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A Study in Preparation of $^{113m}In$ colloid as Scanning Agent and it's Organ Distribution in Rats (주사용(走査用) $^{113m}In$ 교질(膠質)의 조제(調製) 및 흰쥐에서의 장기분포(臟器分布)에 관(關)한 연구(硏究))

  • Koh, Chang-Soon;Rhee, Chong-Heon;Chang, Ko-Chang;Hong, Chang-Gi D.
    • The Korean Journal of Nuclear Medicine
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    • v.3 no.1
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    • pp.73-82
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    • 1969
  • The newly developed diagnostic method with application of $^{113}Sn-^{113m}In$ cow system ($^{113}Sn:\;T\frac{1}{2}$ 118 days, $^{113m}In:\;T\frac{1}{2}$ 1.7 hrs, 390 Kev, Single ${\gamma}$) has the remarkable advantages such as increased diagnostic ability by single large dose administration of $^{113m}In$ with no subsequent radiation hazard and shortened examining time. We reformed the research of following scope with the use of developed $^{113}Sn-^{113m}In$ cow (25 mCi) generator: The sizes of particles produced under various conditions were investigated, and possibility for application to the scannings of various organs such as brain, liver, lung, bone marrow and blood pool etc. were studied. Results: $^{113m}InCl_3$ solution eluted from diluted HCl solution (pH 1.5) passed through $^{113}Sn-^{113m}In$ generator, and there can be produced various sized particles of colloidal indium. And there observed the state of distribution of $^{113m}In$ in each organ which showed many differences according to the particle sizes of colloidal indium. The results are stated as follows: 1. The adjustment of pH is the most important factor in making the desirable particle size of colloidal indium. The colloid for blood pool showed the highest level as 7.1%/gm blood, at pH 1.7, the colloid of pH 3.5 for liver scanning showed the highest level, 88.4%, in the liver, the colloid pH 6 showed the highest level, 3.1%, in the spleen, and the colloid of pH 11.0 showed the highest level, 85.3%/gm, in the lung. 2. The colloid for liver scanning made with NaCl-NaOH system showed the highest liver uptake at pH 7.2, and at either higher or lower pH than 7.2 showed decrease of liver uptake more or less. 3. The activity of $^{113m}In$ eluted through $^{113}Sn-^{113m}In$ generator indicated over 90% in the initial 4 ml, and particularly 88.1%-86.0% in the initial 2 ml. 4. The incubation time, tempertaure and mechanical irritation related to colloid formation and coating of colloid were not the definite condition of influence.

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Improving evaluation metric of mobile application service with user review data (사용자 리뷰 데이터를 활용한 모바일 어플리케이션 서비스 평가 척도 개선)

  • Lee, Burmguk;Son, Changho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.1
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    • pp.380-386
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    • 2020
  • The mobile application market has grown over the past decade since the advent of smartphones, making it the largest market for electronic device software. As competition intensifies in the mobile application market, the impact of application evaluations on the consumption and usage patterns of users has also significantly increased. Therefore, research has been conducted on measures to evaluate mobile applications, but most of the research has relied on qualitative methods such as expert-centered interviews or surveys. In addition, evaluation measures are being constructed from the service provider's perspective, not from the service user's perspective. However, the possibility of application-specific analyses that minimize the subjectivity of researchers is growing, as large amounts of user review data enable quantitative analysis of actual users' assessment of applications. Therefore, this study presents a methodology that can complement current problems with existing quality assessments for mobile applications by utilizing user review data. To this end, the Topic Modeling technique LDA (Latent Dirichlet allocation) is applied in order to elucidate ways to improve existing evaluation measures from a user's perspective. The study is expected to reduce bias in service assessment due to the subjectivity of service providers and researchers as well as provide a measure of assessment by area of mobile applications from a consumer perspective.

