• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3265-3269
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• 2016

Background: Around half of input data in the global burden of disease cancer collaboration (GBD-CC) and GLOBOCAN projects come from low quality sources, mainly from developing countries. This may lead to loss of precision in estimates. Our question was: Are the absolute values and trends of the GBD-CC and GLOBOCAN estimates for lung cancer (LC) in Iran consistent with available statistics?. Materials and Methods: Incidence and mortality statistics were extracted from national reports (N.IRs & N.MRs) and GBD-CC (GBD-incidence & mortality) and GLOBOCAN databases for 1990-2013 where available. Trends were analyzed and absolute values and annual percentage changes (APCs) were estimated and compared. Incompleteness of case ascertainment at the Iranian national cancer registry and Iranian national civil registration was assessed for better understanding. Results: Trends of N.IRs were significantly rising for males (APC: 19.4; 95% CI: 12.5-26.7) and females (23.2; 16.0-30.8). Trends of GBD-incidence were stable for males (-0.2; -1.5-1.1) and females (-1.0; -2.3-0.4). Absolute N.IRs were less than GBD-incidence steadily except for 2009. Trend of N.MRs was increasing up to 2004, but stable thereafter. Trends of GBD-mortality were also stable. Absolute N.MRs were less than GBD-mortality for years up to 2003 and more than GBD-mortality since 2005. The estimates of GLOBOCAN were more than N.IRs and N.MRs. Conclusions: The GBD-CC and GLOBOCAN values for LC in Iran are underestimates. Generation of data quality indices to present along with country specific estimates is highly recommended.

• 생명과학회지
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• 제29권9호
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• pp.964-971
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• 2019

간의 지질 축적과 인슐린 저항성은 비알콜성 지방간 환자에게서 증가한다. Piperine은 후추(Piper nigrum)와 필발(인도산 후추, P. longum)의 주요 성분으로 항암, 항비만, 항 당뇨병, 항염증 및 항산화 등의 생리활성이 보고되었다. 그러나 piperine의 인간 간세포 HepG2 세포에서 지질 축적과 인슐린 저항성의 억제제로서의 연구는 보고된 바가 없다. 본 연구의 목적은 지질 축적 및 인슐린 저항성에 대한 piperine의 효과를 palmitate처리된 HepG2 세포에서 잠재적인 분자 기전을 밝히는 것이다. 그 결과 piperine처리군은 지질 함량을 감소시켰고, 지방 형성 표적 유전자인 SREBP-1c와 FAS의 발현을 억제함으로써 palmitate처리된 세포내 지질 축적을 감소시켰다. 게다가 piperine처리군은 지방산 산화에 관련된 CPT-1과 인산화된 ACC 및 인산화된 IRS-1 (Tyr632)와 Akt의 레벨을 증가시켰다. 또한, piperine처리군은 인산화된 IRS-1 (Ser307)의 레벨을 감소시켰다. 결론적으로 palmitate처리된 HepG2 세포에서 piperine은 SREBP-1와 FAS발현의 감소 및 CPT-1과 ACC 인산화의 증가 및 인산화된 IRS-1(Try632)와 Akt 신호전달 경로를 조절함으로써 지질 축적 및 인슐린 저항성을 개선함을 확인하였다. 따라서 piperine의 지질 축적 및 인슐린 저항성을 예방하는 약물로써 가능성이 제시되었다.

