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Quantitative and Qualitative Gradient of Pain Experience, Sleep Quality and Psychological Distress in Patients with Different Phenotypes of Temporomandibular Disorders

  • Choi, Hee Hun;Kim, Hye-Kyoung;Kim, Mee-Eun
    • Journal of Oral Medicine and Pain
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    • v.45 no.3
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    • pp.56-64
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    • 2020
  • Purpose: Temporomandibular disorders (TMD) is a mosaic of clinical signs and symptoms that can be regarded as a set of phenotypes that are affected by various factors including pain sensitivity, pain disability, sleep and psychological functioning. The aims of this study were to evaluate association of pain experience, sleep quality and psychological distress with different phenotypes of TMD patients. Methods: This retrospective study included a cohort (n=1,858; 63.8% for female, mean age=34.9±15.9 years) of patients with TMD. A set of self-administered questionnaires concerning pain interference (Brief Pain Inventory), pain disability (Graded Chronic Pain Scale), sleep quality (Pittsburg Sleep Questionnaire Index), psychological distress (Symptom Checklist-90 revised), and pain catastrophizing (Pain Catastrophizing Scale) were administered to all participants at the first consultation. All TMD patients were classified into four groups including TMD with internal derangement without pain (TMD_ID, n=370), TMD with joint pain (TMD_J, n=571), TMD with muscle pain (TMD_M, n=541) and TMD with muscle-joint combined pain (TMD_MJ, n=376). Results: The female ratio was particularly high in the group with TMD_MJ (p=0.001). The patients with muscle pain and both muscle and joint pain had longer symptom duration (p=0.004) and presented significantly higher scores in pain experience (p<0.001), subjective sleep quality (p<0.001), pain catastrophizing (p<0.001) and psychological distress (p<0.05) except for paranoid-ideation than the groups with only joint problems. Conclusions: The results of this study highlight the importance of multi-dimensional approach that consider pain disability, sleep quality, and psychological functioning in the management of TMD with muscle component. This study would contribute to a better understanding of interaction between heterogeneous TMD and multiple risk factors in order to build tailored treatment based on different phenotypes.

Improving the Key Search using Parallelism in RFID Privacy Protection

  • Shin, Myeong-Sook;Kim, Choong-Woon;Lee, Joon
    • The Journal of the Korea institute of electronic communication sciences
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    • v.2 no.1
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    • pp.19-24
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    • 2007
  • Abstract. In the ubiquitous environment of the next generation, RFID is predicted to occupy an important technical location and also expected to apply to various fields. However, the properties of tags in itself which is the core of RFID have a dysfunction like an invasion of privacy for user. An existing cryptanalytic protection scheme of the information leakage have a difficult problem to apply to RFID tags for privacy protection. We applied Ohkubo et al.'s scheme to the protection of the tag's information efficiently in the RFID system environment using low-cost tags. But, this method has all informations of tagsto identify tag's ID and then performs the process of identification in sequence in the Back-end server. These processes have lots of computations so that it have problems about a scalability. In this paper, we are based on Ohkubo et al.'s scheme to solve problems, and then analyze the parallelism with the Hellman's tradeoff method, divide it into nodesin parallel. In this paper, we are based on Okubo et al.'s scheme to solve problems, and then analyze the parallelism with Hellman's tradeoff method, divide it into the ${\omega}$ node in parallel. as a result, we can reduce the computing complexity of key search to $O(\frac{m^{2/3}n^{2/3}}{\omega})$ seconds from O(mm) seconds. finally we show the results to be enhanced the scalability.

