• 한국정보통신학회논문지
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• 제17권9호
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• pp.1996-2002
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• 2013

본 논문에서는 코플래너 도파관으로 급전되는 소형 광대역 평면 모노폴 안테나의 설계방법에 대해 연구하였다. 제안된 구조의 광대역 모노폴을 지상파 디지털방송 수신용으로 최적화 설계하였다. 모노폴과 접지면을 광대역 특성을 갖도록 완만한 테이퍼 구조로 하였다. 모노폴과 접지면에 슬릿을 장하하여 안테나를 소형화하였다. 광대역 모노폴은 특성 임피던스 75옴의 코플래너 도파관으로 급전되고 $100mm{\times}200mm$ 크기의 FR4 기판에 설계하였다. 디지털 방송 주파수 대역인 470-806 MHz 대역에서 동작하도록 설계된 안테나를 FR4 기판 상에 제작 후 실험을 통하여 연구결과의 타당성을 검증하였다.

• BMB Reports
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• 제30권5호
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• pp.326-331
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• 1997

To construct a competitive ELISA standard curve for the detection of glucose-6-phosphate debydrogenase (G6PD), we used highly purified native G6PD (nG6PD) as both immobilized and soluble antigens and anti-G6PD serum raised against nG6PD as antibody. The polystyrene cuvettes coated with nG6PD were challenged with a mixture of a limiting amount of anti-G6PD serum and various doses of nG6PD as competitors followed by incubation with alkaline phosphatase-anti-IgG conjugate. The competitive ELISA did not exhibit the typical sigmoidal dose-response curve characteristic of competition immunoassays under the optimal concentrations of antigen and antibody. The soluble nG6PD used as competitor failed to effectively inhibit the binding of antibodies to the immobilized nG6PD. The addition of NADP, a cofactor of G6PD enzyme, to coating buffer used for immobilizing nG6PD to the cuvettes and PBS-Tween-BSA buffer for diluting competitors did not improve the inhibition of antibody binding to immobilized nG6PD by soluble n/G6PD. The addition of BSA to coating buffer did not increase inhibition, either. Surprisingly, when partially active G6PD (paG6PD), obtained by repeated freeze-thawing, was used as competitor, the antibody binding to either immobilized nG6PD or immobilized paG6PD was inhibited 49-58%. We conclude that an effective competitive ELISA system with nG6PD enzyme and anti-G6PD serum for the detection of G6PD may not be established due to the poor inhibition of antibody binding to immobilized nG6PD by soluble nG6PD under the present assay conditions and that the inhibition may be improved by using an inactivated enzyme as competitor regardless of the type of immobilized antigen used. These results imply that the immobilized nG6PD may undergo denaturation upon binding to the polystyrene cuvettes and that our anti-G6PD serum may recognize denatured enzyme better than active enzyme.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2018년도 춘계학술대회
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• pp.61-62
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• 2018

본 논문은 동작하는 3.5 GHz 대역(WiMAX)의 광대역 양면 다이폴 안테나에 대해 연구하였다. 다이폴은 유전체 기판의 양면에 인쇄함으로써 쉽게 구현될 수 있고 능동회로와의 접속에 적합하다. 광대역 특성을 얻기 위해 다이폴 안테나의 모양은 두꺼운 직사각형 모양으로 하였다. $50{\Omega}$ 마이크로스트립 급전 선로에 정합 되도록 배열 급전회로와 밸런을 설계하였다. 시뮬레이션을 통해 3.4~3.7 GHz 대역의 안테나를 설계하고 반사손실, 이득, 방사패턴 등의 안테나 특성을 확인하였다. 시뮬레이션 결과 3.5GHz 대역의 최대이득은 5.5 dBi이고 VSWR이 2 미만인 대역폭은 약 1GHz이다.

• 대한전자공학회논문지SD
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• 제46권2호
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• pp.31-37
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• 2009

본 논문은 위성방송 표준인 DVB-S2 (Digital Video Broadcasting-Satellite second generation) 에 적용 가능한 효율적인 변조모드 추정 가능한 프레임 동기 검출 회로를 제안한다. 매우 낮은 SNR에서 SOF (Start Of Frame)를 검출하고 변조 모드를 추정하기 위해 본 논문에서는 새로운 상관기 방식의 프레임 동기 검출 회로 구조와 낮은 복잡도의 AGC (Automatic Gain Controller)를 제안한다. 제안한 프레임 동기 검출 회로는 복잡도가 높은 기존의 D-GPDI (Differential - Generalized Post Detection Integration) 알고리즘을 직접 구현한 방식과 비교하여 약 93%의 곱셈기 개수와 89%의 덧셈기 개수를 줄일 수 있었으며 Xilinx Virtex II FPGA 검증 보드를 이용하여 제안된 구조를 검증하였다.

