT images and FS signal from a plant tissue are measured simultaneously.

• 한국광물학회지
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• 제32권1호
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• pp.63-69
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• 2019

광물 구조에 분포하는 철의 산화수 정보는 유 무기적 퇴적광물형성 시 산화환원 조건 등 과거 퇴적 환경에 대한 정보를 제공한다. 특히, 생광물화작용에서 미생물의 역할을 규명하기 위해서는 고분해능 투과 전자현미경(HRTEM) 및 전자에너지 손실 분광기(EELS)를 활용한 나노스케일 분석이 필요하다. HRTEM-EELS를 이용한 광물구조 내 철의 산화수 및 탄소 결합 구조 분석, Fe(II)/Fe(III) 및 탄소 기원 분포영상으로부터 광물생성의 생물학적 요소를 판별할 수 있다. 이와 같은 나노스케일 분석을 통하여 지질미생물학자들은 미생물-광물작용의 증거를 직접적으로 얻을 수 있다.

• Nuclear Engineering and Technology
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• 제55권5호
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• pp.1718-1733
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• 2023

The virtual Frisch-grid method for room-temperature radiation detectors has been widely used because of its simplicity and high performance. Recently, side electrodes were separately attached to each surface of the detectors instead of covering the entire detector surface with a single electrode. The side-electrode structure enables the measurement of the three-dimensional (3D) gamma-ray interaction in the detector. The positional information of the interaction can then be utilized to precisely calibrate the response of the detector for gamma-ray spectroscopy and imaging. In this study, we developed a 3D position-sensitive 5 × 5 × 12 mm³ cadmium-zinc-telluride (CZT) detector and applied a flattening method to correct detector responses. Collimated gamma-rays incident on the surface of the detector were scanned to evaluate the positional accuracy of the detection system. Positional distributions of the radiation interactions with the detector were imaged for quantitative and qualitative evaluation. The energy spectra of various radioisotopes were measured and improved by the detector response calibration according to the calculated positional information. The energy spectra ranged from 59.5 keV (emitted by ²⁴¹Am) to 1332 keV (emitted by ⁶⁰Co). The best energy resolution was 1.06% at 662 keV when the CZT detector was voxelized to 20 × 20 × 10.

• Investigative Magnetic Resonance Imaging
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• 제8권1호
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• pp.42-49
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• 2004

목적 : 자기공명영상시스템에서 양자화잡음을 분석하였다. 신호대양자화잡음비를 이론적으로 유도하였고 다양한 자기공명영상시스템에서 신호대양자화잡음비를 계산하였다. 이러한 계산으로부터 고자장영상시스템에서는 양자화잡음이 전체시스템의 신호대잡음비를 결정짓는 주된 잡음원이 될 수 있음을 보였다. 하드웨어의 교체없이 양자화잡음을 줄일 수 있는 방법들을 제시하였다. 대상 및 방법 : 자기공명영상에서 사용되는 Fourier 영상기법에서는 위상 및 주파수 인코딩 방법으로 자기공명신호를 공간주파수 형태의 신호로 변환하여 측정하게 된다. 따라서 공간주파수 영역에서 발생하는 양자화잡음을 재구성된 영상에서의 신호대양자화잡음비로 나타내었다. 컴퓨터 시뮬레이션 및 실험을 통하여 유도된 식의 타당성을 보였다. 결과 : 유도된 식을 이용하여 다양한 주 자장 및 수신 시스템에 대하여 신호대양자잡음비를 계산하였다. 양자화잡음은 신호의 크기에 비례하여 증가하므로 상대적으로 신호가 큰 고자장 시스템에서 보다 큰 문제점으로 부각될 수 있다. 많은 수신 시스템에서 채택하고 있는 16 bits/샘플 양자기로는 양자화 잡음이 고자장 시스템에서 기대되는 신호대잡음비의 향상을 제한할 수 있는 주된 잡음원이 될 수 있음을 보였다. 결론 : fMRI나 spectroscopy를 위하여 자기공명영상의 주 자장은 지속적으로 높아지고 있다. 고자장에서는 신호가 커지고, susceptibility와 스펙트럼의 분리가 커져서 fMRI 나 spectroscopy에 유리한 면이 많다. 양자화잡음은 신호의 크기에 비례하여 증가하기 때문에 만약 양자기의 변환 비트가 충분히 크지 않을 경우 양자화잡음이 커져 신호의 증가에 비례하는 신호대잡음비의 향상을 이룰 수 없다. 이 논문에서는 신호대양자화잡음비를 이론적으로 유도하고, 다양한 자장의 세기 및 수신 시스템에 대하여 신호대양자화잡음비를 계산함으로써 고자장에서, 특히 상대적으로 신호가 큰 3차원영상에서 , 양자화잡음이 전체 시스템의 신호대잡음비를 제한할 수 있는 주된 잡음원이 될 수 있음을 보였다. 근원적인 해결책은 아닐 수 있으나 oversampling과 에코의 센터를 비껴가는 샘플링으로 하드웨어의 향상없이 양자화잡음을 줄일 수 있는 방법을 제시하였다.

