• Journal of Microbiology and Biotechnology
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• v.26 no.11
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• pp.1836-1844
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• 2016

Adipogenesis is one of the cellular processes and a highly controlled program. Nowadays, inhibition of adipogenesis has received attention as an effective way to regulate obesity. In the current study, we investigated the inhibition effect of a chloroform extract of Pleurotus eryngii var. ferulae 'Beesan No. 2' (CEBT) on adipogenesis in 3T3-L1 murine preadipocytes. Pleurotus eryngii var. ferulae is one of many varieties of King oyster mushroom and has been reported to have various biological activities, including antitumor and anti-inflammation effects. Biological activities of 'Beesan No. 2', a new cultivar of Pleurotus eryngii var. ferulae, have not yet been reported. In this study, we found that CEBT suppressed adipogenesis in 3T3-L1 cells through inhibition of key adipogenic transcription factors, such as peroxisome proliferatoractivated receptor ${\gamma}$ and CCAAT/enhancer binding protein ${\alpha}$. Additionally, CEBT reduced the expression of the IRS/PI3K/Akt signaling pathway and its downstream factors, including mammalian target of rapamycin and p70S6 kinase, which stimulate adipogenesis. Furthermore, ${\beta}-catenin$, a suppressor of adipogenesis, was increased in CEBT-treated cells. These results indicate that Pleurotus eryngii var. ferulae 'Beesan No. 2' effectively inhibited adipogenesis, so this mushroom has potential as an anti-obesity food and drug.

• Korean Journal of Remote Sensing
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• v.24 no.5
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• pp.483-496
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• 2008

Qualified ground control points (GCPs) are required to construct a digital elevation model (DEM) from a pushbroom stereo pair. An inverse geolocation algorithm for extracting GCPs from ERS SAR data and the SRTM DEM was recently developed. However, not all GCPs established by this method are accurate enough for direct application to the geometric correction of pushbroom images such as SPOT, IRS, etc, and thus a method for selecting and removing inaccurate points from the sets of GCPs is needed. In this study, we propose a method for evaluating GCP accuracy and winnowing sets of GCPs through orientation modeling of pushbroom image and validate performance of this method using SPOT stereo pair of Daejon City. It has been found that the statistical distribution of GCP positional errors is approximately Gaussian without bias, and that the residual errors estimated by orientation modeling have a linear relationship with the positional errors. Inaccurate GCPs have large positional errors and can be iteratively eliminated by thresholding the residual errors. Forty-one GCPs were initially extracted for the test, with mean the positional error values of 25.6m, 2.5m and -6.1m in the X-, Y- and Z-directions, respectively, and standard deviations of 62.4m, 37.6m and 15.0m. Twenty-one GCPs were eliminated by the proposed method, resulting in the standard deviations of the positional errors of the 20 final GCPs being reduced to 13.9m, 8.5m and 7.5m in the X-, Y- and Z-directions, respectively. Orientation modeling of the SPOT stereo pair was performed using the 20 GCPs, and the model was checked against 15 map-based points. The root mean square errors (RMSEs) of the model were 10.4m, 7.1m and 12.1m in X-, Y- and Z-directions, respectively. A SPOT DEM with a 20m ground resolution was successfully constructed using a automatic matching procedure.

• Herbal Formula Science
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• v.27 no.3
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• pp.223-236
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• 2019

Dengropanax morfiferus (D), Broussonitia kazinoki (B), and Cudriania tricuspidata (E), a widely cultivated species in South Korea, has been used as traditional medicine to treat numerous diseases. In this study, we evaluated the antidiabetic effects in a various signaling mechanisms using mixed extract and major component contents were analyzed by HPLC in the combined extracts from Dengropanax morfiferus, Broussonitia kazinoki, and Cudriania tricuspidata (DBCE). DBCE inhibited ${\alpha}$-glucosidase and ${\alpha}$-amylase activation and showed potent antioxidant effects, which are evaluated using DPPH, ABTS, and SOD assay. Cytokines, which are released by inflammatory cells in pancreatic islets, are involved in the pathogenesis of type 1 diabetes mellitus. DBCE showed the protective effects in RINm5F cells against cytokines-induced damage by suppressing inducible nitric oxide (NO) synthase and COX-2 expression and NO production. Insulin resistance is the primary characteristic of type 2 diabetes. Therefore, the regulatory effect of DBCE on glucose uptake and production are investigated in insulin-responsive human HepG2 cells. DBCE stimulated glucose uptake, prevented Glut2 and phosphor-IRS1 downregulation induced by high glucose (HG, 30 mM). Moreover, DBCE pretreatment diminished glucose levels, PEPCK and G6Pase overexpression provoked by HG. These findings suggest that DBCE might be used for diabetes treatment through alpha-glucosidase or alpha-amylase activity regulation, pancreatic beta cell protection, hepatic glucose sensitivity improvement. Cytokines, which are released by inflammatory cells' infiltrations around the pancreatic islets, are involved in the pathogenesis of type 1 diabetes mellitus.

