• International Journal of Computer Science & Network Security
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• 제22권6호
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• pp.246-250
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• 2022

The article analyzes the regulations of current criminal law and current issues, combating drug crime on the Internet, as well as measures to combat drug crime in the field of modern information technology. In connection with the growth of crimes in the field of drug trafficking committed with the use of information and telecommunications technologies, the urgent task of the state is to find effective ways to reduce drug crime. The article considers criminologically significant aspects of the mechanism of illicit drug trafficking, which is carried out with the use of information and telecommunication technologies and means of remote communication.

• 지역사회간호학회지
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• 제18권1호
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• pp.136-145
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• 2007

Purpose: This study was attempted to illuminate danger signals through an extensive analysis of factors influencing adolescents' illicit drug use. On this basis, it built predictive factors of adolescents' illicit drug use. Method: A questionnaire was distributed to 1,238 subjects living in Seoul, and of them 1,082 answers were analyzed using the SAS 8.2 program. Also logistic regression analysis was conducted based on the stepwise selection method for constructing the predictive factors. Results: The findings of this study are as follows. Individual-related factors were psycho-somatic symptoms, self-esteem, fortune delinquent experience, and sexual-violence delinquent experience. Home-related factors were insincerity, threatening and the assessment of the parent (rearer)-adolescent communication type. Society-related factors were affection of friends and friends' attitude toward delinquency. Conclusion: These findings of this study suggest that a broad intervention program should be provided to nurture wholesome youth culture related to illicit drug use. It is also recommended that a variety of individual, home and society-related programs should be developed for drug users.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.705-714
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• 2012

Objectives: This study assessed the associations between socio-demographic, health and wellbeing variables (independent variables) and daily smoking, attempts to quit smoking, and agreement with smoking ban (dependent variables). Methods: Data from 3,706 undergraduate students were collected from seven universities in England, Wales, and Northern Ireland using a standardised questionnaire. Results: About 15.8% of the whole sample reported daily smoking, while 12% were occasional smokers. Smoking was significantly more prevalent among males, but the difference was due to a higher rate of occasional smokers. About every second smoker (55%) had attempted to quit smoking. Almost 45% of the whole sample agreed or strongly agreed with implementing a total smoking ban on campus. Daily smoking was more likely among students with not sufficient income, students whose fathers had at least a bachelor degree; and, students who reported binge drinking. Conversely, daily smoking was less likely among students who rated their health as very good/ excellent, those who ate ${\geq}5$ portions of fruit or vegetables, and those who had never taken illicit drugs. Previous attempt/s to quit smoking were more likely among students who have never taken illicit drugs and those who agreed with a total smoking ban; and less likely among those with not sufficient income. Daily smokers were less likely to report quit attempts as compared to occasional smokers. An agreement with smoking ban was more likely among students who rated their health as very good/excellent, those who ate ${\geq}5$ portions of fruit or vegetables daily, and those who had never taken illicit drugs, but less likely among daily smokers. Conclusion: Favourable health practices and positive attitudes towards smoking ban were associated with each other. Interventions would need to comprise multi-component programmes that do not solely focus on smoking prevention/cessation, but also on other health promoting practices as well.

• Journal of Preventive Medicine and Public Health
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• 제51권1호
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• pp.23-32
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• 2018

