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Bioavailability of Aspartic Acid Chelated Iron on Iron-deficient Rats (아스파르트산 킬레이트 철분의 철분 결핍쥐에서의 생물학적 유용성)

  • Park, Myoung-Gyu;Ha, Tae-Yul;Shin, Kwang-Soon
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.40 no.12
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    • pp.1720-1725
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    • 2011
  • Aspartic acid chelated iron (Asp-Fe) was synthesized by a new method using calcium carbonate, aspartic acid, and ferrous sulfate. This study was carried out to investigate the bioavailability of Asp-Fe in iron-deficient rats. We divided the rats into four experimental groups. The first was the normal diet control group, or NC. The second was the no treated control group of iron-deficient (ID) rats, or ID+C. The third was the heme-iron (heme-Fe) treated group of ID rats, ID+heme-Fe. And the fourth was the Asp-Fe treated group of ID rats, or ID+Asp-Fe. There were no differences among any of the experimental groups in diet consumption, change of body weight, or the weight of the livers, kidneys, or spleens. After 7 days of feeding, the iron content in the sera of the ID+Asp-Fe group (175.2 ${\mu}g$/dL) and the ID+heme-Fe group (140.8 ${\mu}g$/dL) were significantly higher than that of the ID-C group (96.1 ${\mu}g$/dL). The total iron binding capacity (TIBC) of the ID+Asp-Fe group (735.4 ${\mu}g$/dL) was significantly normalized compared to the ID+C group (841.9 ${\mu}g$/dL) or ID+heme-Fe group (824.6 ${\mu}g$/dL). The hematocrit level of the ID+Asp-Fe group was increased to normal levels, but there was no statistical difference among ID groups. The absorption ratio of heme-Fe was 21.3% and that of Asp-Fe was 50.2%, which indicates a 2.3 times higher ratio in comparison with heme iron. With the above results we found that Asp-Fe seems to be an efficient form of iron to supply iron deficient rats in order to cure them of anemia. Thus, these findings suggest that aspartic acid chelated iron has the potential to serve as a functional food related to iron metabolism.

Implementation of a very small 13.56[MHz] RFID Reader ensuring machine ID recognition in a noise space within 3Cm (3Cm 이내의 잡음 공간 속 기계 ID 인식을 보장하는 초소형 13.56[MHz] RFID Reader의 구현)

  • Park, Seung-Chang;Kim, Dae-Jin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.43 no.10 s.352
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    • pp.27-34
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    • 2006
  • This paper has implemented a very small($1.4{\times}2.8[Cm^2]$) 13.56[MHz] RFID reader ensuring machine ID recognition correctly in a noise space of Tag-to-Reader within 3Cm. For operation of the RFID system, at first, this paper has designed the loop antenna of a reader and the fading model of back-scattering on microwave propagation following to 13.56[MHz] RFID Air Interface ISO/IEC specification. Secondly, this paper has proposed the automatically path selected RF switching circuit and the firmware operation relationship by measuring and analyzing the very small RFID RF issues. Finally, as a very small reader main body, this paper has shown the DSP board and software functions made for extraction of $1{\sim}2$ machine ID information and error prevention simultaneously with carrying of 13.56[MHz] RFID signals that the international standard specification ISO/IEC 18000-3 defined.

Two Dimensional Explicit ID(Isotropic-Dispersion)-FDTD Scheme for Lossy Media (손실 매질에 대한 2차원 등방 시간 영역 유한 차분법)

  • Koh, Il-Suek;Kim, Hyun;Yook, Jong-Gwan
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.18 no.6 s.121
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    • pp.664-673
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    • 2007
  • In this paper, the ID-FDTD scheme, proposed in Reference [1] and [2], is modified and completely analyzed. The modifications are composed of three parts: rigorous stability analysis, dispersion relation for linear lossy media, and new scaling factors for permittivity, permeability, and conductivity. As a result, it is shown that the proposed scheme has lower dispersion error in spite of larger time step than the conventional standard scheme of Reference [3]. To validate the scheme, there are presented two scattering examples, which show excellent results.

