• 한국ITS학회 논문지
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• 제7권4호
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• pp.97-106
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• 2008

본 시스템은 ITS 정보 감사를 지원하기 위한 내부 통제 시스템의 일부이다. 이 시스템은 중요 도로정보 시스템 서버에 접근하는 패킷을 가로챈 후 SQL 쿼리를 분석하여, 접속한 사용자 정보와 데이터 베이스에 접근하려는 DB 정보, 데이터에 대한 조회, 변경, 삭제 정보를 로그로 기록한다. 이 로그 정보는 사용자의 내부 통제 및 데이터베이스 접근 증거로 사용될 수 있다.

• 천문학회보
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• 제40권2호
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• pp.60.1-60.1
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• 2015

We present the current operation status of StarDB web services by showing its user access statistics. The StarDB web services started its operation in late November, allowing world-wide users to access results of new variability analysis for Northern Sky Variability Survey light curves. New analysis results of various time-series data have been added to the StarDB services. Importantly, our services have supported a simple cone search, which is an internationally well-defined catalog search interface in the international Virtual Observatory systems. We have collected user access statistics such as how users find our analysis data since its operation in later November. We expect our analysis of the StarDB operation to help Korean community members who plan and operate their own web services preparing for a future era of big survey data.

• 생약학회지
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• 제33권4호통권131호
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• pp.332-336
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• 2002

Opuntia ficus-indica var. sabotan was administered with diet for 5 weeks on db/db diabetic mice and its antidiabetic activity was investigated. Leaves of Opuntia ficus-indica var. sabotan inhibited the increase of body weight, glucose elevation in blood and urine, and protein excretion in urine, and protein excretion in urine. Opuntia ficus-indica var. sabotan also inhibited the intestinal maltase and sucrase activity on db/db Mice loaded with maltose and sucrose. However, it did not significantly lower HbAlc in blood of db/db mice. These results suggest that leaves of Opuntia ficus-indica var. sabotan could be effective on insulin-independent diabetic mellitus type 2.

• 한국정보처리학회논문지
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• 제1권2호
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• pp.141-153
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• 1994

본 연구는 데이터베이스 서비스 요금산정에 관한 기준을 설정하는데 필요한 데이 터베이스 서비스의 원가계산방법을 연구.제안하는 것에서 출발하였다. 이를 위해 첫 번째로 정보생산, 정보관리, 정보제공,정보이용 분야로 구성되는 정보유통체계를 기 준으로 각 분야별 업무내용을 조사하였다. 두번째로 원가계산에 필요한 비목을 결정 하는 요소를 분류하였다. 원가계산요소는 인건비, 재료비, 전산기관리비, 외주비, 경 비, 마케팅비, 기타비용으로 크게 나눈다. 세번째로 원가요소를 정보유통체계의 각 분야별 업무내용에 적용시키는 것이다. 이때 해당 기업과 정보의 특성에 맞게 원가 요소를 재 분류시킬 필요가 있다. 재분류 작업중 대표적인 것은 비용의 배분문제이다. 마지막으로 원가요소에 실제 비용을 적용해서 정보별 원가계산표를 작성한다. 이와 같은 일련의 작업을 통해서 단계적으로 실행된 정보별 원가계산은 해당 정보에 대한 원가관리 뿐만 아니라, 정보별 요금산정에 필요한 기본자료로 이용될 것이다.

• 대한본초학회지
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• 제21권2호
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• pp.37-46
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• 2006

Objectives : The purpose of this study was to investigate the effect of Dangguibohyultang (DB) and its combination (DB-I; Astragali membraneus BUNGE : Angelica gigas NAKAI=5:1, DB-II; Astragali membraneus BUNGE:Angelica gigas NAKAI=1:1, DB-III; Astragali membraneus BUNGE:Angelica gigas NAKAI=1:5,) on apoptosis in human colorectal adenocarcinoma HCT116 cells. Methods : To study the cytotoxic effect of methanol extract of DB-I, DB-II and DB-III on HCT116 cells, the cell viability was determined by XTT reduction method and ttypan blue exclusion assay. To confirm the induction of apoptosis, the cleavage of poly ADP-ribose polymerase (PARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of procaspase-3, -8 and -9 were examined by western blot analysis. Furthermore, DB-induced apoptosis was confirmed by DNA fragmentation. The release of cytochrome C from mitochondria to cytosol, the level of Bcl-2 and Bax, and the expressions of Raf/MEK/ERK were examined by western blot analysis. Results : DB-I and DB-II reduced proliferation of HCT116 cells in a dose-dependent manner. DB-I and DB-II decreased procaspase-3, -8, -9 levels in a dose-dependent manner and induced the clevage of PARP. DB-I and DB-II also triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome C from mitochondria to cytosol, decreasing of anti-apoptotic Bcl-2, and increasing of pro-apoptotic Bax. DB-I and DB-II decreased the activation of Ras/Raf/MEK/ERK cascade in a dose-dependent manner. Conclusion : These results suggest that DB-I and DB-II induce apoptosis via mitochondrial pathway in HCT116 cells. Furthermore, Raf/MEK/ERK cascade is involved in DB-induced apoptosis. These results suggest that DB is potentially useful as a chemotherapeutic agent in human liver cancer.

