• The Korean Journal of Physiology and Pharmacology
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• v.8 no.5
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• pp.289-293
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• 2004

To investigate whether VacA (vacuolating toxin) produced by Helicobacter pylori Korean stain 99 induces intestinal secretion, purified VacA was added to T84 cell monolayers mounted in Ussing chambers, and electrical parameters were monitored. Mucosal addition of low pH-pretreated VacA increased short circuit current (Isc). The effect was time- and dose-dependent and saturable. The time-to-peak Isc was concentration-dependent. Chloride channel inhibitors, niflumic acid or 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), inhibited VacA-stimulated Isc. Carbachol (CCh)-induced increase of Isc was prolonged by the addition of VacA to the mucosal side only. The effect was unaltered by the addition of niflumic acid. VacA did not show cytopathic effects. These studies indicate that VacA is a nonlethal toxin that acts in a polar manner on T84 monolayers to potentiate $Cl^-$ secretion and the response to CCh secretion without decrease in monolayer resistance. VacA may contribute to diarrhea diseases in human intestinal epithelial cells.

• 한국태양에너지학회:학술대회논문집
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• 2009.11a
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• pp.86-91
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• 2009

In this paper, we analyze the Transition of Isc by natural solar spectrum of c-Si and a-Si PV module. Commonly, performance of photovoltaic (PV) module is estimated under the standard test condition (STC). That is, solar irradiance $1kW/m^2$, solar spectrum distribution: AM1 5G, module temperature $25^{\circ}C$ This means it rarely meets actual outdoor conditions. The solar spectrum always changes. So it is rare to fit the standard solar spectrum AM1 5G defined in ASTM G173-03 or IEC 60904-3. Thus spectral response of PV module is different depending on the material. so we estimated the variation of Isc at every minutes by comparing c-Si PV module with a-si PV module for outdoor conditions.

• Archives of Pharmacal Research
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• v.19 no.3
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• pp.191-196
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• 1996

Bizelesin is a promising novel anticancer agent which is known to alkylate N3 of adenine to induce DNA interstrand cross-links (ISC) with in $5^I-TAATTA\; and\; 5^I-TAAAAAA$. We have investigated the base specificity for DNA ISC induced by bizelesin using oligomers containing the cross-linkable sequence $5^I-TAATTA\; and\; 5^I-TAAAAAA$. in which "N" was either A, C, G, or T. An analysis of denaturing polyacrylamide gel showed that bizelesin is able to induce DNA ISC in the duplex oligomer containing sequences $5^I-TAATTA\; and\; 5^I-TAAAAAA$. The formation of interstrand crosslinking did not occur in the sequences $5^I-TAATTA\; and\; 5^I-TAAAAAA$. DNA strand cleavage assay to determine the cross-linking site within $5^I-TAATTA$sequence showed that bizelesin alkylates guanine. These results demonstrate that bizelesin is able to induce DNA ISC at guanine but not at cytosine or thymine. In addition, guanine adducts have been found to be susceptible to DNA strand cleavage by exposure to hot piperidine. The extent of DNA strand cleavage, however, was not 100% efficient in either neutral pH buffer or hot piperidine.

• Industrial Engineering and Management Systems
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• v.14 no.2
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• pp.111-121
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• 2015

A correct information of customer returns ratio under e-commerce is not always shared between supply chain (SC) members. Also, it is important issue for SC members to handle the unsold products in a market. This paper discusses the impact of information sharing of customer returns ratio on an optimal sales strategy including resale of customer returns and buyback policy for a SC under e-commerce with a manufacturer and a retailer. A retailer sells a single product and resells the resalable customer returns in the same market. A manufacturer produces the products and buys back the unsold products as to their quality from the retailer. The integrated SC (ISC) determines the optimal product order quantity to maximize the expected profit of the whole SC. The decentralized SC (DSC) makes the optimal decisions for order quantity and the wholesale price of products to maximize the expected profit of each SC member. The effect of information sharing is discussed between SC members under ISC and DSC. The analysis numerically investigates how information sharing of the returns ratio affects the optimal decision and the expected profits under ISC and DSC. Besides, effect of SC coordination to encourage the shift to ISC is discussed.

• Tuberculosis and Respiratory Diseases
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• v.40 no.3
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• pp.236-249
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• 1993