• 대한한의학방제학회지
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• 제21권1호
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• pp.161-176
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• 2013

Objectives : To clarify the anti-arthritic activity of Ostericum koreanum Maxim. (OS) plus Aralia continentalis Kitagawa (AC) in vivo. Methods : All mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with OS plus AC once a day for 7 weeks. Oral administration of OS plus AC (200 or 50 mg/kg) significantly suppressed the progression of CIA, which extend is comparable to that of methotrexate (MTX, 0.3 mg/kg), a positive control. The severity of arthritis within the knee joints was evaluated by histological assessment of cartilage destruction and pannus formation. Results : Administration of OS plus AC significantly suppressed the progression of CIA and inhibited the production of TNF-${\alpha}$ and IL-6 in serum. The erosion of cartilage was dramatically reduced in mouse knees after treatment with OS plus AC. In conclusion, our results demonstrates that OS plus AC significantly suppressed the progression of CIA and that this action was characterized by the decreased production of IL-6, IFN-${\gamma}$ and collagen II specific antibody in serum, CD3+CD69+ T cells, MHC class II+/CD11c+ (in DLN), CD11b+Gr-1+ cells (in PBMC), CD11b +Gr-1+ cells, B220+/CD23+ (in paw joint). Conclusions : The the levels of IFN-${\gamma}$ in the culture supernatant of splenocytes stimulated with CD3/CD28 or collagen were dramatically decreased, while those of IL-4 was increased. In the serum of OS and AC-treated mice, the levels of IgM RA factor were decreased.

• Clinical and Experimental Pediatrics
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• 제60권8호
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• pp.261-265
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• 2017

Purpose: Studies on cytomegalovirus (CMV) infections in immunocompetent children are lacking, and minimal information is available in the medical literature on hepatic manifestations and complications of CMV. The aims of this study were to evaluate the clinical characteristics, laboratory data, and prognosis of children with CMV hepatitis, and to investigate its prevalence at a single medical center in Korea over a 10-year period. Methods: One hundred thirty-two children diagnosed with CMV infection based on specific markers (anti-CMV IgM, CMV polymerase chain reaction in blood and urine, or CMV culture of urine) were included in the study. Clinical and biochemical characteristics, immunological markers, and outcomes of hepatic CMV infection were determined. Results: The median age of patients (n=132) was 8.5 months (range, 14 days-11.3 years). Peak total bilirubin and alanine aminotransferase levels in serum ranged from 0.11-21.97 mg/dL, and 5-1,517 IU/L, respectively. Alanine aminotransferase remained elevated from 2-48 weeks. Jaundice was the most common clinical feature of hepatic CMV infection during infancy. The hematologic findings revealed anemia, leukocytosis, and monocytosis in CMV-infected patients. All participants recovered without administration of ganciclovir. Conclusion: In children with CMV hepatitis, fever was the most common symptom at presentation, and jaundice was the most common clinical feature of hepatic CMV infection in infants younger than 3 months of age. Hepatic CMV infection in immunocompetent children is often a self-limited illness that does not require antiviral therapy, as most patients in this study had favorable outcomes.

• Parasites, Hosts and Diseases
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• 제51권2호
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• pp.247-253
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• 2013

Neospora caninum is the etiologic agent of bovine neosporosis, which affects the reproductive performance of cattle worldwide. The transmembrane protein, NcSRS2, and dense-granule protein, NcGRA7, were identified as protective antigens based on their ability to induce significant protective immune responses in murine neosporosis models. In the current study, NcSRS2 and NcGRA7 genes were spliced by overlap-extension PCR in a recombinant adenovirus termed Ad5-NcSRS2-NcGRA 7, expressing the NcSRS2-NcGRA7 gene, and the efficacy was evaluated in mice. The results showed that the titer of the recombinant adenovirus was $10^9TCID_{50}/ml$. Three weeks post-boost immunization (w.p.b.i.), the IgG antibody titer in sera was as high as 1:4,096. IFN-${\gamma}$ and IL-4 levels were significantly different from the control group (P<0.01). This research established a solid foundation for the development of a recombinant adenovirus vaccine against bovine N. caninum.

