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Endothelin-1 Levels in Patients with Heart Disease Associated with Pulmonary Hypertension ; Potential role of Endothelin-1 in genesis of pulmonary artery vasospasm (개심술 환자에서 술전및 술후의 폐동맥 고혈압및 혈역학적 변수들과 ET-1치와의 관계에 대한 연구)

  • 박형주
    • Journal of Chest Surgery
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    • v.25 no.6
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    • pp.650-660
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    • 1992
  • To elucidate a potential contribution of endotheline-1[ET-1] to the genesis of pulmonary hypertension and postoperative pulmonary hypertensive crisis in the patients with heart disease, we measured plasma levels of the ET-1 during perioperative period of open heart surgery. In addition, we examined changes of ET-1 during perioperative period and correlations between ET-1 levels and hemodynamic variables. 12 patients including 5 acquired heart disease and 7 congenital heart disease patients were selected randomly as a study group, Group A and B, respectively. 6 patients proved not having heart or hemodynamic problem were selected as a control, Group C. 110 blood samples from pulmonary artery[ET-P] and radial artery[ET-S] were taken and assayed by Sep-pak extraction and RIA. ET-1 levels of Group A were ET-P, 3.94$\pm$5.31pg /ml, ET-S, 3.10$\pm$2.90pg/ml[p>0.05], Group B were ET-P, 1.63$\pm$0.62pg/ml, ET-S, 1.99$\pm$2.45pg/ml[p>0.05], Group C were ET-P, 1.97$\pm$2.02pg/ml, ET-S, 1.72$\pm$0.77pg/ml[p>0.05]. There were no statistically significant differences of ET-1 levels among the Group A, B, C[p>0.05]. There was no correlation between pulmonary artery pressure[PAP] and ET-1 level[p>0.05], and ET-1 levels were not increased even in the cases of pulmonary hypertensive criwis or low cardiac output syndrome, whereas significant correlation between ET-S and pulmonary vascular res-istance[Rp] [r=0.36, p<0.05], and negative correlation between ET-S and OS saturation of pulmonary artery[OS-P][r= -0.49, p<0.01] were identified. Another significant finding was peak increase of ET-1 levels in the postoperative period 1 hour[p<0.05] and then gra-dualy decrease through the postoperative period. In conclusion, ET-1 has no correlation with PAP, whereas correlation with Rp, and inverse correlation with OS-P. It is suggested that ET-1 is neither the direct causative substance of pulmonary hypertension nor pulmonary vasospasm but there must be increased production of ET-1 in chronic pulmonary hypertensive state. Counter-regulatory mechanism to ET-1 is speculated during the pulmonary vasospasm.

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INFLUENCE OF BRADYKININ ON CATECHOLAMINE SECRETION FROM THE ISOLATED PERFUSED RAT ADRENAL GLAND

  • Lim, Dong-Yoon;Kang, Moo-Jin
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.128-128
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    • 2003
  • Bradykinin modulates the sympathetic system in various ways. It can stimulate sympathetic neurotransmission directly through presynaptic receptors (Llona et al., 1991) and indirectly via its hypotensive or nociceptive effects which activate central and ganglionic mechanisms (Kuo and Keeton, 1991; Dray et al., 1988). However, it has been found that bradykinin can also liberate prostaglandins in peripheral tissues, thereby attenuating the release of catecholamines(Starke et al., 1977). (omitted)

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Alkyl Hydroxy Benzoate Preservatives (Parabens) Are Estrogenic Compounds; Their Adverse Effects on Animals and Human

  • Kang, Kyung-Sun;Che, Jeong-Hwan;Park, Jin-Sung;Lee, Yong-Soon
    • Toxicological Research
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    • v.17
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    • pp.309-312
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    • 2001
  • It has recently been suggested that the release of "endocrine disrupters (EDs)" into the environment has resulted in adverse health effects on wild life populations and humans (Golden et al., 1998; Tyler et al., 1998; Kang et al., 2000). Human sperm counts have declined significantly throughout the world during the past fifty years, and which is a significant public health concern (Carlsen et al., 1992; Carlsen et al.. 1995). In addition, the EDs persisting in the environment are known to disrupt the normal endocrine systems of wildlife (Colborn, 1995; Crewet al., 1995; Folmer et at, 1996; Sumpter, 1995; Tyler, 1998). Some estrogenic chemicals bind to estrogen receptors (Bolger et al.. 1998), interfere with the binding of physiological ligands to steroid hormone-binding proteins (Danjo, 1997; Milligan et al., 1998). and show immunotoxicity (Sakae et al., 1998). (omitted) (omitted)