• 한국식품과학회지
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• 제39권6호
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• pp.701-707
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• 2007

민간요법에서 항당뇨 및 항비만 효과가 있는 것으로 알려진 길경의 항당뇨 효과가 있는 지 여부를 in vitro에서 조사하기 위해서 길경을 70% 에탄올로 추출한 후 메탄올과 물을 섞은 용액으로 단계별로 XAD-4 column으로 분획하였다. 본 연구에서는 1) 3T3-L1 섬유아세포와 지방세포에서 길경의 추출 분획물이 인슐린처럼 작용하는 인슐린성 물질이거나, 2) 인슐린 작용을 향상시키는 인슐린 민감성 물질이거나, 또는 3) 포도당 자극에 의한 인슐린 분비를 향상시키거나, 4) 베타세포의 기능과 양을 증가시키는데 관여하는 유전자인 IRS-2, glucokinase, PDX-1의 mRNA 발현을 향상시키거나, 5) $\alpha-glucoamylase$ 활성을 억제하는 물질로 작용하는 지 여부를 조사하였다. 길경 추출 분획물은 인슐린성 물질로 작용하지 않았다. 반면에 0, 20와 100%메탄올층은 3T3-L1 지방세포에서 인슐린 자극에 의한 포도당 흡수를 증가시켰다. 이 분획층 중에서 특히 0%과 100% 메탄올 분획층은 분화 유도물질의 작용을 향상시켜 3T3-L1 섬유아세포에서 지방세포로의 분화 및 중성 지방의 축적을 증가시켰다. 그러므로 이들은 $PPAR-{\gamma}$ agonist로 작용하는 물질을 함유할 가능성이 매우 높다. 인슐린을 분비하는 세포인 Min6 세포에서 포도당 자극에 의한 인슐린 분비를 향상시키는 지 여부를 조사하였는데 20, 80 그리고 100% 메탄올층은 포도당 자극에 의한 인슐린 분비를 증가시켰다. 그 기전은 인슐린 분비와 베타세포의 증식에 관여하는 유전자의 IRS-2, glucokinase 그리고 PDX-1의 mRNA의 양을 증가시키는 것과 관련이 있다. 결론적으로 길경은 지방 세포의 분화를 촉진하는 물질, 인슐린 민감성을 향상시키는 물질 그리고 베타세포의 기능과 증식을 촉진시키는 물질을 함유하고 있으므로 우리나라 및 아시아의 사람들에서 많이 유발되는 비만을 동반하지 않은 당뇨병 및 인슐린 저항성의 치료와 예방에 중요한 역할을 할 것으로 사료된다.

• 대한원격탐사학회지
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• 제14권2호
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• pp.149-164
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• 1998

본 연구에서는 지구자원탐사용 인공위성 화상데이터중에서 공간해상력이 우수한 RS-1C PAN 데이터와 Landsat TM 데이터를 중합(merging)하는데 있어서, 어떤 중합방법이 유효한지를 밝히고자 하였다. 각기 다른 두 화상데이터를 중합하기 위하여 IHS, PCA, HPF, ratio enhanoement 및 LUT방법을 적용하였으며, 이 방법들에 의하여 얻어진 화상들의 평가에 있어서는, 분광반사특성 보존성부분과 공간해상력 부분으로 나누어서 평가하였다. 그 결과 ratio enhancement방법이 분광반사특성의 보존성에 있어서 가장 좋은 결과를 나타내었다. 전체적인 화상의 시각적 판독평가에 있어서는 PCA방법이 다른 방법에 비하여 공간해상력이 우수한 것으로 파악되었으며 다음으로 HPF, ratio enhancement, IHS, LUT방법의 순으로 나타났다.

• 천문학회보
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• 제38권2호
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• pp.65.1-65.1
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• 2013

Our understanding of how brown dwarfs form is limited by observational evidence. We report identification of a L328-IRS as a proto-brown dwarf embedded in an isolated dense molecular core. This source exhibits typical properties of a protostar, however, its luminosity (~0.05 $L{\odot}$) is far below than expected from the least massive protostar by the standard star formation theory. The most likely mass accretion rate (~2.4 10-7 $M{\odot}$ yr-1) inferred from its small bipolar outflow is an order of magnitude less than the canonical value for a protostar. The mass available in its envelope is less than 0.1 $M{\odot}$. These points suggest that L328-IRS will accrete the mass of a brown dwarf, but not that of a star. L328 is found to be fairly well isolated from other nearby clouds and seems to be forming three sub-cores simultaneously through a gravitational fragmentation process. Altogether with these, our direct detection of inward motions in L328 which harbors this proto-brown dwarf clearly supports the idea that a brown dwarf forms like a normal star.

