• Journal of Food Hygiene and Safety
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• v.31 no.1
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• pp.51-58
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• 2016

This research examined the effects of Compositae extract on the inhibition of proliferation and apoptosis in human breast and human gastric cancer cells. Compositae extracts which is used in the experiment are Taraxacum coreanum (TC), Youngia sonchifolia (YS) and Ixeris dentata (ID). The proliferation of SK-BR-3, MDA-MB-231 and AGS cells were investigated by MTT assay. ID and YS extracts inhibited proliferation of SK-BR-3, MDA-MB-231 and AGS cells in a dose-dependent manner, but TC have barely affected. In addition, the most effective extract was ID. To assess the apoptosis of ID extract, the nuclei of human cancer cells were stained with DAPI solution respectively. Chromatin condensation, indicated apoptosis, was increased in a dose-dependent manner. We investigated change of ID extract-induced apoptosis proteins on human cancer cells by western blot analysis. The level of Bcl-2 decreased, whereas the level of Bax, cleaved-PARP increased in dose-dependent manner compared with non-treatment. Also Bax/Bcl-2 ratio, which is used in clinical indicator of apoptosis, was increased at ID extract treatment group compared with non-treatment. Moreover the Bax/Bcl-2 ratio of MDA-MB-231 cell was significantly increased as against SK-BR-3, AGS cells. These results indicated that ID extract have anti-proliferation effect better than YS or TC, and induced apoptosis in human breast cancer MDA-MB-231 cell better than human breast cancer SK-BR-3 cell, human gastric cancer. Even if further research is needed, ID can be developed as a chemopreventive or therapeutic agent of breast cancer.

• Archives of Pharmacal Research
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• v.18 no.6
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• pp.415-422
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• 1995

Twenty-four flavones were synthesized with various hydroxyl and/or methoxyl groups on A and B rings. Their antimutagenic properties were evaluated against ben:w(a)pyrene (BaP) and a pool of mutagenic urine concentrate (U) using a modified liquid incubation method of Ames test. The tester strain was Salmonella typhimurium TA98+S9 Mix. The antimutagenic activities were calculated by non linear regression analysis and the doses of flavones (in nmoles) required for a 50% reduction of induced revertants with BaP and U were defined as the inhibition doses (TEX>$ID_{508}{\;}and{\;}ID_{508}$ respectively). Seventeen flavones possessed significant antimutagenic activity against BaP. $ID_{508}$ ranged from 15.1 nmoles (F22) to 1000.6 nmoles (F13). Eighteen f1avones showed significant antimutagenic activity against U. $ID_{50U}$ ranged from 23.5 nmoles (F22) to 354.6 nmoles (F3). The 2',3',4'-trihydroxyflavone (F22, $ID_{508}=15.1$ nmoles, $ID_{50U}=23.5$ nmoles) and the 2',3',4',7-tetrahydroxyflavone (F20, $ID_{508}=37.8$ nmoles; $ID_{50U}=62.3$ nmoles) had antimutagenic activities similar to those of chlorophyllin ($ID_{508}=19.6$ nmoles and $ID_{50U}=44.2$ nmoles) and were evaluated against B(alP 7,8-dihydrodiol-9,10-epoxide. Against this last mutagen, the flavones which included three OH in B ring showed the highest activity and this property seemed independent of the substituent groups on A ring.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.10C
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• pp.764-777
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• 2008

In 4G environments, which is the next generation technology for mobile network, it is forecasted that the wireless Internet using a mobile devices such as a mobile phone, PDA will increase because of expansion of Internet and integration of heterogeneous networks. Therefore, we need a Digital ID management technology that can prevent illegal uses and manage private information efficiently in wired and wireless environments. In this paper, we analyze various Digital ID management technologies, and then define requirements of user-centric Digital ID management technology. In addition, we newly propose the authentication mechanism for mobile applications in LTE/SAE network. Finally, we propose the mobile Digital ID Wallet mechanism suitable for 4G environments.

• Korean Journal of Food Science and Technology
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• v.47 no.4
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• pp.499-503
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• 2015

We investigated the anti-obesity effects of ethanolic extract (ID1216) of Polygonatum sibiricum rhizome and its potential underlying mechanism in an animal model. ID1216 treatment decreased body weight gain and white adipose tissue weight in the prevention study. The mRNA levels of sirtuin-1 (SIRT1), peroxisome proliferator-activated receptor ${\gamma}$ coactivator-$1{\alpha}$ ($PGC1{\alpha}$), and peroxisome proliferator-activated receptor ${\alpha}$ ($PPAR{\alpha}$) significantly increased in the epididymal white adipose tissue of ID1216-administered mice. The stimulation effects of ID1216 on these gene expressions were also observed in a cell-based assay using differentiated 3T3-L1 adipocytes. In addition, similar to orlistat, ID1216 treatment improved weight gain and reduced epididymal fat in the treatment model. These results suggest that ID1216 has potential as an anti-obesity agent by modulating the expression of genes related to thermogenesis, lipid metabolism and fatty acid oxidation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.13 no.3
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• pp.129-134
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• 2003

Hierarchical ID-based Cryptography proposed by C. Gentry and A. Silverberg has the problem that the length of the ciphertext is proportional to the depth of the recipient in the hierarchy. In this paper, we propose the new methods to shorten the length of the ciphertext by using HlDS(Hierarchical ID-based Signature).

