Roles and signaling pathway of M2 pyruvate kinase in RBL-2H3 cells

  • Sul Ill-Woung (Pharmacology Lab, College of Pharmacy, Chonnam National University) ;
  • Kuo NaYeon (Pharmacology Lab, College of Pharmacy, Chonnam National University) ;
  • Cho ChoonSil (Pharmacology Lab, College of Pharmacy, Chonnam National University) ;
  • Kim SoYoung (Pharmacology Lab, College of Pharmacy, Chonnam National University) ;
  • Kim Kyeong-Man (Pharmacology Lab, College of Pharmacy, Chonnam National University)
  • Published : 2002.10.01

Abstract

Aggregation of the high affinity 1gE receptor on mast cells results in many biochemical. events leading to the release of histamine. serotonin. prostaglandins arachidonic acid metabolites, and cytokines. Previously we have shown that M2 pyruvate kinase interacts with the gamma chain of 1gE receptor on the ITAM (immunoreceptor tyrosine-based activation motif) region. (omitted)

Keywords