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The Characteristics of Solid Mixing in a Vibrating Type Feeder and Pressure Fluctuation of Packing Materials for a Fluidized Bed Combustor (유동층 연소로에서 진동형 공급기의 고체혼합 및 충전물에 대한 압력요동 특성)

  • 김미영;김의식
    • Journal of the Korean Society of Safety
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    • v.14 no.3
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    • pp.101-109
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    • 1999
  • This study attempts to analyse the solid mixing in the feeder and the packing effect for pressure fluctuations in the fluidized bed. To study the mixing characteristics of solid in vibrating feeder for the stable operations of fluidized combustion, the system consisted of two groups of particles such that fine particles were located on the top of the coarse particles before vibratory mixing had started. The effects of packing materials on the pressure fluctuations in a fluidized bed were analysed by using a statistical method to interpret the behavior of fluidized bed. The experiments were carried out in a fluidized bed of 6.7cm-ID, and the experimental variables were particle sizes, of 115 to 1,015$\mu\textrm{m}$ in diameter and the multi-sized particles haying Rosin-Rammler and Gaussian distributions. The settled bed heights of particles to diameter ratios (L/D) were ranged from 0.5 to 2.0. And fluidizing of particles was carried out by air. The packing materials used were screen packing, and the properties of the pressure fluctuations in the fluidized bed were measured by a differential pressure transducer. The properties of the pressure fluctuations calculated were the mean, the standard deviation, and the major frequency of the power spectral density functions. From the characteristics of fluidizing, it was found that the standard deviation of pressure fluctuations could be effectively used to explain the fluidized phenomena, and the packing materials affected severely the properties of the pressure fluctuations. As a result, from the interpretation by spectral analysis, the effects of measuring radius of pressure fluctuations on standard deviation were constant in the case of the fluidized bed with and without packing materials. However, the effects of measuring the height of pressure fluctuations on standard deviations were linear increasing for the fluidized bed with packing materials, but were constant for the fluidized bed without packing materials at 4.5cm above the gas distributor. The major frequency of pressure fluctuations was found to be nearly independent of fluidized system. Also, the major frequency of pressure fluctuations decreased with increasing packing size, and it had maximum value at 10% of the packing amount.

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Design of a CMOS RFID Transponder IC Using a New Damping Circuit (새로운 감폭회로를 사용한 CMOS RFID 트랜스폰더 IC 설계)

  • O, Won-Seok;Lee, Sang-Hun;Lee, Gang-Myeong;Park, Jong-Tae;Yu, Jong-Geun
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.38 no.3
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    • pp.211-219
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    • 2001
  • This paper describes a read-only CMOS transponder IC for RFID applications. A full-wave rectifier implemented using NMOS transistors supplies the transponder with a dc supply voltage using the magnetic field generated from a reader. A 64-bit ROM has been designed for a data memory. Front-end impedance modulation and Manchester coding are used for transmitting the data from the transponder memory to the reader. A new damping circuit which has almost constant damping rate under the variations of the distance between the transponder and the reader has been employed for impedance modulation. The designed circuit has been fabricated using a 0.65${\mu}{\textrm}{m}$2-poly, 2-metal CMOS process. Die area is 0.9mm$\times$0.4mm. Measurement results show that it has a constant damping rate of around 20~25% and a data transmission rate of 3.9kbps at a 125KHz RF carrier. The power required for reading operation is about 100㎼. The measured reading distance is around 7cm.

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A Method for IPv6 Address Assignments of the Next Generation Defense Network (차세대 국방정보통신망을 위한 IPv6 주소 할당 방안)

  • Kim, Kwon-Il;Lee, Sang-Hoon
    • Journal of KIISE:Computing Practices and Letters
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    • v.14 no.4
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    • pp.441-445
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    • 2008
  • Korean military is propelling the M&S on new warfare concept, such as NCW(Network Centric Warfare) which is the aspect of future war. IPv6 is the essential element of next generation defense network which is supporting the future battlefield. There have been many studies on allocating the IPv6 address for next generation defense network. However, they assigned the address by level on the basis of the military organization or assigned it from the service network, so it had the defect, the big size routing table. This study reviews the topology of next generation defense network and adjusts the position of service network ID on the basis of the network topology. Finally, it improved the efficiency of route aggregation and minimized the routing table size in comparison with the previous studies and it was proved by OPNET simulator.