Objectives: To identify the associations of characteristics of the neighborhood environment with substance abuse among clients receiving treatment for drug abuse in Thailand. Methods: A cross-sectional study was conducted of 1128 drug addicts from 28 neighborhoods who were receiving treatment at all 7 compulsory drug detention centers in Thailand. A trained interviewer conducted structured interviews with the subjects about substance use and the perceived neighborhood environment in their community. A multilevel logistic regression model was applied to estimate the effects of the neighborhood environment on substance use. Results: The majority of participants, 53.8% only used methamphetamine pills, 31.3% used other illicit drugs as well as methamphetamine pills, and 14.9% used an illicit drug other than methamphetamine. Three neighborhood characteristics were associated with substance use. A 1-unit increase in the perceived neighborhood cohesion score was associated with a 15% reduction in methamphetamine pill use and an 11% reduction of the use of both methamphetamine pills and another illicit drug. Conversely, a 1-unit increase in perceived neighborhood crime predicted 19 and 14% increases in the use of methamphetamine pills and the use of both methamphetamine pills and another illicit drug, respectively. In addition, a 1-unit increase in the scores for stigma surrounding addiction corresponded to a 25% increase of the use of methamphetamine pills and a 12% increase in the use of both methamphetamine pills and another illicit drug. Conclusions: Substance use among drug addicts was influenced by characteristics of the neighborhood environment. Therefore, prevention and intervention strategies should be designed based on a consideration of the impact of neighborhood context on substance use behaviors.

• Nuclear Medicine and Molecular Imaging
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• 제40권1호
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• pp.1-8
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• 2006

Addiction to illicit drugs is one of today's most important social issues. Most addictive drugs lead to irreversible parenchymal changes in the human brain. Neuroimaging data bring to light the pharmacodynamics and pharmacokinetics of the abused drugs, and demonstrate that addiction is a disease of the brain. Continuous researches better illustrate the neurochemical alterations in brain function, and attempt to discover the links to consequent behavioral changes. Newer hypotheses and theories follow the numerous results, and more rational methods of approaching therapy are being developed. Substance abuse is on the rise in Korea, and social interest in the matter as well. On the other hand, diagnosis and treatment of drug addiction is still very difficult, because how the abused substance acts in the brain, or how it leads to behavioral problems is not widely known. Therefore, understanding the mechanism of drug addiction can improve the process of diagnosing addict patients, planning therapy, and predicting the prognosis. Neuroimaging approaches by nuclear medicine methods are expected to objectively judge behavioral and neurochemical changes, and response to treatment. In audition, as genes associated with addictive behavior are discovered, functional nuclear medicine images will aid in the assessment of individuals. Reviewing published literature on neuroimaging regarding nuclear medicine is expected to be of assistance to the management of drug addict patients. What's more, means of applying nuclear medicine to the care of drug addict patients should be investigated further.

• 아동학회지
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• 제26권2호
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• pp.91-106
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• 2005

The subjects for this study consisted of 301 Korean-American students in grades 6 to 12. Findings of this study showed that most of the risk factors in all domains demonstrated a strong relationship to the use of alcohol, tobacco, and other illicit drugs. In the community domain the most common risk factor was "laws favorable toward drug use"(60.2%); this risk factor increased the odds of substance use by approximately 3 times. The protective factor, "opportunity for positive involvement" in school domain reported by 82% of the sample decreased the probability of substance use by 3 times. The percentage of students "resilient" on all protective factors in the family domain was much lower than that of protective factors in other domains. The strongest predictors of substance use were shown in the peer-individual domain.

• 대한임상독성학회지
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• 제18권1호
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• pp.47-50
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• 2020

A 21-year-old female patient complaining of hemiparesis was diagnosed with right middle cerebral artery infarction. No risk factor was found, despite an extensive young-age stroke work-up, except her history of marijuana use. The patient had smoked marijuana for treating depression for more than five years. Magnetic resonance angiography showed multifocal intra- and extracranial stenoses, suggesting cannabinoid-induced vasculopathy. Since the use of illicit drugs has increased nationwide, physicians should consider it as a possible cause of a stroke due to an unknown etiology.