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Phase Transition and Surface Morphological Characteristics of Intermediate Product Feitknechtite According to Aging Time during the Synthesis of Birnessite (버네사이트 합성 시 에이징 시간에 따른 중간생성물 페이크네타이트 상전이 및 표면 형태학적 특성)

  • Min, Soyoung;Kim, Yeongkyoo
    • Journal of the Mineralogical Society of Korea
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    • v.32 no.3
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    • pp.213-222
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    • 2019
  • Birnessite (birnessite, $7{\AA}$ manganate, ${\delta}-MnO_2$) is a major mineral comprising manganese nodule. Various synthetic methods have been studied and evaluated because it can be used as an ion exchange agent and a battery recharging material. However, it is difficult to obtain a single birnessite phase because it does not have a stoichiometric chemical composition. Feitknechtite (${\beta}-MnOOH$) is formed as an intermediate product during birnessite synthesis and in this study, the transition of this phase to birnessite was compared by using XRD and SEM. Two different methods, Feng et al. (2004) and Luo et al. (1998), based on redox reaction were used. It was possible to obtain the impurity-free birnessite for the sample aged 60 days at $27^{\circ}C$ by Feng et al. (2004) method and 3 days at $60^{\circ}C$ by Luo et al. (1998) method. The phase transition rate of the feitknechtite phase was slower in the case of $Mg^{2+}$ doped birnessite which was synthesized by Luo et al. (1998) method, and almost single phase almost single phase birnessite was identified at high temperature. Crystal surface and morphology also confirmed the difference between the samples synthesized by two methods.

Review On Current Issues Of The Unrelated Randomized Response Technique

  • Choi, Kyung-Ho
    • Journal of the Korean Data and Information Science Society
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    • v.13 no.1
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    • pp.79-86
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    • 2002
  • Recently, it is shown that the unrelated quest ion randomized response models proposed by Moors (1971), Folsom et al.(1973), Greenberg et al.(1971) are in capable of protecting the privacy of the respondent. Thus, in this paper, we review recent days research tendency. Also modification model of Mahmood et al.(1998) is proposed, and we show th at this model is more efficient than Greenberg et al.(1969). Furthermore we treat the privacy protection based on Lanke's (1975) risk of suspicion measure.

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Review on Abies koreana Community in Mt. Halla National Park, Korea (漢拏山 國立公圓 구상나무群集의 再檢討)

  • Yim, Yang-Jai;Kim, Jeong-Un
    • The Korean Journal of Ecology
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    • v.13 no.3
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    • pp.247-249
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    • 1990
  • The character species of Abies koreana community in Mt. Halla national park, Korea, and it s nomenclature was reviewed. According to the code of phytosociological nomenclature (Barkman et al., 1986), the association name was corrected from Saso-Abietetum koreanae Yim et al. 1990 nov. in the Korean J. Ecol. 13(2): 101-130 (1990) to Saso quelpaertensi-Abietetum koreanae (Song et Nakanishi) corr. Yim et Kim 1990.

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Characteristics of Greenup and Senescence for Evapotranspiration in Gyeongan Watershed Using Landsat Imagery (Landsat 인공위성 이미지를 이용한 경안천 유역 증발산의 생장기와 휴면기 분포 특성 분석)

  • Choi, Minha;Hwang, Kyotaek;Kim, Tae-Woong
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.31 no.1B
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    • pp.29-36
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    • 2011
  • Evapotranspiration (ET) from the various surfaces needs to be understood because it is a crucial hydrological factor to grasp interaction between the land surface and the atmosphere. A traditional way of estimating it, which is calculating it empirically using lysimeter and pan evaporation observations, has a limitation that the measurements represent only point values. However, these measurements cannot describe ET because it is easily affected by outer circumstances. Thus, remote sensing technology was applied to estimate spatial distribution of ET. In this study, we estimated major components of energy balance method (i.e. net radiation flux, soil heat flux, sensible heat flux, and latent heat flux) and ET as a map using Mapping Evapo-Transpiration with Internalized Calibration (METRIC) satellite-based image processing model. This model was run using Landsat imagery of Gyeongan watershed in Korea on Feb 1, 2003 and Sep 13, 2006. Basic statistical analyses were also conducted. The estimated mean daily ETs had respectively 22% and 11% of errors with pan evaporation data acquired from the Suwon Weather Station. This result represented similar distribution compared with previous studies and confirmed that the METRIC algorithm had high reliability in the watershed. In addition, ET distribution of each land use type was separately examined. As a result, it was identified that vegetation density had dominant impacts on distribution of ET. Seasonally, ET in a growing season represented significantly higher than in a dormant season due to more active transpiration. The ET maps will be useful to analyze how ET behaves along with the circumstantial conditions; land cover classification, vegetation density, elevation, topography.