Contactless Power Transfer System using Voltage Phase (전압위상을 이용한 무접점 전원공급 시스템에 관한 연구)

  • Yu, Joo-Hee;Kim, Choon-Sam
    • The Transactions of the Korean Institute of Power Electronics
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    • v.16 no.3
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    • pp.219-226
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    • 2011
  • As the existing contactless power transfer system(CPTS) is adopting the principle of contactless transformer enables to supply power in contactless way using RFID(radio frequency identification)/ID communication method between primary and secondary sides of contactless transformer and detect the alien load. Such CPTS requires the circuit that generates ID in addition, and the ID identification and control generated from the secondary side is performed at the primary side, which cuases complexity of the circuit. Therefore, this study suggested the CPTS using voltage phase, and In order to verify the validity of this study, 3[W] class CPTS shall be designed, and the simulation and test of CPTS using current and voltage phases shall be carried out.

Improving the QoS using the Modulation and Coding Selection scheme by temperature characteristic of LED in the LED-ID system (LED-ID 시스템에서 LED의 온도 특성에 따른 선택적 변조 및 부호화를 통한 QoS 향상 기법 연구)

  • Lee, Kyu-Jin;Seo, Hyo-Duck;Han, Doo-Hee;Lee, Kye-San
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.12 no.1
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    • pp.66-74
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    • 2013
  • This paper introduces the improvement of QoS to compensate the decreasing LED performance by temperature characteristic in the LED-ID communication system. LED does not only use as a lighting device, but also uses as a communication device. The conventional system is transmitted by RGB of LED following the mixture color ratio, which determined the color of lighting, and the BER performance of each RGB signals. However, when the LED used consistently, it has occurred the heat temperature. As a result, LED is degraded the performance by increased temperature each device. To solve this problem, we proposed the adaptive modulation and coding scheme by temperature of device to improve the performance of system and satisfied the QoS in the LED-ID system.

Design of Digital Broadcasting Data Service showing Supplementary Information of each Type of ID Advertisement (ID 광고의 유형별 부가정보를 보여주는 디지털방송 데이터서비스 설계)

  • KO, Kwangil
    • Journal of Digital Contents Society
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    • v.19 no.9
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    • pp.1671-1677
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    • 2018
  • The advertisement market is an industry that is heavily influenced by media changes. As the digital broadcasting has settled, TV, a typical advertisement medium, has evolved from a passive content consuming medium into a platform for operating various data services as well as broadcasting programs. These changes mean that viewers are able to actively consume TV contents including advertisement, so the broadcasting industry needs to consider about the growth strategies that link the advertisement market with data services. This study designed a digital broadcasting data service that provides supplementary information of ID advertisement with short exposure time (less than 10 seconds) and insufficient space (less than 1/4 of TV screen). Specifically, we designed the user scenario and user interface of the data service, defined representative types of ID advertisement and the supplementary information for each type, developed a method, based on the international digital broadcasting standard DVB, for providing the supplementary information to the data service.

FPGA Design of Adaptive Digital Receiver for Wireless Identification (무선인식을 위한 적응적 디지털 수신기의 FPGA 설계)

  • Seo Young-Ho;Kim Dong-Wook
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.9 no.4
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    • pp.745-752
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    • 2005
  • In this paper we propose and implement a digital part of a receiver system for identifying a moving object and its tracking position in wireless environment. We assumed UWB(Ultra Wide Band)-based communication system for target application and used serial communication method(RS-232). The proposed digital receiver consists of RS-232-type1/RS-232-type2 for input and output of serial communication, ID Detector for detecting IDs, and PISO&Buffer circuit to buffer input signals for appropriate operation of ID Detector. We implemented the digital receiver with minimal hardware(H/W) resource according to target application of UWB-based communication system. So it correlates input patterns with pre-stored patterns though repeated detecting method for multiple IDs. Since it has reference panerns in the Ve-stored form, it can detect various IDs instantly. Also we can program content and size of reference patterns considering compatibility with other systems .The implemented H/W was mapped into XC2S100PQ208-5 FPGA of Xilinx, occupied 727($30\%$) cells, and stably operated in the clock frequency of 75MHz(13.341ns).