• Agribusiness and Information Management
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• v.8 no.1
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• pp.17-26
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• 2016

India is largest producer of banana in the world producing 29.72 million tonnes from an area of 0.803 million ha with a productivity of 35.7 MT ha-1 and accounted for 15.48 and 27.01 per cent of the world's area and production respectively (www.nhb.gov.in). In India, Tamil Nadu leads other states both in terms of area and production followed by Maharashtra, Gujarat and Andhra Pradesh. In Rayalaseema region of Andhra Pradesh, Kurnool district had special reputation in the cultivation of banana in an area of 5765 hectares with an annual production of 2.01 lakh tonnes in the year 2012-13 and hence, it was purposively chosen for the study. On $23^{rd}$ November 2003, the Government of Andhra Pradesh has commenced a comprehensive project called 'Andhra Pradesh Micro Irrigation Project (APMIP)', first of its kind in the world so as to promote water use efficiency. APMIP is offering 100 per cent of subsidy in case of SC, ST and 90 per cent in case of other categories of farmers up to 5.0 acres of land. In case of acreage between 5-10 acres, 70 per cent subsidy and acreage above 10, 50 per cent of subsidy is given to the farmer beneficiaries. The sampling frame consists of Kurnool district, two mandals, four villages and 180 sample farmers comprising of 60 farmers each from Marginal (<1ha), Small (1-2ha) and Other (>2ha) categories. A well structured pre-tested schedule was employed to collect the requisite information pertaining to the performance of drip irrigation among the sample farmers and Data Envelopment Analysis (DEA) model was employed to analyze the performance of drip irrigation in banana farms. The performance of drip irrigation was assessed based on the parameters like: Land Development Works (LDW), Fertigation costs (FC), Volume of water supplied (VWS), Annual maintenance costs of drip irrigation (AMC), Economic Status of the farmer (ES), Crop Productivity (CP) etc. The first four parameters are considered as inputs and last two as outputs for DEA modelling purposes. The findings revealed that, the number of farms operating at CRS are more in number in other farms (46.66%) followed by marginal (45%) and small farms (28.33%). Similarly, regarding the number of farmers operating at VRS, the other farms are again more in number with 61.66 per cent followed by marginal (53.33%) and small farms (35%). With reference to scale efficiency, marginal farms dominate the scenario with 57 per cent followed by others (55%) and small farms (50%). At pooled level, 26.11 per cent of the farms are being operated at CRS with an average technical efficiency score of 0.6138 i.e., 47 out of 180 farms. Nearly 40 per cent of the farmers at pooled level are being operated at VRS with an average technical efficiency score of 0.7241. As regards to scale efficiency, nearly 52 per cent of the farmers (94 out of 180 farmers) at pooled level, either performed at the optimum scale or were close to the optimum scale (farms having scale efficiency values equal to or more than 0.90). Majority of the farms (39.44%) are operating at IRS and only 29 per cent of the farmers are operating at DRS. This signifies that, more resources should be provided to these farms operating at IRS and the same should be decreased towards the farms operating at DRS. Nearly 32 per cent of the farms are operating at CRS indicating efficient utilization of resources. Log linear regression model was used to analyze the major determinants of input use efficiency in banana farms. The input variables considered under DEA model were again considered as influential factors for the CRS obtained for the three categories of farmers. Volume of water supplied ($X_1$) and fertigation cost ($X_2$) are the major determinants of banana farms across all the farmer categories and even at pooled level. In view of their positive influence on the CRS, it is essential to strengthen modern irrigation infrastructure like drip irrigation and offer more fertilizer subsidies to the farmer to enhance the crop production on cost-effective basis in Kurnool district of Andhra Pradesh, India. This study further suggests that, the present era of Information Technology will help the irrigation management in the context of generating new techniques, extension, adoption and information. It will also guide the farmers in irrigation scheduling and quantifying the irrigation water requirements in accordance with the water availability in a particular season. So, it is high time for the Government of India to pay adequate attention towards the applications of 'Information and Communication Technology (ICT) and its applications in irrigation water management' for facilitating the deployment of Decision Supports Systems (DSSs) at various levels of planning and management of water resources in the country.