• Proceedings of the Korean Vacuum Society Conference
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• 2016.02a
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• pp.348-348
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• 2016

Low dark current (off-current) and high photo current are both essential for a solution processed organic photodetector (OPD) to achieve high photo-responsivity. Currently, most OPDs utilize a bulk heterojunction (BHJ) photo-active layer that is prepared by the one-step deposition of a polymer:fullerene blend solution. However, the BHJ structure is the main cause of the high dark current in solution processed OPDs. It is revealed that the detectivity and spectral responsivity of the OPD can be improved by utilizing a photo-active layer consisting of an interdiffused polymer/fullerene bilayer (ID-BL). This ID-BL is prepared by the sequential solution deposition (SqD) of poly(3-hexylthiophene) (P3HT) and [6,6] phenyl C61 butyric acid methyl ester (PCBM) solutions. The ID-BL OPD is found to prevent undesirable electron injection from the hole collecting electrode to the ID-BL photo-active layer resulting in a reduced dark current in the ID-BL OPD. Based on dark current and external quantum efficiency (EQE) analysis, the detectivity of the ID-BL OPD is determined to be $7.60{\times}1011$ Jones at 620 nm. This value is 3.4 times higher than that of BHJ OPDs. Furthermore, compared to BHJ OPDs, the ID-BL OPD exhibited a more consistent spectral response in the range of 400 - 660 nm.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.325-326
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• 2010

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2017.06a
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• pp.131-132
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• 2017

본 논문에서는 차세대 ATSC 3.0 표준 기반 단일주파수망 (Single frequency network, SFN) 지상파 방송시스템에서의 송신기 식별 (Transmitter identification, TxID) 기술을 살펴보고 그 성능을 분석한다. SFN 기반 지상파 방송은 복수의 송신기를 동일한 주파수 대역에서 운용하는 것에서 발생하는 간섭으로 인한 영향을 최소화하기 위해 적절한 망 설계를 필요로 한다. 용이한 망 설계를 위해, ATSC 3.0 물리계층 표준은 TxID 기술을 통해 개별 송신기에서 전송된 신호를 판별할 수 있도록 지원한다. 이에 본 논문에서는 ATSC 3.0 표준에서 지원하는 TxID 신호 생성 및 검출 기술을 소개한다. 더불어, 전산 실험을 통해 해당 TxID 기술의 식별 성능이 TxID 신호의 삽입 준위가 매우 낮은 환경에서도 보장됨을 확인한다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1997.10a
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• pp.170-174
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• 1997

This paper studies a method for making more efficient classification rules in the ID3 using the rough set theory. Decision tree technique of the ID3 always uses all the attributes in a table of examples for making a new decision tree, but rough set technique can in advance eleminate dispensable attributes. And the former generates only one type of classification rules, but the latter generates all the possibles types of them. The rules generated by the rough set technique are the simplist from as proved by the rough set theory. Therefore, ID3, applying the rough set technique, can reduct the size of the table of examples, generate the simplist form of the classification rules, and also implement an effectie classification system.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1465-1470
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• 2014

Inhibitor of DNA binding 1 (Id1) plays an important role in genesis and metastatic progression of prostate cancer. We previously reported that down regulation of Id1 by small interfering RNA could inhibit the proliferation of PC3 cells and growth of its xenografted tumors. Curcumin, the active ingredient of turmeric, has shown anti-cancer properties via modulation of a number of different molecular regulators. Here we investigated whether Id1 might be involved in the anti-cancer effects of curcumin in vivo and in vitro. We firstly confirmed that curcumin inhibited cell viability in a dose-dependent fashion, and induced apoptosis in PC3 cells, associated with significant decrease in the mRNA and protein expression of Id1. Similar effects of curcumin were observed in tumors of the PC3 xenografted mouse model with introperitoneal injection of curcumin once a day for one month. Tumor growth in mice was obviously suppressed by curcumin during the period of 24 to 30 days. Both mRNA and protein levels of Id1 were significantly down-regulated in xenografted tumors. Our findings point to a novel molecular pathway for curcumin anti-cancer effects. Curcumin may be used as an Id1 inhibitor to modulate Id1 expression.