Two independent mechanisms mediate discrimination of IID textures varying in mean luminance and contrast (평균밝기와 대비성의 차원으로 구성된 결 공간에서 결 분리에 작용하는 두 가지 기제)

  • 남종호
    • Korean Journal of Cognitive Science
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    • v.10 no.3
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    • pp.39-49
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    • 1999
  • The space of IID([ndependently, Identically Distributed) textures was built with axes of mean luminance and contrast, and studied on what kind of mechanisms were required to mediate texture segregation in this space. The conjecture was tested that one of these mechanisms is sensitive to the differences between the means of textures to be discriminated, whereas the other is sensitive to the differences between variances. The probability of discrimination was measured for various pairs of textures in the lID space The data were well fit by a model in which discrimination depends on two mechanisms whose responses are combined by probability summation. The conjecture was rejected that two mechanisms respectively tuned to mean and variance of texture function in segregation. Discrimination within space is mediated by 2 independent channels however: the 2 independent channels are not exactly tuned to texture mean and variance. One m mechanism was primarily sensitive to texture mean, whereas the other was sensitive to b both texture mean and variance.

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INHERENT SAFETY ANALYSIS OF THE KALIMER UNDER A LOFA WITH A REDUCED PRIMARY PUMP HALVING TIME

  • Chang, W.P.;Kwon, Y.M.;Jeong, H.Y.;Suk, S.D.;Lee, Y.B.
    • Nuclear Engineering and Technology
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    • v.43 no.1
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    • pp.63-74
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    • 2011
  • The 600 MWe, pool-type, sodium-cooled, metallic fuel loaded KALIMER-600 (Korea Advanced LiquId MEtal Reactor, 600 MWe) has been conceptually designed with an emphasis on safety by self-regulating (inherent/intrinsic) negative reactivity feedback in the core. Its inherent safety under the ATWS (Anticipated Transient Without Scram) events was demonstrated in an earlier study. Initiating events of an HCDA (Hypothetical Core Disruptive Accident), however, also need to be analyzed for assessment of the margins in the current design. In this study, a hypothetical triple-fault accident, ULOF (Unprotected Loss Of Flow) with a reduced pump halving time, is investigated as an initiator of a core disruptive accident. A ULOF with insufficient primary pump inertia may cause core sodium boiling due to a power-to-flow mismatch. If the positive sodium reactivity resulting from this boiling is not compensated for by other intrinsic negative reactivity feedbacks, the resulting core power burst would challenge the fuel integrity. The present study focuses on determination of the limit of the pump inertia for assuring inherent reactivity feedback and behavior of the core after sodium boiling as well. Transient analyses are performed with the safety analysis code SSC-K, which now incorporates a new sodium boiling model. The results show that a halving time of more than 6.0 s does not allow sodium boiling even with very conservative assumptions. Boiling takes place for a halving time of 1.8 s, and its behavior can be predicted reasonably by the SSC-K.

A Docking Study of Newly Found Natural Neuraminidase Inhibitor: Erystagallin A

  • Madhavan, Thirumurthy
    • Journal of Integrative Natural Science
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    • v.4 no.4
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    • pp.273-277
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    • 2011
  • It's a threat for the public health that H1N1 (Influenza virus A) causes disease and transmits among humans. WHO (world health organization) declared that the infections caused by the new strain had reached pandemic proportions. The approved neuraminidase inhibitors (Zanamivir and Oseltamivir) and related investigative drug (BCX-1812) are potent, specific inhibitors of influenza A and B viruses. These drugs are highly effective to prevent influenza A and B infections. Early therapeutic use reduces illness duration and respiratory complications. Recently, we found one of the potent inhibitor of erystagallin A ($IC_{50}$ of 2.04 ${\mu}M$) for neuraminidase target, this inhibitor shows most similar structure to its natural substrate, sialic acid. Therefore, we chose 1l7f to get the receptor structure for docking study among many crystal structures. A docking study has been performed in Surflex-Dock module in SYBYL 8.1. In the present study, we attempt to compare the docking studies of pterocarpin and erystagallin A with neuraminidase receptor structure. In the previous report, the methoxy group of pterocarpin had H-bonding with Arg residues. The present docking results for erystagallin A showed the backbone of hydroxyl group shows significant H-bonding interactions with Arg152 and Arg292. The results showed that erystagallin A interacts more favorably with distinctive binding site rather than original active site. Therefore, we tried to reveal plausible binding mode and important amino acid for this inhibitor using docking and site id search calculations of Sybyl. The results obtained from this work may be utilized to design novel inhibitors for neuraminidase.