Background: Among the injurious agents to which the lung airspaces are constantly exposed are reactive species of oxygen. It has been widely believed that reactive oxygen species may be implicated in the etiology of lung injuries. In order to elucidated how this oxidant causes lung cell injury, we investigated the effects of exogenous $H_2O_2$ on alveolar epithelial barrier characteristics. Methods: Rat type II alveolar epithelial cells were plated onto tissue culture-treated polycarbonate membrane filters. The resulting confluent monolayers on days 3 and 4 were mounted in a modified Ussing chamber and bathed on both sides with HEPES-buffered Ringer solution. The changes in short-circuit current (Isc) and monolayer resistance (R) in response to the exogenous hydroperoxide were measured. To determine the degree of cellular catalase participation in protection against $H_2O_2$ injury to the barrier, experiments were repeated in the presence of 20 mM aminotriazole (ATAZ, an inhibitor of catalase) in the same bathing fluid as the hydroperoxide. Results: These monolayers have a high transepithelial resistance (>2000 ohm-$cm^2$) and actively transport $Na^+$ from apical fluid. $H_2O_2$(0-100 mM) was then delivered to either apical or basolateral fluid. Resulting indicated that $H_2O_2$ decreased Isc and R gradually in dose-dependent manner. The effective concentration of apical $H_2O_2$ at which Isc (or R) was decreased by 50% at one hour ($ED_{50}$) was about 4 mM. However, basolateral $H_2O_2$ exposure led to $ED_{50}$ for Isc (and R) of about 0.04 mM. Inhibition of cellular catalase yielded $ED_{50}$ for Isc (and R) of about 0.4 mM when $H_2O_2$ was given apically, while $ED_{50}$ for basolateral exposure to $H_2O_2$ did not change in the presence of ATAZ. The rate of $H_2O_2$ consumption in apical and basolateral bathing fluids was the same, while cellualr catalase activity rose gradually with time in culture. Conclusion: Our data suggest that basolateral $H_2O_2$ may affect directly membrane component (e.g., $Na^+,\;K^+$-ATPase) located on the basolateral cell surface. Apical $H_2O_2$, on the other hand, may be largely degraded by catalase as it passes through the cells before reaching these membrane components. We conclude that alveolar epithelial barrier integrity as measured by Isc and R are compromised by $H_2O_2$ being relatively sensitive to basolateral (and insensitive to apical) $H_2O_2$.

• The Proceedings of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.9 no.4
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• pp.93-102
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• 1995

The purpose of this paper is to analyze the streaming electrification mechanism (SEM) generated in UHV transformer. This experiment used Couette Charger and interpreted the mechanism hydromechanically and electromagnetically. This work estimated the turbulent core density ($\rho$o) by measuring the short circuit current (isc) and the open circuit voltage (νoc) generated in Couette Charger and also studied the changes of the short circuit (isc), the open circuit voltage (νoc), the turbulent core density ($\rho$o) and the conductivity ($\sigma$) with adding BTA to restrain streaming electrification. as a result adding BTA increased the conductivity of oil and decreased the turbulent core density($\rho$o).

• Transactions of the Korean Society of Automotive Engineers
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• v.7 no.5
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• pp.66-72
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• 1999

It is necessary to discuss lightening engine parts and reducing the friction of sliding parts to improve fuel consumption and combustion stability at idling condition. Lean best torque combustion which produce maximum power at a lean air-fuel ratio is effective for the reduction of exhaust gas emission and the improvement of fuel consumption. Accordingly, this study deals with the expansion of lean combustible limitation, the combustion stability and the reduction of idle speed through the analysis of combustion characteristics on the base of the control technique of precise air-fuel ratio because it does not need to maximum power at idling condition. The idle speed is increased proportional to ISC(Idle Speed Control) duty ratio. On the other hand the idle speed decreased by lean air-fuel ratio. The COV in engine speed is stable within maximum two percent up to 17.6 mixture ratio by the control of ISC duty ratio.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.247.1-247.1
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• 2003

Iron deficiency is the most common nutritional problem worldwide. Oral iron supplementation programs have failed because of noncompliance and gastrointestinal toxicity. The purpose of this study was to explore the possibility of alginate gel bead as an oral controlled release system of iron supplements and increase the stability of iron succinyl casein (ISC). Alginate beads containing ISC were prepared by the gelation of sodium alginate with calcium cations. The release profiles of ISC were investigated according to the concentration of polymer, the drug/sodium alginate ratio, the concentration and type of cation, curing time and pH of calcium chloride solution. (omitted)

• Journal of the Korean Society for Precision Engineering
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• v.10 no.3
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• pp.125-132
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• 1993

On this study, magnetic force versus input currents is analyzed by modeling taper plunger type proportional electromagnet of ISC valve using the permernce method. And, the reliabiliy of simulation is verified by comparing the experimental values with the calaulate magnetic force. From the result of this study, it is found that the taper angles at plunger and core, the length of air gap between plunger and yoke are the prumary factors in designing taper plunget type proportional electromagnet. Magnetic force is decreased as a whole according to increasing the air gap between pluger and yoke, and vise versa. But, the magnetic force is not proportional to current, when the air gap is very small. In case of decreasing the taper angle of pluger, the stroke range of plunger where magnetic force is proportional to current becomes farther from core.

• 제어로봇시스템학회:학술대회논문집
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• 1996.10b
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• pp.1115-1119
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• 1996

The objective of this paper is to study on the idle speed control sing the fuzzy logic controller under load disturbance. The inputs of the fuzzy controller are error of rpm and rpm variation. The output of fuzzy controller is an ISC motor step. The airflow is controlled by the ISC motor movement and the idle speed is controlled by the airflow control. During the control, air to fuel ratio was checked by LAMBDA sensor. All experiments were carried in real vehicle.