• Clinical and Experimental Pediatrics
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• 제55권10호
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• pp.397-402
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• 2012

Pelizaeus-Merzbacher disease (PMD) is a rare, X-linked recessive disorder characterized by dysmyelination in the central nervous system. PMD results from deletion, mutation, or duplication of the proteolipid protein gene (PLP1) located at Xq22, leading to the failure of axon myelination by oligodendrocytes in the central nervous system. PMD may be suspected when there are clinical manifestations such as nystagmus, developmental delays, and spasticity, and genetic analysis can confirm the diagnosis. Further diagnostic manifestations of the disease include a lack of myelination on brain magnetic resonance (MR) imaging and aberrant N-acetyl aspartate (NAA) and choline concentrations that reflect axonal and myelination abnormalities on phroton MR spectroscopy. We report 5 cases of PMD (in 1 girl and 4 boys). PLP1 duplication was detected in 2 patients. Brain MR analyses and MR spectroscopy were performed for all the patients. The brain MR images showed white matter abnormalities typical of PMD, and the MR spectroscopic images showed diverse patterns of NAA, creatinine, and choline concentrations. We propose that MR spectroscopic analysis of metabolic alterations can aid the PMD diagnosis and can contribute to a better understanding of the pathogenesis of the disease.

• Investigative Magnetic Resonance Imaging
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• 제19권4호
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• pp.231-236
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• 2015

A 17-year-old girl presented with complaints of headache and decreasing vision of one month's duration, without any history of fever, weight loss, or any evidence of an immuno-compromised state. Her neurological examination was normal, except for papilledema. Laboratory investigations were within normal limits, except for a slightly increased Erythrocyte Sedimentation Rate (ESR). Non-contrast computerized tomography of her head revealed complex mass in left frontal lobe with a concentric, slightly hyperdense, thickened wall, and moderate perilesional edema with mass effect. Differential diagnoses considered in this case were pilocytic astrocytoma, metastasis and abscess. Magnetic resonance imaging (MRI) obtained in 3.0 Tesla (3.0T) scanner revealed a lobulated outline cystic mass in the left frontal lobe with two concentric layers of T2 hypointense wall, with T2 hyperintensity between the concentric ring. Moderate perilesional edema and mass effect were seen. Post gadolinium study showed a markedly enhancing irregular wall with some enhancing nodular solid component. No restricted diffusion was seen in this mass in diffusion weighted imaging (DWI). Magnetic resonance spectroscopy (MRS) showed increased lactate and lipid peaks in the central part of this mass, although some areas at the wall and perilesional T2 hyperintensity showed an increased choline peak without significant decrease in N-acetylaspartate (NAA) level. Arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) enhanced perfusion study showed decrease in relative cerebral blood volume at this region. These features in MRI were suggestive of brain abscess. The patient underwent craniotomy with excision of a grayish nodular lesion. Abundant acid fast bacilli (AFB) in acid fast staining, and epithelioid cell granulomas, caseation necrosis and Langhans giant cells in histopathology, were conclusive of tubercular abscess. Tubercular brain abscess is a rare manifestation that simulates malignancy and cause diagnostic dilemma. MRI along with MRS and magnetic resonance perfusion studies, are powerful tools to differentiate lesions in such equivocal cases.

