Journal of Chest Surgery
- Volume 25 Issue 6
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- Pages.650-660
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- 1992
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- 2765-1606(pISSN)
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- 2765-1614(eISSN)
Endothelin-1 Levels in Patients with Heart Disease Associated with Pulmonary Hypertension ; Potential role of Endothelin-1 in genesis of pulmonary artery vasospasm
개심술 환자에서 술전및 술후의 폐동맥 고혈압및 혈역학적 변수들과 ET-1치와의 관계에 대한 연구
Abstract
To elucidate a potential contribution of endotheline-1[ET-1] to the genesis of pulmonary hypertension and postoperative pulmonary hypertensive crisis in the patients with heart disease, we measured plasma levels of the ET-1 during perioperative period of open heart surgery. In addition, we examined changes of ET-1 during perioperative period and correlations between ET-1 levels and hemodynamic variables. 12 patients including 5 acquired heart disease and 7 congenital heart disease patients were selected randomly as a study group, Group A and B, respectively. 6 patients proved not having heart or hemodynamic problem were selected as a control, Group C. 110 blood samples from pulmonary artery[ET-P] and radial artery[ET-S] were taken and assayed by Sep-pak extraction and RIA. ET-1 levels of Group A were ET-P, 3.94