• 한방안이비인후피부과학회지
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• 제24권3호
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• pp.84-107
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• 2011

Purposes : The purpose of present study is to detect the effects of ointment contained Takrisodok-Eum on the skin barrier's recovery of the Atopic dermatitis. Methods : A total of 44 patients who visited Semyung Oriental Medical Center from April 27th, 2011 to September 20th, 2011 were included in the study. In this study, the patients were treated with Takrisodok-Eum (experimental group) and positive control group. For 8 weeks of gross examination, hematological examination and instrumental asessment were made before and after the study to examine how well the products for experimental group with those for control group in recovering the damaged skin barriers by Atopic dermatitis. Results : 1. In the primary endpoint, SCORAD Index showed a statistically significant decline in experimental group. 2. In the secondary endpoint index of skin hydration, both the experimental group and the control group showed statistical significance. 3. In the secondary endpoint index of TEWL, the experimental group showed greater statistical significance than the control group. 4. In the secondary endpoint index of skin pH, skin pH showed a statistically significant decline in both the control group and the experimental group within the normal range. 5. In the secondary endpoint index of Total IgE, Eosinophil count, IL-10, IL-13, both the experimental group and the control group showed no statistical significance. 6. To evaluate the safety of the products for the human body, hematological examination and hematological biochemical examination, vital sign check were conducted; both control group and experimental group showed no abnormal level. And There were no severe adverse events during this study. Therefore, it is suggested that the safety of the products, if used for certain period, should be safe for the human body. Conclusions : According to the above experiments, it is suggested that Takrisodok-Eum should be effective for the Atopic dermatitis.

• 한국지하수토양환경학회지:지하수토양환경
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• 제12권5호
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• pp.98-104
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• 2007

국내 지하수의 라돈 함량을 파악하기 위하여 1999년부터 2002년까지 4년에 걸쳐서 615개 지하수 시료에 대한 분석이 이루어졌다. 조사된 농도범위는 4 pCi/L에서 40,010 pCi/L까지로 나타났으며, 평균값과 중간값은 각각 1,862 pCi/L와 920 pCi/L이었다. 조사한 지하수시료를 지질조건에 따라 5개의 집단으로 구분한 결과 평균 라돈함량은 화강암 지역 지하수에서 2,595 pCi/L로 가장 높았으며, 제주화산암 지하수에서는 238 pCi/L로 가장 낮았다. 또한, 풍화대와 암반지하수에서 2,298 pCi/L로 가장 높았으며, 충적층지하수에서는 672 pCi/L로 가장 낮게 나타났다. 국내 지하수중 라돈의 평균 함량과 최고 함량은 유사한 지질환경을 가지는 외국의 경우와 비교하면 낮은 편이나 보다 확실한 결론을 위해서는 추가 분석자료가 필요하다.

• 대한전자공학회논문지SD
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• 제46권10호
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• pp.40-45
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• 2009

본 논문에서는 사용자의 일상적인 동작 분석자료를 기반으로 실시간으로 사용자의 움직임 추정이 가능한 휴대형 센서 디바이스 및 활용 결과를 소개한다. 센서 디바이스는 3차원 가속센서와 GPS를 장착하고 있으며 센서 데이터 처리 및 움직임 추정을 위한 32비트 마이크로컨트롤러, 그리고 센서 데이터 및 추정결과를 전송하기 위한 블루투스 타입의 무선 통신 모듈을 포함한다. 완성된 디바이스는 50*47*14(mm)의 크기이며 리튬이온 소형 배터리 기준으로 연속 사용시 최대 10시간, 대기시간은 약 160시간 정도의 소형/저전력 형태로 구현되었다. 추정 가능한 사용자 움직임의 종류는 크게 3가지("서기", "달리기", "걷기")이며 피실험자군에 의한 동일 동작에 대한 가속센서 변화량을 학습하여 결정 트리 형식으로 사용자 움직임을 결정한다. 실험 결과 사용자 움직임 추정에 대한 정확도는 90% 이상인 것으로 확인되었다.