An Untraceable ECC-Based Remote User Authentication Scheme

  • Mehmood, Zahid;Chen, Gongliang;Li, Jianhua;Albeshri, Aiiad
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.3
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    • pp.1742-1760
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    • 2017
  • Recent evolution in the open access internet technology demands that the identifying information of a user must be protected. Authentication is a prerequisite to ensure the protection of user identification. To improve Qu et al.'s scheme for remote user authentication, a recent proposal has been published by Huang et al., which presents a key agreement protocol in combination with ECC. It has been claimed that Huang et al. proposal is more robust and provides improved security. However, in the light of our experiment, it has been observed that Huang et al.'s proposal is breakable in case of user impersonation. Moreover, this paper presents an improved scheme to overcome the limitations of Huang et al.'s scheme. Security of the proposed scheme is evaluated using the well-known random oracle model. In comparison with Huang et al.'s protocol, the proposed scheme is lightweight with improved security.

Validation of Complementary Relationship Hypothesis for Evapotranspiration in Multipurpose Dam Basins (다목적댐유역에서의 증발산 보완관계가설 검증)

  • Kim, Jihoon;Kang, Boosik;Kim, Jin-Gyeom
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.37 no.3
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    • pp.549-559
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    • 2017
  • The complementary relationship hypothesis for areal evapotranspirations was validated in the regional-scale area of multipurpose dam basins in Korea and the long-term water balances were indirectly identified. Annual actual evapotranspiration ($ET_A$) was assumed the difference between total annual precipitation and total annual inflow and the available moisture was assumed the total precipitation. The seasonally varying pan coefficient (kp) is estimated as the ratio of the $ET_{pan}$ and the evapotranspiration calculated by FAO Penman-Monteith equation ($ET_{PM}$). The complementary relationships using ground observation data of $ET_P$ and $ET_A$ in the multipurpose dam basins follow generally the typical pattern that $ET_P$ and $ET_A$ is complementary and converges to equivalent evapotranspiration ($ET_W$) under the extreme wet environment. However, $ET_A$ of Juam dam was estimated relatively greater than other basins and exceeds even $ET_P$ at certain range with high moisture availability, which can be understood as the results of possible over-estimation of precipitation or under-estimation of dam inflow. It is expected that the use of evapotranspiration complementary relationship for validating hydrological water balances will contribute to controlling uncertainties in estimating dam inflows during flood season in particular.

Kinetic Study on Nucleophilic Substitution Reactions of 4-Nitrophenyl X-Substituted-Benzoates with Potassium Ethoxide: Reaction Mechanism and Role of K+ Ion

  • Kim, Song-I;Kim, Min-Young;Um, Ik-Hwan
    • Bulletin of the Korean Chemical Society
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    • v.35 no.1
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    • pp.225-230
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    • 2014
  • A kinetic study on nucleophilic substitution reactions of 4-nitrophenyl X-substituted-benzoates (7a-i) with EtOK in anhydrous ethanol at $25.0{\pm}0.1^{\circ}C$ is reported. The plots of pseudo-first-order rate constants ($k_{obsd}$) vs. [EtOK] curve upward. Dissection of $k_{obsd}$ into the second-order rate constants for the reactions with the dissociated $EtO^-$ and ion-paired EtOK (i.e., $k_{EtO^-}$ and $k_{EtOK}$, respectively) has revealed that the ion-paired EtOK is more reactive than the dissociated $EtO^-$. Hammett plots for the reactions of 7a-i with the dissociated $EtO^-$ and ion-paired EtOK exhibit excellent linear correlations with ${\rho}_X$ = 3.00 and 2.47, respectively. The reactions have been suggested to proceed through a stepwise mechanism in which departure of the leaving-group occurs after the RDS. The correlation of the $k_{EtOK}/k_{EtO^-}$ ratio with the ${\sigma}_X$ constants exhibits excellent linearity with a slope of -0.53. It is concluded that the ion-paired EtOK catalyzes the reaction by increasing the electrophilicity of the reaction center rather than by enhancing the nucleofugality of the leaving group.