A Study on Reliability and Shelf-Life of DELAY M9 (DELAY M9 탄약의 신뢰도 및 저장수명 연구)

  • Lee, Jeong-Ho;Choi, Jae-Sung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.21 no.9
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    • pp.64-72
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    • 2020
  • DELAY M9 is an ammunition used in combination with the fuse M904 and M905 of aviation drop-off ammunitions. Due to the properties of the ammunition, the performance or safety of the ammunition cannot be verified until it is used, because of its one-time function, no reproduction and is finally destroyed at the same time. Long-term storage of ammunition in use by the army is inevitable due to its operational characteristics, and a test evaluation is required to maintain and verify the performance of stored ammunition for immediate use in case of emergency. This paper estimates the reliability and shelf life of the DELAY M9 ammunition by using the test data obtained through ASRP performed from the past to the present. The result of the performance evaluation test for the currently stored DELAY M9 ammunition is analyzed, and the reliability and shelf-life of the stored ammunition are assessed by examining the number of defects according to the storage time and production year. This research result can be used to manage the stored ammunition, such as ASRP planning and evaluation test, result analysis and munition state decision.

Assessment of Volatile Organic Compounds in Blood and Urine among Residents around Camp Carroll (캠프 캐럴 인근 주민의 혈중 및 요중 휘발성 유기화합물 평가)

  • Lim, Hyun-Sul;Yang, Wonho;Kim, Geun-Bae;Cho, Young-Sung;Min, Young-Sun;Lee, Kwan;Lee, Duk Hee;Ju, Young-Su;Kim, Sunshin;Heo, Jung;Jung, Dayoung
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.26 no.1
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    • pp.11-19
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    • 2016
  • Objectives: Exposure to volatile organic compounds such as trichloroethylene(TCE) and perchloroethylene(PCE), along with Agent Orange, that were issued around Camp Carroll US Army Base situated in Waegwan, Chilgok-gun, Gyeongsangbuk-do Province, Korea. The main objective of this study was to assess the exposure to TCE and PCE of residents of the area surrounding Camp Carroll. Methods: The TCE, PCE and trichloroethanol(TCEOH) concentrations in blood and trichlroroacetic acid(TCA) and TCEOH concentrations in urine were measured and analyzed in a total of 1,033 residents around Camp Carroll. TCA and TCEOH are metabolites of TCE and PCE, respectively. The information on demographic characteristics and exposure variables in relation to underground water were obtained through a questionnaire completed by the subjects. Results: TCE, PCE and TCEOH concentrations were not detected in blood. Detection rates of TCA and TECOH concentrations in urine were 98.5% and 36.6%, respectively. Creatinine-corrected average TCA and TCEOH concentrations were $12.23{\pm}23.81{\mu}g/g$ and $0.66{\pm}4.31{\mu}g/g$, respectively. A significant difference was not shown between the drinking group and no drinking group for underground water, which was assumed as a potential route of exposure to TCE and PCE through the consumption of ground water. However, females drinking ground water showed a significantly higher mean level of TCA in urine than did males. There was no significant difference according to drinking ground water as a potential source of exposure to TCE and PCE in residents around Camp Carroll. Conclusions: Considering the statistical analysis of factors affecting exposure to TCE and PCE in ground water along with previous reports, TCA in urine as exposure to TCE and PCE might not be appropriate because it is found in chlorinated drinking water. Therefore, TCA concentration in urine may be the result of drinking of chlorinated water.

Development of newly recruited privates on-the-job Training Achievements Group Classification Model (신병 주특기교육 성취집단 예측모형 개발)

  • Kwak, Ki-Hyo;Suh, Yong-Moo
    • Journal of the military operations research society of Korea
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    • v.33 no.2
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    • pp.101-113
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    • 2007
  • The period of military personnel service will be phased down by 2014 according to 'The law of National Defense Reformation' issued by the Ministry of National Defense. For this reason, the ROK army provides discrimination education to 'newly recruited privates' for more effective individual performance in the on-the-job training. For the training to be more effective, it would be essential to predict the degree of achievements by new privates in the training. Thus, we used data mining techniques to develop a classification model which classifies the new privates into one of two achievements groups, so that different skills of education are applied to each group. The target variable for this model is a binary variable, whose value can be either 'a group of general control' or 'a group of special control'. We developed four pure classification models using Neural Network, Decision Tree, Support Vector Machine and Naive Bayesian. We also built four hybrid models, each of which combines k-means clustering algorithm with one of these four mining technique. Experimental results demonstrated that the highest performance model was the hybrid model of k-means and Neural Network. We expect that various military education programs could be supported by these classification models for better educational performance.