• The Plant Pathology Journal
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• v.24 no.1
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• pp.46-51
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• 2008

With the goal of achieving better integrated pest management for hot pepper, a disease-forecasting system was compared to a conventional disease-control method. Experimental field plots were established at Asan, Chungnam, in 2005 to 2006, and hourly temperature and leaf wetness were measured and used as model inputs. One treatment group received applications of a protective fungicide, dithianon, every 7 days, whereas another received a curative fungicide, dimethomorph, when the model-determined infection risk (IR) exceeded a value of 3. In the unsprayed plot, fruits showed 18.9% (2005) and 14.0% (2006) anthracnose infection. Fruits sprayed with dithianon at 7-day intervals had 4.7% (2005) and 15.4% (2006) infection. The receiving model-advised sprays of dimethomorph had 9.4% (2005) and 10.9% (2006) anthracnose infection. Differences in the anthracnose levels between the conventional and model-advised treatments were not statistically significant. The efficacy of 10 (2005) and 8 (2006) applications of calendar-based sprays was same as that of three (2005 and 2006) sprays based on the disease-forecast system. In addition, we found much higher the IRs with the leaf wetness sensor from the field plots comparing without leaf wetness sensor from the weather station at Asan within 10km away. Since the wetness-periods were critical to forecast anthracnose in the model, the measurement of wetness-period in commercial fields must be refined to improve the anthracnose-forecast model.

• Proceedings of the Korea Contents Association Conference
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• 2013.05a
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• pp.383-384
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• 2013

본 연구는 스포츠용 탄력 압박 스타킹(Essential compression calf sleeve, SKINS, Australia)을 착용하고 최대 운동을 하였을 때, 하지 부종에 어떠한 효과가 있는지를 알아보고자 한다. 실험 대상자는 젊은 성인 남녀 30명으로(남자 15명, 여자15명) 근 골격계 및 심혈관계에 특이 병력이나 사고에 의한 외상 등이 없었으며, 규칙적으로 운동을 하는 자는 제외하였다. 대상자들의 신체적 특성을 파악하기 위해서 자동 신장계(BSM330, Biospace, Korea)를 사용하였다. 부종정도를 알기위해서 줄자로 운동 전후의 장딴지 근(종아리)의 둘레와 체성분 분석기(InBody 720, Biospace, Korea)를 사용하여 하지의 부종 수치를 측정하였다. 최대의 운동은 호흡가스 분석기와 연결된 트레이드밀(CPEX-1, IRS, Japan)을 사용하여 변형된 BRUCE Protocol TR-3에 따라 호흡 교환율(R) 값이 1.15이상 되거나 all-out 될 때까지 하였다. 실험 대상자들은 동일 집단으로 전이효과를 방지하기 위하여 일주일의 간격을 두고 스포츠 탄력 압박 스타킹 착용 유무에 따른 동일한 실험을 두 번 하였다. 측정은 최대 운동 전후의 장딴지 근(종아리)의 둘레와 부종 수치를 하였다. 스포츠용 탄력 압박 스타킹 착용 유무와 운동 전후를 비교하기 위하여 MANOVA(다변량 분산분석)를 사용하였고 유의수준은 .05로 설정하였다. 탄력 압박 스타킹을 착용한 상태에서 최대 운동 전후의 부종 정도를 측정한 결과 스타킹을 착용하지 않았을 때 운동 전후의 둘레가 유의하게 증가하였고(p<0.05), 스타킹을 착용 하였을 때 운동 전후의 둘레가 유의하게 증가하지 않았다(p>0.05). 부종 수치(세포외액/전체체액)는 탄력 압박 스타킹을 착용하였을 때 오른쪽 다리는 유의하지 않게 감소하였고(p>0.05), 왼쪽 다리는 유의하게 감소하였다(p>0.05). 탄력 압박 스타킹을 착용하고 운동할 경우 하지의 부종 경감에 어느 정도 효과가 있다고 사료된다.

