• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.7 no.4
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• pp.97-106
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• 2008

This proposed system is a part of internal control system that national highway need to support their ITS information audit. This paper explains the design and implementation of a packet interceptor and a DB query analyzer. The packet interceptor sniffs users' query packets, and then the DB query analyzer parses the SQL queries and stores the users' DB access information such as SQL queries, access data and changing data. The information may be used as the evidences on internal control of users and users' accesses.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.60.1-60.1
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• 2015

We present the current operation status of StarDB web services by showing its user access statistics. The StarDB web services started its operation in late November, allowing world-wide users to access results of new variability analysis for Northern Sky Variability Survey light curves. New analysis results of various time-series data have been added to the StarDB services. Importantly, our services have supported a simple cone search, which is an internationally well-defined catalog search interface in the international Virtual Observatory systems. We have collected user access statistics such as how users find our analysis data since its operation in later November. We expect our analysis of the StarDB operation to help Korean community members who plan and operate their own web services preparing for a future era of big survey data.

• Korean Journal of Pharmacognosy
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• v.33 no.4 s.131
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• pp.332-336
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• 2002

Opuntia ficus-indica var. sabotan was administered with diet for 5 weeks on db/db diabetic mice and its antidiabetic activity was investigated. Leaves of Opuntia ficus-indica var. sabotan inhibited the increase of body weight, glucose elevation in blood and urine, and protein excretion in urine, and protein excretion in urine. Opuntia ficus-indica var. sabotan also inhibited the intestinal maltase and sucrase activity on db/db Mice loaded with maltose and sucrose. However, it did not significantly lower HbAlc in blood of db/db mice. These results suggest that leaves of Opuntia ficus-indica var. sabotan could be effective on insulin-independent diabetic mellitus type 2.

• The Transactions of the Korea Information Processing Society
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• v.1 no.2
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• pp.141-153
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• 1994

According to various information needs of end-users in information society, it brings forward a study on a database(DB) product costing method in order to activate the DB industry. The objective of this paper is to propose the DB product costing method of the DB service. The first thing classifies the elements of DB product cost accounting by the activities of the circulation system of information in the DB service. Based on the assumptions in terms of DB product cost accounting, the second is to develop its model. The last is to present the process of DB product cost accounting by applying the model to a company which provides the DB service. It is necessary to research continuously regarding the DB product costing method because its purpose is to decide a DB service charge. The right pricing decision in the DB service charge will contribute toward the growth of the DB industry acceleratedly.

• The Korea Journal of Herbology
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• v.21 no.2
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• pp.37-46
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• 2006

Objectives : The purpose of this study was to investigate the effect of Dangguibohyultang (DB) and its combination (DB-I; Astragali membraneus BUNGE : Angelica gigas NAKAI=5:1, DB-II; Astragali membraneus BUNGE:Angelica gigas NAKAI=1:1, DB-III; Astragali membraneus BUNGE:Angelica gigas NAKAI=1:5,) on apoptosis in human colorectal adenocarcinoma HCT116 cells. Methods : To study the cytotoxic effect of methanol extract of DB-I, DB-II and DB-III on HCT116 cells, the cell viability was determined by XTT reduction method and ttypan blue exclusion assay. To confirm the induction of apoptosis, the cleavage of poly ADP-ribose polymerase (PARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of procaspase-3, -8 and -9 were examined by western blot analysis. Furthermore, DB-induced apoptosis was confirmed by DNA fragmentation. The release of cytochrome C from mitochondria to cytosol, the level of Bcl-2 and Bax, and the expressions of Raf/MEK/ERK were examined by western blot analysis. Results : DB-I and DB-II reduced proliferation of HCT116 cells in a dose-dependent manner. DB-I and DB-II decreased procaspase-3, -8, -9 levels in a dose-dependent manner and induced the clevage of PARP. DB-I and DB-II also triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome C from mitochondria to cytosol, decreasing of anti-apoptotic Bcl-2, and increasing of pro-apoptotic Bax. DB-I and DB-II decreased the activation of Ras/Raf/MEK/ERK cascade in a dose-dependent manner. Conclusion : These results suggest that DB-I and DB-II induce apoptosis via mitochondrial pathway in HCT116 cells. Furthermore, Raf/MEK/ERK cascade is involved in DB-induced apoptosis. These results suggest that DB is potentially useful as a chemotherapeutic agent in human liver cancer.