The Immune Response of Mice Vaccinated with Japanese Encephalitis Vaccine, CJ50003 Produced in Vero Cells (베로 세포에서 생산된 2세대 일본뇌염 백신의 마우스에서의 면역원성)

  • ;;;;;;Kenneth H. Eckels
    • Korean Journal of Microbiology
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    • v.35 no.1
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    • pp.82-88
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    • 1999
  • In this study, to evaluate newly developed Japanese encephalitis (JE) vaccine candidate CJ50003, we assessed its immunogenicity along with a previously commercialized inactivated JE Biken vaccine. The CR0003 viral antigens produced in Vero cells were administered suhcutaneouly to mice either with alum-adjuvanled or free form. The ELISA titers and neutralizing (NEUV antibody titers accounting for major protective immunity in JE were determined. Mice given alum-adjuvanted vaccine had a 10 times higher antigen-specific NEUT antibody response than did those which {lad received free antigens. This NEUT antibody response was maintained until day 168 with NEUT titer more than 1:160. Even with the 0.5 ng of alum-adjuvanted antigen dose, NEUT titer was induced more than 1:10 which is considered as an evidence for seroconversion and protection. Thc mice immune sera had a similar rate of cross-reactivity against three different viral antigens, Nakayama-NlH, P3 and SA14; as determined by ELISA assay. In a mice challenge model, vaccination with the GI50003 conferred more protection than with commercialized Biken vaccine against Nakayama virus. These data demonstrated that CJ50003 vaccine candidate has an excellent prophylactic efficacy and implicated it has a strong potential for further development and commercialization.

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A Time Variable Modeling Study of Vertical Temperature Profiles in the Okjung Lake (옥정호의 연직 수온분포에 관한 시변화 모델 연구)

  • Park, Ok-Ran;Park, Seok-Soon
    • Korean Journal of Ecology and Environment
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    • v.35 no.2 s.98
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    • pp.79-91
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    • 2002
  • A time variable modeling study was performed for seasonal variations of vertical temperature profiles in the Okjung Lake located in upstream of the Sumjin River. Based on the model structure of the US Army Corps of Engineer's CE-QUAL-W2, the lake was divided into 3 branches, 50 longitudinal segments and 49 vertical layers and vertical profiles of water temperature and current velocity were simulated over one year. The model results were calibrated and verified against vertical profiles of water temperature measured every month from March 1998 to February 1999 at 5 different locations. The model results showed a good agreement with the field measurements. The hydrologic balance during this period was validated by comparing the simulated values of surface elevation level with the measured data. There was some discrepancy in July data between the model results and the fleld measurements. This could be attributed partially to the inadequacy of the model to the highly hydrodynamic nature of water body and partially to the lack of accuracy in local atmospheric temperature data during summer monsoon period. The model results have shown that there was no seasonal over-turn in most part of the Okjung Lake, where water temperature maintained above $4^{\circ}C$ over one year. In the upstream shal-low area (depth<20 meter), however, temperature at surface layer fell below $4^{\circ}C$ and water was frozen such that slight over-turn would occur during winter period. From this study, we concluded that the Okjung Lake is oligomictic. This conclusionis significantly different from the general pattern that the lakes located from $20^{\circ}C$ to $40^{\circ}C$ latitude would be warm monomictic. From the examination of simulated current velocity distribution, it was found that the upstream inflows would infiltrate into mesolimnion of the lake during hydrodynamic summer monsoon periods due to the thermal density of water.

The Rearch Of Method in the Appropriate number of Demand and Supply of OMD (한의사인력(韓醫師人力) 공급(供給)의 적정화방안(適定化方案) 연구(硏究))