An Evaluation of Data Delivery Mechanisms in Clustered Sensor Networks (클러스터 기반 센서 망에서 데이터 전달 방법들의 성능 분석)

  • Park Tae-Keun
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.3A
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    • pp.304-310
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    • 2006
  • This paper evaluates the performance of three types of data delivery mechanisms in clustered sensor networks, as a basic research to develop an energy efficient topology management scheme. In the first mechanism, one node per cluster(clusterhead) turns on its radio(or wakes up) to transmit and receive RTS/CTS/DATA/ACK messages, but in the second one, k nodes per cluster wake up and participate in the message exchange. In the last mechanism, clusterheads turn on the radio to exchange RTS/CTS messages, and if a clusterhead receives RTS containing its cluster m as a destination, it makes k nodes in the cluster hun on the radio to receive DATA and transmit ACK. Through simulation, we show the energy consumption of the three types of data delivery mechanisms as functions of the number of active nodes per cluster, offered load, and packet loss probability.

In Vitro Properties and Biodistribution of Tc-99m and Re-188 Labeled Monoclonal Antibody CEA79.4 (Re-188과 Tc-99m 표지 단일클론항체 CEA79.4의 생체외 특성과 생체내 분포)

  • Hong, Mee-Kyoung;Jeong, Jae-Min;Yeo, Jeong-Seok;Kim, Kyung-Min;Chang, Young-Soo;Lee, Yong-Jin;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Lee, Seung-Jin
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.6
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    • pp.516-524
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    • 1998
  • Purpose: Radiolabeled CEA79.4 antibody has a possibility to be used in radioimmunoscintigraphy or radioimmunotherapy of cancer. We investigated the in vitro properties and biodistribution of CEA79.4 antibody labeled with Re-188 or Tc-99m. Materials and Methods: CEA79.4 was reduced by 2-mercaptoethanol to produce-SH residue, and was labeled with Re-188 or Tc-99m. For direct labeling of Tc-99m, methylene-diphosphonate was used as transchelating agent. CEA79.4 in 50 mM Acetate Buffered Saline (ABS, pH 5.3) was labeled with Re-188, using stannous tartrate as reducing agent. In order to measure immunoreactivity and the affinity constant of radiolabeled antibody, cell binding assay and Scatchard analysis using human colon cancer cells SNU-C4, were performed. Biodistribution study of labeled CEA79.4 was carried out at 1, 14 and 24 hr in ICR mice. Results: Labeling efficiencies of Tc-99m and Re-188 labeled antibodies were $92.4{\pm}5.9%$ and $84.7{\pm}4.6%$, respectively, In vitro stability of Tc-99m-CEA79.4 in human serum was higher than Re-188-CEA79.4. Immunoreactivity and affinity constant of Tc-99m-CEA79.4 were 59.2% and $6.59{\times}10^9\;M^{-1}$, respectively, while those of Re-188-CEA79.4 were 41.6% and $4.2{\times}10^9\;M^{-1}$, respectively. After 24 hr of administrations of Re-188 and Tc-99m labeled antibody, the remaining antibodies in blood were 6.32 and 9.35% ID/g respectively. The biodistribution of each labeled antibody in other organs was similar because they did not accumulate in non-targeted organs. Conclusion: In vitro properties and biodistribution of Re-188-CEA79.4 were similar to those of Tc-99m-CEA79.4. It appears that Re-188-CEA79.4 can be used as a suitable agent for radioimmunotheraphy.

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