• 대한기계학회논문집A
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• 제31권2호
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• pp.211-220
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• 2007

This work presents an iterated improved reduced system (IIRS) procedure combined with sub-structuring scheme for large structures. Iterated IRS methods are usually more efficient than others because the dynamic condensation matrix is updated repeatedly until the desired convergent values are obtained. However, using these methods simply for large structures causes expensive computational cost and even makes analyses intractable because of the limited computer storage. Therefore, the application of sub-structuring scheme is necessary. Because the large structures are subdivided into several (or more) sub-domains, the construction of dynamic condensation matrix does not require much computation cost in every iteration. This makes the present method much more efficient to compute the eigenpairs both in lower and intermediate modes. In Part I, iterated IRS method combined with sub-structuring scheme for undamped structures is presented. The validation of the proposed method and the evaluation of computational efficiency are demonstrated through the numerical examples.

• 대한기계학회논문집A
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• 제31권2호
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• pp.221-230
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• 2007

An iterated improved reduced system (IIRS) procedure combined with sub-structuring scheme for nonclassically damped structural systems is presented. For dynamic analysis of such systems, complex eigenproperties are required to incorporate properly the nonclassical damping effect. In complex structural systems, the equations of motion are written in the state space from. Thus, the number of degrees of freedom of the new equations of motion and the size of the associated eigenvalue problem required to obtain the complex eigenvalues and eigenvectors are doubled. Iterated IRS method is an efficient reduction technique because the eigenproperties obtained in each iteration step improve the condensation matrix in the next iteration step. However, although this reduction technique reduces the size of problem drastically, it is not efficient to apply this technique to a single domain finite element model with degrees of freedom over several thousands. Therefore, for a practical application of the reduction method, accompanying sub-structuring scheme is necessary. In the present study, iterated IRS method combined with sub-structuring scheme for nonclssically damped structures is developed. Numerical examples demonstrate the convergence and the efficiency of a newly developed scheme.

• 천문학회보
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• 제36권1호
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• pp.83.2-83.2
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• 2011

I present results from the Spitzer/IRS study to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on Spitzer/IRAC colors in the central 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over $5{\mu}m$ to $35{\mu}m$, and identified massive YSOs by the presence of a $15.4{\mu}m$ shoulder on the absorption profile of $15{\mu}m$ $CO_2$ ice, suggestive of high $CH_3OH$ abundance on $CO_2$ ice grains. This $15.4{\mu}m$ shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We further show that 9 massive YSOs reveal molecular gas-phase absorption from $CO_2$, $C_2H_2$, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC.

• 천문학회보
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• 제28권2호
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• pp.87-87
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• 2003

• 동의생리병리학회지
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• 제34권3호
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• pp.136-141
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• 2020

The purpose of this study was to investigate the action mechanism of the roots of Adenophora triphylla var. japonica extract (ATE) in 3T3-L1 adipocytes. Cell toxicity test by MTT assay and lipid accumulation was performed to evaluate the inhibitory effect on the differentiation of adipocyte from preadipocytes induced by MDI differentiation medium, while adipogenesis related proteins expression level were evaluated by western blotting. As a result, ATE inhibited MDI-induced adipocyte differentiation in 3T3-L1 cells dose-dependently without cytotoxicity. Our results showed that ATE inhibited the phosphorylation of IRS1, thereby decreasing the expression of PI3K110α and reducing the phosphorylation of AKT and mTOR, resulting in attenuated protein expression of C/EBPα, PPARγ, ap2 and FAS in 3T3-L1 cells. These results suggest anti-adipogenic functions for ATE, and identified IRS1 as a novel target for ATE in adipogenesis.