• 한국자기공명학회논문지
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• 제10권1호
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• pp.105-114
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• 2006

Purpose: We achieved high resolution MR imaging and spectra of human skin in vitro with using a 14.1 T MRI/MRS system, and evaluated the hydration effect of various cosmetic products by measuring the skin's. moisture concentration. Materials and Methods: We used the Bruker 14.1 T MRI/MRS system with a vertical standard bore that was equipped with a DMX spectrometer gradient system (200 G/cm at a maximum 40 A), RF resonators (2, 5 and 10 mm) and Para Vision software. Spin echo and fast spin echo pulse sequences were employed for obtaining the high resolution MR images. The 3D-localized point resolved spectroscopy (PRESS) method was used to acquire the MR spectra. Results: The high resolution MR images and spectra of human skin in vitro were successfully obtained on a 14.1 T system. The water concentration of human skin after applying a moisturizer was higher than that before applying a moisturizer. Conclusions: The present study demonstrated that the high-resolution MR images and spectra of human skin from a high field NMR instrument could be applicable to evaluating the hydration state of the stratum corneum.

• Journal of Biosystems Engineering
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• 제40권2호
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• pp.124-136
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• 2015

Purpose: Grain quality is a general concept that covers many characteristics, ranging from physical to biochemical and physiochemical properties. Rice aging during storage is currently a challenge in the rice industry, and is a complicated process involving changes in all of the above properties. Spectroscopic techniques can be used to obtain information on the quality of rice samples in a non-destructive manner. Methods: The objective of this review was to highlight the factors that contribute to rice quality and aging, and to describe various spectroscopic modalities, particularly vibrational and hyperspectral imaging, for the assessment of rice quality. Results: Starch and protein are the main components of the rice endosperm, and are therefore key factors contributing to eating and cooking quality. While the overall starch, protein, and lipid content in the rice grain remains essentially unchanged during storage, structural changes do occur. These changes affect pasting and gel properties, and ultimately the flavor of cooked rice. In addition, grain quality is significantly affected by growing and environmental conditions, such as water availability, temperature, fertilizer application, and salinity stress. These properties can be evaluated using spectroscopic techniques, and rice samples can be discriminated by using multivariate statistical analysis methods. Conclusion: Hyperspectral imaging and vibrational spectroscopy techniques have good potential for determining rice quality properties in a non-invasive manner, i.e., not requiring the introduction of instruments into the rice grain.

• Investigative Magnetic Resonance Imaging
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• 제19권4호
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• pp.212-217
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• 2015

Purpose: For a single time-point hyperpolarized $^{13}C$ magnetic resonance spectroscopy imaging (MRSI) of animal models, scan-time window after injecting substrates is critical in terms of signal-to-noise ratio (SNR) of downstream metabolites. Pre-scans of time-resolved magnetic resonance spectroscopy (MRS) can be performed to determine the scan-time window. In this study, based on two-site exchange model, protocol-specific simulation approaches were developed for $^{13}C$ MRSI and the optimal scan-time window was determined to maximize the SNR of downstream metabolites. Materials and Methods: The arterial input function and conversion rate constant from injected substrates (pyruvate) to downstream metabolite (lactate) were precalibrated, based on pre-scans of time-resolved MRS. MRSI was simulated using two-site exchange model with considerations of scan parameters of MRSI. Optimal scan-time window for mapping lactate was chosen from simulated lactate intensity maps. The performance was validated by multiple in vivo experiments of BALB/C nude mice with MDA-MB-231 breast tumor cells. As a comparison, MRSI were performed with other scan-time windows simply chosen from the lactate signal intensities of pre-scan time-resolved MRS. Results: The optimal scan timing for our animal models was determined by simulation, and was found to be 15 s after injection of the pyruvate. Compared to the simple approach, we observed that the lactate peak signal to noise ratio (PSNR) was increased by 230%. Conclusion: Optimal scan timing to measure downstream metabolites using hyperpolarized $^{13}C$ MRSI can be determined by the proposed protocol-specific simulation approaches.