• Toxicological Research
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• 제27권1호
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• pp.37-41
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• 2011

This study investigated the antioxidative action of Corni Fructus aqueous extract on kidneys of diabetic mice. The electron donating abilities of Corni Fructus aqueous extract and its antioxidant activities (XO, SOD, CAT, GST, eNOS) in kidneys of C57BL/6 or db/db mice were evaluated. For in vivo study, seven week-old male mice were divided into normal control group (NC, C57BL/6 mice), diabetic control group (DC, db/db mice) and Corni Fructus (500 mg/kg/day for 8 weeks) treated diabetic group (DCF, db/db mice). The electron donating abilities of Corni Fructus aqueous extract exhibited 7%, 24.4%, and 42.7% at concentrations of 100, 500, and $1000\;{\mu}g/ml$, respectively. The activity of XO in the DCF group was significantly lower than the DC group by 35% (p < 0.05). The SOD activity was significantly higher in the DCF group than the DC group by 26% (p < 0.05). The activities of CAT and GST were lowered in the DCF group than the DC group by 26% (p < 0.05) and 7.6%, respectively. The mRNA expression of eNOS in kidneys was lower in the DCF group than the DC group by 24%. These results indicate that Corni Fructus reduced oxidation stress as evidenced by the restoration of the enzymatic antioxidative defense system in renal tissues of db/db mice. It is suggested that these antioxidative actions of Corni Fructus on renal tissues in db/db mice could contribute to its renoprotective effects on diabetic nephropathy.

• Journal of Ginseng Research
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• 제32권3호
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• pp.187-193
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• 2008

The present study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng in C57BL/KsJ db/db mice. The db/db mice were divided into three groups: diabetic control group (DC), Korean red ginseng group (KRG, 100 mg/kg) and metformin group (MET, 300 mg/kg), and treated with drugs once per day for 10 weeks. Compared to the DC group, fasting blood glucose levels were decreased by 19.8% in KRG-, 67.7% in MET-treated group. With decreased plasma glucose and insulin levels, the insulin resistance index of the KRG-treated group was reduced by 27.6% compared to the DC group. The HbA1c levels in KRG and MET-treated groups were also decreased by 11.0% and 18.9% compared to that of DC group, respectively. Plasma triglyceride and non-esterified fatty acid levels were decreased by 18.8% and 16.8%, respectively, and plasma adiponectin and leptin levels were increased by 20.6% and 12.1%, respectively, in the KRG-treated group compared to those in DC group. Histological analyses of the liver and fat tissue of mice treated with KRG revealed significantly decreased number of lipid droplets and decreased size of adipocytes compared to the DC group. From the pancreatic islet double-immunofluorescence staining, we observed KRG has increased insulin contents, but decreased glucagon production. To elucidate action mechanism of KRG, effects on AMP-activated protein kinase (AMPK) and its downstream target proteins responsible for fatty acid oxidation and gluconeogenesis were explored in the liver. KRG activated AMPK and acetyl-coA carboxylase (ACC) phosphorylations, resulting in stimulation of fatty acid oxidation. KRG also caused to down regulation of SREBP1a and its target gene expressions such as FAS, SCD1 and GPAT. In summary, our results suggest that KRG exerted the anti-diabetic effect through AMPK activation in the liver of db/db mice.

• Genomics & Informatics
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• 제4권4호
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• pp.170-172
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• 2006

ESTin is an easy-to-use tool that allows EST researchers to build a dbEST submission file with EST sequences and related data. The advantages of ESTin are its user-friendly interface, various editing functions, and rigorous validation function.

• 한국ITS학회:학술대회논문집
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• 한국ITS학회 2008년도 제7회 추계학술대회 및 정기총회
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• pp.262-268
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• 2008

• 한국ITS학회 논문지
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• 제11권5호
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• pp.78-88
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• 2012

도로상에 설치되어 있는 AVI는 두 가지 목적으로 (1) 방범용, (2) 교통용으로 구분되며, 관리기관 또한 (1) 경찰청, (2) 지자체, (3) 지방국토관리청, (4) 한국도로공사로 다양하다. 하지만 수집데이터는 차량번호, 통행시간, 차량사진으로 동일함에도 불구하고 구축된 목적에 따라서만 데이터가 이용되고 있어 관리주체가 상이하기 때문에 데이터간의 연계가 어려운 실정이다. 따라서 본 연구는 이 데이터를 통합하여 교통정보 생성용으로 활용가능성을 평가하고, 센터속도의 신뢰성 제고를 목적으로 방범-교통 AVI DB를 연계 통합한 구간검지체계의 도입방안을 제시하는 것을 목적으로 한다. 향후 교통용과 방범용의 AVI의 DB를 통합하여 교통정보 생성용으로 활용할 경우 구간소통정보를 산출할 수 있는 구간이 확대되고, 센터속도와 실측값 사이의 오차율을 감소시키는 방안으로 활용될 수 있을 것으로 판단되며, 방범 측면에서도 범죄 예방률 및 검거율이 향상될 것으로 기대된다.