INFLUENCE OF BRADYKININ ON CATECHOLAMINE SECRETION FROM THE ISOLATED PERFUSED RAT ADRENAL GLAND

  • Lim, Dong-Yoon (Department of Pharmacology, College of Medicine, Chosun University) ;
  • Kang, Moo-Jin (Department of Pharmacology, College of Medicine, Chosun University)
  • Published : 2003.04.01

Abstract

Bradykinin modulates the sympathetic system in various ways. It can stimulate sympathetic neurotransmission directly through presynaptic receptors (Llona et al., 1991) and indirectly via its hypotensive or nociceptive effects which activate central and ganglionic mechanisms (Kuo and Keeton, 1991; Dray et al., 1988). However, it has been found that bradykinin can also liberate prostaglandins in peripheral tissues, thereby attenuating the release of catecholamines(Starke et al., 1977). (omitted)

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