• Journal of Sasang Constitutional Medicine
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• v.17 no.2
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• pp.15-26
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• 2005

1. Objectives The pesent study purposed to examine Dongmu Lee Je-Ma's Sasang philosophy from the viewpoint of Che-Yong relation and to understand the effect of Che-Yong relation on Dongmu philosophy. 2. Methods First, we briefly compared the concept of Che-Yong relation in Jeongju philosophy, which has a dualistic philosophical structure, with the concept of Han Suk-Ji's harmonious Che-Yong relation, which has a monistic philosophical struaure and, based on rhe result, analyzed the characteristics of rhe concept of Che-Yong in Dongmu philosophy focused on Seongmyeong rheory, Sadan rheory and Hwakchung theory in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$. 3 Results and Conclusions Jeongju philosophy is different from Dongmu philosophy in irs philosophical struaure characterized by Che-Yong relation, and the concept of Che-Yong in Dongmu philosophy forms the characteristics of Han Suk-ji's monistic harmonious Ole- Y ong relation. This produces results as follows. (1) Form a universal view of human beings centering of man's autonomous will and possibility. (2) Have a philosophical structure understood nor as a partial thought but as a total thought. (3) Assert that man has a good nature fundamentally and is obliged to practice goodness. (4) Assume that all human beings are equal. (5) It is assumed that the structural characteristics of harmonious Che-Yong relation in Dongmu philosophy can be the ground of definition of Silhak (practical science) in Oriental philosophy. It can be said that the realities of the universe and human beings can be discussed in philosophical structure with the logic of harmonious Che-Yong relation based on the unity of time and space. The philosophical logic based on the tealities can be defined as Silhak.

• Journal of Korea Port Economic Association
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• v.26 no.4
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• pp.188-206
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• 2010

Data Envelopment Analysis(DEA) is an operations research-based method for measuring the performance efficiency of decision units that are characterized by multiple inputs and outputs. DEA has been applied successfully as a performance evaluation tool in many fields. However, it has not been extensively applied in the shipbuilding industry. This paper applied the input-oriented DEA model, and Malmquist indices to the 7 shipbuilding firms to measure the efficiency and productivity changes during the period of 2004 to 2009. The Malmquist indices will be decomposed into three components such as pure efficiency change, scale efficiency change, and technical change. The empirical results show the following findings. First, the DEA findings indicate that main source of inefficiency is scale rather than pure technical. Second, the Malmquist indices show that an overall decrease in productivity.

• Journal of Life Science
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• v.29 no.5
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• pp.570-579
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• 2019

Diabetes is one of the serious chronic metabolic diseases caused by Westernized eating habits, and the goal of diabetes treatment is to keep blood glucose at a normal level and prevent diabetic complications. This study was designed to investigate the anti-diabetic effects of a mealworm (Tenebrio molitor larva) extract (MWE) on hyperglycemia in an animal model with type 2 diabetes. Diabetic C57BL/Ksj-db/db mice were divided into three groups: diabetic control, rosiglitazone, and MWE. The mice supplemented with MWE showed significantly lower blood levels of glucose and glycosylated hemoglobin when compared with the diabetic control mice. The homeostatic index of insulin resistance was significantly lower in mice supplemented with MWE than in diabetic control mice. MWE supplementation significantly stimulated the phosphorylation of insulin receptor substrate-1 and Akt, and activation of phosphatidylinositol 3-kinase in insulin signaling pathway of skeletal muscles. Eventually, MWE increased the expression of the plasma membrane glucose transporter 4 (GLUT4) via PI3K/Akt activation. These findings demonstrate that the increase in plasma membrane GLUT4 expression by MWE promoted the uptake of blood glucose into cells and relieved hyperglycemia in skeletal muscles of diabetic C57BL/Ksj-db/db mice. Therefore, mealworms are expected to prove useful for the prevention and treatment of diabetes, and further studies are needed to improve type 2 diabetes in the future.

• Journal of KIISE:Databases
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• v.27 no.1
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• pp.22-32
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• 2000

The Digital Library is the integrated system of Information Retrieval System(IRS) and Database Management system(DBMS). In the Digital Library environment where dynamic query and update processes are required, however, the existing transaction management methods cause the following problems. First, since the traditional consistency criteria is too restrictive, it causes increment of query processing time and cannot guarantee the reflection of recency. Second, query result could be unreliable because the consistency criteria between source data and metadata is not defined. This paper models the access to metadata based on Dublin Core as query transactions and update transactions, and gives the efficient method to manage them. Particularly, this paper describes the consistency criteria of metadata which takes it Into consideration the consistency between the result of query transaction and status of source data in the Digital Library, that is different from the consistency criteria in traditional transaction management. It also presents analysis of the view point of query transaction to reflect recency and proposes metadata management to guarantee recency within metadata consistency.