Physiological activities of ethanol extract of Allium tuberosum root (부추뿌리 추출물의 생리활성)

  • Kim, Hyun-Soo
    • Korean Journal of Food Science and Technology
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    • v.53 no.2
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    • pp.160-164
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    • 2021
  • This study investigated various physiological activities to examine the applicability of the functional materials of Allium tuberosum root extract. The A. tuberosum root extract showed a low cytotoxicity against murine melanoma B16F10 cells. It also showed high DPPH radical scavenging activity (ID50, 6.2 ㎍/mL), inhibited tyrosinase activity (ID50, 115.4 ㎍/mL), and decreased melanin content (ID50, 31.5 ㎍/mL). Treatment of B16F10 cells with A. tuberosum root extract suppressed the protein expression of tyrosinase in a dose-dependent manner. These findings suggest that A. tuberosum root extract inhibits melanin synthesis by suppressing intracellular tyrosinase expression. Additionally, A. tuberosum root extract inhibited elastase with an ID50 value of 145.1 ㎍/mL and contained isoquercitrin. These results indicate that A. tuberosum root extract is an appropriate natural material.

Induction of Apoptosis in Human Cancer Cells with Extracts of Taraxacum coreanum, Youngia sonchifolia and Ixeris dentate (흰민들레, 고들빼기, 씀바귀 추출물의 암세포 증식 억제 효과)

  • Shin, Seong-Ah;Lee, Hae-Nim;Choo, Gang-Sik;Kim, Hyeong-Jin;Park, Byung-Kwon;Kim, Byeong-Soo;Jung, Ji-Youn
    • Journal of Food Hygiene and Safety
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    • v.31 no.1
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    • pp.51-58
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    • 2016
  • This research examined the effects of Compositae extract on the inhibition of proliferation and apoptosis in human breast and human gastric cancer cells. Compositae extracts which is used in the experiment are Taraxacum coreanum (TC), Youngia sonchifolia (YS) and Ixeris dentata (ID). The proliferation of SK-BR-3, MDA-MB-231 and AGS cells were investigated by MTT assay. ID and YS extracts inhibited proliferation of SK-BR-3, MDA-MB-231 and AGS cells in a dose-dependent manner, but TC have barely affected. In addition, the most effective extract was ID. To assess the apoptosis of ID extract, the nuclei of human cancer cells were stained with DAPI solution respectively. Chromatin condensation, indicated apoptosis, was increased in a dose-dependent manner. We investigated change of ID extract-induced apoptosis proteins on human cancer cells by western blot analysis. The level of Bcl-2 decreased, whereas the level of Bax, cleaved-PARP increased in dose-dependent manner compared with non-treatment. Also Bax/Bcl-2 ratio, which is used in clinical indicator of apoptosis, was increased at ID extract treatment group compared with non-treatment. Moreover the Bax/Bcl-2 ratio of MDA-MB-231 cell was significantly increased as against SK-BR-3, AGS cells. These results indicated that ID extract have anti-proliferation effect better than YS or TC, and induced apoptosis in human breast cancer MDA-MB-231 cell better than human breast cancer SK-BR-3 cell, human gastric cancer. Even if further research is needed, ID can be developed as a chemopreventive or therapeutic agent of breast cancer.

Four-Week Repeated-Dose Toxicity Studies of Hyrubicin ID6105, a Novel Anthracycline Anticancer Agent, in Rats (랫드에서 새로운 Anthracycline계 항암제 Hyrubicin ID6105에 대한 4주 반복투여 독성연구)

  • 장호송;서동석;인창훈;황재식;이수해;정미숙;신지순;이홍섭;유정수
    • Toxicological Research
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    • v.18 no.4
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    • pp.375-384
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    • 2002
  • Repeated-dose toxicity of hyrubicin ID6105, a novel anthrarycline anticancer agent, was investigated in Sprague-Dawley rats. ID6105 was injected intravenously to rats at dose levels of 0.04, 0.2 or 1.0 mg/kg/day for 4 week. As a result, there were no dose-related mortality and specific clinical signs of all animals treated with the drug. However body weight gain of both male and female rats treated with a high dose (l.0 mg/kg/day) of ID6105 significantly decreased compared to control. Interestingly, the numbers of RBC and platelets, and concentration of hemoglobin remarkably increased, while protein synthesis was suppressed, which may be related to the atrophy of spleen, thymus and liver. Moreover there were severe lymphocytic depletion in spleen and thymus as well as decrease in the number of hematopoietic cells in bone marrow. Also, degeneration of cardiac muscles and testicular germinal epithelia were observed. Taken together, it is suggested that Long-term administration of ID6105 at high doses over 0.2 mg/kg/day might cause hematopoietic and male reproductive system injuries, in addition to hepatic dysfunction.