• Toxicological Research
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• v.27 no.1
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• pp.37-41
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• 2011

This study investigated the antioxidative action of Corni Fructus aqueous extract on kidneys of diabetic mice. The electron donating abilities of Corni Fructus aqueous extract and its antioxidant activities (XO, SOD, CAT, GST, eNOS) in kidneys of C57BL/6 or db/db mice were evaluated. For in vivo study, seven week-old male mice were divided into normal control group (NC, C57BL/6 mice), diabetic control group (DC, db/db mice) and Corni Fructus (500 mg/kg/day for 8 weeks) treated diabetic group (DCF, db/db mice). The electron donating abilities of Corni Fructus aqueous extract exhibited 7%, 24.4%, and 42.7% at concentrations of 100, 500, and $1000\;{\mu}g/ml$, respectively. The activity of XO in the DCF group was significantly lower than the DC group by 35% (p < 0.05). The SOD activity was significantly higher in the DCF group than the DC group by 26% (p < 0.05). The activities of CAT and GST were lowered in the DCF group than the DC group by 26% (p < 0.05) and 7.6%, respectively. The mRNA expression of eNOS in kidneys was lower in the DCF group than the DC group by 24%. These results indicate that Corni Fructus reduced oxidation stress as evidenced by the restoration of the enzymatic antioxidative defense system in renal tissues of db/db mice. It is suggested that these antioxidative actions of Corni Fructus on renal tissues in db/db mice could contribute to its renoprotective effects on diabetic nephropathy.

• Journal of Ginseng Research
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• v.32 no.3
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• pp.187-193
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• 2008

The present study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db mice. The db/db mice were divided into three groups: diabetic control group (DC), Korean red ginseng group (KRG, 100 mg/kg) and metformin group (MET, 300 mg/kg), and treated with drugs once per day for 10 weeks. Compared to the DC group, fasting blood glucose levels were decreased by 19.8% in KRG-, 67.7% in MET-treated group. With decreased plasma glucose and insulin levels, the insulin resistance index of the KRG-treated group was reduced by 27.6% compared to the DC group. The HbA1c levels in KRG and MET-treated groups were also decreased by 11.0% and 18.9% compared to that of DC group, respectively. Plasma triglyceride and non-esterified fatty acid levels were decreased by 18.8% and 16.8%, respectively, and plasma adiponectin and leptin levels were increased by 20.6% and 12.1%, respectively, in the KRG-treated group compared to those in DC group. Histological analyses of the liver and fat tissue of mice treated with KRG revealed significantly decreased number of lipid droplets and decreased size of adipocytes compared to the DC group. From the pancreatic islet double-immunofluorescence staining, we observed KRG has increased insulin contents, but decreased glucagon production. To elucidate action mechanism of KRG, effects on AMP-activated protein kinase (AMPK) and its downstream target proteins responsible for fatty acid oxidation and gluconeogenesis were explored in the liver. KRG activated AMPK and acetyl-coA carboxylase (ACC) phosphorylations, resulting in stimulation of fatty acid oxidation. KRG also caused to down regulation of SREBP1a and its target gene expressions such as FAS, SCD1 and GPAT. In summary, our results suggest that KRG exerted the anti-diabetic effect through AMPK activation in the liver of db/db mice.

• Genomics & Informatics
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• v.4 no.4
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• pp.170-172
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• 2006

ESTin is an easy-to-use tool that allows EST researchers to build a dbEST submission file with EST sequences and related data. The advantages of ESTin are its user-friendly interface, various editing functions, and rigorous validation function.

• 한국ITS학회:학술대회논문집
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• 2008.11a
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• pp.262-268
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• 2008

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.11 no.5
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• pp.78-88
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• 2012

AVIs on the road are installed for (1) security (2) and for traffic, and they are various managed by (1) police department, (2) local government, (3) national highway management, (4) Korean highway corporation. But although the collected data of the plate number, the travel time, the picture of the car are same, they are used in purposes of its installation because the managements are different and the data are difficult to be connected with each other. For this reason, this study is to appraise the application for creating traffic information by integrating these data, and to suggest the introduction of spatial detection system which integrated security-traffic AVI DB for the purpose of reliability improvement of center's velocity. The estimating sections of link travel information seems to be expanded, and the error rate between the center's velocity and the experimental value will be reduced if integrated DB of traffic and security AVIs is used for creating traffic information. Also, the crime prevention and arrest rate is expected to rise in the future.