  • Lee, Jong-Soo
    • The Journal of Korean Medicine
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    • v.19 no.1
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    • pp.299-326
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    • 1998
  • 1. Comparison of demand and supply A. Assumption of estimation of demand and supply we will briefly assumptions used for presumption once more before comparing the result of estimation of demand and supply examined previously 1) supply - The average applying rate for state. examination of graduate: ${\alpha}$=1.03109 - The ratio of successful applicants of state examinations: ${\beta}$=0.97091 - Mortality classified by age : presumed data of the Bureau of statistics - Emigrating rate: 0 % - Time of retire: unconsidered - An army doctor number: unconsidered and regard number of employed oriental medicine doctor. - Standard of 1995 : The number of survival oriental medicine doctor is 8195. the number of employed oriental medicine doctor is 7419. 2) demand - derivated demand method Daily the average amount of medical treatment: according to medical insurance federation data. there is 16 or 6 non allowance patient, we consider amount of medical treatment as 22 persons in practical because 21.94 persons (founded practical examination) are converted to allowance in comming demand. Daily the proper amount of medical treatment: 7 hours form -35 persons 5 hours 30 minutes form -28 persons. Yearly medical treatment days: 229 days. 255 days. 269 days . Increasing rate of visiting hospital days: -1996 year. 1997 year. 1998 year- . Rate of applying insurance: yearly average 71.51% (among the investigated patient) B. Comparison of total sum result 1) supply (provision) Table Ⅳ-1 below shows the estimation of the oriental medicine doctor in the future.

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  • Development and Effectiveness Verification of CBT and ACT Group Counseling Programs for Maladjusted Soldiers (부적응 병사를 위한 인지행동치료 및 수용전념치료 집단상담 프로그램 개발 및 효과 검증)

    • Cho, Ju Sung;Choi, Jaegwang;Kang, Yohan;Yu, Han Byeol;Song, Wonyoung
      • Journal of Convergence for Information Technology
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      • v.10 no.11
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      • pp.224-231
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      • 2020
    • This study was conducted to develop a group counseling program to solve the problem of maladjustment of military personnel and to verify the effectiveness of the program. The 12 session CBT and ACT program for military soldiers experiencing emotional and behavioral problems was developed and the effectiveness was verified by conducting a program once a week for soldiers in the army units based in South Chungcheong Province. Adult Self Report scale(ASR) was implemented for pre-post test and analysis, and descriptive statistical analysis, cross-analysis, paired sample t-test, and independent sample t-test were performed to analyze the results. The results indicated are as follows: First, the preliminary homogeneity test between groups showed that the two groups had homogeneous demographic characteristics and the characteristics of the variables. Second, as a result of the pre-post test verification, both CBT and ACT groups showed significant changes in problem behavior totals, internalizations, and externalizations. Third, there was no difference between the pre-post-examination of the CBT group and the ACT group. This study is meaningful in that it was involved in the maladjustment problem within the military unit, and compared the effectiveness between the two theories, and proposed the study of control groups and further studies on more diverse and diverse subjects that were not implemented under the circumstances of the unit.

    Study on the simulation of a spark ignition engine using BOOST (상용 소프트웨어를 이용한 스파크 점화 기관의 시뮬레이션에 관한 연구)

    • Jeong, Chang-Sik;Woo, Seok-Keun;Ryu, Soon-Pil;Yoon, Keon-Sik
      • Journal of Advanced Marine Engineering and Technology
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      • v.40 no.9
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      • pp.733-742
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      • 2016
    • In recent years, gas engines fueled with LNG or synthetic gas have been attracting considerable attention for marine use owing to their potential to facilitate better fuel economy and to reduce emissions. It has been confirmed that gas engines using the Otto cycle, which involves premixed combustion, can satisfy Tier III regulations without the EGR or SCR system. The objective of this study is to acquire simulation technologies for predicting gas engine performances in industrial fields. Using the commercial software BOOST, the simulation is conducted on a gasoline engine rather than a marine engine due to the gasoline engine's easier accessibility. This study consists of two stages. In the first stage published previously, the optimal modeling techniques for representing the behavior of the gas in the intake and exhaust systems were determined. In the current study, we formulated a method to evaluate the combustion and heat transfer processes in the cylinder and to ultimately determine the major performance parameters, given that the analytical model derived from the previous stage has been applied. Through this study, we were able to determine a combustion and heat transfer model and a valve discharge coefficient that are less reliant on empirical data: we were also able to formulate a methodology through which relevant constants are decided. We confirmed that the values of transient cylinder pressure variation, indicated mean effective pressure, and air supply can be successfully predicted using our modeling techniques.