• 한국콘텐츠학회논문지
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• 제22권6호
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• pp.580-595
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• 2022

본 연구는 중독의 재발예방(Relapse Prevention, RP) 모형을 적용하여 국내외 청년의 라이프스타일과 물질 중독 유병의 관계를 조사하였다. 자료는 온라인 설문(Depression and Anxiety Assessment Test)으로 수집된 단면 데이터를 사용하였으며, 미국과 한국 등 24개국에 거주하는 만 18~24세 청년 926명을 대상으로 하였다. 이 중 17.6%가 심각한 물질중독이 있다고 답했으며, 알코올 중독이 11.2%로 가장 많았고, 다음은 니코틴 중독 10.3%, 마약중독 8.7% 순이었다. 카이제곱 검정과 로지스틱 회귀분석 결과, 모든 라이프스타일 요인(규칙적인 운동, 미량영양소, 트립토판, 엽산 및 오메가-3 지방산이 함유된 음식 섭취량, 성경읽기, 기도와 같은 영적 활동)과 물질중독(마약, 알코올, 니코틴)의 관련성이 통계적으로 유의하였으며, 우울 역시 물질중독과 유의한 상관을 나타냈다. 특히 알코올 중독의 위험은 '성경을 안 읽는다'가 '성경을 읽는다'에 비해 9.870배(95% CI: 4.525-21.525)로 가장 높았고, 니코틴 중독과 마약중독의 위험은 하루 미량영양소 섭취량 '1회 미만'이 '5회 이상'에 비해 각각 9.060배(95% CI: 2.726-30.111), 8.642배(95% CI: 2.022-37.378)로 가장 높았다. 결론적으로, 전인적 라이프스타일 개입은 물질중독 예방과 감소에 도움이 될 수 있다는 것을 시사한다.

• Asian-Australasian Journal of Animal Sciences
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• 제31권7호
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• pp.1062-1071
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• 2018

The misuse of anabolic hormones or illegal drugs is a ubiquitous problem in animal husbandry and in food safety. The ban on growth promotants in food producing animals in the European Union is well controlled. However, application regimens that are difficult to detect persist, including newly designed anabolic drugs and complex hormone cocktails. Therefore identification of molecular endogenous biomarkers which are based on the physiological response after the illicit treatment has become a focus of detection methods. The analysis of the 'transcriptome' has been shown to have promise to discover the misuse of anabolic drugs, by indirect detection of their pharmacological action in organs or selected tissues. Various studies have measured gene expression changes after illegal drug or hormone application. So-called transcriptomic biomarkers were quantified at the mRNA and/or microRNA level by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) technology or by more modern 'omics' and high throughput technologies including RNA-sequencing (RNA-Seq). With the addition of advanced bioinformatical approaches such as hierarchical clustering analysis or dynamic principal components analysis, a valid 'biomarker signature' can be established to discriminate between treated and untreated individuals. It has been shown in numerous animal and cell culture studies, that identification of treated animals is possible via our transcriptional biomarker approach. The high throughput sequencing approach is also capable of discovering new biomarker candidates and, in combination with quantitative RT-qPCR, validation and confirmation of biomarkers has been possible. These results from animal production and food safety studies demonstrate that analysis of the transcriptome has high potential as a new screening method using transcriptional 'biomarker signatures' based on the physiological response triggered by illegal substances.

• 약학회지
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• 제41권6호
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• pp.698-703
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• 1997

Recently, l-deprenyl (selegiline), a relative new antiparkinson`s drug, has been marketed in Korea. As its metabolites, l-methamphetamine and l-amphetamine, are the enantiomers of illicit drugs,d-methamphetamine and d-amphetamine, a method for analysis of enantiomers of methamphetamine and amphetamine in rat urine was investigated. The optical isomers of methamphetamine and amphetamine were analyzed with the chiral derivatizing reagent (S)-(-)-N-(trifluoroacetyl)-prolyl chloride (l-TFP), which was used to form the diastereomers of methamphetamine and amphetamine. And all diastereomers (l-TFP -l-AM, lTFP-d-AM, l-TFP-l-MA & l-TFP-d-MA) were well resolved by capillary gas chromatography. After administration of 10mg/kg l-deprenyl to rat, l-methamphetamine and l-amphetamine were detected without autoracemization to the d form in all urine samples collected during 24hrs, and the ratios of l-amphetamine/l-methamphetamine were 1.1~3.3. l-Amphetamine was detected in only 3 out of 8 urine samples collected during 24~48hrs where as no l-methamphetamine was detected in all cases.