• 한국전산유체공학회:학술대회논문집
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• 2008.08a
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• pp.61.2-61.2
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• 2008

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.9
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• pp.211-226
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• 2019

Pig CD45, the leukocyte common antigen, is encoded by the PTPRC gene and CD45 is a T cell-type specific tyrosine phosphatase with alternative splicing of its exons. The CD45 is a coordinated regulator of T cell antigen receptor (TCR) signal transduction achieved by dephosphorylating the phosphotyrosine of its substances, including $CD3{\zeta}$ chain of TCR, Lck, Fyn, and Zap-70 kinase. A dysregulation of CD45 is associated with a multitude of immune disease and has been a target for immuno-drug discovery. To characterize its key structural features with the effects of regulating TCR signaling, this study predicted the unknown structure of pig CD45RO (the smallest isoform) and the complex structure bound to the ITAM (REEpYDV) of $CD3{\zeta}$ chain via homology modeling and docking the peptide, based on the known human CD45 structures. These features were integrated into the structural plasticity of extracellular domains and functional KNRY and PTP signature motifs (the role of a narrow entrance into ITAM binding site) of the tyrosine phosphatase domains in a cytoplasmic region from pig CD45RO. This contributes to the selective recognition of phosphotyrosine from its substrates by adjusting the structural stability and binding affinity of the complex. The characterized features of pigCD45RO can be applied in virtual screening of the T-cell specific immunomodulator.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.30-33
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• 2007

DSMC method is now widely accepted CFD approach to compute and simulate the nozzle plume in rarefied regimes. In this study, using SMILE(Statistical Modeling in Low-density Environment) code which was developed in ITAM, Russia and coded using DSMC method, the internal flow of the Rothe micronozzle was simulated. Moreover, to show the validity of the SMILE code, the centerline temperatures according to the Reynold's number were compared with the ones obtained by the Rothe's experiment.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.116.1-116.1
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• 2000

• Korean Chemical Engineering Research
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• v.61 no.2
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• pp.278-286
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• 2023

The present work evaluated the production of biohydrogen under mesophilic and thermophilic conditions through dark fermentation of palm oil mill effluent (POME) in batch mode using the design of experiment methodology. Response surface methodology (RSM) was applied to investigate the influence of the two significant parameters, POME concentration as substrate (5, 12.5, and 20 g/l), and volumetric substrate to inoculum ratio (1:1, 1:1.5, and 1:2, v/v.%), with inoculum concentration of 14.3 g VSS/l. All the experiments were analyzed at 37 ℃ and 55 ℃ at an incubation time of 24 h. The highest chemical oxygen demand (COD) removal, hydrogen content (H₂%), and hydrogen yield (HY) at a substrate concentration of 12.5 g COD/l and S:I ratio of 1:1.5 in mesophilic and thermophilic conditions were obtained (27.3, 24.2%), (57.92, 66.24%), and (6.43, 12.27 ml H₂/g COD_rem), respectively. The results show that thermophilic temperature in terms of COD removal was more effective for higher COD concentrations than for lower concentrations. Optimum parameters projected by RSM with S:I ratio of 1:1.6 and POME concentration of 14.3 g COD/l showed higher results in both temperatures. It is recognized how RSM and optimization processes can predict and affect the process performance under different operational conditions.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.147.1-147.1
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• 2000

• 정보화사회
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• s.184
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• pp.28-39
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• 2007

IT산업은 항상 끊임없는 '혁신'을 통해서만 성장의 자양분을 얻는다. 기술적 또는 개념적 진보가 없다면 IT산업은 당연히 산업으로서의 존재가치가 없다. 그렇다면 2007년, 한국의 IT시장을 주도할 '10대 핵심 IT기술'들은 어떤 것들일까. 국내 통신 및 네트워크, 솔루션 업계가 가장 관심 있게 지켜보는 IT기술등 중 10개를 선별했다. 10대 IT기술에 포함된 것들 중에는 개념적으로는 10년전부터 출현해 알려져 있지만, 그동안 단순히 개념에 머물렀을 뿐 아직 상용화가 안 된 것들도 일부 포함돼 있다. 참신성보다는 실질적인 의미와 중요성에 무게들 둔 때문이다. 2007년에 주목할 만한 10대 IT기술로는 먼저 'IP 멀티미디어 서브시스템(IMS)이 꼽힌다. 유무선을 비롯한 다양한 네트워크를 자연스럽게 연결해주고 여러 서비스들의 다양한 조합이 가능해 고객맞춤형서비스를 가능하게 하는 '멀티미디어 멀티캐스트 컨트롤(MMC)도 10대 IT기술에 포함됐다. 이와 함께 100Mbps 초고속 인터넷 서비스를 가능하게 하는 ETTH (Ethernet To The Home), 차세대 보안이슈인 네트워크접근제어(NAC), 금융회사나 이동통신회사의 상품개발을 신속하게 지원하는 '프로덕트 팩토리', 하드웨어시스템의 최적화를 보장한 가상화 및 ILM, 컴퓨팅산업을 한 단계 이상 진화시킬 쿼드코어 CPU, 소프트웨어 시장의 새로운 패러다임인 SOA(서비스지향아키텍처), 본격적인 시장 확산이 기대되는 전자태그(RFID), IT거버넌스의 열기로 급부상하고 있는 ITAM(IT자산관리) 등도 올해 주목할 10대 IT기술 반열에 올랐다.

• Resources Recycling
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• v.13 no.1
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• pp.59-67
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• 2004

A universal plasma-chemical module (PChM) for the industrial processing of different hydrocarbon raw material pyrolysis was designed and tested. Laboratory investigations for the plasma-chemical method of acetylene production from natural gas and different coals were made. Similar laboratory tests on the industrial production of acetylene as a raw material for organic syn-thesis were developed using the PChM. A comparison of the suggested plasma-chemical method with the traditional process of acetylene production were carried out. The outlook of the plasma-chemical method was shown.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.267.3-268
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• 2002

Aggregation of the high affinity 1gE receptor on mast cells results in many biochemical. events leading to the release of histamine. serotonin. prostaglandins arachidonic acid metabolites, and cytokines. Previously we have shown that M2 pyruvate kinase interacts with the gamma chain of 1gE receptor on the ITAM (immunoreceptor tyrosine-based activation motif) region. (omitted)

• Fisheries and Aquatic Sciences
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• v.8 no.2
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• pp.56-64
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• 2005

Two distinct CD3 homologue genes, $CD3\gamma/\delta\;and\;CD\varepsilon$, were isolated from a olive flounder leukocyte cDNA library and a BAC library. $CD3\gamma/\delta$ consisted of 961 bp encoding 178 amino acid residues, and $CD3\varepsilon$ consisted of 1006 bp encoding 164 amino acid residues. When compared with other known CD3 peptide sequences, the most conserved region of the two olive flounder CD3 chain peptides are the cytoplasmic domain and the least conserved are the extracellular domain. A phylogenetic analysis based on the deduced amino acid sequence grouped the two olive flounder CD3 sequences with $CD3\varepsilon$ and $CD3\gamma/\delta$, respectively. The olive flounder CD3 cluster (consisting of $CD3\varepsilon\;and\;CD3\gamma/\delta$) spans only 10.4 kb. The $CD3\varepsilon\;and\;CD3\gamma/\delta$ genes are oppositely transcribed only 3.8 kb apart. Both olive flounder CD3 genes have five exons. The two olive flounder CD3 genes were predominantly expressed in PBLs, kidney, spleen, and gills.